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Disease on EC 4.2.1.3 - aconitate hydratase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Acidosis, Lactic
A novel de novo dominant mutation in
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
aconitate hydratase deficiency
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Functional cellular analyses reveal energy metabolism defect and mitochondrial DNA depletion in a case of mitochondrial aconitase deficiency.
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain.
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency.
Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies.
[Aconitase deficiency]
Adenocarcinoma
Activated macrophage conditioned medium: identification of the soluble factors inducing cytotoxicity and the L-arginine dependent effector mechanism.
Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells.
Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.
The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.
Adenocarcinoma of Lung
Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis.
Alkalosis
Regulation of aconitate hydratase activity from rat kidney cortex by bicarbonate.
Alzheimer Disease
Abnormal localization of iron regulatory protein in Alzheimer's disease.
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment.
Mitochondrial oxidative stress index, activity of redox-sensitive aconitase and effects of endogenous anti- and pro-oxidants on its activity in control, Alzheimer's disease and Swedish Familial Alzheimer's disease brain.
Amyotrophic Lateral Sclerosis
Superoxide dismutase 1 modulates expression of transferrin receptor.
Anemia
Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.
The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload.
[Clinical and diagnostic significance of gepsidin level in the regulation of iron metabolism in patients with inflammatory bowel disease].
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Anemia, Hypochromic
Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana.
Anemia, Iron-Deficiency
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Anemia, Sickle Cell
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Asthenozoospermia
The role of mitochondrial aconitate (ACO2) in human sperm motility.
Ataxia
Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients.
beta-Thalassemia
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Brain Diseases
Aggravated effects of coexisting marginal thiamine deficits and zinc excess on SN56 neuronal cells.
Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice.
Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
Breast Neoplasms
IRP2 regulates breast tumor growth.
Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.
Racial disparities in breast cancer diagnosis in Central Georgia in the United States.
The African American Women and Mass Media campaign: a CDC breast cancer screening project.
Bronchopulmonary Dysplasia
Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates.
Candidiasis
The mitogen-activated protein kinase CgHog1 is required for iron homeostasis, adherence and virulence in Candida glabrata.
Carcinogenesis
Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Carcinoma
Changes induced by Ehrlich ascites carcinoma in hepatic fumarase and aconitase activities.
Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells.
Cyclic adenosine 3',5'-monosphosphate mediate prolactin regulation of mitochondrial aconitase in human prostate carcinoma cells.
Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis.
Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells.
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.
Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells.
Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells.
Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells.
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Nitroprusside stimulates mitochondrial aconitase gene expression through the cyclic adenosine 3',5'-monosphosphate signal transduction pathway in human prostate carcinoma cells.
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Purification and partial amino acid sequence of human aconitase.
Testosterone modulates mitochondrial aconitase in the full-length human androgen receptor-transfected PC-3 prostatic carcinoma cells.
Zinc blocks gene expression of mitochondrial aconitase in human prostatic carcinoma cells.
Carcinoma, Ehrlich Tumor
Characterization of aconitate hydratase from mitochondria and cytoplasm of ascites tumor cells.
Carcinoma, Hepatocellular
Cholesterol modulation of the expression of mitochondrial aconitase in human prostatic carcinoma cells.
Influence of parenteral iron preparations on non-transferrin bound iron uptake, the iron regulatory protein and the expression of ferritin and the divalent metal transporter DMT-1 in HepG2 human hepatoma cells.
Nitric oxide: a cytotoxic activated macrophage effector molecule.
Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation.
Cardiomegaly
Renal and cardiac Na+-K +-ATPase and aconitase in a rat model of fetal programming.
Cardiomyopathy, Dilated
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Cardiotoxicity
Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity.
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management.
Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.
The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein-1 in cytosolic fractions from human myocardium.
Cataract
Extension of mouse lifespan by overexpression of catalase.
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Chemical and Drug Induced Liver Injury
Effect of N-[Imino(4-morpholyl)methyl]guanidine on the oxidative status in rats with toxic hepatitis.
Free radical oxidation and catalytic activity of aconitate hydratase in rat liver under normal conditions and during toxic hepatitis.
[Citrate influence on oxidative status of rats tissues under experimental toxic hepatitis].
