Information on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
4.1.1.28
-
RECOMMENDED NAME
GeneOntology No.
aromatic-L-amino-acid decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2
show the reaction diagram
-
-
-
-
L-dopa = dopamine + CO2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(S)-reticuline biosynthesis I
-
-
betaxanthin biosynthesis
-
-
betaxanthin biosynthesis (via dopamine)
-
-
catecholamine biosynthesis
-
-
serotonin and melatonin biosynthesis
-
-
catecholamine biosynthesis
-
-
tryptophan metabolism
-
-
Tyrosine metabolism
-
-
Phenylalanine metabolism
-
-
Tryptophan metabolism
-
-
Isoquinoline alkaloid biosynthesis
-
-
Betalain biosynthesis
-
-
Metabolic pathways
-
-
Biosynthesis of secondary metabolites
-
-
SYSTEMATIC NAME
IUBMB Comments
Aromatic-L-amino-acid carboxy-lyase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9042-64-2
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
TrEMBL
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
filarial nematode, causative agent of heartworm disease in dogs and cats
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
migratory locust, subspecies migratorioides R.F.
-
-
Manually annotated by BRENDA team
-
TrEMBL
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Micrococcus percitreus
-
-
-
Manually annotated by BRENDA team
Micrococcus percitreus AJ 1065
-
-
-
Manually annotated by BRENDA team
Micrococcus percitreus AJ1065
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Mus musculus C57BL / 129SV
male C57B1/129SV
-
-
Manually annotated by BRENDA team
-
Q95YG8
TrEMBL
Manually annotated by BRENDA team
tobacco
-
-
Manually annotated by BRENDA team
no activity in Penicillium raistrickii
strain ATCC 46878
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
H10BA2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Thalictrum rugosum
-
-
-
Manually annotated by BRENDA team
red flour beetle
UniProt
Manually annotated by BRENDA team
cultivar Vidal blanc
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-Dibromo-DL-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
75% of the activity with L-Trp
-
-
-
2,4-dihydroxyphenyl-L-alanine
?
show the reaction diagram
Micrococcus percitreus
-
75% activity compared to L-tryptophan
-
-
?
2-Chloro-L-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
77% of the activity with L-Trp
-
-
-
2-chloro-L-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
77% activity compared to L-tryptophan
-
-
?
2-fluoro-L-(3,4-dihydroxyphenyl)alanine
4-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
2-Methyl-L-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
75% of the activity with L-Trp
-
-
-
2-methyl-L-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
75% activity compared to L-tryptophan
-
-
?
3,4-Dibromo-DL-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
10% of the activity with L-Trp
-
-
-
3,4-Dihydroxy-L-phenylalanine
?
show the reaction diagram
3,4-Dihydroxyphenylalanine
3-Hydroxytyramine + CO2
show the reaction diagram
3,4-dihydroxyphenylalanine
4-(2-aminoethyl)benzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
3,4-dihydroxyphenylalanine
? + CO2
show the reaction diagram
-
regulation of the ganglionic dopamine level
-
?
3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
3,5-Dibromo-DL-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
72% of the activity with L-Trp
-
-
-
3,5-dibromo-DL-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
72% activity compared to L-tryptophan
-
-
?
3-Chloro-L-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
81% of the activity with L-Trp
-
-
-
3-chloro-L-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
81% activity compared to L-tryptophan
-
-
?
3-Hydroxy-DL-kynurenine
?
show the reaction diagram
3-Methyl-L-Tyr
?
show the reaction diagram
Micrococcus percitreus
-
80% of the activity with L-Trp
-
-
-
3-methyl-L-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
80% activity compared to L-tryptophan
-
-
?
4-fluoro-L-tryptophan
4-fluorotryptamine + CO2
show the reaction diagram
-
-
?
4-methyl-L-tryptophan
4-methyltryptamine + CO2
show the reaction diagram
-
-
?
5-Fluoro-DL-Trp
?
show the reaction diagram
Micrococcus percitreus
-
75% of the activity with L-Trp
-
-
-
5-fluoro-DL-tryptophan
?
show the reaction diagram
Micrococcus percitreus
-
75% activity compared to L-tryptophan
-
-
?
