BRENDA Home
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
The expected taxonomic range for this enzyme is: Tetrapoda
Synonyms
dglucy, d-glutamate cyclase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cyclase, D-glutamate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-glutamate = 5-oxo-D-proline + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acylation
-
-
intramolecular
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Also acts on various derivatives of D-glutamate.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5-oxo-D-proline + H2O
D-glutamate
-
-
-
r
cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
-
-
-
?
D,L-allo-alpha-aminotricaballylate
?
-
-
-
-
?
D,L-alpha-aminotricaballylyate
?
-
-
-
-
?
D,L-alpha-methlylglutamate
?
-
-
-
-
?
D,L-beta-hydroxyglutamate
?
-
-
-
-
?
D,L-beta-methylglutamate
?
-
-
-
-
?
D,L-gamma-hydroxyglutamate
?
-
-
-
-
?
D,L-gamma-methylglutamate
?
-
-
-
-
?
D,L-glutamate
?
-
-
-
-
?
D-alpha-methylglutamate
?
-
-
-
-
?
D-gamma-methylglutamate
?
-
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
D-glutamate
?
-
pathway for the elimination of D-glutamate
-
-
?
erythro-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
-
-
-
?
threo-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
-
-
-
?
trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
-
-
-
?
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
-
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
r
D-glutamate
5-oxo-D-proline + H2O
the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
D-glutamate
5-oxo-D-proline + H2O
D-glutamate
?
-
pathway for the elimination of D-glutamate
-
-
?
D-glutamate
5-oxo-D-proline + H2O
-
-
-
?
D-glutamate
5-oxo-D-proline + H2O
the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells
-
-
r
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CaCl2
no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate
CuCl2
no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate
Mg2+
-
optimal activity with 3.3 mM
MgCl2
no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate
ZnCl2
no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate
Mn2+
-
optimal activity with 3.3 mM
Mn2+
completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ADP
significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate
ATP
significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate
Mn2+
completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate
EDTA
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Heart Failure
Structural and enzymatic properties of mammalian d-glutamate cyclase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
200
cis-D-3-fluoro-2-pyrrolidone-5-carboxylate
-
-
1500
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate
-
-
31.9
D-glutamate
pH 8.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7.67
5-oxo-D-proline
pH 8.0, 37°C
35.6
D-glutamate
pH 8.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1121
D-glutamate
pH 8.0, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
6 - 8
small but significant increase in activity occurrs between pH 6.0 to 8.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
-
-
brenda
-
SwissProt
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
-
brenda
-
brenda
highly expressed in the mitochondrial matrix in the heart
brenda
-
low activity
brenda
-
-
brenda
-
-
brenda
-
low activity
brenda
-
-
brenda
-
low activity
brenda
-
-
brenda
-
-
brenda
-
low activity
brenda
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
matrix
brenda
highly expressed in the mitochondrial matrix
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
metabolism
disrupts D-glutamate and/or 5-oxo-D-proline levels, contributing to the onset and/or exacerbation of heart failure
metabolism
the enzyme is involved in D-glutamate metabolism
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GLUCM_HUMAN
616
0
66437
Swiss-Prot
Mitochondrion (Reliability: 2)
GLUCM_MOUSE
617
0
66366
Swiss-Prot
Mitochondrion (Reliability: 1)
Q08D26_XENTR
616
0
67186
TrEMBL
Mitochondrion (Reliability: 2)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
146000
non-denaturing PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
2 * 65874, calculated from sequence
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
decreased expression under conditions of heart failure
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Xu, T.; Meister, A.
Preparation of optically pure isotopically labeled L-glutamate
Methods Enzymol.
113
59-63
1985
Mus musculus
brenda
Unkeless, J.C.; Goldman, P.
Thermodynamic and kinetic aspects of the reaction of gamma-fluoroglutamate with D-glutamate cyclase
J. Biol. Chem.
246
2354-2359
1971
Mus musculus
brenda
Meister, A.
D-Glutamic acid cyclotransferase (mouse kidney, liver)
Methods Enzymol.
17A
860-863
1974
Mus musculus
-
brenda
Meister, A.; Bukenberger, M.W.; Strassburger, M.
The optically-specific enzymatic cyclization of D-glutamate
Biochem. Z.
338
217-229
1963
Homo sapiens, Mus musculus
brenda
Orlowski, M.; Meister, A.
Enzymology of pyrrolidone carboxylic acid
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
123-151
1971
Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
-
brenda
Katane, M.; Ariyoshi, M.; Tateishi, S.; Koiwai, S.; Takaku, K.; Nagai, K.; Nakayama, K.; Saitoh, Y.; Miyamoto, T.; Sekine, M.; Mita, M.; Hamase, K.; Matoba, S.; Homma, H.
Structural and enzymatic properties of mammalian D-glutamate cyclase
Arch. Biochem. Biophys.
654
10-18
2018
Mus musculus (Q8BH86), Mus musculus
brenda
Ariyoshi, M.; Katane, M.; Hamase, K.; Miyoshi, Y.; Nakane, M.; Hoshino, A.; Okawa, Y.; Mita, Y.; Kaimoto, S.; Uchihashi, M.; Fukai, K.; Ono, K.; Tateishi, S.; Hato, D.; Yamanaka, R.; Honda, S.; Fushimura, Y.; Iwai-Kanai, E.; Ishihara, N.; Mita, M.; Homma,
D-Glutamate is metabolized in the heart mitochondria
Sci. Rep.
7
43911
2017
Mus musculus (Q8BH86)
brenda
Select items on the left to see more content.
html completed