Information on EC 4.1.2.13 - fructose-bisphosphate aldolase and Organism(s) Mus musculus

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea


The taxonomic range for the selected organisms is: Mus musculus

EC NUMBER
COMMENTARY hide
4.1.2.13
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RECOMMENDED NAME
GeneOntology No.
fructose-bisphosphate aldolase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
condensation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1,3-propanediol biosynthesis (engineered)
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Calvin-Benson-Bassham cycle
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formaldehyde assimilation II (assimilatory RuMP Cycle)
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formaldehyde assimilation III (dihydroxyacetone cycle)
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gluconeogenesis I
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gluconeogenesis II (Methanobacterium thermoautotrophicum)
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gluconeogenesis III
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glycolysis I (from glucose 6-phosphate)
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glycolysis II (from fructose 6-phosphate)
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glycolysis III (from glucose)
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glycolysis IV (plant cytosol)
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glycolysis V (Pyrococcus)
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sucrose biosynthesis I (from photosynthesis)
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sucrose degradation V (sucrose alpha-glucosidase)
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glycolysis
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photosynthesis
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Glycolysis / Gluconeogenesis
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Pentose phosphate pathway
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Fructose and mannose metabolism
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Methane metabolism
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Carbon fixation in photosynthetic organisms
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-52-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
C3KO or wild-type mice
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Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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flexor digitorum brevis
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
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probably specific subcellular location regulated by calpain-3, calpain-3 necessary for proper localization; triad
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Manually annotated by BRENDA team