5-fluoro-L-(3,4-dihydroxyphenyl)alanine
5-(2-aminoethyl)-3-fluorobenzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
5-fluoro-L-tryptophan
5-fluorotryptamine + CO2
show the reaction diagram
-
-
?
5-hydroxy-L-tryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
5-hydroxy-L-tryptophan
?
show the reaction diagram
Micrococcus percitreus
-
24% activity compared to L-tryptophan
-
-
?
5-hydroxy-L-tryptophan
serotonin + CO2
show the reaction diagram
5-hydroxytryptamine + O2
5-hydroxyindolacetaldehyde + NH3
show the reaction diagram
-
side reaction, decarboxylation-dependent transamination
-
?
5-hydroxytryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
5-Hydroxytryptophan
Serotonin + CO2
show the reaction diagram
5-Methyl-DL-Trp
?
show the reaction diagram
Micrococcus percitreus
-
17% of the activity with L-Trp
-
-
-
5-methyl-DL-tryptophan
?
show the reaction diagram
Micrococcus percitreus
-
17% activity compared to L-tryptophan
-
-
?
6-fluoro-L-(3,4-dihydroxyphenyl)alanine
4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
6-fluoro-threo-(3,4-dihydroxyphenyl)serine
4-(2-aminoethyl)-5-fluorobenzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
7-Aza-DL-Trp
?
show the reaction diagram
Micrococcus percitreus
-
8% of the activity with L-Trp
-
-
-
7-aza-DL-tryptophan
?
show the reaction diagram
Micrococcus percitreus
-
8% activity compared to L-tryptophan
-
-
?
alpha-methyl-DL-phenylalanine
?
show the reaction diagram
Micrococcus percitreus
-
2% activity compared to L-tryptophan
-
-
?
alpha-methyl-DL-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
1% activity compared to L-tryptophan
-
-
?
alpha-methyl-dopamine + O2
3,4-dihydroxyphenylacetone + NH3
show the reaction diagram
-
side reaction, decarboxylation-dependent transamination
-
?
alpha-methyl-L-Dopa
alpha-methyl-dopamine + CO2
show the reaction diagram
carbidopa
?
show the reaction diagram
-
interaction of carbidopa with the Phe103 residue of the enzyme, the residue forms a displaced sandwich-type sigma-complex with carbidopa
-
-
?
Carboxyl-L-Trp
?
show the reaction diagram
-
-
-
-
-
DOPA
dopamine + CO2
show the reaction diagram
-
-
-
?
dopamine + O2
3,4-dihydroxyphenylacetaldehyde + NH3
show the reaction diagram
-
-
-
?
L-(3,4-dihydroxyphenyl)alanine
4-(2-aminoethyl)benzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
L-3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
L-5-hydroxytryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
-
-
-
?
L-5-hydroxytryptophan
serotonin + CO2
show the reaction diagram
L-Dopa
dopamine + CO2
show the reaction diagram
L-kynurenine
3-amino-1-(2-aminophenyl)propan-1-one + CO2
show the reaction diagram
Micrococcus percitreus
-
15% of the activity with L-Trp
-
-
-
L-kynurenine
?
show the reaction diagram
Micrococcus percitreus
-
15% activity compared to L-tryptophan
-
-
?
L-Phe
phenylethylamine + CO2
show the reaction diagram
L-phenylalanine
2-phenylethylamine + CO2
show the reaction diagram
L-phenylalanine
?
show the reaction diagram
L-phenylalanine
L-phenethylamine + CO2
show the reaction diagram
Q1KSC5, Q1KSC6
-
-
-
?
L-phenylalanine
phenylethylamine + CO2
show the reaction diagram
L-threo-(3,4-dihydroxyphenyl)serine
4-[(2-hydroxyethyl)amino]benzene-1,2-diol + CO2
show the reaction diagram
-
-
-
?
L-Trp
Tryptamine + CO2
show the reaction diagram
L-tryptophan
tryptamine + CO2
show the reaction diagram
L-typtophan
tryptamine + CO2
show the reaction diagram
L-tyrosine
?
show the reaction diagram
L-Tyrosine
Tyramine + CO2
show the reaction diagram
m-DL-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
5% activity compared to L-tryptophan
-
-
?
m-Tyr
?
show the reaction diagram
m-tyrosine
m-tyramine + CO2
show the reaction diagram
-
-
-
-
?
Methylene-L-Trp
?
show the reaction diagram
-
-
-
-
-
N-methyl-L-dopa
N-methyldopamine + CO2
show the reaction diagram
o-DL-tyrosine
?
show the reaction diagram
Micrococcus percitreus
-
32% activity compared to L-tryptophan
-
-
?
o-fluorophenylalanine
o-fluorophenylethylamine + CO2
show the reaction diagram
o-Tyr
?
show the reaction diagram
p-fluorophenylalanine
p-fluorophenylethylamine + CO2
show the reaction diagram
-
-
-
?
p-tyrosine
p-tyramine + CO2
show the reaction diagram
-
-
-
-
?
Phe-7-amido-4-methylcoumarin
? + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
phenylalanine
phenylethylamine + CO2
show the reaction diagram
-
-
-
-
?
Trp-7-amido-4-methylcoumarin
? + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Tryptophan
Tryptamine + CO2
show the reaction diagram
-
-
-
-
?
Tyr-7-amido-4-methylcoumarin
? + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
tyrosine
tyramine + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3,4-dihydroxyphenylalanine
? + CO2
show the reaction diagram
-
regulation of the ganglionic dopamine level
-
?
3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
5-hydroxy-L-tryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
-
-
-
-
?
5-hydroxy-L-tryptophan
serotonin + CO2
show the reaction diagram
5-hydroxytryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
5-Hydroxytryptophan
Serotonin + CO2
show the reaction diagram
L-3,4-Dihydroxyphenylalanine
Dopamine + CO2
show the reaction diagram
L-5-hydroxytryptophan
serotonin + CO2
show the reaction diagram
-
-
-
-
?
L-Dopa
dopamine + CO2
show the reaction diagram
L-phenylalanine
2-phenylethylamine + CO2
show the reaction diagram
L-phenylalanine
phenylethylamine + CO2
show the reaction diagram
-
-
-
-
ir
L-Trp
Tryptamine + CO2
show the reaction diagram
L-tryptophan
tryptamine + CO2
show the reaction diagram
L-typtophan
tryptamine + CO2
show the reaction diagram
L-Tyrosine
Tyramine + CO2
show the reaction diagram
-
-
-
-
?
m-tyrosine
m-tyramine + CO2
show the reaction diagram
-
-
-
-
?
p-tyrosine
p-tyramine + CO2
show the reaction diagram
-
-
-
-
?
phenylalanine
phenylethylamine + CO2
show the reaction diagram
-
-
-
-
?
Tryptophan
Tryptamine + CO2
show the reaction diagram
-
-
-
-
?
tyrosine
tyramine + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
additional information
-
no absolute requirement for exogenous pyridoxal 5'-phosphate
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Al3+
-
activates
Fe2+
-
stimulation
Mn2+
-
stimulation
Na+
-
inverse correlation between DDC activity and sodium reabsorption in the kidney, confirming the hypothesis that dopamine inhibits sodium absorption
additional information
-
increasing concentrations of Zn2+ result in a raise in the solubilization of the membrane-associated enzyme, while the presence of increasing concentrations of Ca2+ and Mg2+ inhibits enzyme release from the MF sample
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid
-
-
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
-
-
(S)-alpha-(fluoromethyl)tryptophan
-
the suicide substrate effectively inhibits TDC activity extracted from rice leaves infected by Bipolaris oryzae and the inhibition rate increases dependent on preincubation time
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
MPTP, after 7 days of treatment, AAAD activities are decreased by more than 50% in the mouse striatum
2,2'-dipyridyl
-
weak
2,3,4-Trihydroxybenzylhydrazine
-
-
2-Phenylethylamine
Micrococcus percitreus
-
competitive inhibition, 80% inhibition at 0.5 mM
2-[1-[4-hydroxy-5-[3-(3-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenyl]-3-(4-hydroxy-3-methoxyphenyl)propyl]-5-methoxycyclohexa-2,5-diene-1,4-dione
-
inhibitor isolated from Euonymus glabra Roxb.
