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Reference on EC 4.1.2.25 - dihydroneopterin aldolase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mathis, J.B.; Brown, G.M.
Dihydroneopterin aldolase from Escherichia coli
Methods Enzymol.
66
556-560
1980
Escherichia coli
Manually annotated by BRENDA team
Mathis, J.B.; Brown, G.M.
The biosynthesis of folic acid. XI. Purification and properties of dihydroneopterin aldolase
J. Biol. Chem.
245
3015-3025
1970
Escherichia coli, Escherichia coli B / ATCC 11303
Manually annotated by BRENDA team
Volpe, F.; Ballantine, S.P.; Delves, C.J.
Two domains with amino-acid sequence similarity are required for dihydroneopterin aldolase function in the multifunctional folic acid synthesis Fas protein of Pneumocystis carnii
Gene
160
41-46
1995
Pneumocystis carinii
Manually annotated by BRENDA team
Thomas, M.C.; Ballantine, S.P.; Bethell, S.S.; Bains, S.; Kellam, P.; Delves, C.J.
Single amino acid substitutions dirupts tetramer formation in the dihydroneopterin aldolase enzyme of Pneumocystis carnii
Biochemistry
37
11629-11636
1998
Pneumocystis carinii
Manually annotated by BRENDA team
Lopez, P.; Lacks, S.A.
A bifunctional protein in the folate biosynthetic pathway of Streptococcus pneumoniae with dihydroneopterin aldolase and hydroxymethyldihydropterin pyrophosphokinase activities
J. Bacteriol.
175
2214-2220
1993
Streptococcus pneumoniae
Manually annotated by BRENDA team
Volpe, F.; Ballantine, S.P.; Delves, C.J.
The multifunctional folic acid synthesis fas gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase
Eur. J. Biochem.
216
449-458
1993
no activity in mammalia, Pneumocystis carinii
Manually annotated by BRENDA team
Haumann, C.; Rohdich, F.; Schmidt, E.; Bacher, A.; Richter, G.
Biosynthesis of pteridines in Escherichia coli. Structural and mechanistic similarity of dihydroneopterin-triphosphate epimerase and dihydroneopterin aldolase
J. Biol. Chem.
273
17418-17424
1998
Escherichia coli, Haemophilus influenzae
Manually annotated by BRENDA team
Hennig, M.; D'Arcy, A.; Hampele, I.C.; Page, M.G.P.; Oefner, C.; Dale, G.E.
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus
Nat. Struct. Biol.
5
357-362
1998
Staphylococcus aureus
Manually annotated by BRENDA team
Deng, H.; Callender, R.; Dale, G.E.
A vibrational structure of 7,8-dihydrobiopterin bound to dihydroneopterin aldolase
J. Biol. Chem.
275
30139-30143
2000
Escherichia coli
Manually annotated by BRENDA team
Illarionova, V.; Eisenreich, W.; Fischer, M.; Haussmann, C.; Romisch, W.; Richter, G.; Bacher, A.
Biosynthesis of tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase
J. Biol. Chem.
277
28841-28847
2002
Escherichia coli
Manually annotated by BRENDA team
Goyer, A.; Illarionova, V.; Roje, S.; Fischer, M.; Bacher, A.; Hanson, A.D.
Folate biosynthesis in higher plants. cDNA cloning, heterologous expression, and characterization of Dihydroneopterin aldolases
Plant Physiol.
135
103-111
2004
Arabidopsis thaliana, Arabidopsis thaliana (Q9FM54), Arabidopsis thaliana (Q9SF23), Solanum lycopersicum
Manually annotated by BRENDA team
Scherperel, G.; Yan, H.; Wang, Y.; Reid, G.E.
'Top-down' characterization of site-directed mutagenesis products of Staphylococcus aureus dihydroneopterin aldolase by multistage tandem mass spectrometry in a linear quadrupole ion trap
Analyst
131
291-302
2006
Staphylococcus aureus
Manually annotated by BRENDA team
Sanders, W.J.; Nienaber, V.L.; Lerner, C.G.; McCall, J.O.; Merrick, S.M.; Swanson, S.J.; Harlan, J.E.; Stoll, V.S.; Stamper, G.F.; Betz, S.F.; Condroski, K.R.; Meadows, R.P.; Severin, J.M.; Walter, K.A.; Magdalinos, P.; Jakob, C.G.; Wagner, R.; Beutel, B.A.
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization
J. Med. Chem.
47
1709-1718
2004
Staphylococcus aureus
Manually annotated by BRENDA team
Bauer, S.; Schott, A.K.; Illarionova, V.; Bacher, A.; Huber, R.; Fischer, M.
Biosynthesis of tetrahydrofolate in plants: crystal structure of 7,8-dihydroneopterin aldolase from Arabidopsis thaliana reveals a novel adolase class
J. Mol. Biol.
339
967-979
2004
Arabidopsis thaliana (Q9SF23), Arabidopsis thaliana
Manually annotated by BRENDA team
Garcon, A.; Levy, C.; Derrick, J.P.
Crystal structure of the bifunctional dihydroneopterin aldolase/6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Streptococcus pneumoniae
J. Mol. Biol.
360
644-653
2006
Streptococcus pneumoniae
Manually annotated by BRENDA team
Wang, Y.; Li, Y.; Yan, H.
