Information on EC 3.8.1.1 - alkylhalidase

for references in articles please use BRENDA:EC3.8.1.1
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
3.8.1.1
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RECOMMENDED NAME
GeneOntology No.
alkylhalidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
bromochloromethane + H2O = formaldehyde + bromide + chloride
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-halide hydrolysis
hydrolysis of C-halide
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SYSTEMATIC NAME
IUBMB Comments
alkyl-halide halidohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
9025-22-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain DSM5908, gene bhaA in the balhimycin biosynthesis gene cluster
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Manually annotated by BRENDA team
strain DSM5908, gene bhaA in the balhimycin biosynthesis gene cluster
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
BrH2CCH2Br + 2 H2O
OHCCHO + 6 H+ + 2 Br-
show the reaction diagram
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-
-
-
?
CH2Br-CH2Cl + H2O
?
show the reaction diagram
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-
-
-
?
CH2Br2 + H2O
HCHO + 2 H+ + 2 Br-
show the reaction diagram
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-
-
-
?
CH2BrCl + H2O
HCHO + H+ + Br- + Cl-
show the reaction diagram
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-
-
-
?
CH2Cl2 + H2O
HCHO + H+ + Cl-
show the reaction diagram
-
-
-
-
?
CH3Br + H2O
?
show the reaction diagram
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-
-
-
?
CHCl3 + H2O
?
show the reaction diagram
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-
-
-
?
ClH2CCH2Cl + 2 H2O
OHCCHO + 6 H+ + 2 Cl-
show the reaction diagram
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-
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-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
BrH2CCH2Br + 2 H2O
OHCCHO + 6 H+ + 2 Br-
show the reaction diagram
-
-
-
-
?
CH2Br-CH2Cl + H2O
?
show the reaction diagram
-
-
-
-
?
CH2Br2 + H2O
HCHO + 2 H+ + 2 Br-
show the reaction diagram
-
-
-
-
?
CH2BrCl + H2O
HCHO + H+ + Br- + Cl-
show the reaction diagram
-
-
-
-
?
CH2Cl2 + H2O
HCHO + H+ + Cl-
show the reaction diagram
-
-
-
-
?
CH3Br + H2O
?
show the reaction diagram
-
-
-
-
?
CHCl3 + H2O
?
show the reaction diagram
-
-
-
-
?
ClH2CCH2Cl + 2 H2O
OHCCHO + 6 H+ + 2 Cl-
show the reaction diagram
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-
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cysteine
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glutathione
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PDB
SCOP
CATH
UNIPROT
ORGANISM
Q4KCZ0
Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5);
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially by ammonium sulfate fractionation
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination, genomic organiszation in the balhimycin biosynthesis gene cluster, expression of mutant enzymes in Amycolatopsis mediterranei, subcloning in Escherichia coli
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis