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Disease on EC 4.1.1.23 - orotidine-5'-phosphate decarboxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Hypoplastic, Congenital
Elevation of pyrimidine enzyme activities in the RBC of patients with congenital hypoplastic anaemia and their parents.
Aspergillosis
Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus.
Candidiasis
Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus.
Carcinoma
Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase.
Potential for ambiguity in the interpretation of immunochemical studies on multienzymic proteins. The case of uridylate synthase.
Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma.
The purification and preliminary characterization of UMP synthase from human placenta.
Carcinoma, Hepatocellular
Amplification of the UMP synthase gene and enzyme overproduction in pyrazofurin-resistant rat hepatoma cells. Molecular cloning of a cDNA for UMP synthase.
Increased levels of UMP synthase protein and mRNA in pyrazofurin-resistant rat hepatoma cells.
Orotate phosphoribosyl transferase and orotidylic acid decarboxylase activities in liver and Morris hepatomas.
Potentiation of antimetabolite action by dibromodulcitol in cell culture.
Communicable Diseases
Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics.
Inhibition of orotidine 5'-monophosphate decarboxylase and its therapeutic potential.
Cysts
Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection.
Hepatitis B
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Herpes Simplex
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
HIV Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Infections
Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies, and perspectives.
Leukemia
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Lymphoma
Pyrimidine pathway variants of cultured mouse lymphoma cells with altered levels of both orotate phosphoribosyltransferase and orotidylate decarboxylase.
Malaria
A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization.
A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.
A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase.
Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.
Design of inhibitors of ODCase.
Inhibition of orotidine 5'-monophosphate decarboxylase and its therapeutic potential.
Insights into the pyrimidine biosynthetic pathway of human malaria parasite Plasmodium falciparum as chemotherapeutic target.
Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum.
Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist.
Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum.
Mycosis Fungoides
Clinical trial of weekly pyrazofurin.
Neoplasm Metastasis
Hypoxia enhances aggressiveness of cholangiocarcinoma cells.
Neoplasms
Enzymes of the de novo and salvage pathways for pyrimidine biosynthesis in normal colon, colon carcinoma, and xenografts.
Inhibition of orotidine 5'-monophosphate decarboxylase and its therapeutic potential.
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
ornithine carbamoyltransferase deficiency
Activity of orotate metabolizing enzyme complex and various urea-cycle enzymes in mutant mice with ornithine transcarbamylase deficiency.
Ornithine Carbamoyltransferase Deficiency Disease
Activity of orotate metabolizing enzyme complex and various urea-cycle enzymes in mutant mice with ornithine transcarbamylase deficiency.
orotidine-5'-phosphate decarboxylase deficiency
Consequences of UMP synthase deficiency in cattle.
Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria.
Detection and prevalence of UMP synthase deficiency among dairy cattle.
Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families.
pantoate-beta-alanine ligase (amp-forming) deficiency
Disorders of purine and pyrimidine metabolism.
Parasitic Diseases
Design of inhibitors of ODCase.
Inhibition of orotidine 5'-monophosphate decarboxylase and its therapeutic potential.
Persistent Infection
Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection.
Polycythemia Vera
Clinical trial of weekly pyrazofurin.
Poxviridae Infections
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Psoriasis
Clinical trial of weekly pyrazofurin.
Sarcoma, Avian
Activation of ornithine decarboxylase in monolayer cells treated with trypsin.
Smallpox
Therapy and short-term prophylaxis of poxvirus infections: historical background and perspectives.
Starvation
Cloning and characterization of the pyrF operon of Salmonella typhimurium.
Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis.