Reference on EC 4.1.1.50 - adenosylmethionine decarboxylase and Organism(s) Homo sapiens
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White Tabor, C.; Tabor, H.
Methionine adenosyltransferase (S-adenosylmethionine synthetase) and S-adenosylmethionine decarboxylase
Adv. Enzymol. Relat. Areas Mol. Biol.
56
251-282
1984
Bos taurus, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Lytechinus pictus, Mus musculus, Rattus norvegicus
Manni, A.; Badger, B.; Grove, R.; Kunselman, S.; Demers, L.
Isolation and characterization of human breast cancer cell overexpressing S-adenosylmethionine decarboxylase
Cancer Lett.
95
23-28
1995
Homo sapiens
Shantz, L.M.; Stanley, B.A.; Secrist III, J.A.; Pegg, A.E.
Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
Biochemistry
31
6848-6855
1992
Homo sapiens
Regenass, U.; Caravatti, G.; Mett, M.; Stanek, J.; Schneider, P.; Mueller, M.; Matter, A.; Vertino, P.; Porter, C.W.
New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity
Cancer Res.
52
4712-4718
1992
Homo sapiens, Mus musculus
Regenass, U.; Mett, H.; Stanek, J.; Mueller, M.; Kramer, D.; Porter, C.W.
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity
Cancer Res.
54
3210-3217
1994
Homo sapiens, Mus musculus
White, E.L.; Arnett, G.; Secrist III, J.A.; Shannon, W.M.
Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection
Virus Res.
31
255-263
1994
Homo sapiens
Xiong, H.; Stanley, B.A.; Pegg, A.E.
Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase
Biochemistry
38
2462-2470
1999
Homo sapiens
Tolbert, W.D.; Ekstrom, J.L.; Mathews, II; Secrist, J.A., 3rd; Kapoor, P.; Pegg, A.E.; Ealick, S.E.
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase
Biochemistry
40
9484-9494
2001
Homo sapiens (P17707), Homo sapiens
Ndjonka, D.; Zou, Y.; Bi, X.; Woster, P.; Walter, R.D.; Luersen, K.
The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target
Biol. Chem.
384
1195-1201
2003
Homo sapiens, Onchocerca volvulus
Nummela, P.; Yin, M.; Kielosto, M.; Leaner, V.; Birrer, M.J.; Holtta, E.
Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts
Cancer Res.
66
701-712
2006
Homo sapiens
Greco, A.; Calle, A.; Morfin, F.; Thouvenot, D.; Cayre, M.; Kindbeiter, K.; Martin, L.; Levillain, O.; Diaz, J.J.
S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target
FASEB J.
19
1128-1130
2005
Homo sapiens
Lam, K.; Zhang, L.; Bewick, M.; Lafrenie, R.M.
HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase
J. Cell. Physiol.
203
353-361
2005
Homo sapiens
Tian, H.; Liu, X.; Zhang, B.; Sun, Q.; Sun, D.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth
Acta Biochim. Biophys. Sin.
39
423-430
2007
Homo sapiens
Kim, J.S.; Kim, T.L.; Kim, K.C.; Choe, C.; Chung, H.W.; Cho, E.W.; Kim, I.G.
S-Adenosylmethionine decarboxylase partially regulates cell growth of HL-60 cells by controlling the intracellular ROS level: Early senescence and sensitization to gamma-radiation
Arch. Biochem. Biophys.
456
58-70
2006
Homo sapiens (P17707)
Gong, L.; Zhang, B.; Zhang, Y.; Hu, H.; Zhao, Z.; Liu, X.
Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit
Chin. J. Physiol.
50
29-33
2007
Homo sapiens
Gong, L.; Jiang, C.; Zhang, B.; Hu, H.; Wang, W.; Liu, X.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells
J. Biochem. Mol. Biol.
39
730-736
2006
Homo sapiens
Brooks, W.H.; McCloskey, D.E.; Daniel, K.G.; Ealick, S.E.; Secrist, J.A.; Waud, W.R.; Pegg, A.E.; Guida, W.C.
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase
J. Chem. Inf. Model.
47
1897-1905
2007
Homo sapiens (P17707), Homo sapiens
Bale, S.; Ealick, S.E.
Structural biology of S-adenosylmethionine decarboxylase
Amino Acids
38
451-460
2010
Trypanosoma brucei, Aquifex aeolicus (O66615), Aquifex aeolicus, Homo sapiens (P17707), Homo sapiens, Solanum tuberosum (Q04694), Solanum tuberosum, Thermotoga maritima (Q9WZC3), Thermotoga maritima
Barker, R.H.; Liu, H.; Hirth, B.; Celatka, C.A.; Fitzpatrick, R.; Xiang, Y.; Willert, E.K.; Phillips, M.A.; Kaiser, M.; Bacchi, C.J.; Rodriguez, A.; Yarlett, N.; Klinger, J.D.; Sybertz, E.
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis
Antimicrob. Agents Chemother.
53
2052-2058
2009
Homo sapiens, Trypanosoma brucei
Hyvoenen, M.T.; Howard, M.T.; Anderson, C.B.; Grigorenko, N.; Khomutov, A.R.; Vepsaelaeinen, J.; Alhonen, L.; Jaenne, J.; Keinaenen, T.A.
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues
Biochem. J.
422
321-328
2009
Homo sapiens
Bale, S.; Brooks, W.; Hanes, J.W.; Mahesan, A.M.; Guida, W.C.; Ealick, S.E.
Role of the sulfonium center in determining the ligand specificity of human S-adenosylmethionine decarboxylase
Biochemistry
48
6423-6430
2009
Homo sapiens (P17707), Homo sapiens
Pegg, A.E.
S-Adenosylmethionine decarboxylase
Essays Biochem.
46
25-45
2009
Bacillus subtilis, Saccharomyces cerevisiae, Catharanthus roseus, Clostridium acetobutylicum, Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii, Solanum tuberosum, Thermotoga maritima, Trypanosoma brucei, Trypanosoma cruzi
McCloskey, D.E.; Bale, S.; Secrist, J.A.; Tiwari, A.; Moss, T.H.; Valiyaveettil, J.; Brooks, W.H.; Guida, W.C.; Pegg, A.E.; Ealick, S.E.
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: Studies of adenine C8 substitution in structural analogues of S-adenosylmethionine
J. Med. Chem.
52
1388-1407
2009
Homo sapiens (P17707), Homo sapiens
Koomoa, D.L.; Borsics, T.; Feith, D.J.; Coleman, C.C.; Wallick, C.J.; Gamper, I.; Pegg, A.E.; Bachmann, A.S.
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma
Mol. Cancer Ther.
8
2067-2075
2009
Homo sapiens
Paasinen-Sohns, A.; Kaeaeriaeinen, E.; Yin, M.; Jaervinen, K.; Nummela, P.; Hoelttae, E.
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase
Int. J. Biochem. Cell Biol.
43
441-454
2011
Homo sapiens