Disease on EC 4.2.2.8 - heparin-sulfate lyase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Sialoglycopeptides obtained from a transplantable rat colorectal adenocarcinoma: a comparison with those from normal colonic mucosa.
Albuminuria
Removal of heparan sulfate from the glomerular basement membrane blocks protein passage.
Alzheimer Disease
Characterization of proteoglycans in Alzheimer's disease fibroblasts.
Arthritis
FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
Atherosclerosis
CD143 in the development of atherosclerosis.
Bone Resorption
J774A.1 macrophage cell line produces PDGF-like and non-PDGF-like growth factors for bone cells.
Carcinoma
Ovarian carcinoma cells synthesize both chondroitin sulfate and heparan sulfate cell surface proteoglycans that mediate cell adhesion to interstitial matrix.
VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.
Carcinoma, Hepatocellular
Degradative removal of heparan sulfate from the surface of an ascites hepatoma, AH 66, by heparitinase.
Dengue
Internalization and propagation of the dengue virus in human hepatoma (HepG2) cells.
Productive dengue virus infection of human endothelial cells is directed by heparan sulfate-containing proteoglycan receptors.
Diabetes Mellitus, Type 1
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes.
Focal Nodular Hyperplasia
[Expression of CD143 and its significance in focal nodular hyperplasia of liver]
Glaucoma
Flicker defined form perimetry in glaucoma suspects with normal achromatic visual fields.
Hypoglycemia
Hypoglycemia, S-ACE and ACE genotypes in a Danish nationwide population of children and adolescents with type 1 diabetes.
Infection
Cell membrane bound N-acetylneuraminic acid is involved in the infection of fibroblasts and phorbol-ester differentiated monocyte-like cells with human cytomegalovirus (HCMV).
Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes.
Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines.
Cellular invasion of Orientia tsutsugamushi requires initial interaction with cell surface heparan sulfate.
Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.
Heparin-mediated inhibition of Chlamydia psittaci adherence to HeLa cells.
Membrane-associated heparan sulfate is not required for rAAV-2 infection of human respiratory epithelia.
Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors.
Primary attachment of murine leukaemia virus vector mediated by particle-associated heparan sulfate proteoglycan.
Proteoglycans act as cellular hepatitis delta virus attachment receptors.
Role of cell surface glycosaminoglycans of human T cells in human immunodeficiency virus type-1 (HIV-1) infection.
Role of heparan sulfate in attachment to and infection of the murine female genital tract by human papillomavirus.
Shielding of a lipooligosaccharide IgM epitope allows evasion of neutrophil-mediated killing of an invasive strain of nontypeable Haemophilus influenzae.
The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding.
Lymphocytosis
Value of s-ACE, BAL lymphocytosis, and CD4+/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis.
Lymphoma
Activation of platelet heparitinase by tumor cell-derived factors.
Measles
Analysis of the molecules involved in human T-cell leukaemia virus type 1 entry by a vesicular stomatitis virus pseudotype bearing its envelope glycoproteins.
Melanoma
A synthetic peptide from the heparin-binding domain III (repeats III4-5) of fibronectin promotes stress-fibre and focal-adhesion formation in melanoma cells.
Activation of platelet heparitinase by vascular cell lysates.
Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide.
Glycosaminoglycans of cultured human fetal uveal melanocytes and comparison with those produced by cultured human melanoma cells.
Neoplasm Metastasis
Activation of platelet heparitinase by tumor cell-derived factors.
Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
Partial sequence of human platelet heparitinase and evidence of its ability to polymerize.
Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis.
Neoplasms
Activation of platelet heparitinase by tumor cell-derived factors.
Activation of platelet heparitinase by vascular cell lysates.
Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycans.
Expression of N-CAM by human renal cell carcinomas correlates with growth rate and adhesive properties.
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.
Interference with tumor cell-induced degradation of endothelial matrix on the antimetastatic action of nafazatrom.
Partial characterization of proteoglycans synthesized by human glomerular epithelial cells in culture.
Partial sequence of human platelet heparitinase and evidence of its ability to polymerize.
Platelet-tumor cell interaction with the subendothelial extracellular matrix: relationship to cancer metastasis.
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.
[CD143 expression in testicular germ cell tumors]
Neoplasms, Germ Cell and Embryonal
[CD143 expression in testicular germ cell tumors]
Neuroblastoma
A cell-surface heparan sulfate proteoglycan mediates neural cell adhesion and spreading on a defined sequence from the C-terminal cell and heparin binding domain of fibronectin, FN-C/H II.
Ovarian Neoplasms
[Hypoxia increases the expression of heparitinase and the invasiveness through the hypoxia inducible factor-1alpha dependent pathway in human ovarian cancer cell line SKOV3]
Pneumonia
Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk: A Meta Analysis.
Psoriasis
Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis.
Reperfusion Injury
Heparinase III exerts endothelial and cardioprotective effects in feline myocardial ischemia-reperfusion injury.
Sarcoidosis
Value of s-ACE, BAL lymphocytosis, and CD4+/CD8+ and CD103+CD4+/CD4+ T-cell ratios in diagnosis of sarcoidosis.
Scleroderma, Diffuse
Compositional changes of urinary acidic glycosaminoglycans in progressive systemic sclerosis.
Sepsis
Increased susceptibility of sepsis associated with CD143 deletion/insertion polymorphism in Caucasians: a meta analysis.
Stomach Neoplasms
The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer.
Thrombasthenia
Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor.
Trachoma
Chlamydia trachomatis glycosaminoglycan-dependent and independent attachment to eukaryotic cells.