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Disease on EC 3.6.5.5 - dynamin GTPase and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Adenocarcinoma
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep.
Adenocarcinoma of Lung
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1.
Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas.
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Adenoviridae Infections
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2.
Albuminuria
Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
Alzheimer Disease
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.
Blocking GSK3?-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease.
Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models.
Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease.
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.
DNMBP is genetically associated with Alzheimer dementia in the Belgian population.
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells.
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin protein in stroke and vascular dementia.
Dynamin-2 in nervous system disorders.
Dynamin-like protein 1 cleavage by calpain in Alzheimer's disease.
Dynamin-like protein 1 reduction underlies mitochondrial morphology and distribution abnormalities in fibroblasts from sporadic Alzheimer's disease patients.
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer's Disease: Implications for Neuronal Damage.
Increased phosphorylation of dynamin-related protein 1 and mitochondrial fission in okadaic acid-treated neurons.
Mitochondrial dysfunction, mitophagy, and role of dynamin-related protein 1 in Alzheimer's disease.
Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease.
Mitophagy in degenerative joint diseases.
Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis.
No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer's and Parkinson's diseases.
Reduced Dynamin-related Protein 1 Protects Against Phosphorylated Tau-induced Mitochondrial Dysfunction and Synaptic Damage in Alzheimer's Disease.
Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
S-Nitrosylation of Critical Protein Thiols Mediates Protein Misfolding and Mitochondrial Dysfunction in Neurodegenerative Diseases.
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
[Recent advances in the study of synaptic endocytosis key protein: Dynamin].
Amyotrophic Lateral Sclerosis
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation.
Anaphylaxis
The large GTPase Rab44 regulates granule exocytosis in mast cells and IgE-mediated anaphylaxis.
Anemia
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Anthrax
Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process.
Effects of dynamin inactivation on pathways of anthrax toxin uptake.
Arrhythmias, Cardiac
Reduction in dynamin-2 is implicated in ischaemic cardiac arrhythmias.
Arthritis, Rheumatoid
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Asthma
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Ataxia
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons.
Atherosclerosis
Vav GEF regulates CD36-mediated macrophage foam cell formation via calcium and dynamin-dependent processes.
Blindness
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Mitochondrial fission in apoptosis, neurodegeneration and aging.
Variation in OPA1 does not explain the incomplete penetrance of Leber hereditary optic neuropathy.
Bone Resorption
Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
Dynamin reduces Pyk2 Y402 phosphorylation and Src binding in Osteoclasts.
The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.
Botulism
Dynamin inhibition blocks botulinum neurotoxin type-A endocytosis in neurons and delays botulism.
Brain Diseases
A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
Clinical-genetic features and peculiar muscle histopathology in infantile DNM1L-related mitochondrial epileptic encephalopathy.
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy.
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Insights into dynamin-associated disorders through analysis of equivalent mutations in the yeast dynamin Vps1.
Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.
Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model.
[Analysis of DNM1L gene variant in a case of fatal encephalopathy caused by mitochondrial peroxidase division deficiency].
[DNM1L gene variant caused encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1: three cases report and literature review].
Brain Injuries
Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1-Drp1 pathway.
Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.
Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats.
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.
Brain Ischemia
Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1.
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Roles of PTEN-induced putative kinase 1 and dynamin-related protein 1 in transient global ischemia-induced hippocampal neuronal injury.
Brain Neoplasms
Hippocampal Dosimetry and the Necessity of Hippocampal-Sparing in Gamma Knife Stereotactic Radiosurgery for Extensive Brain Metastases.
Breast Neoplasms
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein-1 and Implication for Breast Cancer Treatment.
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death.
Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells.
Epstein-Barr virus latent membrane protein-2A alters mitochondrial dynamics promoting cellular migration mediated by Notch signaling pathway.
Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells.
Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells.
Functional regulation of oestrogen receptor pathway by the dynein light chain 1.
Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion.
Illuminating Superoxide Anion and pH Enhancements in Apoptosis of Breast Cancer Cells Induced by Mitochondrial Hyperfusion Using a New Two-Photon Fluorescence Probe.
Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells.
Investigation of cellular uptake mechanism of functionalised gold nanoparticles into breast cancer using SERS.
Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells.
Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells.
Carcinogenesis
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells.
Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea.
Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma.
Loss of dynamin-related protein 1 (Drp1) does not affect epidermal development or UVB-induced apoptosis but does accelerate UVB-induced carcinogenesis.
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
shibire's enhancer is cancer's suppressor.
The expression and prognostic significance of Drp1 in lung cancer: A bioinformatics analysis and immunohistochemistry.
Carcinoma
Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.
Clathrin-mediated endocytosis is required for ANE 30-100K-induced autophagy.
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner.
Carcinoma, Hepatocellular
Aerobic exercise suppresses hepatocellular carcinoma by downregulating dynamin-related protein 1 through PI3K/AKT pathway.
DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53.
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production.
Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis.
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Dynasore potentiates c-Met inhibitors against hepatocellular carcinoma through destabilizing c-Met.
Glucocorticoid Modulation of Mitochondrial Function in Hepatoma Cells Requires the Mitochondrial Fission Protein Drp1.
Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells.
Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways.
Mitochondrial fission promotes cell migration by Ca
The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles.
The Expression of Dynamin 1, 2, and 3 in Human Hepatocellular Carcinoma and Patient Prognosis.
Carcinoma, Non-Small-Cell Lung
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Carcinoma, Pancreatic Ductal
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma.
Carcinoma, Squamous Cell
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Cardiomegaly
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Mitochondrial fission protein, dynamin-related protein 1, contributes to the promotion of hypertensive cardiac hypertrophy and fibrosis in Dahl-salt sensitive rats.
Quantitative phosphoproteomic study of pressure-overloaded mouse heart reveals dynamin-related protein 1 as a modulator of cardiac hypertrophy.
Cardiomyopathies
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy.
Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects.
Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts.
Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction.
LCZ696 improves cardiac function via alleviating Drp1-mediated mitochondrial dysfunction in mice with doxorubicin-induced dilated cardiomyopathy.
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
Cardiomyopathy, Dilated
Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.
Cardiovascular Diseases
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes.
Cataract
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
Phenotypic spectrum of dynamin 2 mutations in Charcot-Marie-Tooth neuropathy.
Cerebral Infarction
YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKC
Cerebrovascular Disorders
Dynamin protein in stroke and vascular dementia.
Cervical Intraepithelial Neoplasia
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Charcot-Marie-Tooth Disease
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
Dynamin 2 and human diseases.
Dynamin 2 in Charcot-Marie-Tooth disease.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.
Magnetic resonance imaging findings of leg musculature in Charcot-Marie-Tooth disease type 2 due to dynamin 2 mutation.
Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
[Non-fortuitous dynamin II mutation-related association: Neutropenia and Charcot-Marie-Tooth disease.]
Chlamydia Infections
Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth.
Cholangiocarcinoma
Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines.
Cholera
Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum.
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts.
Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.
Internalization of cholera toxin by different endocytic mechanisms.
Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells.
Choriocarcinoma
Selection of choriocarcinoma-associated genes using bioinformatics.
Ciliary Motility Disorders
Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1.
Classical Swine Fever
Viral strategies for triggering and manipulating mitophagy.
Coinfection
Infectious pancreatic necrosis virus inhibits infectious hematopoietic necrosis virus at the early stage of infection in a time dependent manner during Co-infection in Chinook salmon embryo cell lines.
Colitis
Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen Disease.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
Colonic Neoplasms
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Colorectal Neoplasms
HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.
Coma
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Contracture
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
COVID-19
Multi-omics analysis of respiratory specimen characterizes baseline molecular determinants associated with SARS-CoV-2 outcome.
Crohn Disease
Emerging views of mitophagy in immunity and autoimmune diseases.
Cysts
Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila.
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
PsVPS1, a Dynamin-Related Protein, Is Involved in Cyst Germination and Soybean Infection of Phytophthora sojae.
Cytomegalovirus Infections
Dynamin Is Required for Efficient Cytomegalovirus Maturation and Envelopment.
NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.
Deafness
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
Dementia
Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.
Dynamin protein in stroke and vascular dementia.
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.
Dementia, Vascular
Dynamin protein in stroke and vascular dementia.
Demyelinating Diseases
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
Dengue
Viral strategies for triggering and manipulating mitophagy.
Diabetes Mellitus
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Diabetes Mellitus, Type 1
Effect of photobiomodulation on mitochondrial dynamics in peripheral nervous system in streptozotocin-induced type 1 diabetes in rats.
Diabetes Mellitus, Type 2
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Diabetic Nephropathies
Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.
Diabetic Retinopathy
Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy.
Diffuse Axonal Injury
Dynamin and reverse-mode sodium calcium exchanger blockade confers neuroprotection from diffuse axonal injury.
Diphtheria
Effects of dynamin inactivation on pathways of anthrax toxin uptake.
Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor.
Expression of mutant dynamin protects cells against diphtheria toxin but not against ricin.
Down Syndrome
Activity-Dependent Phosphorylation of Dynamin 1 at Serine 857.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Drug Resistant Epilepsy
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
dynamin gtpase deficiency
Clathrin- and dynamin-dependent endocytosis limits canonical NF-?B signaling triggered by lymphotoxin ? receptor.
DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries.
Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice.
Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy.
Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3-Mediated Necroptotic Neurodegeneration.
Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI.
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Dysarthria
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Dystonia
De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus.
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Encephalitis
Focal status and acute encephalopathy in a 13-year-old boy with de novo DNM1L mutation: Video-polygraphic pattern and clues for differential diagnosis.
Encephalitis, Japanese
Japanese encephalitis virus enters rat neuroblastoma cells via a pH-dependent, dynamin and caveola-mediated endocytosis pathway.
Endometrial Neoplasms
Drp1 mediates high glucose-induced mitochondrial dysfunction and epithelial-mesenchymal transition in endometrial cancer cells.
Ephemeral Fever
Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules.
Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF-?B pathways as well as Cox-2-mediated PGE2 /EP receptor signalling to enhance clathrin-mediated virus endocytosis.
Epilepsy
A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice.
Atlastin-1 modulates seizure activity and neuronal excitability.
De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy.
De-novo mutations in patients with chronic ultra-refractory epilepsy with onset after age five years.
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Mdivi-1 Protects Epileptic Hippocampal Neurons from Apoptosis via Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress in Vitro.
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
[Expression of dynamin-1 and phosphor-dynamin-1 in the hippocampus of children and rats with mesial temporal lobe epilepsy].
[Recent advances in the study of synaptic endocytosis key protein: Dynamin].
Epilepsy, Temporal Lobe
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
[Expression of dynamin-1 and phosphor-dynamin-1 in the hippocampus of children and rats with mesial temporal lobe epilepsy].
Epileptic Syndromes
De novo DNM1L mutation associated with mitochondrial epilepsy syndrome with fever sensitivity.
Esophageal Neoplasms
Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics.
Feline Infectious Peritonitis
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Gastroenteritis
Viral strategies for triggering and manipulating mitophagy.
Gaucher Disease
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Glaucoma
Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis.
DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
Glaucoma, Open-Angle
Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis.
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations.
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma.
Glioblastoma
Dynamin 2 mediates PDGFR?-SHP-2-promoted glioblastoma growth and invasion.
Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells.
Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Glioma
A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression.
Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics.
Divide et Impera: Drp1-mediated Mitochondrial Fission in Glioma Malignancy.
Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA.
Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.
Glomerulonephritis
Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
Glucose Intolerance
Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis.
Hearing Loss
[Expression of Dynamin in the cochlea of mice of different ages].
Heart Arrest
Dynamin-related protein 1 as a therapeutic target in cardiac arrest.
Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest.
Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model.
Therapeutic hypothermia attenuates global cerebral reperfusion-induced mitochondrial damage by suppressing dynamin-related protein 1 activation and mitochondria-mediated apoptosis in a cardiac arrest rat model.
Heart Failure
'Mitotherapy' for Heart Failure.
Cardiac-specific LRP6 knockout induces lipid accumulation through Drp1/CPT1b pathway in adult mice.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin-2 mediates heart failure by modulating Ca(2+)-dependent cardiomyocyte apoptosis.
Dysregulation of Mfn2 and Drp-1 proteins in heart failure.
Mitochondrial Dynamics in Tachycardiomyopathy.
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.
Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure.
Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure.
Hepatitis B
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
The large GTPase dynamin is required for hepatitis B virus protein secretion from hepatocytes.
Hepatitis E
Hepatitis E Virus enters liver cells through a Dynamin-2, Clathrin and membrane cholesterol dependent pathway.
Herpes Simplex
Cellular internalization of green fluorescent protein fused with herpes simplex virus protein VP22 via a lipid raft-mediated endocytic pathway independent of caveolae and Rho family GTPases but dependent on dynamin and Arf6.
Dynasore disrupts trafficking of herpes simplex virus proteins.
Herpes Simplex Virus 1 Can Enter Dynamin 1 and 2 Double-Knockout Fibroblasts.
Hsv-1 Endocytic Entry into a Human Oligodendrocytic Cell Line is Mediated by Clathrin and Dynamin but Not Caveolin.
Viral strategies for triggering and manipulating mitophagy.
{alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2.
Herpes Zoster
Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.
HIV Infections
HIV infection is influenced by dynamin at 3 independent points in the viral life cycle.
Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry.
TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function.
Huntington Disease
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.
S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease.
Hyperglycemia
Dynamin deficiency causes insulin secretion failure and hyperglycemia.
Estrogen deprivation aggravates cardiac hypertrophy in non-obese type 2 diabetic Goto-kakizaki (GK) rats.
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Hyperinsulinism
Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion Neurons.
Hyperinsulinemia-induced vascular smooth muscle cell (VSMC) migration and proliferation is mediated by converging mechanisms of mitochondrial dysfunction and oxidative stress.
Hypertension
Correlation between the expression of Drp1 in vascular endothelial cells and inflammatory factors in hypertension rats.
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Hypertension, Pulmonary
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.
Reactive oxygen species effect PASMCs apoptosis via regulation of dynamin-related protein 1 in hypoxic pulmonary hypertension.
Hypothyroidism
A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism.
Hypothyroidism after 3-dimensional conformal radiotherapy and intensity modulated radiotherapy for head and neck cancers: Prospective data from two randomized controlled trials.
Infarction, Middle Cerebral Artery
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
Cannabinoid CB1 receptor agonist ACEA alleviates brain ischemia/reperfusion injury via CB1-Drp1 pathway.
Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion.
Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells.
Infections
A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells.
A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.
A mutation in the GTP hydrolysis site of Arabidopsis dynamin-related protein 1E confers enhanced cell death in response to powdery mildew infection.
A plant RNA virus hijacks endocytic proteins to establish its infection in plants.
Adenovirus internalization and infection require dynamin.
Alternative endocytosis pathway for productive entry of hepatitis C virus.
Association of chemokine-mediated block to HIV entry with coreceptor internalization.
Blockade of dengue virus entry into myeloid cells by endocytic inhibitors in the presence or absence of antibodies.
Bovine ephemeral fever virus uses a clathrin-mediated and dynamin 2-dependent endocytosis pathway that requires Rab5 and Rab7 as well as microtubules.
Bovine Parainfluenza Virus Type 3 (BPIV3) Enters HeLa Cells via Clathrin-Mediated Endocytosis in a Cholesterol- and Dynamin-Dependent Manner.
Caveolin-1 is involved in encephalomyocarditis virus replication in BHK-21 cells.
Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein.
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes.
Characterization of human astrovirus cell entry.
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).
Contribution of MX dynamin, oligoadenylate synthetase, and protein kinase R to anti-paramyxovirus activity of type 1 interferons in vitro.
DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.
Dengue virus induces mitochondrial elongation through impairment of Drp1-triggered mitochondrial fission.
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification.
Dynamin Is Required for Efficient Cytomegalovirus Maturation and Envelopment.
Dynamin is required for recombinant adeno-associated virus type 2 infection.
Dynamin-2 Stabilizes the HIV-1 Fusion Pore with a Low Oligomeric State.
Dynamin-related protein Drp1 and mitochondria are important for Shigella flexneri infection.
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Dynasore disrupts trafficking of herpes simplex virus proteins.
Early stages of influenza virus entry into Mv-1 lung cells: involvement of dynamin.
Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events.
Echovirus 7 entry into polarized intestinal epithelial cells requires clathrin and Rab7.
Elevated endosomal pH in HeLa cells overexpressing mutant dynamin can affect infection by pH-sensitive viruses.
Endocytosis, Cytotoxicity, and Translocation of Shiga Toxin-2 Are Stimulated by Infection of Human Intestinal (HCT-8) Monolayers With an Hypervirulent E. coli O157:H7 Lacking stx2 Gene.
Entry of Challenge Virus Standard (CVS) -11 into N2a cells via a clathrin-mediated, cholesterol-, dynamin-, pH-dependent endocytic pathway.
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
Experimental pathogenicity of viscerotropic and dermotropic isolates of Leishmania infantum from immunocompromised and immunocompetent patients in a murine model.
Formation of a stable mimic of ambient particulate matter containing viable infectious respiratory syncytial virus and its dry-deposition directly onto cell cultures.
Ginsenoside Rg3 restores hepatitis C virus-induced aberrant mitochondrial dynamics and inhibits virus propagation.
Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells.
Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence.
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
HIV infection is influenced by dynamin at 3 independent points in the viral life cycle.
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore.
Hsv-1 Endocytic Entry into a Human Oligodendrocytic Cell Line is Mediated by Clathrin and Dynamin but Not Caveolin.
Human Metapneumovirus Is Capable of Entering Cells by Fusion with Endosomal Membranes.
Human papillomavirus type 31 uses a caveolin 1- and dynamin 2-mediated entry pathway for infection of human keratinocytes.
Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis.
Impact of dynamin 2 on adenovirus nuclear entry.
Impact of dynasore an inhibitor of dynamin II on Shigella flexneri infection.
Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent.
Infectious pancreatic necrosis virus inhibits infectious hematopoietic necrosis virus at the early stage of infection in a time dependent manner during Co-infection in Chinook salmon embryo cell lines.
Inhibitor analysis revealed that clathrin-mediated endocytosis is involed in cellular entry of type III grass carp reovirus.
Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase (Salmonella typhimurium) and protective antigen (Bacillus anthraci) might be the potential cause of human infection.
Interplay between Clathrin and Rab5 Controls the Early Phagocytic Trafficking and Intracellular Survival of Brucella abortus within HeLa cells.
JC Polyomavirus Entry by Clathrin-Mediated Endocytosis is Driven by ?-arrestin.
Lymphocystis Disease Virus (Iridoviridae) Enters Flounder (Paralichthys olivaceus) Gill Cells via a Caveolae-Mediated Endocytosis Mechanism Facilitated by Viral Receptors.
Macropinocytosis is the entry mechanism of amphotropic murine leukemia virus.
Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy.
Mitogen-activated protein kinases are required for effective infection of human choroid plexus epithelial cells by Listeria monocytogenes.
Molecular identification and comparative transcriptional analysis of myxovirus resistance GTPase (Mx) gene in goose (Anser cygnoide) after H9N2 AIV infection.
Murine norovirus-1 cell entry is mediated through a non-clathrin, non-caveolae, dynamin and cholesterol dependent pathway.
Oncolytic H-1 Parvovirus Enters Cancer Cells through Clathrin-Mediated Endocytosis.
PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles.
Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.
Porcine sapovirus Cowden strain enters LLC-PK cells via clathrin- and cholesterol-dependent endocytosis with the requirement of dynamin II.
Proteome dynamics in primary target organ of infectious bursal disease virus.
PsVPS1, a Dynamin-Related Protein, Is Involved in Cyst Germination and Soybean Infection of Phytophthora sojae.
Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.
Rift Valley fever virus strain MP-12 enters mammalian host cells via caveola-mediated endocytosis.
Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations.
Rotaviral nonstructural protein 4 triggers dynamin-related protein 1-dependent mitochondrial fragmentation during infection.
Synchronised infection identifies early rate-limiting steps in the hepatitis B virus life cycle.
Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors.
The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus.
The Mitochondrial Fission Regulator DRP1 Controls Post-Transcriptional Regulation of TNF-?.
Transmembrane TNF-? Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy.
Transplant Energize Me Patient Outcome (TEMPO): A Quality Improvement Project that Maintains Functional Mobility in Pediatric Patients Admitted for Allogeneic Hematopoietic Cell Transplantation.
Uptake of Rabies Virus into Epithelial Cells by Clathrin-Mediated Endocytosis Depends upon Actin.
[Role of the adaptins, dynamin like GTP-ases and Rab proteins in metabolic disorders and various infections]
Infertility
Aberrant Expression of Dynein light chain 1 (DYNLT1) is Associated with Human Male Factor Infertility.
Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Influenza, Human
Early stages of influenza virus entry into Mv-1 lung cells: involvement of dynamin.
Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.
Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Viral strategies for triggering and manipulating mitophagy.
Insulin Resistance
A multiscale study of the role of dynamin in the regulation of glucose uptake.
Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat-Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts.
Pharmacological inhibition of dynamin-related protein 1 attenuates skeletal muscle insulin resistance in obesity.
Insulinoma
A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic ?-Cells.
Intellectual Disability
Activity-Dependent Phosphorylation of Dynamin 1 at Serine 857.
Intervertebral Disc Degeneration
Mitophagy in degenerative joint diseases.
Iron Overload
Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection.
Ischemic Attack, Transient
Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice.
Ischemic Stroke
Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke.
Kidney Diseases
Increased dynamin expression precedes proteinuria in glomerular disease.
More expression, less function: cleaved dynamin in glomerular kidney disease.
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Lennox Gastaut Syndrome
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Leukemia
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells.
Leukemia, Myeloid
Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells.
Lewy Body Disease
Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.
Increased Cerebrospinal Fluid Concentration of ZnT3 Is Associated with Cognitive Impairment in Alzheimer's Disease.
Listeriosis
Atypical mitochondrial fission upon bacterial infection.
Liver Cirrhosis
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Low Tension Glaucoma
Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis.
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
Lung Neoplasms
Bcl-2-enhanced efficacy of microtubule-targeting chemotherapy through Bim overexpression: implications for cancer treatment.
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Crosstalk between Akt/GSK3? signaling and dynamin-1 regulates clathrin-mediated endocytosis.
Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model.
Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET-GBR2-STAT3 Complex Formation.
Dynasore suppresses proliferation and induces apoptosis of the non-small-cell lung cancer cell line A549.
Effects of Dynamin-related Protein 1 Regulated Mitochondrial Dynamic Changes on Invasion and Metastasis of Lung Cancer Cells.
High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
The expression and prognostic significance of Drp1 in lung cancer: A bioinformatics analysis and immunohistochemistry.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Expression of DDX11 and DNM1L at the 12p11 Locus Modulates Systemic Lupus Erythematosus Susceptibility.
Lymphatic Metastasis
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Lymphocytic Choriomeningitis
Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.
Lymphoma
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation.
Lymphoma, B-Cell
Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice.
Effects of biphasic and monophasic electrical stimulation on mitochondrial dynamics, cell apoptosis, and cell proliferation.
Mitochondrial separation protein inhibitor inhibits cell apoptosis in rat lungs during intermittent hypoxia.
T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway.
Lymphopenia
Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.
Measles
Viral strategies for triggering and manipulating mitophagy.
Megalencephaly
Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development.
Melanoma
Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells.
BH3 mimetics induce apoptosis independent of DRP-1 in melanoma.
Emerging views of mitophagy in immunity and autoimmune diseases.
Mitochondrial dynamic alterations regulate melanoma cell progression.
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas.
Memory Disorders
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation.
Microcephaly
A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function.
Mitochondrial Diseases
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
DNM1L-Related Mitochondrial Fission Defects Presenting as Encephalopathy: A Case Report and Literature Review.
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Multiple Sclerosis
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Muscle Hypotonia
Lethal Disorder of Mitochondrial Fission Caused by Mutations in DNM1L.
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Reducing dynamin 2 expression rescues X-linked centronuclear myopathy.
Muscle Weakness
Clinical, Electrophysiology, and Pathology Features of Dynamin Centronuclear Myopathy: A Case Report and Review of Literature.
Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness.
Muscular Atrophy
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
Muscular Diseases
A novel dynamin-2 gene mutation associated with a late-onset centronuclear myopathy with necklace fibres.
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
Allele-Specific CRISPR/Cas9 Correction of a Heterozygous DNM2 Mutation Rescues Centronuclear Myopathy Cell Phenotypes.
Dynamin 2 and human diseases.
Dynamin 2 the rescue for centronuclear myopathy.
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.
Impaired excitation-contraction coupling in muscle fibres from the dynamin2
Mice carrying an analogous heterozygous Dynamin 2 K562E mutation that causes neuropathy in humans develop predominant characteristics of a primary myopathy.
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Pathogenic mechanisms in centronuclear myopathies.
Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations.
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice.
Myocardial Infarction
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart.
Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Myocardial Ischemia
Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing.
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Myoclonus
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Myopathies, Structural, Congenital
A case of de novo dynamin 2-related centronuclear myopathy with electrical but not clinical myotonia.
A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.
A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells.
A new centronuclear myopathy phenotype due to a novel dynamin 2 mutation.
A novel dynamin-2 gene mutation associated with a late-onset centronuclear myopathy with necklace fibres.
A novel mutation in the DNM2 gene impairs dynamin 2 localization in skeletal muscle of a patient with late onset centronuclear myopathy.
A novel mutation in the dynamin 2 gene in a Charcot-Marie-Tooth type 2 patient: clinical and pathological findings.
A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.
Adult course in dynamin 2 dominant centronuclear myopathy with neonatal onset.
Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2.
Allele-Specific CRISPR/Cas9 Correction of a Heterozygous DNM2 Mutation Rescues Centronuclear Myopathy Cell Phenotypes.
Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.
Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.
BIN1/M-Amphiphysin2 induces clustering of phosphoinositides to recruit its downstream partner dynamin.
Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy.
Centronuclear myopathies under attack: A plethora of therapeutic targets.
