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IUBMB Comments The enzyme takes part in a D -galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina ).
Synonyms LGA1 ,
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GAAC
-
Kdg1
-
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2-dehydro-3-deoxy-L-galactonate = pyruvate + L-glyceraldehyde
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-
-
-
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MetaCyc
D-galacturonate degradation IV
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2-dehydro-3-deoxy-L-galactonate L-glyceraldehyde-lyase (pyruvate-forming)
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina).
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2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
pyruvate + glycolaldehyde
?
Substrates: -
?
pyruvate + L-glyceraldehyde
2-dehydro-3-deoxy-L-galactonate
Substrates: -
r
pyruvate + methylglyoxal
?
Substrates: -
?
additional information
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Substrates: the reaction with D-glyceraldehyde, dihydroxyacetone, diacetyl, acetone, glyoxal, acetaldehyde or formaldehyde plus pyruvate is below the detection limit
?
2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
Substrates: the enzyme is part of the fungal pathway of D-galacturonate degradation
r
2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
Substrates: the reverse reaction is significantly stronger with L-glyceraldehyde as a substrate than with D-glyceraldehyde. No activity with D-threo-3-deoxy-hexulosonate
r
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2-dehydro-3-deoxy-L-galactonate
pyruvate + L-glyceraldehyde
Substrates: the enzyme is part of the fungal pathway of D-galacturonate degradation
r
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D-glyceraldehyde
inhibits reverse reaction with pyruvate and L-glyceraldehyde
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3.5
2-dehydro-3-deoxy-L-galactonate
pH 7.0, 30°C
1.2
L-glyceraldehyde
pH 7.0, 30°C
0.5
pyruvate
pH 7.0, 30°C
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UniProt
brenda
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UniProt
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UniProt
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UniProt
brenda
i.e. Trichoderma reesei
UniProt
brenda
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the L-threo-3-deoxy-hexulosonate aldolase activity is induced during growth on D-galacturonate
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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malfunction
the deletion of the gene results in a strain unable to grow on D-galacturonate and accumulating L-threo-3-deoxy-hexulosonate
physiological function
the enzyme is induced during growth on D-galacturonate
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LGA1_HYPJE
315
0
33407
Swiss-Prot
other Location (Reliability: 2 )
LGA1_ASPNG
335
0
35845
Swiss-Prot
-
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33407
x * 33407, calculated from sequence
37000
x * 37000, SDS-PAGE
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?
x * 33407, calculated from sequence
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expression in Saccharomyces cerevisiae as a histidine-tagged protein
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induced in Hypocrea jecorina during growth on D-galacturonate
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Martens-Uzunova, E.S.; Schaap, P.J.
An evolutionary conserved D-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation
Fungal Genet. Biol.
45
1449-1457
2008
Aspergillus niger (A8DRH7), Aspergillus niger CBS 120.49 (A8DRH7), Trichoderma reesei (A6Y9S5), Trichoderma reesei CBS 383.78 (QM6a) (A6Y9S5)
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Hilditch, S.; Berghll, S.; Kalkkinen, N.; Penttil, M.; Richard, P.
The missing link in the fungal D-galacturonate pathway: identification of the L-threo-3-deoxy-hexulosonate aldolase
J. Biol. Chem.
282
26195-26201
2007
Trichoderma reesei (A6Y9S5)
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