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Information on EC 4.2.1.111 - 1,5-anhydro-D-fructose dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.111 1,5-anhydro-D-fructose dehydratase
IUBMB Comments
This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 [exo-(1->4)-alpha-D-glucan lyase] and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC 4.2.1.110, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M and it cannot convert ascopyrone M into microthecin, as can EC 4.2.1.110.
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The expected taxonomic range for this enzyme is: Pezizales
Synonyms
1,5-anhydro-D-arabino-hex-2-ulose dehydratase, 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydro-lyase, 1,5-anhydro-D-fructose hydrolyase, AF dehydratase, AFDH, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
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PATHWAY SOURCE
PATHWAYS
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