Centronuclear myopathy related to dynamin 2 mutations: Clinical, morphological, muscle imaging and genetic features of an Italian cohort.
Centronuclear myopathy with cataracts due to a novel dynamin 2 (DNM2) mutation.
Characterization of the muscle involvement in dynamin 2-related centronuclear myopathy.
Clathrin plaques and associated actin anchor intermediate filaments in skeletal muscle.
Clinical, Electrophysiology, and Pathology Features of Dynamin Centronuclear Myopathy: A Case Report and Review of Literature.
Clinical, pathological, and genetic features of dynamin-2-related centronuclear myopathy in China.
Clinicopathological features of centronuclear myopathy in Japanese populations harboring mutations in dynamin 2.
Correlative SICM-FCM reveals changes in morphology and kinetics of endocytic pits induced by disease-associated mutations in dynamin.
Defective membrane remodeling in neuromuscular diseases: insights from animal models.
Diaphragm assessment in mice overexpressing phospholamban in slow-twitch type I muscle fibers.
Different in vivo impacts of dynamin 2 mutations implicated in Charcot-Marie-Tooth neuropathy or centronuclear myopathy.
Dynamin 2 and human diseases.
Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.
Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers.
Dynamin 2 mutations cause sporadic centronuclear myopathy with neonatal onset.
Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination.
Dynamin 2 the rescue for centronuclear myopathy.
Dynamin 2-related centronuclear myopathy: clinical, histological and genetic aspects of further patients and review of the literature.
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Dynamin-2 Function and Dysfunction Along the Secretory Pathway.
Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.
Expanding the clinical, pathological and MRI phenotype of DNM2-related centronuclear myopathy.
Histopathologic changes in the extraocular muscle in centronuclear myopathy with a Dynamin 2 mutation.
Impaired excitation-contraction coupling in muscle fibres from the dynamin2
Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness.
Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy.
Mice with muscle-specific deletion of Bin1 recapitulate centronuclear myopathy and acute downregulation of dynamin 2 improves their phenotypes.
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.
Mitochondrial alterations in dynamin 2-related centronuclear myopathy.
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
Multi-omics comparisons of different forms of centronuclear myopathies and the effects of several therapeutic strategies.
Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves.
Mutant BIN1-Dynamin 2 complexes dysregulate membrane remodeling in the pathogenesis of centronuclear myopathy.
Mutation Spectrum in the Large GTPase Dynamin 2, and Genotype-Phenotype Correlation in Autosomal Dominant Centronuclear Myopathy.
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
Mutations in dynamin 2 cause dominant centronuclear myopathy.
Myopathic (not neuropathic) electrophysiological abnormalities in dynamin 2-related centronuclear myopathy.
N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Novel molecular diagnostic approaches for X-linked centronuclear (myotubular) myopathy reveal intronic mutations.
Nuclear defects in skeletal muscle from a Dynamin 2-linked centronuclear myopathy mouse model.
Oligomerization of dynamin superfamily proteins in health and disease.
Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.
Phenotype variability and histopathological findings in centronuclear myopathy due to DNM2 mutations.
Phenotype variability and histopathological findings in patients with a novel DNM2 mutation.
Phenotypic variability in a large Czech family with a Dynamin 2-associated Charcot-Marie-Tooth neuropathy.
Physiological impact and disease reversion for the severe form of centronuclear myopathy linked to dynamin.
Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy.
Reducing dynamin 2 expression rescues X-linked centronuclear myopathy.
Satellite cells deficiency and defective regeneration in dynamin 2-related centronuclear myopathy.
Sporadic centronuclear myopathy with muscle pseudohypertrophy, neutropenia, and necklace fibers due to a DNM2 mutation.
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
The coexistence of dynamin 2 mutation and multiple mitochondrial DNA (mtDNA) deletions in the background of severe cardiomyopathy and centronuclear myopathy.
The intragenic microRNA miR199A1 in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy.
Two novel mutations in dynamin-2 cause axonal Charcot-Marie-Tooth disease.
Zebrafish as a Model to Investigate Dynamin 2-Related Diseases.
[Mutations in dynamin 2 cause dominant centronuclear myopathy.]
[Recent advances in the study of synaptic endocytosis key protein: Dynamin].
Myopathy, Central Core
MRI in DNM2-related centronuclear myopathy: evidence for highly selective muscle involvement.
Myotonia
A case of de novo dynamin 2-related centronuclear myopathy with electrical but not clinical myotonia.
nadh:ubiquinone reductase (h+-translocating) deficiency
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.
Nasopharyngeal Carcinoma
Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.
Neoplasm Metastasis
A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells.
Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.
Alteration of nuclear protein profiling for NIH-3T3 cells exposed to H?O?.
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Dynamic Change of Polarity in Primary Cultured Spheroids of Human Colorectal Adenocarcinoma and Its Role in Metastasis.
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein.
Dynamin-Related Protein 1 at the Crossroads of Cancer.
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Effects of Dynamin-related Protein 1 Regulated Mitochondrial Dynamic Changes on Invasion and Metastasis of Lung Cancer Cells.
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility.
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Mitochondrial dynamics regulates migration and invasion of breast cancer cells.
Mitochondrial fission promotes cell migration by Ca
Neoplasms
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target.
Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.
Bronchial mucus properties in lung cancer: relationship with site of lesion.
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
CEACAM6 is a prognostic biomarker and potential therapeutic target for gastric carcinoma.
Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression.
Construction of a recombinant eukaryotic expression vector containing DNM3 gene and its expression in colon cancer cells.
Correlation between intensity modulated radiotherapy and bone marrow suppression in breast cancer.
Cytoplasmic interaction of the tumour suppressor protein hSNF5 with dynamin-2 controls endocytosis.
Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission.
Development of the "Day 100 Talk": Addressing existing communication gaps during the early cancer treatment period in childhood cancer.
Distinct functions of dynamin isoforms in tumorigenesis and their potential as therapeutic targets in cancer.
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study.
Dosimetry, efficacy, and safety of three-dimensional printing noncoplanar template-assisted and CT-guided 125I seed implantation for recurrent retroperitoneal lymphatic metastasis after external beam radiotherapy.
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Downregulation of apoptosis-related genes in keloid tissues.
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.
Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance.
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells.
Dynamin 2 interacts with ?-actinin 4 to drive tumor cell invasion.
Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1.
Dynamin 3 Inhibits the Proliferation of Non-small-Cell Lung Cancer Cells by Suppressing c-MET-GBR2-STAT3 Complex Formation.
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production.
Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.
Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.
Dynamin-Related Protein 1 at the Crossroads of Cancer.
Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death.
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma.
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells.
Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments.
