Disease on EC 4.1.1.50 - adenosylmethionine decarboxylase and Organism(s) Homo sapiens
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Adenocarcinoma
A comparison of ornithine decarboxylase and S-adenosylmethionine decarboxylase activity in human large bowel mucosa, polyps, and colorectal adenocarcinoma.
Adenocarcinoma
Observations with an S-adenosylmethionine decarboxylase inhibitor in rats with prostatic adenocarcinoma.
Adenocarcinoma
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
Adenocarcinoma
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study]
Alzheimer Disease
Brain S-adenosylmethionine decarboxylase activity is increased in Alzheimer's disease.
Bacterial Infections
Rainbow trout (Oncorhynchus mykiss) urea cycle and polyamine synthesis gene families show dynamic expression responses to inflammation.
Brain Injuries
Brain S-adenosylmethionine decarboxylase activity is increased in Alzheimer's disease.
Brain Injuries, Traumatic
S-adenosylmethionine decarboxylase activity is decreased in the rat cortex after traumatic brain injury.
Brain Neoplasms
Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy.
Brain Neoplasms
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Brain Neoplasms
Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors.
Brain Neoplasms
Polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate.
Brain Neoplasms
Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase.
Breast Neoplasms
Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo.
Breast Neoplasms
Isolation and characterization of human breast cancer cells overexpressing S-adenosylmethionine decarboxylase.
Breast Neoplasms
S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells.
Breast Neoplasms
Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells.
Breast Neoplasms
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Carcinogenesis
S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion.
Carcinoma
4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase.
Carcinoma
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Carcinoma
Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma.
Carcinoma
Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy.
Carcinoma
Effect of methionine deprivation on S-adenosylmethionine decarboxylase of tumour cells.
Carcinoma
Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors.
Carcinoma
Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas.
Carcinoma
S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone).
Carcinoma, Basal Cell
Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas.
Carcinoma, Hepatocellular
Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.
Carcinoma, Hepatocellular
Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.
Carcinoma, Hepatocellular
S-adenosylmethionine decarboxylase gene expression in rat hepatoma cells: regulation by insulin and by inhibition of protein synthesis.
Carcinoma, Lewis Lung
Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma.
Carcinoma, Renal Cell
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
Carcinoma, Squamous Cell
Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas.
Cell Transformation, Neoplastic
c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase.
Cell Transformation, Neoplastic
Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes.
Central Nervous System Neoplasms
Degrees of malignancy in human primary central nervous system tumors: ornithine decarboxylase levels as better indicators than adenosylmethionine decarboxylase levels.
Cholera
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Cholera
Synergistic stimulation of S-adenosylmethionine decarboxylase activity by Ca2+ ionophore A23187, cholera toxin and 1-oleoyl-2-acetylglycerol.
Colonic Neoplasms
Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit.
Colonic Neoplasms
Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth.
Colonic Neoplasms
S-adenosylmethionine decarboxylase activity and utilization of exogenous putrescine are enhanced in colon cancer cells stimulated to grow by EGF.
Colorectal Neoplasms
Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro.
Colorectal Neoplasms
Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo.
Cystic Fibrosis
Ornithine decarboxylase and S-adenosyl methionine decarboxylase in skin fibroblasts of normal and cystic fibrosis patients.
Cytomegalovirus Infections
Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection.
Dehydration
Genome-wide identification of genes involved in polyamine biosynthesis and the role of exogenous polyamines in Malus hupehensis Rehd. under alkaline stress.
Dehydration
Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought.
Dehydration
Validation of novel reference genes for reverse transcription quantitative real-time PCR in drought-stressed sugarcane.
Dwarfism
Cholesterol accumulation by suppression of SMT1 leads to dwarfism and improved drought tolerance in herbaceous plants.
Epilepsy
Activity of S-adenosylmethionine decarboxylase, a key regulatory enzyme in polyamine biosynthesis, is increased in epileptogenic human cortex.
