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Disease on EC 4.2.2.20 - chondroitin-sulfate-ABC endolyase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries.
Adenocarcinoma
Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth.
Sialoglycopeptides obtained from a transplantable rat colorectal adenocarcinoma: a comparison with those from normal colonic mucosa.
Alzheimer Disease
Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice.
The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.
Anaphylaxis
Chemonucleolysis with calpain I in rabbits.
Arteriovenous Malformations
Chondroitinase ABC for neurological recovery after acute brain injury: systematic review and meta-analyses of preclinical studies.
Aspartylglucosaminuria
Abnormal dermal proteoglycan in aspartylglycosaminuria: a possible mechanism for ultrastructural changes of collagen fibrils in a glycoprotein storage disorder.
Brain Contusion
Chondroitinase ABC Enhances Pericontusion Axonal Sprouting But Does Not Confer Robust Improvements in Behavioral Recovery.
Brain Edema
Chondroitinase ABC reduces brain tissue swelling in vitro.
Intracerebroventricular administration of chondroitinase ABC reduces acute edema after traumatic brain injury in mice.
Brain Injuries
Chondroitinase ABC for neurological recovery after acute brain injury: systematic review and meta-analyses of preclinical studies.
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats.
Reduction of brain injury in neonatal hypoxic-ischemic rats by intracerebroventricular injection of neural stem/progenitor cells together with chondroitinase ABC.
Brain Injuries, Traumatic
Chondroitinase ABC for neurological recovery after acute brain injury: systematic review and meta-analyses of preclinical studies.
Intracerebroventricular administration of chondroitinase ABC reduces acute edema after traumatic brain injury in mice.
Brain Ischemia
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Carcinoma
Ovarian carcinoma cells synthesize both chondroitin sulfate and heparan sulfate cell surface proteoglycans that mediate cell adhesion to interstitial matrix.
Carcinoma, Hepatocellular
Altered glycosaminoglycan composition in reactive and neoplastic human liver.
Cerebral Infarction
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats.
Cholera
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury.
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury.
Chondrosarcoma
An unsulphated region of the rat chondrosarcoma chondroitin sulphate chain and its binding to monoclonal antibody 3B3.
Biosynthesis of hyaluronic acid in cultures of chondrocytes from the Swarm rat chondrosarcoma.
Isolation and characterization of proteoglycans from the swarm rat chondrosarcoma.
Mercuric salt-catalyzed removal of unsaturated glucuronic acid from chondroitinase-treated proteochondroitin sulfate.
Monoclonal antibodies directed against epitopes within the core protein structure of the large aggregating proteoglycan (aggrecan) from the swarm rat chondrosarcoma.
Occurrence of the HNK-1 epitope (3-sulfoglucuronic acid) in PC12 pheochromocytoma cells, chromaffin granule membranes, and chondroitin sulfate proteoglycans.
Structural studies on sulfated glycopeptides from the carbohydrate-protein linkage region of chondroitin 4-sulfate proteoglycans of swarm rat chondrosarcoma. Demonstration of the structure Gal(4-O-sulfate)beta 1-3Gal beta 1-4XYL beta 1-O-Ser.
Contracture
Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Comparison of the regeneration induced by acellular nerve allografts processed with or without chondroitinase in a rat model.
Costello Syndrome
Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein.
Cystic Fibrosis
Effect of chondroitinase ABC on purulent sputum from cystic fibrosis and other patients.
Demyelinating Diseases
Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles.
Dental Plaque
Bacterial chondroitinase ABC and hyaluronidase in human dental plaque and inflamed gingiva.
Dupuytren Contracture
Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Glaucoma
Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma.
Glaucoma, Open-Angle
[An ultrahistochemical study of the trabecular meshwork in normal and open-angle glaucomatous eyes]
Glioblastoma
Humanized chondroitinase ABC sensitizes glioblastoma cells to temozolomide.
Glioma
Choindroitinase ABC I-mediated enhancement of oncolytic virus spread and anti tumor efficacy: a mathematical model.
Immunohistochemical localization of glycosaminoglycans in experimental rat glioma models.