Efficacy and safety of CT-guided high-dose-rate interstitial brachytherapy in primary and secondary malignancies of the pancreas.
Efficacy and safety of percutaneous computed tomography-guided high-dose-rate interstitial brachytherapy in treatment of oligometastatic lymph node metastases of retroperitoneal space.
Emerging views of mitophagy in immunity and autoimmune diseases.
Energy and redox homeostasis in tumor cells.
EPA and DHA attenuate deoxynivalenol-induced intestinal porcine epithelial cell injury and protect barrier function integrity by inhibiting necroptosis signaling pathway.
Expression of dynamin immunoreactivity in experimental pancreatic tumors induced in rat by mancozeb-nitrosomethylurea.
Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes.
Extracellular NME proteins: a player or a bystander?
Feasibility and acceptability of the "Day 100 Talk": An interdisciplinary communication intervention during the first six months of childhood cancer treatment.
GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway.
Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts.
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells.
Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells.
Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy.
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma.
Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.
Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota.
Intratumoral administration of cGAMP transiently accumulates potent macrophages for anti-tumor immunity at a mouse tumor site.
Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2.
Isolation of polysaccharides from Dendrobium officinale leaves and anti-inflammatory activity in LPS-stimulated THP-1 cells.
Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study.
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Low dynamin 2 expression is associated with tumor invasion and metastasis in invasive squamous cell carcinoma of cervix.
Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer.
MAPK-Driven Transformation Requires DRP1-Mediated Mitochondrial Division.
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Methylation of an intronic region regulates miR-199a in testicular tumor malignancy.
Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics.
Mitochondrial control by DRP1 in brain tumor initiating cells.
Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer.
Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance.
Mitophagy in degenerative joint diseases.
Modulation of dynamin function by small molecules.
Multi-kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin-related protein 1.
N'-[4-(dipropylamino)benzylidene]-2-hydroxybenzohydrazide is a dynamin GTPase inhibitor that suppresses cancer cell migration and invasion by inhibiting actin polymerization.
Nuclear expression of dynamin-related protein 1 in lung adenocarcinomas.
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions.
Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.
Pathophysiology of anorexia in the cancer cachexia syndrome.
Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.
Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell.
Regulation of dynamin by nucleoside diphosphate kinase.
Role of dynamin in elongated cell migration in a 3D matrix.
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
shibire's enhancer is cancer's suppressor.
Silencing Drp1 inhibits glioma cells proliferation and invasion by RHOA/ ROCK1 pathway.
The blood-testis barrier and its implications for male contraception.
The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.
The invasive proteome of glioblastoma revealed by laser-capture microdissection.
The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy.
The role of dynamin-related protein 1 in cancer growth: a promising therapeutic target?
TRAIL-death receptor endocytosis and apoptosis are selectively regulated by dynamin-1 activation.
Triptolide induces toxicity in inner ear stem cells via promoting DNA damage.
[Effects of heme oxygenase-1/carbon monoxide pathway on the mitochondrial fusion in rat alveolar epithelial type II cells stimulated by lipopolysaccharide].
Nephrotic Syndrome
Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome.
Nervous System Diseases
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
DNM1L-Related Mitochondrial Fission Defects Presenting as Encephalopathy: A Case Report and Literature Review.
Dynamin-2 in nervous system disorders.
Dynamin-related protein 1 (Drp1) mediating mitophagy contributes to the pathophysiology of nervous system diseases and brain injury.
OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database.
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein.
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Nervous System Malformations
Subtle central and peripheral nervous system abnormalities in a family with centronuclear myopathy and a novel dynamin 2 gene mutation.
Neuralgia
Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats.
Neuropathic Pain: the Dysfunction of Drp1, Mitochondria, and ROS Homeostasis.
Neuroblastoma
Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons.
Hypoxia Induces Internalization of ?-Opioid Receptor.
Japanese encephalitis virus enters rat neuroblastoma cells via a pH-dependent, dynamin and caveola-mediated endocytosis pathway.
Stabilization of Actin Bundles by a Dynamin 1/Cortactin Ring Complex Is Necessary for Growth Cone Filopodia.
Neurodegenerative Diseases
A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.
Analysis of mitochondrial structure and function in the Drosophila larval musculature.
Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Mdivi-1 pretreatment mitigates isoflurane-induced cognitive deficits in developmental rats.
Mitochondrial dynamics in health and disease.
Mitochondrial fission in apoptosis, neurodegeneration and aging.
Presynaptic loss of dynamin related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of held.
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy.
The Fine Tuning of Drp1-Dependent Mitochondrial Remodeling and Autophagy Controls Neuronal Differentiation.
Neuroinflammatory Diseases
HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.
Neuromuscular Diseases
Defective membrane remodeling in neuromuscular diseases: insights from animal models.
Dynamin 2 (DNM2) as Cause of, and Modifier for, Human Neuromuscular Disease.
Neutropenia
Impact of Preemptive Therapy for Cytomegalovirus on Toxicities after Allogeneic Hematopoietic Cell Transplantation in Clinical Practice: A Retrospective Single-Center Cohort Study.
[Non-fortuitous dynamin II mutation-related association: Neutropenia and Charcot-Marie-Tooth disease.]
Newcastle Disease
Newcastle Disease Virus Entry into Chicken Macrophages via a pH-Dependent, Dynamin and Caveola-Mediated Endocytic Pathway That Requires Rab5.
Viral strategies for triggering and manipulating mitophagy.
Non-alcoholic Fatty Liver Disease
Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity.
Obesity
Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.
Pharmacological inhibition of dynamin-related protein 1 attenuates skeletal muscle insulin resistance in obesity.
Obesity, Morbid
Distinct Adaptations of Mitochondrial Dynamics to Electrical Pulse Stimulation in Lean and Severely Obese Primary Myotubes.
Optic Atrophies, Hereditary
Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation.
Optic Atrophy
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function.
A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis.
Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents.
Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics.
Allyl Methyl Sulfide Preserved Pressure Overload-Induced Heart Failure Via Modulation of Mitochondrial Function.
Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Bromodomain-containing protein 4 inhibitor JQ1 promotes melanoma cell apoptosis by regulating mitochondrial dynamics.
Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission.
Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells.
Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-?B-Crystallin-Induced Desmin-Related Cardiomyopathy.
Effect of Mahuang Gancao Ganjiang Decoction on Fusion and Fission of Mitochondria and Apoptosis of Lymphocytes in Mice under Cold Stress.
Effects of clenbuterol administration on mitochondrial morphology and its regulatory proteins in rat skeletal muscle.
Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes.
Exercise mitigates mitochondrial permeability transition pore and quality control mechanisms alterations in nonalcoholic steatohepatitis.
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells.
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.
