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Information on EC 4.2.1.79 - 2-methylcitrate dehydratase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC4.2.1.79

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IUBMB Comments

The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate . The enzyme can also use cis-aconitate as a substrate but more slowly . Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate .

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
2-methylcitrate dehydratase, methylcitrate dehydratase, seprpd, 2-mc dehydratase, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-Methylcitrate hydro-lyase
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-
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Dehydratase, 2-methylcitrate
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination of H2O
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-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
2-methylcitrate cycle I
SYSTEMATIC NAME
IUBMB Comments
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]
The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2].
CAS REGISTRY NUMBER
COMMENTARY hide
80891-26-5
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A0C6F962_PSEAI
494
0
54852
TrEMBL
-
A0A2C9X0N1_PSEAI
494
0
54881
TrEMBL
-
A0A367M6T3_PSEAI
494
0
54866
TrEMBL
-
A0A5D4V4V9_PSEAI
494
0
54882
TrEMBL
-
A0A5E5QZ41_PSEAI
494
0
54896
TrEMBL
-
A0A643IXD1_PSEAI
494
0
54896
TrEMBL
-
A0A7M2ZX50_PSEAI
494
0
54882
TrEMBL
other Location (Reliability: 2)
A0AAQ3LJK2_PSEAI
494
0
54865
TrEMBL
-
A0ABD7JYL6_PSEAI
494
0
54835
TrEMBL
Secretory Pathway (Reliability: 2)