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(2S)-2-amino-4-oxo-4-phenylbutanoic acid + H2O
benzoate + L-alanine
-
the rate-determining step is Cbeta-Cgamma bond cleavage
-
?
(2S,3S)-erythro-beta-methyl-L-kynurenine
?
-
-
-
?
(4R)-5-bromodihydro-L-kynurenine + H2O
? + L-alanine
-
slow substrate, no activity with (4S)-5-bromodihydro-L-kynurenine
-
?
(4R)-dihydro-L-kynurenine + H2O
2-aminobenzaldehyde + L-alanine
(alphaS,4R)-dihydrokynurenine + H2O
?
the (alphaS,4R) diastereomer is a slow substrate for a retro-aldol reaction, and the (alphaS,4S) isomer is a potent competitive inhibitor, proposed mechanism for reaction of dihydrokynurenine
-
?
2-amino-4-(2-chlorophenyl)-4-oxobutanoic acid + H2O
?
-
-
-
?
2-amino-4-(2-methoxyphenyl)-4-oxobutanoic acid + H2O
?
-
-
-
?
2-amino-4-(4-methoxyphenyl)-4-oxobutanoic acid + H2O
?
-
-
-
?
2-fluorobenzoyl-DL-alanine + H2O
2-fluorobenzoate + beta-alanine
-
-
-
?
3,5-dibromo-L-kynurenine + H2O
3,5-dibromoanthranilate + DL-kynurenine
3-bromo-L-kynurenine + H2O
3-bromoanthranilate + L-alanine
3-chloro-DL-kynurenine + H2O
3-chloroanthranilate + DL-alanine
3-fluoro-DL-kynurenine + H2O
3-fluoroanthranilate + DL-alanine
3-hydroxy-DL-kynurenine + H2O
3-hydroxyanthranilate + DL-alanine
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
3-methyl-DL-kynurenine + H2O
3-methylanthranilate + DL-alanine
4-fluoro-L-kynurenine + H2O
4-fluoroanthranilate + L-alanine
-
-
-
?
5-bromo-3-chloro-DL-kynurenine + H2O
5-bromo-3-chloroanthranilate + DL-alanine
5-bromo-L-kynurenine + H2O
5-bromoanthranilate + L-alanine
5-chloro-L-kynurenine + H2O
5-chloroanthranilate + L-alanine
5-fluoro-L-kynurenine + H2O
5-fluoroanthranilate + L-alanine
-
-
-
?
5-hydroxy-L-kynurenine + H2O
5-hydroxyanthranilate + L-alanine
-
-
-
?
5-methyl-L-kynurenine + H2O
5-methylanthranilate + L-alanine
-
-
-
?
beta-(4-chlorobenzoyl)-DL-alanine + H2O
4-chlorobenzoate + beta-alanine
-
-
-
?
beta-(4-methylbenzoyl)-DL-alanine + H2O
4-methylbenzoate + beta-alanine
-
-
-
?
beta-(4-trifluoromethylbenzoyl)-DL-alanine + H2O
4-trifluoromethylbenzoate + beta-alanine
-
-
-
?
beta-benzoyl-DL-alanine + H2O
benzoate + DL-alanine
-
-
-
?
beta-benzoyl-L-alanine + H2O
benzoate + L-alanine
beta-benzoyl-L-kynurenine + H2O
?
-
-
-
?
beta-chloro-L-alanine + H2O
?
-
-
-
?
gamma-(o-aminophenyl)-L-homoserine + H2O
L-alanine + o-aminobenzaldehyde
-
-
-
?
kynurenine + H2O
excitotoxin quinolinate
-
-
-
?
kynurenine + H2O
quinolinate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
L-kynurenine + benzaldehyde
(2S,4R)-2-amino-4-hydroxy-4-phenylbutanoic acid + ?
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
L-ornithine + H2O
?
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
O-benzoyl-L-serine + H2O
benzoate + pyruvate + ammonium
additional information
?
-
(4R)-dihydro-L-kynurenine + H2O

2-aminobenzaldehyde + L-alanine
-
-
-
?
(4R)-dihydro-L-kynurenine + H2O
2-aminobenzaldehyde + L-alanine
-
-
-
?
3,5-dibromo-L-kynurenine + H2O

3,5-dibromoanthranilate + DL-kynurenine
-
-
?
3,5-dibromo-L-kynurenine + H2O
3,5-dibromoanthranilate + DL-kynurenine
-
-
?
3-bromo-L-kynurenine + H2O

3-bromoanthranilate + L-alanine
-
-
?
3-bromo-L-kynurenine + H2O
3-bromoanthranilate + L-alanine
-
-
-
?
3-bromo-L-kynurenine + H2O
3-bromoanthranilate + L-alanine
-
-
?
3-chloro-DL-kynurenine + H2O

3-chloroanthranilate + DL-alanine
-
-
?
3-chloro-DL-kynurenine + H2O
3-chloroanthranilate + DL-alanine
-
-
?
3-fluoro-DL-kynurenine + H2O

3-fluoroanthranilate + DL-alanine
-
-
?
3-fluoro-DL-kynurenine + H2O
3-fluoroanthranilate + DL-alanine
-
-
?
3-hydroxy-L-kynurenine + H2O

3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O

3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
preferred substrate
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
biosynthesis of NAD+
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
L-tryptophan metabolism, biosynthesis of nicotinamide nucleotides
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
the hydroxyl group at the 3-position thus appears to be an important recognition element
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
biosynthesis of NAD+
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-methyl-DL-kynurenine + H2O

3-methylanthranilate + DL-alanine
-
-
?
3-methyl-DL-kynurenine + H2O
3-methylanthranilate + DL-alanine
-
-
?
5-bromo-3-chloro-DL-kynurenine + H2O

5-bromo-3-chloroanthranilate + DL-alanine
-
-
?
5-bromo-3-chloro-DL-kynurenine + H2O
5-bromo-3-chloroanthranilate + DL-alanine
-
-
?
5-bromo-L-kynurenine + H2O

5-bromoanthranilate + L-alanine
-
-
?
5-bromo-L-kynurenine + H2O
5-bromoanthranilate + L-alanine
-
-
-
?
5-bromo-L-kynurenine + H2O
5-bromoanthranilate + L-alanine
-
-
?
5-chloro-L-kynurenine + H2O

5-chloroanthranilate + L-alanine
-
-
?
5-chloro-L-kynurenine + H2O
5-chloroanthranilate + L-alanine
-
-
?
beta-benzoyl-L-alanine + H2O

benzoate + L-alanine
-
-
-
?
beta-benzoyl-L-alanine + H2O
benzoate + L-alanine
-
-
?
beta-benzoyl-L-alanine + H2O
benzoate + L-alanine
-
good substrate
-
?
L-alanine + pyridoxal 5'-phosphate

pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-kynurenine + H2O

anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
the rate-determining step is to be deprotonation of the pyruvate-ketimine intermediate
-
?
L-kynurenine + H2O
anthranilate + L-alanine
the enzyme catalyzes the hydrolytic Cbeta-Cgamma cleavage of L-kynurenine to alanine and anthranilic acid catalyzing a retro-Claisen reaction
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O

N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
N-formyl-L-kynurenine + H2O
N-formylanthranilate + L-alanine
-
-
-
?
O-benzoyl-L-serine + H2O

benzoate + pyruvate + ammonium
-
-
?
O-benzoyl-L-serine + H2O
benzoate + pyruvate + ammonium
O-benzoyl-L-serine is an alternate substrate for kynureninase, which undergoes a normal beta-elimination reaction, proposed mechanism for reaction of O-benzoyl-L-serine, overview
-
?
additional information

?
-
for the human enzyme, 3- and 5-substituted kynurenines have kcat and kcat/Km values higher than L-kynurenine, but less than that of the physiological substrate, 3-hydroxykynurenine. 3,5-Dibromo- and 5-bromo-3-chlorokynurenine have kcat and kcat/Km values close to that of 3-hydroxykynurenine with human kynureninase. The effects of the 3-halo substituents on the reactivity with human kynureninase may be due to electronic effects and/or halogen bonding. 5-Bromo and 5-chloro-L-kynurenine are good substrates the human enzyme, indicating that the enzyme has space for substituents in the active site near C-5. The increased activity of the 5-halokynurenines may be due to van der Waals contacts or hydrophobic effects. The mammalian kynureninase cleaves 3-hydroxy-L-kynurenine more rapidly than L-kynurenine, substrate synthesis and specificity, overview
-
?
additional information
?
-
-
for the human enzyme, 3- and 5-substituted kynurenines have kcat and kcat/Km values higher than L-kynurenine, but less than that of the physiological substrate, 3-hydroxykynurenine. 3,5-Dibromo- and 5-bromo-3-chlorokynurenine have kcat and kcat/Km values close to that of 3-hydroxykynurenine with human kynureninase. The effects of the 3-halo substituents on the reactivity with human kynureninase may be due to electronic effects and/or halogen bonding. 5-Bromo and 5-chloro-L-kynurenine are good substrates the human enzyme, indicating that the enzyme has space for substituents in the active site near C-5. The increased activity of the 5-halokynurenines may be due to van der Waals contacts or hydrophobic effects. The mammalian kynureninase cleaves 3-hydroxy-L-kynurenine more rapidly than L-kynurenine, substrate synthesis and specificity, overview
-
?
additional information
?
-
for the bacterial enzyme, 3-methyl-, 3-halo- and 3,5-dihalokynurenines are much poorer substrates, while 3-fluoro, 5-bromo, and 5-chlorokynurenine have kcat and kcat/Km values comparable to that of its physiological substrate, L-kynurenine. 5-Bromo and 5-chloro-L-kynurenine are good substrates for the bacterial enzyme, indicating that the enzyme has space for substituents in the active site near C-5. The increased activity of the 5-halokynurenines may be due to van der Waals contacts or hydrophobic effects. The bacterial kynureninase cleaves L-kynurenine more rapidly than 3-hydroxy-L-kynurenine, substrate synthesis and specificity, overview
-
?
additional information
?
-
-
for the bacterial enzyme, 3-methyl-, 3-halo- and 3,5-dihalokynurenines are much poorer substrates, while 3-fluoro, 5-bromo, and 5-chlorokynurenine have kcat and kcat/Km values comparable to that of its physiological substrate, L-kynurenine. 5-Bromo and 5-chloro-L-kynurenine are good substrates for the bacterial enzyme, indicating that the enzyme has space for substituents in the active site near C-5. The increased activity of the 5-halokynurenines may be due to van der Waals contacts or hydrophobic effects. The bacterial kynureninase cleaves L-kynurenine more rapidly than 3-hydroxy-L-kynurenine, substrate synthesis and specificity, overview
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
5-hydroxy-L-kynurenine + H2O
5-hydroxyanthranilate + L-alanine
-
-
-
?
5-methyl-L-kynurenine + H2O
5-methylanthranilate + L-alanine
-
-
-
?
kynurenine + H2O
quinolinate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
L-kynurenine + H2O
anthranilate + L-alanine
3-hydroxy-L-kynurenine + H2O

3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-Ala
-
-
-
?
3-hydroxy-L-kynurenine + H2O

3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
biosynthesis of NAD+
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
L-tryptophan metabolism, biosynthesis of nicotinamide nucleotides
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
biosynthesis of NAD+
-
-
?
3-hydroxy-L-kynurenine + H2O
3-hydroxyanthranilate + L-alanine
-
-
-
-
?
L-alanine + pyridoxal 5'-phosphate

pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-alanine + pyridoxal 5'-phosphate
pyruvate + pyridoxamine 5'-phosphate
-
-
-
?
L-kynurenine + H2O

anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
L-tryptophan metabolism
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
L-kynurenine + H2O
anthranilate + L-alanine
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2S)-2-amino-4-oxo-4-phenylbutanoic acid
-
competitive inhibitor of the reaction of L-kynurenine with the enzyme
(4R)-5-bromodihydro-L-kynurenine
-
-
(4S)-5-bromodihydro-L-kynurenine
-
-
(4S)-dihydro-L-kynurenine
(alphaS,4S)-dihydrokynurenine
the (alphaS,4R) diastereomer is a slow substrate for a retro-aldol reaction, and the (alphaS,4S) isomer is a potent competitive inhibitor, proposed mechanism for reaction of dihydrokynurenine
(S)-(2-amino-4-bromophenyl)-L-cysteine S,S-dioxide
-
competitive inhibition
(S)-(2-amino-5-bromophenyl)-L-cysteine S,S-dioxide
-
competitive inhibition
(S)-(2-aminophenyl)-L-cysteine S,S-dioxide
-
-
2-amino-(4-oxo-4-naphthyl)-butyric acid
2-amino-3-fluoro-S-phenyl cysteine S,S-dioxide
-
-
2-amino-3-methoxy-S-phenyl cysteine S,S-dioxide
-
-
2-amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid
most potent inhibitor
2-amino-5-methyl-S-phenyl cysteine S,S-dioxide
-
-
2-amino-S-phenyl cysteine S,S-dioxide
-
-
3,5-dihydroxydeaminokynurenine
-
-
3,7-dihydroxy-deamino-DL-kynurenine
-
mixed inhibition
3-guanidino-L-alanine
-
0.001 mM in 0.2 mM Tris-HCl buffer
3-hydroxy-DL-kynurenine
-
-
3-Hydroxyanthranilate
-
0.001 mM in 0.06 mM Tris-HCl buffer
3-hydroxydeaminokynurenine
3-methoxydeaminokynurenine
5-bromodihydrokynurenine
a potent transition-state analogue inhibitor
amino-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-acetic acid
amino-(1-oxo-2,3-dihydro-1H-inden-2-yl)-acetic acid
amino-(4-oxo-3,4-dihydro-2H-chromen-3-yl)-acetic acid
beta-Alanine
-
competitive inhibition, 10 mM
beta-benzoyl-L-alanine
-
competitive inhibition, at 25ĀŗC, pH 7.8
D-alanine
-
competitive inhibition, 10 mM
D-serine
-
competitive inhibition, 10 mM
deaminokynurenine
-
competitive and non competitive inhibition
delta-N-acetyl-L-ornithine
DL-5-chloro-kynurenine
-
substantially inhibits
DL-allothreonine
-
competitive inhibition, 10 mM
DL-alpha-aminobutyric acid
-
competitive inhibition, 10 mM
DL-dihydroxyphenylalanine
DL-homoserine
-
competitive inhibition, 10 mM
DL-methionine
-
competitive inhibition, 40 mM
DL-Ornithine
-
competitive inhibition, 10 mM
L-5-chloro-kynurenine
-
substantially inhibits
L-arginine
-
competitive inhibition, 10 mM
L-asparagine
-
competitive inhibition, 10 mM
L-aspartic acid
-
competitive inhibition, 10 mM
L-cysteine
-
competitive inhibition, 10 mM
L-Glutamic acid
-
competitive inhibition, 10 mM
L-glutamine
-
competitive inhibition, 10 mM
L-histidine
-
competitive inhibition, 10 mM
L-serine
-
competitive inhibition, 10 mM
L-threonine
-
competitive inhibition, 10 mM
L-tryptophan
-
competitive inhibition, 10 mM
lanthellamide
-
about 60% residual activity at 1 mM, about 80% residual activity at 0.5 mM, slight inhibition at 0.125 mM
m-nitrobenzoylalanine
-
-
N'-formyl-L-kynurenine
-
-
o-bromobenzoylalanine
-
-
o-ethoxybenzoylalanine
-
-
o-fluorobenzoylalanine
-
-
o-methoxybenzoylalanine
-
-
o-methylbenzoylalanine
-
-
o-trifluoromethylbenzoylalanine
-
-
p-hydroxyphenylpyruvate
-
5 mM
pyridoxal 5'-phosphate
-
-
S-(2-aminophenyl)-L-cysteine dioxide
-
S-(2-aminophenyl)-L-cysteine S,S-dioxide
S-(beta-aminoethyl)-L-cysteine
-
0.001 mM in 0.06 mM Tris-HCl buffer
tryptamine
-
competitive inhibition, 10 mM
(4S)-dihydro-L-kynurenine

-
competitive inhibitor
(4S)-dihydro-L-kynurenine
-
-
2-amino-(4-oxo-4-naphthyl)-butyric acid

-
competitive inhibition, reversible inhibition by dilution
2-amino-(4-oxo-4-naphthyl)-butyric acid
-
competitive inhibition, reversible inhibition by dilution
3-hydroxydeaminokynurenine

-
competitive and non competitive inhibition
3-hydroxydeaminokynurenine
-
competitive and non competitive inhibition
3-hydroxydeaminokynurenine
-
competitive and non competitive inhibition
3-hydroxyhippuric acid

competitive inhibitor of kynureninase
3-hydroxyhippuric acid
a competitive inhibitor
3-methoxydeaminokynurenine

-
competitive and non competitive inhibition
3-methoxydeaminokynurenine
-
competitive and non competitive inhibition
3-methoxydeaminokynurenine
-
competitive and non competitive inhibition
amino-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-acetic acid

