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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
3-Hydroxy-3-isohexenylglutaryl-CoA-hydrolase,
AtuE , Beta-isohexenylglutaconyl-CoA-hydratase, Hydratase, isohexenylglutaconyl coenzyme A, isohexenyl glutaconyl coenzyme A hydratase, Isohexenyl-glutaconyl-CoA-hydratase, Isohexenylglutaconyl CoA hydratase, Isohexenylglutaconyl coenzyme A hydratase,
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3-Hydroxy-3-isohexenylglutaryl-CoA-hydrolase
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Beta-isohexenylglutaconyl-CoA-hydratase
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Hydratase, isohexenylglutaconyl coenzyme A
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isohexenyl glutaconyl coenzyme A hydratase
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Isohexenyl-glutaconyl-CoA-hydratase
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Isohexenylglutaconyl CoA hydratase
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Isohexenylglutaconyl coenzyme A hydratase
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3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
mechanism
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3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
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addition
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of H2O, hydration
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3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
additional information
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
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no literature for reverse raction i.e elimination
hydroxyisohexenylglutaryl-CoA + H2O
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
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isohexenylglutaconyl-CoA
hydroxyisohexenylglutaryl-CoA + H2O
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additional information
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specifity for CoA-derivatives of beta-substituted, alpha, beta-unsaturated dicarbonic acids formed by carboxylation of dimetylacryl-, geranyl- and farnesyl-CoA
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additional information
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involved in the isoprenoid degradation pathway
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additional information
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dicarbonic-acid-CoA-derivatives (alpha,beta-unsaturated, beta-substituted, formed by carboxylation of dimethylacryl-, geranyl- and farnesyl-CoA)
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additional information
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additional information
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involved in the isoprenoid degradation pathway
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additional information
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dicarbonic-acid-CoA-derivatives (alpha,beta-unsaturated, beta-substituted, formed by carboxylation of dimethylacryl-, geranyl- and farnesyl-CoA)
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Mg2+
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added in enzyme assay
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UniProt
brenda
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brenda
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metabolism
the enzyme is involved in the acyclic terpene utilization pathway
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A0A3G7TSL3_9PSED
267
0
28125
TrEMBL
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K7A1Z5_9ALTE
270
0
28923
TrEMBL
-
K6Z4K5_9ALTE
270
0
29354
TrEMBL
-
A0A6I8LK75_9PSEU
285
0
30710
TrEMBL
-
A0A3G8D9A4_9PSED
255
0
26878
TrEMBL
-
U2WTR7_9PROT
395
0
43869
TrEMBL
-
A4ABE7_9GAMM
278
0
29579
TrEMBL
-
A0A3G7C713_9PSED
278
0
29286
TrEMBL
-
A0A3G7NN89_9PSED
265
0
27861
TrEMBL
-
A0A6J4XGA3_9DELT
256
0
28091
TrEMBL
-
A0A0J7JD17_9ALTE
273
0
29010
TrEMBL
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Q4K8Z3_PSEF5
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
265
0
28207
TrEMBL
-
A0A0R2Z373_9PSED
253
0
26839
TrEMBL
-
A0A3G7UD82_9PSED
253
0
26790
TrEMBL
-
A0A0P8BIJ1_9ALTE
274
0
29256
TrEMBL
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A0A173L2Q3_9SPHN
252
0
26432
TrEMBL
-
A0A3G7ARY8_9PSED
265
0
28113
TrEMBL
-
A0A0P7VVC2_9RHOB
266
0
27768
TrEMBL
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U2G1V9_9GAMM
266
0
27741
TrEMBL
-
A0A3G7KA54_9PSED
278
0
29257
TrEMBL
-
A0A3G7A414_9PSED
265
0
27966
TrEMBL
-
A0A3G7HFE0_9PSED
265
0
27800
TrEMBL
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K6YGF7_9ALTE
270
0
28971
TrEMBL
-
A0A6I8LL35_9PSEU
247
0
26788
TrEMBL
-
A0A0N0VJS3_9PSED
263
0
27952
TrEMBL
-
A0A142BGP7_9GAMM
263
0
27884
TrEMBL
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A0A3G7YDY8_9PSED
253
0
26635
TrEMBL
-
A0A656LIF5_9ALTE
270
0
28856
TrEMBL
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A0A6J4Y7L7_9DELT
256
0
27683
TrEMBL
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Q9HZV7_PSEAE
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
264
0
27718
TrEMBL
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hanging-drop vapor diffusion method at 16°C. The structure of AtuE is determined at a 2.13 A resolution
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expression in Escherichia coli JM109
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upregulated in citronellate-grown cells
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Seubert, W.; Fass, E.
Untersuchungen über den bakteriellen Abbau von Isoprenoiden. IV. Reinigung und Eigenschaften der beta-Isohexenylglutaconyl-CoA-hydratase und beta-Hydroxy-beta-isohexenylglutaryl-CoA-lyase
Biochem. Z.
341
23-34
1964
Pseudomonas citronellolis
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brenda
Poudel, N.; Pfannstiel, J.; Simon, O.; Walter, N.; Papageorgiou, A.C.; Jendrossek, D.
The Pseudomonas aeruginosa isohexenyl glutaconyl coenzyme A hydratase (AtuE) is upregulated in citronellate-grown cells and belongs to the crotonase family
Appl. Environ. Microbiol.
81
6558-6566
2015
Pseudomonas aeruginosa (Q9HZV7), Pseudomonas aeruginosa
brenda
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4.2.1.57 Isohexenylglutaconyl-CoA hydratase
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