Mitochondrial dynamics in health and disease.
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications.
Mitochondrial fusion proteins and human diseases.
Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder.
Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effectson mitochondrial fusion and fission.
Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury.
OPA1 expression in the normal rat retina and optic nerve.
OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling.
Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins.
Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery.
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins.
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells.
[Advances in mitochondrial fusion-fission and Ca2+ signaling in mammals].
Optic Atrophy, Autosomal Dominant
2-Bromopalmitate attenuates inflammatory pain by maintaining mitochondrial fission/fusion balance and function.
A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis.
A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family.
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
A novel 3q29 deletion associated with autism, intellectual disability, psychiatric disorders, and obesity.
A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function.
A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders.
A proteomic screen with Drosophila Opa1-like identifies Hsc70-5/Mortalin as a regulator of mitochondrial morphology and cellular homeostasis.
A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family.
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation.
Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation.
Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases.
Activation of protein kinase C-?/heme oxygenase-1 signaling pathway improves mitochondrial dynamics in lipopolysaccharide-activated NR8383 cells.
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells.
Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.
Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics.
Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy.
Ammonia inhalation impaired immune function and mitochondrial integrity in the broilers bursa of fabricius: Implication of oxidative stress and apoptosis.
Analysis of mitochondrial structure and function in the Drosophila larval musculature.
Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene.
Antagonistic effects of selenium on cadmium-induced apoptosis by restoring the mitochondrial dynamic equilibrium and energy metabolism in chicken spleens.
Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.
Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress.
Arsenic-induced cardiotoxicity correlates with mitochondrial damage and trace elements imbalance in broiler chickens.
Association Between L-OPA1 Cleavage and Cardiac Dysfunction During Ischemia-Reperfusion Injury in Rats.
Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population.
Association of OPA1 Polymorphisms with NTG and HTG: A Meta-Analysis.
Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells.
Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy.
Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2.
Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system.
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria.
Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing.
C-Phycocyanin Ameliorates Mitochondrial Fission and Fusion Dynamics in Ischemic Cardiomyocyte Damage.
Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury.
Cardiac mitochondrial dynamics: miR-mediated regulation during cardiac injury.
Cardiac-specific overexpression of thioredoxin 1 attenuates mitochondrial and myocardial dysfunction in septic mice.
Changes in mitochondrial morphology and bioenergetics in human lymphoblastoid cells with four novel OPA1 mutations.
Characterization of Ca2+ signalling in postnatal mouse retinal ganglion cells: involvement of OPA1 in Ca2+ clearance.
Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue.
Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.
Concurrent OPA1 mutation and chromosome 3q deletion leading to Behr syndrome: a case report.
Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division.
Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy.
Cryo-EM structures of S-OPA1 reveal its interactions with membrane and changes upon nucleotide binding.
Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.
Curcumin prevents mitochondrial dynamics disturbances in early 5/6 nephrectomy: Relation to oxidative stress and mitochondrial bioenergetics.
Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
Deficit of in vivo mitochondrial ATP production in OPA1-related dominant optic atrophy.
Deletion of the mitochondria-shaping protein Opa1 during early thymocyte maturation impacts mature memory T cell metabolism.
Depletion of Mitofusin-2 Causes Mitochondrial Damage in Cisplatin-Induced Neuropathy.
Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease.
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1.
Dietary fucoxanthin increases metabolic rate and upregulated mRNA expressions of the PGC-1alpha network, mitochondrial biogenesis and fusion genes in white adipose tissues of mice.
Diluted serum from calorie-restricted animals promotes mitochondrial ?-cell adaptations and protect against glucolipotoxicity.
Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects.
Disturbed mitochondrial dynamics and neurodegenerative disorders.
Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure.
Docosahexaenoic Acid Alleviates Oxidative Stress-Based Apoptosis Via Improving Mitochondrial Dynamics in Early Brain Injury After Subarachnoid Hemorrhage.
Does Metformin Modulate Mitochondrial Dynamics and Function in Type 2 Diabetic Patients?
Dominant optic atrophy, sensorineural hearing loss, ptosis, and ophthalmoplegia: a syndrome caused by a missense mutation in OPA1.
Dominant optic atrophy: updates on the pathophysiology and clinical manifestations of the optic atrophy 1 mutation.
Down-regulation of the mitochondrial i-AAA protease Yme1L induces muscle atrophy via FoxO3a and myostatin activation.
Downregulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.
Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle.
Dynamic changes of mitochondrial fusion and fission proteins after transient cerebral ischemia in mice.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin-related protein 1-mediated mitochondrial fission contributes to IR-783-induced apoptosis in human breast cancer cells.
Dysfunctional Mitochondrial Dynamic and Oxidative Phosphorylation Precedes Cardiac Dysfunction in R120G-?B-Crystallin-Induced Desmin-Related Cardiomyopathy.
Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer.
Effect of mito-TEMPO, a mitochondria-targeted antioxidant, in rats with neuropathic pain.
Effect of Roux-en-Y gastric bypass on liver mitochondrial dynamics in a rat model of obesity.
Effects of Al Exposure on Mitochondrial Dynamics in Rat Hippocampus.
Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.
Effects of trimetazidine on mitochondrial respiratory function, biosynthesis, and fission/fusion in rats with acute myocardial ischemia.
Effects of voluntary wheel running on mitochondrial content and dynamics in rat skeletal muscle.
Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle.
Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner.
Exogenous hydrogen sulphide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement.
Exploring the effect of Gupi Xiaoji Prescription on hepatitis B virus-related liver cancer through network pharmacology and in vitro experiments.
Expression of the Opa1 mitochondrial protein in retinal ganglion cells: its downregulation causes aggregation of the mitochondrial network.
First Cases of Dominant Optic Atrophy in Saudi Arabia: Report of Two Novel OPA1 Mutations.
Fluoride-induced renal dysfunction via respiratory chain complex abnormal expression and fusion elevation in mice.
Fourteen novel OPA1 mutations in autosomal dominant optic atrophy including two de novo mutations in sporadic optic atrophy.
Functional Recovery of Human Cells Harbouring the Mitochondrial DNA Mutation MERRF A8344G via Peptide-Mediated Mitochondrial Delivery.
Generation of optic atrophy 1 patient-derived induced pluripotent stem cells (iPS-OPA1-BEHR) for disease modeling of complex optic atrophy syndromes (Behr syndrome).
Genomics combined with a protein informatics platform to assess a novel pathogenic variant c.1024 A>G (p.K342E) in OPA1 in a patient with autosomal dominant optic atrophy.
Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast.
Glutamate receptor activation triggers OPA1 release and induces apoptotic cell death in ischemic rat retina.
