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Information on EC 4.2.1.57 - Isohexenylglutaconyl-CoA hydratase for references in articles please use BRENDA:EC4.2.1.57
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EC Tree
The expected taxonomic range for this enzyme is: Pseudomonas aeruginosa group
Synonyms
3-Hydroxy-3-isohexenylglutaryl-CoA-hydrolase, AtuE, Beta-isohexenylglutaconyl-CoA-hydratase, Hydratase, isohexenylglutaconyl coenzyme A, isohexenyl glutaconyl coenzyme A hydratase, Isohexenyl-glutaconyl-CoA-hydratase, Isohexenylglutaconyl CoA hydratase, Isohexenylglutaconyl coenzyme A hydratase,
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3-Hydroxy-3-isohexenylglutaryl-CoA-hydrolase
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Beta-isohexenylglutaconyl-CoA-hydratase
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Hydratase, isohexenylglutaconyl coenzyme A
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isohexenyl glutaconyl coenzyme A hydratase
Q9HZV7
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Isohexenyl-glutaconyl-CoA-hydratase
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Isohexenylglutaconyl CoA hydratase
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Isohexenylglutaconyl coenzyme A hydratase
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3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
mechanism
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3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
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addition
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of H2O, hydration
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3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]
Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
additional information
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
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no literature for reverse raction i.e elimination
hydroxyisohexenylglutaryl-CoA + H2O
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3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
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isohexenylglutaconyl-CoA
hydroxyisohexenylglutaryl-CoA + H2O
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additional information
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specifity for CoA-derivatives of beta-substituted, alpha, beta-unsaturated dicarbonic acids formed by carboxylation of dimetylacryl-, geranyl- and farnesyl-CoA
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involved in the isoprenoid degradation pathway
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additional information
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dicarbonic-acid-CoA-derivatives (alpha,beta-unsaturated, beta-substituted, formed by carboxylation of dimethylacryl-, geranyl- and farnesyl-CoA)
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additional information
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additional information
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involved in the isoprenoid degradation pathway
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additional information
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dicarbonic-acid-CoA-derivatives (alpha,beta-unsaturated, beta-substituted, formed by carboxylation of dimethylacryl-, geranyl- and farnesyl-CoA)
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Mg2+
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added in enzyme assay
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Q9HZV7
UniProt
brenda
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brenda
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metabolism
Q9HZV7
the enzyme is involved in the acyclic terpene utilization pathway
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A0A0J7JD17_9ALTE
273
0
29010
TrEMBL
J2MG26_9PSED
265
0
27835
TrEMBL
K6Z4K5_9ALTE
270
0
29354
TrEMBL
U2G1V9_9GAMM
266
0
27741
TrEMBL
A0A3G7TSL3_9PSED
267
0
28125
TrEMBL
K7A1Z5_9ALTE
270
0
28923
TrEMBL
Q4K8Z3_PSEF5
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
265
0
28207
TrEMBL
A0A3G7ARY8_9PSED
265
0
28113
TrEMBL
A0A3G7B7D9_9PSED
278
0
29384
TrEMBL
A0A3G7QQ77_9PSED
265
0
27924
TrEMBL
A0A0N0VJS3_9PSED
263
0
27952
TrEMBL
A0A3G7W728_9PSED
253
0
26917
TrEMBL
A0A3G7IJU7_9PSED
278
0
29147
TrEMBL
A4ABE7_9GAMM
278
0
29579
TrEMBL
A0A3G7I1E8_9PSED
265
0
27765
TrEMBL
A0A3G7MA73_9PSED
278
0
29330
TrEMBL
A0A3G7HFE0_9PSED
265
0
27800
TrEMBL
A0A3G8D9A4_9PSED
255
0
26878
TrEMBL
A0A3G7KA54_9PSED
278
0
29257
TrEMBL
A0A3G7R9Z1_9PSED
265
0
27906
TrEMBL
A0A3G7A414_9PSED
265
0
27966
TrEMBL
A0A3G7J298_9PSED
265
0
27790
TrEMBL
A0A0P7VVC2_9RHOB
266
0
27768
TrEMBL
A0A3G7YDY8_9PSED
253
0
26635
TrEMBL
A0A1Y1TGQ3_PSECL
265
0
27879
TrEMBL
A0A3G7T9Z4_9PSED
265
0
27831
TrEMBL
A0A3G7P6Q9_9PSED
265
0
27891
TrEMBL
A0A3G7C713_9PSED
278
0
29286
TrEMBL
A0A3G7KMA2_9PSED
278
0
29182
TrEMBL
A0A3G7UD82_9PSED
253
0
26790
TrEMBL
A0A3G7L9V7_9PSED
278
0
29147
TrEMBL
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hanging-drop vapor diffusion method at 16°C. The structure of AtuE is determined at a 2.13 A resolution
Q9HZV7
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expression in Escherichia coli JM109
Q9HZV7
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upregulated in citronellate-grown cells
Q9HZV7
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Seubert, W.; Fass, E.
Untersuchungen über den bakteriellen Abbau von Isoprenoiden. IV. Reinigung und Eigenschaften der beta-Isohexenylglutaconyl-CoA-hydratase und beta-Hydroxy-beta-isohexenylglutaryl-CoA-lyase
Biochem. Z.
341
23-34
1964
Pseudomonas citronellolis
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brenda
Poudel, N.; Pfannstiel, J.; Simon, O.; Walter, N.; Papageorgiou, A.C.; Jendrossek, D.
The Pseudomonas aeruginosa isohexenyl glutaconyl coenzyme A hydratase (AtuE) is upregulated in citronellate-grown cells and belongs to the crotonase family
Appl. Environ. Microbiol.
81
6558-6566
2015
Pseudomonas aeruginosa, Pseudomonas aeruginosa (Q9HZV7)
brenda
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4.2.1.57 Isohexenylglutaconyl-CoA hydratase
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