-
competitive inhibition, reversible inhibition by dilution
amino-(1-oxo-1,2,3,4-tetrahydro-2-naphthalenyl)-acetic acid
-
competitive inhibition, reversible inhibition by dilution
amino-(1-oxo-2,3-dihydro-1H-inden-2-yl)-acetic acid

-
competitive inhibition, reversible inhibition by dilution
amino-(1-oxo-2,3-dihydro-1H-inden-2-yl)-acetic acid
-
competitive inhibition, reversible inhibition by dilution
amino-(4-oxo-3,4-dihydro-2H-chromen-3-yl)-acetic acid

-
competitive inhibition, reversible inhibition by dilution
amino-(4-oxo-3,4-dihydro-2H-chromen-3-yl)-acetic acid
-
competitive inhibition, reversible inhibition by dilution
anthranilic acid

-
-
benzaldehyde

-
1 mM
beta-chloro-L-alanine

-
irreversible inhibition
beta-chloro-L-alanine
-
irreversible inhibition
cadaverine

-
competitive inhibition, 10 mM
D-cycloserine

-
1 mM
D-kynurenine

-
-
D-kynurenine
-
mixed inhibition
D-penicillamine

-
1 mM
delta-N-acetyl-L-ornithine

-
0.001 mM in 0.06 mM Tris-HCl buffer
delta-N-acetyl-L-ornithine
-
-
delta-N-acetyl-L-ornithine
-
-
DL-dihydroxyphenylalanine

-
competitive inhibition, 5 mM
DL-dihydroxyphenylalanine
-
-
HgCl2

-
-
KCN

-
1 mM
Kynurenate

-
-
Kynurenate
-
0.001 mM in 0.06 mM Tris-HCl buffer
L-alanine

-
competitive inhibition, 40 mM
L-kynurenine

-
-
L-kynurenine
-
competitive inhibition, at low substrate concentrations; non-competitive inhibition, at higher levels of substrate
L-lysine

-
competitive inhibition, 10 mM
L-ornithine

-
-
L-ornithine
-
0.001 mM in 0.2 mM Tris-HCl buffer
NH2OH

-
0.1 mM
nicotinylalanine

-
-
o-aminoacetophenone

-
1 mM
o-aminobenzaldehyde

-
0.1 mM
o-nitrobenzaldehyde

-
1 mM
p-chloromercuribenzoate

-
-
p-chloromercuribenzoate
-
0.5 mM
p-chloromercuribenzoate
-
-
p-chloromercuribenzoate
-
-
phenylhydrazine-HCl

-
-
phenylhydrazine-HCl
-
1 mM
putrescine

-
competitive inhibition, 10 mM
quinaldinate

-
-
quinaldinate
-
0.001 mM in 0.06 mM Tris-HCl buffer
S-(2-aminophenyl)-L-cysteine S,S-dioxide

-
transition state analogue
S-(2-aminophenyl)-L-cysteine S,S-dioxide
-
-
S-(2-aminophenyl)-L-cysteine S,S-dioxide
potent competitive inhibitor
Semicarbazide

