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Information on EC 4.2.1.150 - short-chain-enoyl-CoA hydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.150 short-chain-enoyl-CoA hydratase
IUBMB Comments
The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents. It is specific for short, C4-C6, chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA. cf. EC 4.2.1.17, enoyl-CoA hydratase and EC 4.2.1.74, long-chain-enoyl-CoA hydratase.
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The enzyme appears in viruses and cellular organisms
Synonyms
3-hydroxyacyl-CoA dehydratase, 3-hydroxybutyryl-CoA dehydratase, CaCRT, CDYL, chromodomain Y-like protein, crotonase, crotonyl-CoA hydratase, crt, L-3-hydroxyacyl-CoA hydro-lyase, More, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a short-chain (3S)-3-hydroxyacyl-CoA = a short-chain trans-2-enoyl-CoA + H2O
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