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Information on EC 4.2.1.117 - 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
IUBMB Comments
Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates . An iron-sulfur protein.
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The expected taxonomic range for this enzyme is: Shewanella oneidensis
Synonyms
AcnD, SO_0343, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O
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PATHWAY SOURCE
PATHWAYS
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