-
-
Sodium borohydride

-
-
additional information

-
catabolite repression of the pathway by glucose and glutamate, arginine does not cause repression
-
additional information
-
not inhibited by DL-4-(ethylsulfonyl)benzoylalanine and its active enatiomer (S)-4-(ethylsulfonyl)benzoylalanine
-
additional information
-
lanthellamide does not inhibit the enzyme at concentrations up to 0.0625 mM
-
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Brain Injuries
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Brain Ischemia
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Breast Neoplasms
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Carcinoma
Down-regulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses PI3K/AKT pathway.
Carcinoma, Squamous Cell
Down-regulation of kynureninase restrains cutaneous squamous cell carcinoma proliferation and represses PI3K/AKT pathway.
Dementia
Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.
Encephalitis
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Epilepsy
Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Essential Hypertension
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
Essential Hypertension
[A polymorphism of kynureninase gene in a hypertensive candidate chromosomal region is associated with essential hypertension]
Glioma
Involvement of the kynurenine pathway in human glioma pathophysiology.
Hypertension
A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.
Hypertension
Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Infections
Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin.
Ischemic Attack, Transient
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
kynureninase deficiency
Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism.
kynureninase deficiency
The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.
kynureninase deficiency
Xanthurenic aciduria due to a mutation in KYNU encoding kynureninase.
kynureninase deficiency
[Kynureninase deficiency]
Meningitis, Pneumococcal
The cerebral protective effect and mechanism of action of vitamin B6 adjuvant ceftriaxone in experimental pneumococcal meningitis.
Metabolic Diseases
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Myocardial Infarction
Sarcopenia and sarcopenic obesity as prognostic predictors in hospitalized elderly patients with acute myocardial infarction.
Neoplasms
A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.
Neoplasms
LIVER KYNURENINASE ACTIVITY OF TUMOR BEARING ANIMALS.
Neoplasms
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Neoplasms
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma.
Neoplasms
Tryptophan pyrrolase, kynureninase and kynurenine transaminase activities of human renal tumours.
Neoplasms
[Importance of E-cadherin; expression in the inmunohistochemical diagnosis of breast cancer]
Neuralgia
Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model.
Obesity
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Pellagra
[Inhibiting effect of amino acids on kynureninase and its significance in the pathogenesis of pellagra.]
Phenylketonurias
[Kynureninase activity and pyridoxine elimination in rats with experimental phenylketonuria]
Psoriasis
Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis.
Psoriasis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Renal Insufficiency
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Seizures
Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Skin Diseases
Effect of psoralen-induced photodermatitis on tryptophan metabolism in rats.
Spasms, Infantile
Liver kynureninase activity of an infant with infantile spasm.
Vitamin B 6 Deficiency
High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels.
Vitamin B 6 Deficiency
Inhibition of kynureninase by oestrogen conjugates: evidence that oestrogens do not cause vitamin B6 deficiency.
Vitamin B 6 Deficiency
LIVER kynureninase activity and tryptophan metabolism in vitamin B6 deficiency.
Vitamin B 6 Deficiency
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency.
Vitamin B Deficiency
Inhibition of kynureninase (L-kynurenine hydrolase, EC 3 . 7. 1 . 3) by oestrone sulphate: an alternative explanation for abnormal results of tryptophan load tests in women receiving oestrogenic steroids.
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0.7
(2S)-2-amino-4-oxo-4-phenylbutanoic acid
-
at pH 7.8
0.08
2-amino-4-(2-chlorophenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.05
2-amino-4-(2-methoxyphenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.38
2-amino-4-(4-methoxyphenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.06
2-fluorobenzoyl-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.23 - 1.2
3,5-dibromo-L-kynurenine
1.9 - 11
3-bromo-L-kynurenine
0.67 - 0.71
3-chloro-DL-kynurenine
0.23 - 6.9
3-fluoro-DL-kynurenine
3.5
3-hydroxy-DL-kynurenine
-
0.0039 - 3.5
3-hydroxy-L-kynurenine
0.33 - 1.5
3-methyl-DL-kynurenine
1.3 - 6.3
5-bromo-3-chloro-DL-kynurenine
0.63 - 11.9
5-bromo-L-kynurenine
0.47 - 8.7
5-chloro-L-kynurenine
1.83
beta-(4-chlorobenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.91
beta-(4-methylbenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.001
beta-(4-trifluoromethylbenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.7
beta-benzoyl-L-alanine
0.1 - 2.5
O-benzoyl-L-serine
0.23
3,5-dibromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
1.2
3,5-dibromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
1.9
3-bromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
11
3-bromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.67
3-chloro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
0.71
3-chloro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.23
3-fluoro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
6.9
3-fluoro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.0039
3-hydroxy-L-kynurenine

kcat less than 0.0039 1/s, mutant enzyme N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.0109
3-hydroxy-L-kynurenine
kcat less than 0.0109 1/s, mutant enzyme S332G/N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
1
3-hydroxy-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
3.5
3-hydroxy-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
3.5
3-hydroxy-L-kynurenine
wild type enzyme, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.33
3-methyl-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
1.5
3-methyl-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
1.3
5-bromo-3-chloro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
6.3
5-bromo-3-chloro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.63
5-bromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
11.9
5-bromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.47
5-chloro-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
8.7
5-chloro-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.7
beta-benzoyl-L-alanine