Erythema
The induction of erythema, edema, and the polyamine synthesis enzymes ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase in hairless mouse skin by psoralens and longwave ultraviolet light.
Esophageal Neoplasms
[Ornithine decarboxylase and S-adenosylmethionine decarboxylase bi-antisense virus inhibit growth and invasion of esophageal cancer cell line Eca109]
Fetal Growth Retardation
[Changes in enzyme activity associated with polyamine metabolism in the liver of experimental IUGR rats]
Fibrosarcoma
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase.
Fibrosarcoma
S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Fibrosarcoma
S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Fibrosarcoma
Tumour promoter mediated altered expression and regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in H-ras-transformed fibrosarcoma cell lines.
Herpes Simplex
S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target.
Hyperthyroidism
Thyroxine effects on polyamine metabolism in rat cerebellum and brain cortex during postnatal development.
Infections
4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase.
Infections
Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.
Infections
Biphasic stimulation of polyamine biosynthesis in primary mouse kidney cells by infection with polyoma virus:uncoupling from DNA and rRNA synthesis.
Infections
Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection.
Infections
Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.
Infections
Cure of Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense infections in mice with an irreversible inhibitor of S-adenosylmethionine decarboxylase.
Infections
Increase in S-adenosyl-L-methionine decarboxylase activity during the transformation of chick embroy fibroblasts by Rous sarcoma virus.
Infections
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.
Infections
Methionine is required for cAMP-PKA-mediated morphogenesis and virulence of Candida albicans.
Infections
MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus.
Infections
S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target.
Infections
Synthesis of Semliki-forest virus in polyamine-depleted baby-hamster kidney cells.
Infections
Temporal studies of factors associated with changes in transcription during Q fever.
Infections
Transcriptional regulation of genes involved in the pathways of biosynthesis and supply of methyl units in response to powdery mildew attack and abiotic stresses in wheat.
Infertility, Male
RNAi silencing of three homologues of S-adenosylmethionine decarboxylase gene in tapetal tissue of tomato results in male sterility.
Intestinal Volvulus
A novel trans-spliced mRNA from Onchocerca volvulus encodes a functional S-adenosylmethionine decarboxylase.
Intestinal Volvulus
Ascaris suum and Onchocerca volvulus: S-adenosylmethionine decarboxylase.
Intestinal Volvulus
MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus.
Intestinal Volvulus
The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target.
Ischemic Attack, Transient
Activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in transient cerebral ischemia: relationship to the duration of vascular occlusion.
Leishmaniasis
Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.
Leishmaniasis
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Leukemia
Antitumor effect of methylglyoxal bis(butylamidinohydrazone), a new inhibitor of S-adenosylmethionine decarboxylase, against human erythroid leukemia K 562 cells.
Leukemia
Combined use of alpha-difluoromethylornithine and an inhibitor of S-adenosylmethionine decarboxylase in mice bearing P388 leukemia or Lewis lung carcinoma.
Leukemia
Diethylglyoxal bis(guanylhydrazone), a potent inhibitor of mammalian S-adenosylmethionine decarboxylase. Effects on cell proliferation and polyamine metabolism in L1210 leukemia cells.
Leukemia
In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.
Leukemia
Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).
Leukemia
Polyamine-mediated regulation of S-adenosylmethionine decarboxylase expression in mammalian cells. Studies using 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, a suicide inhibitor of the enzyme.
Leukemia
Regulation of S-adenosylmethionine decarboxylase in L1210 leukemia cells. Studies using an irreversible inhibitor of the enzyme.
Leukemia, Erythroblastic, Acute
Polyamine biosynthesis enzymes in the induction and inhibition of differentiation in Friend erythroleukemia cells.
Lung Neoplasms
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth.
Lung Neoplasms
[Inhibitory effects of ODC and AdoMetDC biantisense virus on the growth and invasion of lung cancer cell A-549]
Lymphoma
Cyclic AMP-dependent protein kinase mediates a cyclic AMP-stimulated decrease in ornithine and S-adenosylmethionine decarboxylase activities.