Hyperalgesia
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.
Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury.
Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.
The effect of chondroitinase ABC and photobiomodulation therapy on neuropathic pain after spinal cord injury in adult male rats.
Hypertension
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats.
Infarction, Middle Cerebral Artery
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats.
Infections
Cellular invasion of Orientia tsutsugamushi requires initial interaction with cell surface heparan sulfate.
Infertility, Male
[A histochemical study on the testes from patients with idiopathic male infertility: identification of acidic glycoconjugates in the seminiferous tubular walls]
Intervertebral Disc Degeneration
An in vivo model of degenerative disc disease.
An in vivo model of reduced nucleus pulposus glycosaminoglycan content in the rat lumbar intervertebral disc.
Effects of chondroitinase ABC on degenerative intervertebral discs.
Experimental intervertebral disc degeneration induced by chondroitinase ABC in the goat.
Inflammatory cytokine and catabolic enzyme expression in a goat model of intervertebral disc degeneration.
Molecular changes in the degenerated goat intervertebral disc.
Intervertebral Disc Displacement
Treatment of canine intervertebral disc displacement with chondroitinase ABC.
Ischemic Stroke
Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats.
Keloid
Chondroitinase injection improves keloid pathology by reorganizing the extracellular matrix with regenerated elastic fibers.
Leukemia
Characterization of glycosaminoglycans associated with Rauscher murine leukemia virions.
Mastocytoma
Isolation and characterization of heparin from human mastocytoma tissue.
Melanoma
Characterization of monoclonal antibody 155.8 and partial characterization of its proteoglycan antigen on human melanoma cells.
Mucopolysaccharidoses
Liquid-chromatographic determination of urinary glycosaminoglycans for differential diagnosis of genetic mucopolysaccharidoses.
Molecular size difference of urinary heparan sulfates from normal individuals and genetic mucopolysaccharidoses.
Mucopolysaccharidosis II
Chemical structure of urinary dermatan sulfate excreted by a patient with the Hunter syndrome.
Mucopolysaccharidosis IV
Direct quantitation of glycosaminoglycans in 2 mL of urine from patients with mucopolysaccharidoses.
Multiple Sclerosis
Enhancing myelin repair in experimental model of multiple sclerosis using immobilized chondroitinase ABC I on porous silicon nanoparticles.
Neoplasm Metastasis
Elimination of breast tumor-associated chondroitin sulfate promotes metastasis.
Neoplasms
An Inflammatory Nucleus Pulposus Tissue Culture Model to Test Molecular Regenerative Therapies: Validation with Epigallocatechin 3-Gallate.
Anomalous structure of urinary chondroitin sulfate from cancer patients. A potential new marker for diagnosis of neoplasias.
Changes in glycosaminoglycan characteristics during progression of a human gingival carcinoma xenograft line in nude mice.
Elimination of breast tumor-associated chondroitin sulfate promotes metastasis.
[Histochemical studies of bladder tumors]
Neuralgia
The effect of chondroitinase ABC and photobiomodulation therapy on neuropathic pain after spinal cord injury in adult male rats.
Ocular Hypertension
Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma.
Paralysis
Oxygen transport kinetics underpin rapid and robust diaphragm recovery following chronic spinal cord injury.
Rapid and robust restoration of breathing long after spinal cord injury.
Parkinson Disease
Chondroitinase ABC reduces dopaminergic nigral cell death and striatal terminal loss in a 6-hydroxydopamine partial lesion mouse model of Parkinson's disease.
Peripheral Nerve Injuries
Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways.
Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury.
Pulmonary Fibrosis
Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis.
Retinal Degeneration
Chondroitinase ABC treatment enhances synaptogenesis between transplant and host neurons in model of retinal degeneration.
Seizures
AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets.
Perineuronal net degradation in epilepsy.
Spinal Cord Compression
IT Delivery of ChABC Modulates NG2 and Promotes GAP-43 Axonal Regrowth After Spinal Cord Injury.
Spinal Cord Injuries
A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury.
A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.
Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity.
Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel.
Antisense vimentin cDNA combined with chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury in rats.
Antisense vimentin cDNA combined with chondroitinase ABC reduces glial scar and cystic cavity formation following spinal cord injury in rats.
Arylsulfatase B improves locomotor function after mouse spinal cord injury.
Astrocytic and Vascular Remodeling in the Injured Adult Rat Spinal Cord after Chondroitinase ABC Treatment.
Axonal regeneration induced by blockade of glial inhibitors coupled with activation of intrinsic neuronal growth pathways.
Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC.
Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat.
Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury.
Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury.
Chondroitinase ABC enhances axonal regrowth through Schwann cell-seeded guidance channels after spinal cord injury.
Chondroitinase ABC Enzyme: A Potential Treatment Option for Spinal Cord Injury.
Chondroitinase ABC plus bone marrow mesenchymal stem cells for repair of spinal cord injury.
Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury.
Chondroitinase ABC promotes axonal regeneration of Clarke's neurons after spinal cord injury.
Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice.
Chondroitinase ABC promotes functional recovery after spinal cord injury.
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection.
Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.
Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo.
Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury.
Chondroitinase gene therapy improves upper limb function following cervical contusion injury.
Chondrotinase ABC I thermal stability is enhanced by site-directed mutagenesis: a molecular dynamic simulations approach.
Co-solvent mediated thermal stabilization of chondroitinase ABC I form Proteus vulgaris.
Combination of chondroitinase ABC, glial cell line-derived neurotrophic factor and Nogo A antibody delayed-release microspheres promotes the functional recovery of spinal cord injury.
Combination treatment with anti-Nogo-A and chondroitinase ABC is more effective than single treatments at enhancing functional recovery after spinal cord injury.
Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury.
Combine effect of Chondroitinase ABC and low level laser (660nm) on spinal cord injury model in adult male rats.
Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal cord injury.
Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.
Comparison of human adipose-derived stem cells and chondroitinase ABC transplantation on locomotor recovery in the contusion model of spinal cord injury in rats.
Delayed applications of L1 and chondroitinase ABC promote recovery after spinal cord injury.
Delayed treatment with chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injury.
Designing and construction of novel variants of Chondroitinase ABC I to reduce aggregation rate.
Effect of chondroitinase ABC on inflammatory and oxidative response following spinal cord injury.
Effect of combined chondroitinase ABC and hyperbaric oxygen therapy in a rat model of spinal cord injury.
Effect of the combination of mesenchymal stromal cells and chondroitinase ABC on chronic spinal cord injury.
Efficient secretion of biologically active Chondroitinase ABC from mammalian cells in the absence of an N-terminal signal peptide.
Examination of chondroitinase ABC I immobilization onto dextran-coated Fe3O4 nanoparticles and its in-vitro release.
Examination of the combined effects of chondroitinase ABC, growth factors and locomotor training following compressive spinal cord injury on neuroanatomical plasticity and kinematics.
Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury.
Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury.
Impact of local injection of brain-derived neurotrophic factor-expressing mesenchymal stromal cells (MSCs) combined with intravenous MSC delivery in a canine model of chronic spinal cord injury.
Improving the Stability of Chondroitinase ABC I via Interaction with Gold Nanorods.
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3.
Injured mice at the gym: Review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury.
Insulin with chondroitinase ABC treats the rat model of acute spinal cord injury.
IT Delivery of ChABC Modulates NG2 and Promotes GAP-43 Axonal Regrowth After Spinal Cord Injury.
Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons.
Lentivirus-mediated transfection of chondroitinase ABC gene without the bacterial leader sequence enables long-term secretion of functional chondroitinase ABC in human bone marrow stromal cells.
Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury.
Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection.
Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury.
Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury.
Perineuronal net, CSPG receptor and their regulation of neural plasticity.
Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice.
Recent advances in the therapeutic uses of chondroitinase ABC.
Regulation of IL-10 by chondroitinase ABC promotes a distinct immune response following spinal cord injury.
Secretion of bacterial chondroitinase ABC from bone marrow stromal cells by glycosylation site mutation: a promising approach for axon regeneration.
Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries.
Sialidase, chondroitinase ABC and combination therapy after spinal cord contusion injury.
Strategies for neurotrophin-3 and chondroitinase ABC release from freeze-cast chitosan-alginate nerve-guidance scaffolds.
Sustained delivery of chondroitinase ABC by poly(propylene carbonate)-chitosan micron fibers promotes axon regeneration and functional recovery after spinal cord hemisection.
Sustained Delivery of Chondroitinase ABC from Hydrogel System.
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury.
Sustained release of neurotrophin-3 and chondroitinase ABC from electrospun collagen nanofiber scaffold for spinal cord injury repair.
Targeting chondroitinase ABC to axons enhances the ability of chondroitinase to promote neurite outgrowth and sprouting.
The combination of db-cAMP and ChABC with poly(propylene carbonate) microfibers promote axonal regenerative sprouting and functional recovery after spinal cord hemisection injury.
The combined application of human adipose derived stem cells and Chondroitinase ABC in treatment of a spinal cord injury model.
The effect of chondroitinase ABC and photobiomodulation therapy on neuropathic pain after spinal cord injury in adult male rats.
The effects of combining chondroitinase ABC and NEP1-40 on the corticospinal axon growth in organotypic co-cultures.
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury.
The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.
The incorporation of growth factor and chondroitinase ABC into an electrospun scaffold to promote axon regrowth following spinal cord injury.
The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes.
The transplantation of human urine stem cells combined with chondroitinase ABC promotes brain-derived neurotrophic factor and nerve growth factor following spinal cord injury in rats.
The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury.
Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury.
Therapeutic time window for the application of chondroitinase ABC after spinal cord injury.
Transplantation and repair: Combined cell implantation and chondroitinase delivery prevents deterioration of bladder function in rats with complete spinal cord injury.
Transplantation of canine olfactory ensheathing cells producing chondroitinase ABC promotes chondroitin sulphate proteoglycan digestion and axonal sprouting following spinal cord injury.
[Effect of chondroitinase abc on axonal myelination and glial scar after spinal cord injury in rats].
[Effect of chondroitinase ABC on growth associate protein 43 and glial fibrilary acidic protein after spinal cord injury in rats].
[Effects of human urine-derived stem cells combined with chondroitinase ABC on the expressions of nerve growth factor and brain-derived neurotrophic factor in the spinal cord injury].
[Effets of chondroitinase abc combined with bone marrow mesenchymal stem cells transplantation on repair of spinal cord injury in rats].
[Inhibitory effect of chondroitinase ABC on ephrin A4 expression after spinal cord injury in rats].
[Repair of subacute spinal cord crush injury by bone marrow stromal cell transplantation and chondroitinase ABC microinjection in adult rats.]
[Study on repair of subcute spinal cord injury by transplantation of olfactory ensheathing cells combined with chondroitinase ABC in adult rats]
[TRANSPLANTATION OF NEURAL STEM CELLS INDUCED BY ALL-TRANS- RETINOIC ACID COMBINED WITH GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR AND CHONDROITINASE ABC FOR REPAIRING SPINAL CORD INJURY OF RATS].
Stroke
Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice.
Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats.
Enhancing Spinal Plasticity Amplifies the Benefits of Rehabilitative Training and Improves Recovery from Stroke.
Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats.
Neuroprotective effect of chondroitinase ABC on primary and secondary brain injury after stroke in hypertensive rats.
Perilesional Treatment with Chondroitinase ABC and Motor Training Promote Functional Recovery After Stroke in Rats.
The effect of glycosaminoglycan depletion on the friction and deformation of articular cartilage.
Thinking outside the brain: Structural plasticity in the spinal cord promotes recovery from cortical stroke.
Subarachnoid Hemorrhage
Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection.
Tauopathies
Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology.
The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease.
Trauma, Nervous System
Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion site.
Vitreous Detachment
[Posterior vitreous detachment induced by intravitreal injection of the combination of chondroitinase ABC and matrix metalloproteinase-3.]