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Information on EC 4.1.2.51 - 2-dehydro-3-deoxy-D-gluconate aldolase

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
IUBMB Comments
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
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The expected taxonomic range for this enzyme is: Picrophilus torridus
Synonyms
KDG-specific aldolase, KDGA, Pto1279, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde
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