Lymphoma
Effect of methionine deprivation on S-adenosylmethionine decarboxylase of tumour cells.
Lymphoma
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Malaria
In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase.
Malaria
Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling.
Malaria
Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.
Malaria
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions.
Malaria
The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs.
Malaria
The Plasmodium falciparum bifunctional ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase, enables a well balanced polyamine synthesis without domain-domain interaction.
Melanoma
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.
Melanoma
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Melanoma
Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells.
Melanoma
Effects of treatments with alpha-difluoromethylornithine and hyperthermia on the growth and polyamine metabolism of Harding-Passey murine melanoma.
Melanoma
Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma.
Melanoma
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
Melanoma
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Melanoma, Experimental
Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells.
Meningoencephalitis
Putrescine-activated S-adenosylmethionine decarboxylase from Acanthamoeba culbertsoni.
Muscular Diseases
Polyamine biosynthetic decarboxylases in muscles of rats with different experimental myopathies.
Neoplasm Metastasis
Growth factor-mediated altered expression and regulation of S-adenosylmethionine decarboxylase in a H-ras transformed cell line capable of malignant progression.
Neoplasm Metastasis
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Neoplasm Metastasis
Tumour promoter mediated altered expression and regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in H-ras-transformed fibrosarcoma cell lines.
Neoplasms
A novel gene signature for molecular diagnosis of human prostate cancer by RT-qPCR.
Neoplasms
A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.
Neoplasms
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth.
Neoplasms
Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.
Neoplasms
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity.
Neoplasms
Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts.
Neoplasms
Degree of enhancement of polyamine biosynthetic decarboxylase activities in human tumors: a useful new index of degree of malignancy.
Neoplasms
Degrees of malignancy in human primary central nervous system tumors: ornithine decarboxylase levels as better indicators than adenosylmethionine decarboxylase levels.
Neoplasms
Effect of methionine deprivation on S-adenosylmethionine decarboxylase of tumour cells.
Neoplasms
Effects of DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, on the rat mammary tumour induced by 7,12-dimethylbenz[a]anthracene.
Neoplasms
Effects of treatments with alpha-difluoromethylornithine and hyperthermia on the growth and polyamine metabolism of Harding-Passey murine melanoma.
Neoplasms
Gene sequences coding for S-adenosylmethionine decarboxylase are present on human chromosome 6 and the X and are not amplified in colon neoplasia.
Neoplasms
Hormone-independent polyamine metabolism of squamous cell carcinoma of the prostate.
Neoplasms
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.
Neoplasms
In Silico Prediction of Metabolic Fluxes in Cancer Cells with Altered S-adenosylmethionine Decarboxylase Activity.
Neoplasms
In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase.
Neoplasms
Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumor promotion.
Neoplasms
Inhibition by derivatives of diguanidines of cell proliferation in Ehrlich ascites cells grown in cultures.
Neoplasms
Inhibition of mouse skin tumor promotion and of promoter-induced epidermal polyamine biosynthesis by methylglyoxal bis(butylamidinohydrazone).
Neoplasms
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.
Neoplasms
Insulin-mediated alterations in S-adenosylmethionine decarboxylase expression in H-ras transformed cells of varying degrees of malignancy.
Neoplasms
Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes.
Neoplasms
Ornithine decarboxylase activity in mouse tumour tissue in response to refeeding and diet components.
Neoplasms
Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo.
Neoplasms
Polyamine metabolism-based dual functional gene delivery system to synergistically inhibit the proliferation of cancer.
Neoplasms
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers.
Neoplasms
Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer.
Neoplasms
Reference gene selection for quantitative real-time reverse-transcriptase PCR in orchardgrass subjected to various abiotic stresses.
Neoplasms
Regulation of polyamine biosynthesis in normal and transformed hamster cells in culture.
