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Information on EC 4.2.1.119 - enoyl-CoA hydratase 2

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.119 enoyl-CoA hydratase 2
IUBMB Comments
This enzyme catalyses a hydration step in peroxisomal beta-oxidation. The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units . The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
hydratase 2, multifunctional enzyme type 2, phaj4, atech2, d-3-hydroxyacyl-coa hydro-lyase, phajac, permfe-ii, (r)-specific enoyl coenzyme a hydratase, d-(-)-3-hydroxyacyl-coa hydro-lyase, mfe2 hydratase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H2O
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