2-[[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)sulfonyl]amino]-N-phenylbenzamide
-
competitive. Inhibitor is unable to bind free pyridoxal 5'-phosphate, and predicted to not cross the blood-brain barrier
3'-hydroxybenzylhydrazine
-
NSD-1015, a central aromatic L-amino acid decarboxylase inhibitor
3,4-dihydroxyphenylalanine
-
inhibitory effect of 3,4-dihydroxyphenylalanine on the conversion of 5-hydroxy-L-tryptophan
3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl propionic acid
-
carbiDOPA, addition of 10 microM inhibitor to reaction mixtures (Y332F mutant with L-dopa) in the presence or in the absence of catalase or superoxide dismutase, immediately stops the O2 consumption.
3-hydroxy-benzylhydrazine
-
-
3-Indoleacetamide
3-Indolealdehyde
3-iodo-L-tyrosine
-
-
3-methyl-L-tyrosine
-
-
3-[2-hydroxy-5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-4-methoxyphenyl]-2-[3-(4-hydroxy-3-methoxyphenyl)-2-oxopropyl]-5-methoxycyclohexa-2,5-diene-1,4-dione
-
inhibitor isolated from Euonymus glabra Roxb., structural analogue of dopamine. Compound is able to suppress the activity of dopa decarboxylase and dopamine levels in purified enzyme and cell-based assays
4-Bromo-3-hydroxy-benzyloxyamine
-
-
4-[(E)-[(3-phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl]benzene-1,2,3-triol
-
mixed type inhibition. Inhibitor is unable to bind free pyridoxal 5'-phosphate, and predicted to not cross the blood-brain barrier
4-[(E)-[(3-phenyl-5-sulfanyl-4H-1,2,4-triazol-4-yl)imino]methyl]benzene-1,2-diol
-
competitive. Inhibitor is unable to bind free pyridoxal 5'-phosphate, and predicted to not cross the blood-brain barrier
4-[(E)-[[3-(4-chlorophenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]imino]methyl]benzene-1,2-diol
-
competitive. Inhibitor is unable to bind free pyridoxal 5'-phosphate, and predicted to not cross the blood-brain barrier
5-hydroxy indole acetic acid
-
the conversion of 5-hydroxy-L-tryptophan is 20% inhibited by 0.33 mM 5-hydroxy indole acetic acid
5-hydroxy-L-tryptophan
5-hydroxytryptamine
-
-
5-hydroxytryptophan
7-hydroxy-N,N-di-n-propyl-2-aminotetralin
-
reduced AAAD activity in the striatum by acute treatment with the D2-like receptor agonist
alpha-Allenyldopa
-
-
alpha-methyl-2,4-dihydroxyphenylalanine
-
-
alpha-Methyl-5-hydroxytryptophan
-
-
alpha-Methyl-D,L-3,4-dihydroxyphenylalanine
-
-
alpha-methyl-DL-phenylalanine
alpha-methyl-DL-tyrosine
Micrococcus percitreus
-
71% inhibition at 0.2 mM
alpha-methyl-L-Dopa
Micrococcus percitreus
-
60% inhibition at 0.2 mM
alpha-Methylhydrazinodopa
-
-
alpha-monofluoromethyl-DL-3,4-dihydroxyphenylalanine
-
suicide inhibitor
alpha-synuclein
-
significantly reduces AADC activity
-
Amino-oxyacetate
-
-
annexin 5
-
endogenous inhibitor, identified and purified from human placenta presented in the membrane function, shows 30.4% inhibition by incubation of the human placenta samples in the presence of 0.34 unit ddc from mouse kidney homogenate. The inhibitor exhibits an optimum activity at 50 mM NaCl, pH 6.5, is heat labile and is deactivated by boiling. After incubation of the placental homogenate with proteinase K, inhibitory activity is partially abolished, suggesting that a population of inhibitor molecules is embedded in the membrane.