[The oxidative effects of melatonin, the content of citrate and the activity of aconitate hydratase in the rat liver in toxic hepatitis].
Colorectal Neoplasms
Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling.
Craniocerebral Trauma
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.
Cysts
Iron regulatory protein 2 in ovarian endometrial cysts.
Sarcocystis fusiformis: some Krebs cycle enzymes in various fractions of sarcocysts of buffalo (Bubalus bubalis).
Dehydration
AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates.
Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters.
CO2 adducts as reactive analogues of carboxylate substrates for aconitase and other enzymes of carbohydrate metabolism.
Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily.
Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.
The Crystal Structure of Fe4S4 Quinolinate Synthase Unravels an Enzymatic Dehydration Mechanism That Uses Tyrosine and a Hydrolase-Type Triad.
Delirium
CA1-03: Cognitive Impairment in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
PS1-34: Clinical Factors Associated with Cognitive Function in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Dementia
CA1-03: Cognitive Impairment in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias.
Mitochondrial enzymes in schizophrenia.
PS1-34: Clinical Factors Associated with Cognitive Function in Patients Hospitalized for Acute Coronary Syndromes: Preliminary Findings from TRACE-CORE.
Diabetes Mellitus
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus.
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Diabetes Mellitus, Experimental
Alterations in mitochondrial aconitase activity and respiration, and in concentration of citrate in some organs of mice with experimental or genetic diabetes.
Diabetes Mellitus, Type 2
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus.
Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress.
ROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS.
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
dihydrolipoyl dehydrogenase deficiency
The expanding clinical spectrum of mitochondrial diseases.
Encephalomyelitis
The habenula and iron metabolism in cerebral mouse models of multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
The habenula and iron metabolism in cerebral mouse models of multiple sclerosis.
Eosinophilia
Increased glutathione levels contribute to the beneficial effects of hydrogen sulfide and inducible nitric oxide inhibition in allergic lung inflammation.
Epilepsy
The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction.
Fatty Liver
Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19.
[EFFECTS OF MELATONIN ON THE ACONITATE HYDRATASE ACTIVITY, CONTENT OF LIPID PEROXIDATION PRODUCTS AND SOME NON-ENZYMATIC ANTIOXIDANTS IN THE BLOOD OF PATIENTS WITH TYPE 2 DIABETES MELLITUS COMPLICATED BY STEATOHEPATITIS].
[Intensity of apoptotic processes, aconitate hydratase activity and citrate level in patients with type 2 diabetes mellitus complicated steatohepatitis under application of epifamin at basic therapy].
Friedreich Ataxia
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.
Deferiprone targets aconitase: implication for Friedreich's ataxia treatment.
Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.
Highly specific ubiquitin-competing molecules effectively promote frataxin accumulation and partially rescue the aconitase defect in Friedreich ataxia cells.
Novel antibody-based strategies for the rapid diagnosis of mitochondrial disease and dysfunction.
fumarate hydratase deficiency
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency.
The expanding clinical spectrum of mitochondrial diseases.
Gait Ataxia
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome.
Gastritis
The role of transferrin receptor in the Helicobacter pylori pathogenesis; L-ferritin as a novel marker for intestinal metaplasia.
Gastrointestinal Stromal Tumors
FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis.
Glioblastoma
Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.
Glucose Intolerance
Trehalose Protects against Insulin Resistance-Induced Tissue Injury and Excessive Autophagy in Skeletal Muscles and Kidney.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Effects of Glucose 6-Phosphate Dehydrogenase Deficiency on the Metabolic and Cardiac Responses to Obesogenic or High Fructose Diets.
Glucosephosphate Dehydrogenase Deficiency
Effects of Glucose 6-Phosphate Dehydrogenase Deficiency on the Metabolic and Cardiac Responses to Obesogenic or High Fructose Diets.
Heart Arrest
Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrest.
Heart Failure
Mitochondrial Bioenergetics and Dysfunction in Failing Heart.
Hemochromatosis
Down-regulation of liver iron-regulatory protein 1 in haemochromatosis.
Genetic modification of iron metabolism in mice affects the gut microbiota.
Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis.
Iron regulatory protein 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.