Neoplasms
Role of diamine oxidase during the treatment of tumour-bearing mice with combinations of polyamine anti-metabolites.
Neoplasms
S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Neoplasms
S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Neoplasms
S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion.
Neoplasms
S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells.
Neoplasms
Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats.
Neoplasms
Some aspects of clearance of mitoguazone in cancer patients and experimental cancer models.
Neoplasms
The effects of polyamine antimetabolites on polyamine-responsive casein kinase activity.
Neoplasms
The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs.
Neoplasms
The role of polyamines in human cancer: prospects for drug combination therapies.
Neoplasms
Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors.
Neoplasms
Treatment of metastatic Lewis lung carcinoma with DL-alpha-difluoromethylornithine.
Neoplasms
Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens.
Neoplasms
Tumour promoter mediated altered expression and regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in H-ras-transformed fibrosarcoma cell lines.
Neoplasms
[The study of polyamine levels and enzyme activities in metabolic pathway of polyamine in spleen of mice inoculated tumor cells]
Neoplasms
[Therapy of prostate carcinoma with polyamine synthesis inhibitors. I. Physiological and pathophysiological principles]
Neuroblastoma
Induction of S-adenosyl-L-methionine decarboxylase in glioma and neuroblastoma cells.
Neuroblastoma
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma.
Ovarian Neoplasms
Treatment with inhibitors of polyamine biosynthesis, which selectively lower intracellular spermine, does not affect the activity of alkylating agents but antagonizes the cytotoxicity of DNA topoisomerase II inhibitors.
Parasitemia
Antileishmanial activity of berenil and methylglyoxal bis (guanylhydrazone) and its correlation with S-adenosylmethionine decarboxylase and polyamines.
Parasitic Diseases
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme.
Parasitic Diseases
In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, S-adenosylmethionine decarboxylase.
Parasitic Diseases
Molecular and biochemical characterization of S-adenosylmethionine decarboxylase from the free-living nematode Caenorhabditis elegans.
Parasitic Diseases
The ornithine decarboxylase domain of the bifunctional ornithine decarboxylase/S-adenosylmethionine decarboxylase of Plasmodium falciparum: recombinant expression and catalytic properties of two different constructs.
Pneumocystis Infections
4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase.
Prostatic Neoplasms
Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo.
Prostatic Neoplasms
Effects of antisense RNA targeting of ODC and AdoMetDC on the synthesis of polyamine synthesis and cell growth in prostate cancer cells using a prostatic androgen-dependent promoter in adenovirus.
Prostatic Neoplasms
Some aspects of clearance of mitoguazone in cancer patients and experimental cancer models.
Prostatic Neoplasms
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Sarcoma, Avian
Increase in S-adenosyl-L-methionine decarboxylase activity during the transformation of chick embroy fibroblasts by Rous sarcoma virus.
Sepsis
Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats.
Sepsis
Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats.
Sepsis
Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA.
Starvation
Enzyme induction in a temperature-sensitive cell cycle mutant of Chinese hamster fibroblasts.
Starvation
Ornithine decarboxylase activity in mouse tumour tissue in response to refeeding and diet components.
Starvation
Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity.
Starvation
Regulation of the activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in mammary gland and liver of lactating rats. Effects of starvation, prolactin and insulin deficiency.
Trypanosomiasis
Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues.
Trypanosomiasis
Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei.
Trypanosomiasis, African
Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.
Trypanosomiasis, African
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).
Trypanosomiasis, African
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.
Trypanosomiasis, African
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Vitamin A Deficiency
Mechanisms of asbestos-induced squamous metaplasia in tracheobronchial epithelial cells.
Vitamin B 12 Deficiency
Involvement of Spermidine in the Reduced Lifespan of Caenorhabditis elegans During Vitamin B12 Deficiency.
Vitamin B 6 Deficiency
Polyamine biosynthesis and vitamin B6 deficiency. Evidence for pyridoxal phosphate as coenzyme for S-adenosylmethionine decarboxylase.