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Information on EC 4.2.1.1 - carbonic anhydrase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC4.2.1.1

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IUBMB Comments

The enzyme catalyses the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn2+ is the most prevalent, but Cd2+, Co2+, Fe2+, and Mn2+ are also found .

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
hide
H2CO3
=
CO2
+
H2O
=
+

Synonyms
carbonic anhydrase, ca ix, ca ii, hca ii, hca i, carbonic anhydrase ix, carbonic anhydrase ii, hca ix, ca iv, anhydrase, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
anhydrase
-
-
-
-
CA
-
-
-
-
CA-IX
-
-
-
-
CA-VA
-
-
-
-
CA-VB
-
-
-
-
CA-VI
-
-
-
-
CA-VII
-
-
-
-
CA-XII
-
-
-
-
CA-XIV
-
-
-
-
CA1
-
-
-
-
CA2
-
-
-
-
CAIX
-
-
-
-
carbonate anhydrase
-
-
-
-
Carbonate dehydratase
-
-
-
-
Carbonate dehydratase IX
-
-
-
-
Carbonate dehydratase VA
-
-
-
-
Carbonate dehydratase VB
-
-
-
-
Carbonate dehydratase VI
-
-
-
-
Carbonate dehydratase VII
-
-
-
-
Carbonate dehydratase XII
-
-
-
-
Carbonate dehydratase XIV
-
-
-
-
carbonic acid anhydrase
-
-
-
-
carbonic anhydrase
-
-
-
-
carbonic dehydratase
-
-
-
-
carboxyanhydrase
-
-
-
-
dehydratase, carbonate
-
-
-
-
Membrane antigen MN
-
-
-
-
P54/58N
-
-
-
-
pMW1
-
-
-
-
RCC-associated antigen G250
-
-
-
-
Renal cell carcinoma-associated antigen G250
-
-
-
-
Salivary carbonic anhydrase
-
-
-
-
Secreted carbonic anhydrase
-
-
-
-
Tumor antigen HOM-RCC-3.1.3
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
addition
-
-
-
-
elimination
-
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
3-hydroxypropanoate cycle, 3-hydroxypropanoate/4-hydroxybutanate cycle, C4 photosynthetic carbon assimilation cycle, NAD-ME type, C4 photosynthetic carbon assimilation cycle, NADP-ME type, C4 photosynthetic carbon assimilation cycle, PEPCK type, CO2 fixation into oxaloacetate (anaplerotic), cyanate degradation, gluconeogenesis II (Methanobacterium thermoautotrophicum), glyoxylate assimilation
SYSTEMATIC NAME
IUBMB Comments
carbonic acid hydro-lyase (carbon-dioxide-forming)
The enzyme catalyses the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH. It is widespread and found in archaea, bacteria, and eukaryotes. At least eight distinct classes exist and appear to have evolved independently. A large majority of the enzymes contain a metal cofactor. Zn2+ is the most prevalent, but Cd2+, Co2+, Fe2+, and Mn2+ are also found [8].
CAS REGISTRY NUMBER
COMMENTARY hide
9001-03-0
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A072ZBL6_PSEAI
215
0
24224
TrEMBL
-
A0A072ZH59_PSEAI
242
0
26649
TrEMBL
Chloroplast (Reliability: 1)
A0A0C6F093_PSEAI
220
0
23404
TrEMBL
-
A0A0F6RST4_PSEAI
220
0
23413
TrEMBL
-
A0A1Y0GL52_PSEAI
242
0
26707
TrEMBL
-
A0A233TRD2_PSEAI
220
0
23390
TrEMBL
-
A0A367LXF4_PSEAI
113
0
11914
TrEMBL
-
A0A367M191_PSEAI
118
0
13126
TrEMBL
-
A0A3M5ET19_PSEAI
120
0
13549
TrEMBL
-
A0A643IVW0_PSEAI
220
0
23403
TrEMBL
-
A0A6A9K2F9_PSEAI
220
0
23394
TrEMBL
Chloroplast (Reliability: 2)
A0A6H0JJF9_PSEAI
446
0
47828
TrEMBL
-
A0ABD7JT12_PSEAI
220
0
23290
TrEMBL
-
A0ABD7JSZ2_PSEAI
215
0
24264
TrEMBL
Mitochondrion (Reliability: 5)
A0ABD7K987_PSEAI
242
0
26835
TrEMBL
-