Mechanism of dihydroneopterin aldolase: functional roles of the conserved active site glutamate and lysine residues
Biochemistry
45
15232-15239
2006
Escherichia coli, Staphylococcus aureus
Manually annotated by BRENDA team
Wang, Y.; Li, Y.; Wu, Y.; Yan, H.
Mechanism of dihydroneopterin aldolase. NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes
FEBS J.
274
2240-2252
2007
Escherichia coli, Staphylococcus aureus
Manually annotated by BRENDA team
Wang, Y.; Scherperel, G.; Roberts, K.D.; Jones, A.D.; Reid, G.E.; Yan, H.
A point mutation converts dihydroneopterin aldolase to a cofactor-independent oxygenase
J. Am. Chem. Soc.
128
13216-13223
2006
Escherichia coli, Staphylococcus aureus
Manually annotated by BRENDA team
Blaszczyk, J.; Li, Y.; Gan, J.; Yan, H.; Ji, X.
Structural basis for the aldolase and epimerase activities of Staphylococcus aureus dihydroneopterin aldolase
J. Mol. Biol.
368
161-169
2007
Staphylococcus aureus (P56740), Staphylococcus aureus
Manually annotated by BRENDA team
Yao, L.; Yan, H.; Cukier, R.I.
Mechanism of dihydroneopterin aldolase: a molecular dynamics study of the apo enzyme and its product complex
J. Phys. Chem. B
110
1443-1456
2006
Staphylococcus aureus
Manually annotated by BRENDA team
Dittrich, S.; Mitchell, S.L.; Blagborough, A.M.; Wang, Q.; Wang, P.; Sims, P.F.; Hyde, J.E.
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites
Mol. Microbiol.
67
609-618
2008
Escherichia coli, no activity in Plasmodium falciparum
Manually annotated by BRENDA team
Hyde, J.E.; Dittrich, S.; Wang, P.; Sims, P.F.; de Crecy-Lagard, V.; Hanson, A.D.
Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?
Trends Parasitol.
24
502-508
2008
Plasmodium falciparum
Manually annotated by BRENDA team
Pribat, A.; Jeanguenin, L.; Lara-Nunez, A.; Ziemak, M.J.; Hyde, J.E.; de Crecy-Lagard, V.; Hanson, A.D.
6-Pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria
J. Bacteriol.
191
4158-4165
2009
Escherichia coli, Escherichia coli MG1655
Manually annotated by BRENDA team
Waller, J.C.; Akhtar, T.A.; Lara-Nunez, A.; Gregory, J.F.; McQuinn, R.P.; Giovannoni, J.J.; Hanson, A.D.
Developmental and feedforward control of the expression of folate biosynthesis genes in tomato fruit
Mol. Plant
3
66-77
2010
Solanum lycopersicum
Manually annotated by BRENDA team
Almeida, R.; Loss, O.; Colabardini, A.; Brown, N.; Bignell, E.; Savoldi, M.; Pantano, S.; Goldman, M.; Arst Jr., E.; Goldman, G.
Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis
G3 (Bethesda)
3
1129-1141
2013
Aspergillus nidulans
Manually annotated by BRENDA team
Czekster, C.M.; Blanchard, J.S.
One substrate, five products: reactions catalyzed by the dihydroneopterin aldolase from Mycobacterium tuberculosis
J. Am. Chem. Soc.
134
19758-19771
2012
Mycobacterium tuberculosis (P9WNC5), Mycobacterium tuberculosis
Manually annotated by BRENDA team
Falcao, V.C.; Villela, A.D.; Rodrigues-Junior, V.S.; Pissinate, K.; Eichler, P.; Pinto, A.F.; Basso, L.A.; Santos, D.S.; Bizarro, C.V.
Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development
Biochem. Biophys. Res. Commun.
485
814-819
2017
Mycobacterium tuberculosis (P9WNG5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG5)
Manually annotated by BRENDA team
Chaudhary, B.; Singh, N.; Pandey, D.K.
Bioengineering of crop plants for improved tetrahydrofolate production
Bioengineered
9
152-158
2018
Escherichia coli (P0AC16)
Manually annotated by BRENDA team
Blaszczyk, J.; Lu, Z.; Li, Y.; Yan, H.; Ji, X.
Crystallographic and molecular dynamics simulation analysis of Escherichia coli dihydroneopterin aldolase
Cell Biosci.
4
52
2014
Escherichia coli (P0AC16), Escherichia coli
Manually annotated by BRENDA team
Wang, Y.; Xu, H.; Grochowski, L.L.; White, R.H.
Biochemical characterization of a dihydroneopterin aldolase used for methanopterin biosynthesis in methanogens
J. Bacteriol.
196
3191-3198
2014
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii MJ0408
Manually annotated by BRENDA team
Pandey, D.K.; Kumar, A.; Rathore, J.S.; Singh, N.; Chaudhary, B.
Recombinant overexpression of dihydroneopterin aldolase catalyst potentially regulates folate-biofortification
J. Basic Microbiol.
57
517-524
2017
Escherichia coli (P0AC16)
Manually annotated by BRENDA team