-
-
0.7
beta-benzoyl-L-alanine
pH 8.0, 37°C, wild-type enzyme
0.0058
L-kynurenine

enzyme mutant Y226F, pH 8.0, 37°C
0.0058
L-kynurenine
pH 8.0, 37°C, mutant enzyme Y226F
0.007
L-kynurenine
mutant enzyme H102W/N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.017
L-kynurenine
mutant enzyme S332G/N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.018
L-kynurenine
Km above 0.51 mM, mutant enzyme H102W/S332G/N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.026
L-kynurenine
mutant enzyme N333T, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
0.069
L-kynurenine
pH 8.0, 37°C, mutant enzyme S36A
0.23
L-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.23
L-kynurenine
wild type enzyme, in 30 mM potassium phosphate, pH 8.0, and 0.04 mM pyridoxal 5'-phosphate, at 37°C
16
L-kynurenine
pH 8.0, 37°C, wild-type enzyme
16
L-kynurenine
wild-type enzyme, pH 8.0, 37°C
16
L-kynurenine
pH 8.0, 37°C, recombinant enzyme
16
L-kynurenine
-
at pH 7.8
0.1
O-benzoyl-L-serine

enzyme mutant Y226F, pH 8.0, 37°C
0.1
O-benzoyl-L-serine
pH 8.0, 37°C, mutant enzyme Y226F
1.7
O-benzoyl-L-serine
pH 8.0, 37°C, mutant enzyme S36A
2.5
O-benzoyl-L-serine
pH 8.0, 37°C, wild-type enzyme
2.5
O-benzoyl-L-serine
wild-type enzyme, pH 8.0, 37°C
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12
2-amino-4-(2-chlorophenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
1.4
2-amino-4-(2-methoxyphenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
1.6
2-amino-4-(4-methoxyphenyl)-4-oxobutanoic acid
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
1.7
2-fluorobenzoyl-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
7.9 - 21
3,5-dibromo-L-kynurenine
4.4 - 5.5
3-bromo-L-kynurenine
8.2 - 11
3-chloro-DL-kynurenine
2.7 - 90
3-fluoro-DL-kynurenine
2.5 - 123
3-hydroxy-L-kynurenine
1.8 - 22
3-methyl-DL-kynurenine
6.5 - 22
5-bromo-3-chloro-DL-kynurenine
1.5 - 3300
5-bromo-L-kynurenine
1.1 - 1800
5-chloro-L-kynurenine
18
beta-(4-chlorobenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
28
beta-(4-methylbenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
0.019
beta-(4-trifluoromethylbenzoyl)-DL-alanine
-
at 37°C in 0.04 M potassium phosphate, pH 7.8
80
beta-benzoyl-L-alanine
pH 8.0, 37°C, wild-type enzyme
0.0041 - 24
O-benzoyl-L-serine
7.9
3,5-dibromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
21
3,5-dibromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
4.4
3-bromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
5.5
3-bromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
8.2
3-chloro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
11
3-chloro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
2.7
3-fluoro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
90
3-fluoro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
2.5
3-hydroxy-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
123
3-hydroxy-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
1.8
3-methyl-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
22
3-methyl-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
6.5
5-bromo-3-chloro-DL-kynurenine

pH 8.0, 37°C, recombinant enzyme
22
5-bromo-3-chloro-DL-kynurenine
pH 8.0, 37°C, recombinant enzyme
1.5
5-bromo-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
3300
5-bromo-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
1.1
5-chloro-L-kynurenine

pH 8.0, 37°C, recombinant enzyme
1800
5-chloro-L-kynurenine
pH 8.0, 37°C, recombinant enzyme
0.465
L-kynurenine

pH 8.0, 37°C, recombinant enzyme
0.53
L-kynurenine
enzyme mutant Y226F, pH 8.0, 37°C
0.53
L-kynurenine
pH 8.0, 37°C, mutant enzyme Y226F
20
L-kynurenine
pH 8.0, 37°C, mutant enzyme S36A
200
L-kynurenine
wild-type enzyme, pH 8.0, 37°C
600
L-kynurenine
pH 8.0, 37°C, recombinant enzyme
630
L-kynurenine
pH 8.0, 37°C, wild-type enzyme
0.0041
O-benzoyl-L-serine

enzyme mutant Y226F, pH 8.0, 37°C
0.041
O-benzoyl-L-serine
pH 8.0, 37°C, mutant enzyme Y226F
11
O-benzoyl-L-serine
pH 8.0, 37°C, wild-type enzyme
11
O-benzoyl-L-serine
wild-type enzyme, pH 8.0, 37°C
24
O-benzoyl-L-serine
pH 8.0, 37°C, mutant enzyme S36A
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