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Information on EC 4.1.1.14 - valine decarboxylase
for references in articles please use BRENDA:EC4.1.1.14
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IUBMB Comments
A pyridoxal-phosphate protein. Also acts on L-leucine.
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
showSynonyms
valine decarboxylase, leucine decarboxylase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Decarboxylase, leucine
-
-
-
-
Decarboxylase, valine
-
-
-
-
L-Valine carboxy-lyase
-
-
-
-
Leucine decarboxylase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-valine = 2-methylpropanamine + CO2
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
decarboxylation
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
L-valine carboxy-lyase (2-methylpropanamine-forming)
A pyridoxal-phosphate protein. Also acts on L-leucine.
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CAS REGISTRY NUMBER
COMMENTARY
9031-16-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D,L-Homocysteine
?
-
Substrates: 8-17% of the activity with L-Leu
Products: -
Products: -
?
D,L-Homocysteine
?
-
Substrates: 8-17% of the activity with L-Leu
Products: -
Products: -
?
D,L-Homocysteine
?
-
Substrates: 8-17% of the activity with L-Leu
Products: -
Products: -
?
D,L-Homocysteine
?
-
Substrates: 8-17% of the activity with L-Leu
Products: -
Products: -
?
D,L-Homocysteine
?
-
Substrates: 8-17% of the activity with L-Leu
Products: -
Products: -
?
L-2-Aminobutanoate
n-Propylamine + CO2
-
Substrates: 12-37% of the activity with L-Leu
Products: -
Products: -
?
L-2-Aminobutanoate
n-Propylamine + CO2
-
Substrates: 12-37% of the activity with L-Leu
Products: -
Products: -
?
L-2-Aminobutanoate
n-Propylamine + CO2
-
Substrates: 12-37% of the activity with L-Leu
Products: -
Products: -
?
L-2-Aminobutanoate
n-Propylamine + CO2
-
Substrates: 12-37% of the activity with L-Leu
Products: -
Products: -
?
L-2-Aminobutanoate
n-Propylamine + CO2
-
Substrates: 12-37% of the activity with L-Leu
Products: -
Products: -
?
L-Ile
2-Methylbutylamine + CO2
-
Substrates: 5-23% of the activity with L-Leu
Products: -
Products: -
?
L-Ile
2-Methylbutylamine + CO2
-
Substrates: 5-23% of the activity with L-Leu
Products: -
Products: -
?
L-Ile
2-Methylbutylamine + CO2
-
Substrates: 5-23% of the activity with L-Leu
Products: -
Products: -
?
L-Ile
2-Methylbutylamine + CO2
-
Substrates: 5-23% of the activity with L-Leu
Products: -
Products: -
?
L-Ile
2-Methylbutylamine + CO2
-
Substrates: 5-23% of the activity with L-Leu
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: 5-20% of the activity with L-Leu
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: 5-20% of the activity with L-Leu
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: 5-20% of the activity with L-Leu
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: -
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: 5-20% of the activity with L-Leu
Products: -
Products: -
?
L-Met
3-Methylmercaptopropylamine + CO2
-
Substrates: 5-20% of the activity with L-Leu
Products: -
Products: -
?
L-Norleucine
Pentylamine + CO2
-
Substrates: 24-39% of the activity with L-Leu
Products: -
Products: -
?
L-Norleucine
Pentylamine + CO2
-
Substrates: 24-39% of the activity with L-Leu
Products: -
Products: -
?
L-Norleucine
Pentylamine + CO2
-
Substrates: 24-39% of the activity with L-Leu
Products: -
Products: -
?
L-Norleucine
Pentylamine + CO2
-
Substrates: 24-39% of the activity with L-Leu
Products: -
Products: -
?
L-Norleucine
Pentylamine + CO2
-
Substrates: 24-39% of the activity with L-Leu
Products: -
Products: -
?
L-Norvaline
n-Butylamine + CO2
-
Substrates: 26-49% of the activity with L-Leu
Products: -
Products: -
?
L-Norvaline
n-Butylamine + CO2
-
Substrates: 26-49% of the activity with L-Leu
Products: -
Products: -
?
L-Norvaline
n-Butylamine + CO2
-
Substrates: 26-49% of the activity with L-Leu
Products: -
Products: -
?
L-Norvaline
n-Butylamine + CO2
-
Substrates: 26-49% of the activity with L-Leu
Products: -
Products: -
?
L-Norvaline
n-Butylamine + CO2
-
Substrates: 26-49% of the activity with L-Leu
Products: -
Products: -
?
L-valine
i-butylamine + CO2
-
Substrates: 3-13% of the activity with L-Leu
Products: -
Products: -
?
L-valine
i-butylamine + CO2
-
Substrates: 3-13% of the activity with L-Leu
Products: -
Products: -
?
L-valine
i-butylamine + CO2
-
Substrates: 3-13% of the activity with L-Leu
Products: -
Products: -
?
L-valine
i-butylamine + CO2
-
Substrates: 3-13% of the activity with L-Leu
Products: -
Products: -
?
L-valine
i-butylamine + CO2
-
Substrates: 3-13% of the activity with L-Leu
Products: -
Products: -
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.25
5 - 6
5.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
highest activity in very young cultures, decreases rapidly in the early exponential phase of growth
brenda
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hartmann, T.
Leucin-carboxylase aus marinen Rhodophyceae: Vorkommen, Verbreitung und einige Eigenschaften
Phytochemistry
11
1327-1336
1972
Bonnemaisonia hamifera, Ceramium deslongchampsii, Ceramium rubrum, Cystoclonium purpureum, Delesseria sanguinea, Dumontia incrassata, Furcellaria fastigiata, no activity in Bangia fuscopurpurea, no activity in Hildenbrandia prototypus, no activity in Lemanea torulosa, no activity in Porphyra umbilicalis, no activity in Porphyridium purpureum, no activity in Porphyridium violaceum, no activity in Rhodochorton purpureum, Phyllophora brodiaei, Phyllophora membranifolia, Polyides rotunda, Polysiphonia nigrescens, Polysiphonia urceolata, Trailliella intricata
-
brenda
Bast, E.; Hartmann, T.; Steiner, M.
_ber eine Valin-carboxylase aus Bacillus sphaericus
Arch. Mikrobiol.
79
12-24
1971
Lysinibacillus sphaericus
brenda
Sutton, C.R.; King, H.K.
Inhibition of leucine decarboxylase by thiol-binding reagents
Arch. Biochem. Biophys.
96
360-370
1962
Proteus vulgaris
brenda
Cortez-Espinosa, N.; Avina-Verduzco, J.A.; Ramirez-Chavez, E.; Molina-Torres, J.; Rios-Chavez, P.
Valine and phenylalanine as precursors in the biosynthesis of alkamides in Acmella radicans
Nat. Prod. Commun.
6
857-861
2011
Acmella radicans
brenda
EXTERNAL LINKS (specific for EC-Number 4.1.1.14)
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Release 2023.1 (January 2023)
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