Iron-responsive element-binding protein in hemochromatosis liver and intestine.
Response of monocyte iron regulatory protein activity to inflammation: abnormal behavior in genetic hemochromatosis.
Hepatitis
Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.
Mitochondrial aconitase binds to the 3'-UTR of mouse hepatitis virus RNA.
Huntington Disease
Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum.
Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain.
Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.
Hyperferritinemia
Repression of ferritin light chain translation by human eIF3.
Hyperglycemia
Effects of two oral antidiabetics, pioglitazone and repaglinide, on aconitase inactivation, inflammation and oxidative/nitrosative stress in tissues under alloxan-induced hyperglycemia.
Potential Role of Endoplasmic Reticulum Stress in Pathogenesis of Diabetic Retinopathy.
Short-term hyperglycemia produces oxidative damage and apoptosis in neurons.
Hypersensitivity
Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone.
Transsulfuration Pathway Seleno-amino Acids are Mediators of Selenomethionine Toxicity in Saccharomyces cerevisiae.
Hypertension
Genetic Variant Coding for Iron Regulatory Protein HFE Contributes to Hypertension, the TAMRISK Study.
Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.
Hypertension, Pulmonary
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2?.
Therapeutic inhibition of HIF2? reverses polycythemia and pulmonary hypertension in murine models of two human diseases.
Hyperthyroidism
Oxidative status and citrate concentration in rat tissues during experimental hyperthyroidism and melatonin treatment.
[Effect of melaxen and valdoxan on free radical processes intensity, aconitate hydratase activity and citrate content in rats tissues under hyperthyroidism].
Infections
An Unusual Occurrence of Southern Rust, Caused by Rpp9-virulent Puccinia polysora, on Corn in Southwestern Georgia.
Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical.
Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis.
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.
Ehrlichia chaffeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor and up-regulate transferrin receptor mRNA by activating iron-responsive protein 1.
Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages.
Identification of Genes Expressed Differentially in Grapefruit Infected with Candidatus Liberibacter asiaticus in the Late Stage of Disease
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis.
Mitochondrial aconitase binds to the 3' untranslated region of the mouse hepatitis virus genome.
Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice.
The second aconitase (AcnB) of Escherichia coli.
Influenza, Human
Recognition of a sequestered self peptide by influenza virus-specific CD8+ cytolytic T lymphocytes.
Insulin Resistance
Iron regulatory protein 2 deficiency may correlate with insulin resistance.
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1?.
Insulinoma
Heat shock inhibits cytokine-induced nitric oxide synthase expression by rat and human islets.
Iron Deficiencies
Aconitase activity in iron deficiency.
Brain iron, transferrin and ferritin concentrations are altered in developing iron-deficient rats.
Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome.
Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver.
Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress.
Differential translational control of 5' IRE-containing mRNA in response to dietary iron deficiency and acute iron overload.
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain.
Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver.
Iron enzymes in iron deficiency. VI. Aconitase activity and citrate metabolism.
Iron regulatory protein 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.
Mitochondrial cysteine desulfurase iron-sulfur cluster S and aconitase are post-transcriptionally regulated by dietary iron in skeletal muscle of rats.
Nitric oxide and oxidative stress (H2O2) control mammalian iron metabolism by different pathways.
Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation.
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2.
Profile of altered brain iron acquisition in restless legs syndrome.
The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage.
[Clinical and diagnostic significance of gepsidin level in the regulation of iron metabolism in patients with inflammatory bowel disease].
[Expression of iron regulatory protein-2 and ferritins in intestinal mucosa of rats with iron deficiency]
[Expression of iron responsive element binding protein mRNA and analysis of aconitase activity in iron deficiency anemia rats]
Iron Overload
Compartmentalization and regulation of iron metabolism proteins protect male germ cells from iron overload.
Differential translational control of 5' IRE-containing mRNA in response to dietary iron deficiency and acute iron overload.
Effects of hepatocellular iron imbalance on nitric oxide and reactive oxygen intermediates production in a model of sepsis.
Friedreich's ataxia: Oxidative stress and cytoskeletal abnormalities.
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts.
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease.
Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
Iron-responsive element-binding protein in hemochromatosis liver and intestine.
SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY.
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Ketosis
The use of transgenic and mutant mice to study oxygen free radical metabolism.
Leishmaniasis, Visceral
Association of pro-inflammatory cytokines and iron regulatory protein 2 (IRP2) with Leishmania burden in canine visceral leishmaniasis.
Leukemia
2-methoxyestradiol does not inhibit superoxide dismutase.
Leukemia, Erythroblastic, Acute
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.
Leukemia, Myeloid
Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells.
Liver Diseases
Falsely normal value in fluorometric transferase screening of galactosemic blood. A cautionary note.
Lung Neoplasms
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.
Lymphoma
Induction of iron regulatory protein 1 RNA-binding activity by nitric oxide is associated with a concomitant increase in the labile iron pool: implications for DNA damage.
Malaria
The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth.
Melanoma
Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma.
MERRF Syndrome
Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome.
Mitochondrial Diseases
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Identification of novel compound heterozygous mutations in ACO2 in a patient with progressive cerebral and cerebellar atrophy.
Mitochondrial Myopathies
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Movement Disorders
Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders.
Characterization of the human mitochondrial aconitase gene (ACO2).
Multiple Sclerosis
Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis.
Muscular Diseases
A novel de novo dominant mutation in
Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy.
Hereditary myopathy with lactic acidosis, succinate dehydrogenase and aconitase deficiency in northern Sweden: a genealogical study.
Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB.
Myocardial Ischemia
Cardiac mitochondria and reactive oxygen species generation.
Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats.
Myocarditis
Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.
Myoglobinuria
Mitochondrial myopathy with succinate dehydrogenase and aconitase deficiency. Abnormalities of several iron-sulfur proteins.
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance.
Neoplasm Metastasis
Ironing out cancer.
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Neoplasms
Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response.
Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner.
Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.
Aglycemic HepG2 Cells Switch From Aminotransferase Glutaminolytic Pathway of Pyruvate Utilization to Complete Krebs Cycle at Hypoxia.
Characterization of aconitate hydratase from mitochondria and cytoplasm of ascites tumor cells.
Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
Crystal structure of a hemojuvelin-binding fragment of neogenin at 1.8Å
Cytokines induce an L-arginine-dependent effector system in nonmacrophage cells.
Exploiting the passenger ACO1-deficiency arising from 9p21 deletions to kill T-cell lymphoblastic neoplasia cells.
FAM96A Protects Mice From Dextran Sulfate Sodium (DSS)-Induced Colitis by Preventing Microbial Dysbiosis.
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2.
Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.
Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration.
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.
Increased formation of reactive oxygen species during tumor growth: Ex vivo low-temperature EPR and in vivo bioluminescence analyses.
Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages.
Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.
Ironing out cancer.
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.
Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms.
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells.
Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis.
Monokine mediated release of intracellular iron in tumor target cells in vitro.
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.
NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
Overexpression of iron regulatory protein 1 suppresses growth of tumor xenografts.
Racial disparities in breast cancer diagnosis in Central Georgia in the United States.
Removing the cells from adult bone marrow derived stem cell therapy does not eliminate cardioprotection.
SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.
Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
The L-arginine dependent effector mechanism is induced in murine adenocarcinoma cells by culture supernatant from cytotoxic activated macrophages.
The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.
The return of the Scarlet Pimpernel: cobalamin in inflammation II -- cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells.
Neuroblastoma
Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1.
Effects of sodium metavanadate on in vitro neuroblastoma and red blood cells.
Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines.
Neurodegenerative Diseases
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency.
Infantile Cerebellar-Retinal Degeneration Associated with a Mutation in Mitochondrial Aconitase, ACO2.
Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases.
Mitochondrial aconitase in Neurodegenerative disorders: role of a metabolism-related molecule in neurodegeneration.
MRI detection of ferritin iron overload and associated neuronal pathology in iron regulatory protein-2 knockout mice.
Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency.
Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
Neuroinflammatory Diseases
Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich's Ataxia Patients.
Obesity
A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice.
Lysine Acetylation Activates Mitochondrial Aconitase in the Heart.
Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry.
Oligodendroglioma
Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells.
Optic Nerve Diseases
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy.
oxoglutarate dehydrogenase (succinyl-transferring) deficiency
The expanding clinical spectrum of mitochondrial diseases.
Paralysis
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.
Parkinson Disease
A novel treatment strategy to prevent Parkinson's disease: focus on iron regulatory protein 1 (IRP1).
Analysis of nucleotide variations in genes of iron management in patients of Parkinson's disease and other movement disorders.
Characterization of the human mitochondrial aconitase gene (ACO2).
Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease.
Iron-sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson's disease.
Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity.
Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease.
[Mechanism of ?-lipoic acid promoting iron efflux in substantia nigra cells of Parkinson's disease rats].
Pneumothorax
Pneumothorax Clinic In Macon County, Alabama.
Polycythemia
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2?.
Therapeutic inhibition of HIF2? reverses polycythemia and pulmonary hypertension in murine models of two human diseases.
Porphyrias, Hepatic
Interaction between iron metabolism and 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice with variants of the Ahr gene: a hepatic oxidative mechanism.
Prostatic Neoplasms
Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase.
p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells.
Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone.
Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation.
Protein Deficiency
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies.
Proteinuria
Effect of month-long treatment with oral N-acetylcysteine on the oxidative stress and proteinuria in patients with diabetic nephropathy: a pilot study.
protoporphyrin ferrochelatase deficiency
Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.
Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.
Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.
The mitochondrial protein frataxin is essential for heme biosynthesis in plants.
Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia.
Pulmonary Disease, Chronic Obstructive
Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.
Pulmonary Fibrosis
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis.
Renal Insufficiency, Chronic
Hepcidin and risk of anemia in CKD: a cross-sectional and longitudinal analysis in the CKiD cohort.
Restless Legs Syndrome
Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.
Decreased transferrin receptor expression by neuromelanin cells in restless legs syndrome.
Profile of altered brain iron acquisition in restless legs syndrome.
Retinal Degeneration
Dominant ACO2 mutations are a frequent cause of isolated optic atrophy.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
Scurvy
Gene expression of iron-related proteins during iron deficiency caused by scurvy in guinea pigs.
Seizures
Age dependence of seizure-induced oxidative stress.
Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus.
Inhibition of aconitase in astrocytes increases the sensitivity to chemical convulsants.
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Sepsis
SS31, a mitochondrially targeted antioxidant, prevents sepsis-induced reductions in diaphragm strength and endurance.
Shock, Septic
In vitro serial passage of Staphylococcus aureus: changes in physiology, virulence factor production, and agr nucleotide sequence.
Silicosis
[Study of lipid metabolism in the lungs in experimental silicosis i rats. Activity of lung lupases and aconitase]
Starvation
Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.
Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction.
Stability of enzymes in starving Arthrobacter crystallopoietes.
Stomach Neoplasms
Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer.
superoxide dismutase deficiency
Superoxide sensitivity of the Escherichia coli aconitase.
Supranuclear Palsy, Progressive
Brain aconitase activity is not decreased in progressive supranuclear palsy.
Syphilis
The Belmont Report at 40: Reckoning With Time.
The Tuskegee Syphilis Study and the Scientific Concept of Racial Nervous Resistance.
Tuskegee University experience challenges conventional wisdom: is integrative bioethics practice the new ethics for the public's health?
Thalassemia
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
Tics
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Tuberculosis
Identification of fur, aconitase, and other proteins expressed by Mycobacterium tuberculosis under conditions of low and high concentrations of iron by combined two-dimensional gel electrophoresis and mass spectrometry.
Iron-dependent RNA-binding activity of Mycobacterium tuberculosis aconitase.
Mycobacterium tuberculosis Rv1474c is a TetR-like transcriptional repressor that regulates aconitase, an essential enzyme and RNA-binding protein, in an iron-responsive manner.
Superoxide production by the mycobacterial and pseudomonad quinoid pigments phthiocol and pyocyanine in human lung cells.
Uterine Cervical Neoplasms
The African American Women and Mass Media campaign: a CDC breast cancer screening project.
Whooping Cough
A Functional Tricarboxylic Acid Cycle Operates during Growth of Bordetella pertussis on Amino Acid Mixtures as Sole Carbon Substrates.