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IUBMB Comments Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.
The enzyme appears in viruses and cellular organisms
Synonyms decarboxylase, 4-hydroxyphenylpyruvate, p-hydroxyphenylpyruvate decarboxylase, more
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decarboxylase, 4-hydroxyphenylpyruvate
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p-hydroxyphenylpyruvate decarboxylase
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4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2
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MetaCyc
(S)-reticuline biosynthesis I, L-tyrosine degradation III
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4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)
Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: - Products: -
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis Products: phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: - Products: -
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis Products: phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis Products: phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine
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4-hydroxyphenylpyruvate
4-hydroxyphenylacetaldehyde + CO2
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Substrates: involved in tyrosine metabolism, precursor of tyrosine, early steps of isoquinoline alkaloid biosynthesis Products: phenylacetaldehydes furnish the benzylic moiety of the isoquinoline alkaloids in their biosynthesis, formation of the 1-benzylisoquinoline structure requires the condensation of p-hydroxyphenylacetaldehyde with dopamine to form norcoclaurine
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0.67
4-hydroxyphenylpyruvate
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additional information
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values given as pkat/litre of suspension culture
additional information
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values given as pkat/litre of suspension culture
additional information
Berberis regeliana
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values given as pkat/litre of suspension culture
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values given as pkat/litre of suspension culture
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values given as pkat/litre of suspension culture
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Thalictrum dipterocarpum
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values given as pkat/litre of suspension culture
additional information
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values given as pkat/litre of suspension culture
additional information
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values given as pkat/litre of suspension culture
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brenda
produces large amounts of protoberberine alkaloids of the jatrorrhizine type
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Berberis regeliana
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Thalictrum dipterocarpum
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Berberis regeliana
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Thalictrum dipterocarpum
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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ARO10_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
635
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71384
Swiss-Prot
other Location (Reliability: 2 )
A0A1P8BJB2_MASBA
559
0
60043
TrEMBL
other Location (Reliability: 2 )
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30000
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HPLC gel filtration
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29fold partial purification
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Rueffer, M.; Zenk, M.H.
Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation
Z. Naturforsch. C
42
319-332
1987
Berberis aristata, Berberis canadensis, Berberis julianae, Berberis regeliana, Berberis stolonifera, Eschscholzia californica, Hyalosepalum caffrum, Thalictrum dipterocarpum, Thalictrum minus, Tinospora cordifolia
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