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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
3-hydroxy-3-(4-methylpent-3-en-1-yl)-glutaryl-CoA isopentenyl-acetoacetyl-CoA-lyase, 3-Hydroxy-3-isohexenylglutaryl coenzyme A lyase, 3-hydroxy-3-isohexenylglutaryl-CoA lyase, beta-Hydroxy-beta-isohexenylglutaryl CoA-lyase, HIHG-CoA lyase, Hydroxyisohexenylglutaryl CoA:acetate lyase, Hydroxyisohexenylglutaryl-CoA:acetatelyase, LiuE, Lyase, 3-hydroxy-3-isohexenylglutaryl coenzyme A,
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3-hydroxy-3-(4-methylpent-3-en-1-yl)-glutaryl-CoA isopentenyl-acetoacetyl-CoA-lyase
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3-Hydroxy-3-isohexenylglutaryl coenzyme A lyase
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3-hydroxy-3-isohexenylglutaryl-CoA lyase
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beta-Hydroxy-beta-isohexenylglutaryl CoA-lyase
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Hydroxyisohexenylglutaryl CoA:acetate lyase
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Hydroxyisohexenylglutaryl-CoA:acetatelyase
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Lyase, 3-hydroxy-3-isohexenylglutaryl coenzyme A
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3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate
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elimination
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of an oxo acid, C-C bond cleavage
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3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
Also acts on the hydroxy derivative of farnesoyl-CoA.
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3-hydroxy-3-isohexenylglutaryl-CoA
7-methyl-3-oxo-6-octenyl-CoA + acetate
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Hydroxyisohexenylglutaryl-CoA
3-Ketoacyl-CoA derivative + acetate
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additional information
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involved in the degradation of the branched carbon skeletons of geraniol and farnesol
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additional information
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involved in the degradation of the branched carbon skeletons of geraniol and farnesol
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additional information
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UniProt
brenda
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brenda
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metabolism
LiuE displays a bifunctional role in both the leucine/isovalerate and acyclic terpenes catabolic pathways, LiuE shows enzymatic activity of HMG-CoA lyase and also HIHG-CoA lyase activity
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33000
x * 33000, SDS-PAGE
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by affinity chromatography, more than 98% purified
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His-tagged protein expressed in Escherichia coli JM101
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Seubert, W.; Fass, E.
Untersuchungen über den bakteriellen Abbau von Isoprenoiden. IV. Reinigung und Eigenschaften der beta-Isohexenylglutaconyl-CoA-hydratase und beta-Hydroxy-beta-isohexenylglutaryl-CoA-lyase
Biochem. Z.
341
23-34
1964
Pseudomonas citronellolis
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brenda
Chavez-Aviles, M.; Diaz-Perez, A.L.; Campos-Garcia, J.
The bifunctional role of LiuE from Pseudomonas aeruginosa, displays additionally HIHG-CoA lyase enzymatic activity
Mol. Biol. Rep.
37
1787-1791
2010
Pseudomonas aeruginosa PAO1 (Q9I2A0)
brenda
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