-
apomorphine
-
inhibition in rat striatum
Benserazide
benzerazide
O45216
Escherichia coli phagocytosis is blocked by benzerazide, revealing the involvement of Ddc activity in phagocytosis
beta-phenylethylamine
Micrococcus percitreus
-
-
bromocryptine
-
reduced AAAD activity in the striatum by acute and chronic treatment with the D2-like receptor agonist
carbidopa
Cd2+
-
-
Chalcone derivatives
-
-
-
Clorgyline
-
reduced AAAD activity in the striatum by acute treatment with the dopamine receptor indirect agonist
D-5-hydroxytryptophan
-
-
D-Dopa
-
-
D-Trp
-
-
D-tryptophan
-
non-competitive inhibitor
diethyldithiocarbamate
-
-
Difluoromethyldopa
-
-
Dithiobisnitrobenzoate
-
-
dithiothreitol
-
-
DL-alpha-Difluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
-
-
DL-alpha-Monofluoromethyl-beta-(3,4-dihydroxyphenyl)alanine
DL-m-Tyr
Micrococcus percitreus
-
tryptamine formation
DL-m-tyrosine
Micrococcus percitreus
-
50% inhibition at 4 mM
dopamine
EDTA
-
weak
epigallocatechin-3-gallate
-
direct inhibitory effect on both histidine decarboxylase and DOPA decarboxylase. Modeling of binding to the enzymes. Epigallocatechin-3-gallate does not affect the quaternary structure of the enzyme and remains stable in the active site throughout the entire trajectory. After 700 ps of simulation, epigallocatechin-3-gallate moves deeper into the active site. While adopting this conformation, epigallocatechin-3-gallate actually fills the binding pocket and blocks its entrance pathway
epinephrine
Ethynyl dopamine
-
-
Fe2+
-
enzyme from pharate pupae, no effect on the enzyme from white prepupae
Fluoromethyl dopamine
-
-
histamine
Micrococcus percitreus
-
1% inhibition at 4 mM
Hydroxycinnamic acid
-
-
hydroxylamine
Indole acetaldehyde
-
-
indole acetic acid
-
-
iodoacetamide
-
-
L-3,4-dihydroxyphenylalanine
Micrococcus percitreus
-
tryptamine formation
L-alpha-Methyl-alpha-hydrazino-3,4-dihydroxyphenylpropionic acid
-
-
L-alpha-methyl-Dopa
-
-
L-Dopa
L-histidine
Micrococcus percitreus
-
5% inhibition at 4 mM
L-mimosine
-
weak
L-Phe
Micrococcus percitreus
-
tryptamine formation
L-phenylalanine
Micrococcus percitreus
-
uncompetitive inhibition, 53% inhibition at 0.5 mM
L-Tyr
Micrococcus percitreus
-
tryptamine formation
L-tyrosine
Micrococcus percitreus
-
uncompetitive inhibition, 38% inhibition at 0.5 mM
mercaptoethanol
-
-
mercuribenzoate
-
-
Methyldopa
N,N-Dimethyltryptamine
-
-
N-5'-Phosphopyridoxyl-L-dopa
-
-
N-acetyldopamine
N1-Seryl N2-(2,3,4-trihydroxybenzyl) hydrazine
-
-
NaN3
-
weak
norepinephrine
NSD-1015
p-chloromercuribenzoic acid
-
-
Pargyline
-
reduced AAAD activity in the striatum by acute treatment with the dopamine receptor indirect agonist
Phenylthiourea
-
-
potassium bicarbonate
Micrococcus percitreus
-
57% inhibition at 1 M
-
pyridoxal 5'-phosphate
pyridoxamine phosphate
Micrococcus percitreus
-
complete inhibition at 0.2 mM
quinpirole
-
reduced AAAD activity in the striatum by chronic treatment with the D2-like receptor agonist
R-(+)-Amino-4,5-dihydroxy-1,2-7,8-tetrahydronaphthalene
-
-
-
Semicarbazide
serotonin
testosterone propionate
-
repetitive treatment of female mice with testosterone propionate for 2 weeks elicits a marked decrease in renal DCC activity
Thiosemicarbazide
-
-
Thiourea
-
-
tryptamine
tyramine
Vinyl dopamine
-
-
-
additional information
-