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Information on EC 4.2.1.140 - gluconate/galactonate dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.140 gluconate/galactonate dehydratase
IUBMB Comments
The enzyme is involved in glucose and galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway in Picrophilus torridus and via the branched variant of the Entner-Doudoroff pathway in Sulfolobus solfataricus [1,2]. In vitro it utilizes D-gluconate with 6-10 fold higher catalytic efficiency than D-galactonate [1,3]. It requires Mg2+ for activity [1,2]. cf. EC 4.2.1.6, galactonate dehydratase, and EC 4.2.1.39, gluconate dehydratase.
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
D-gluconate dehydratase, GNAD, Pto0485, Sso3198, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O
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D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O
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