Granulosa Cell and Oocyte Mitochondrial Abnormalities in a Mouse Model of Fragile X Primary Ovarian Insufficiency.
H2O2 induces caveolin?1 degradation and impaired mitochondrial function in E11 podocytes.
Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner.
Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.
Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.
Huangqi-Danshen Decoction Ameliorates Adenine-Induced Chronic Kidney Disease by Modulating Mitochondrial Dynamics.
Human muscular mitochondrial fusion in athletes during exercise.
Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling.
Human skeletal muscle fiber type-specific responses to sprint interval and moderate-intensity continuous exercise: acute and training-induced changes.
Human skeletal muscle mRNAResponse to a single hypoxic exercise bout.
Hyperglycemia Alters Mitochondrial Fission and Fusion Proteins in Mice Subjected to Cerebral Ischemia and Reperfusion.
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Indomethacin impairs mitochondrial dynamics by activating the PKC?-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.
Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy.
Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model.
Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes.
Inner membrane fusion mediates spatial distribution of axonal mitochondria.
Interval and continuous exercise overcome memory deficits related to ?-Amyloid accumulation through modulating mitochondrial dynamics.
Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction.
L-OPA1 regulates mitoflash biogenesis independently from membrane fusion.
Leptin enhances glycolysis via OPA1-mediated mitochondrial fusion to promote mesenchymal stem cell survival.
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation.
Levosimendan in rats decreases acute kidney injury after cardiopulmonary resuscitation by improving mitochondrial dysfunction.
Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity.
Loss of Yme1L perturbates mitochondrial dynamics.
Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin.
Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis.
Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways.
Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection.
Meta-analysis of genotype-phenotype analysis of OPA1 mutations in autosomal dominant optic atrophy.
MICOS and the mitochondrial inner membrane morphology - when things get out of shape.
Mitochondrial A-kinase anchoring proteins in cardiac ventricular myocytes.
Mitochondrial cAMP prevents apoptosis modulating Sirt3 protein level and OPA1 processing in cardiac myoblast cells.
Mitochondrial DNA disturbances and deregulated expression of oxidative phosphorylation and mitochondrial fusion proteins in sporadic inclusion body myositis.
Mitochondrial Dynamics and Mitochondrial Dysfunction in Diabetes.
Mitochondrial dynamics and protective effects of a mitochondrial division inhibitor, Mdivi-1, in lipopolysaccharide-induced brain damage.
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis.
Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases.
Mitochondrial Dynamics of Proximal Tubular Epithelial Cells in Nephropathic Cystinosis.
Mitochondrial dynamics: overview of molecular mechanisms.
Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate.
Mitochondrial fission in apoptosis, neurodegeneration and aging.
Mitochondrial fragmentation and superoxide anion production in coronary endothelial cells from a mouse model of type 1 diabetes.
Mitochondrial fragmentation in neurodegeneration.
Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling.
Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way.
Mitochondrial Membrane Dynamics-Functional Positioning of OPA1.
Mitochondrial network structure homeostasis and cell death.
Mitochondrial OPA1, apoptosis, and heart failure.
Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.
Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats.
Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.
Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder.
Multiple functions of mitochondria-shaping proteins.
Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy.
Neural stem cell transplantation enhances mitochondrial biogenesis in a transgenic mouse model of Alzheimer's disease-like pathology.
Neuronal hypoxia disrupts mitochondrial fusion.
Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.
Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production.
NF-?B pathway controls mitochondrial dynamics.
No association between OPA1 polymorphisms and primary open-angle glaucoma in three different populations.
Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease.
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy.
Ontogeny of muscle bioenergetics in Adelie penguin chicks (Pygoscelis adeliae).
OPA1 and cardiolipin team up for mitochondrial fusion.
OPA1 and mitochondrial solute carriers in bioenergetic metabolism.
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.
Opa1 Deficiency Promotes Development of Retinal Vascular Lesions in Diabetic Retinopathy.
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.
OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21.
OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation.
OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma.
OPA1 expression in the normal rat retina and optic nerve.
OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability.
OPA1 overexpression ameliorates mitochondrial cristae remodeling, mitochondrial dysfunction, and neuronal apoptosis in prion diseases.
OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange.
Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control.
OPA1 regulates respiratory supercomplexes assembly: The role of mitochondrial swelling.
OPA1 requires mitofusin 1 to promote mitochondrial fusion.
OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28.
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells.
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion.
OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology.
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis.
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria.
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.
Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts.
Optic atrophy plus phenotype due to mutations in the OPA1 gene: Two more Italian families.
Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction.
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Oxidative stress induced by fluoroquinolone enrofloxacin in zebrafish (Danio rerio) can be ameliorated after a prolonged exposure.
Oxidized LDL Causes Endothelial Apoptosis by Inhibiting Mitochondrial Fusion and Mitochondria Autophagy.
PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels.
PGAM5 regulates PINK1/Parkin-mediated mitophagy via DRP1 in CCCP-induced mitochondrial dysfunction.
Phenoxythiophene sulfonamide compound B355252 protects neuronal cells against glutamate-induced excitotoxicity by attenuating mitochondrial fission and the nuclear translocation of AIF.
Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins.
Phyllanthus urinaria's Inhibition of Human Osteosarcoma Xenografts Growth in Mice is Associated with Modulation of Mitochondrial Fission/Fusion Machinery.
Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells.
Polymorphism Analysis of GSTM1 and OPA1 Genes in Greek Patients with Primary Open-angle Glaucoma.
Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology.
Protease Inhibitor Anti-HIV, Lopinavir, Impairs Placental Endocrine Function.
Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex.
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
Protective effect of hyperoside against renal ischemia-reperfusion injury via modulating mitochondrial fission, oxidative stress, and apoptosis.
Protective Effect of Optic Atrophy 1 on Cardiomyocyte Oxidative Stress: Roles of Mitophagy, Mitochondrial Fission, and MAPK/ERK Signaling.
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy.
Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes NRF2-Independent Mitochondrial Fusion through CXCR4/PSMB5-Mediated Drp1 Degradation in Endothelial Cells.
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion.
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome.
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1.
Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells.
Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion.
Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function.
Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration.
Resveratrol protects retinal ganglion cells against ischemia induced damage by increasing Opa1 expression.
RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity.
Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics.
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs.
Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space.
Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion.
Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.
Silver Nanoparticle Exposure Causes Pulmonary Structural Damage and Mitochondrial Dynamic Imbalance in the Rat: Protective Effects of Sodium Selenite.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
Sirt3 modulate renal ischemia-reperfusion injury through enhancing mitochondrial fusion and activating the ERK-OPA1 signaling pathway.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine Composition, Respiratory Activity, and Cristae Structure of Mitochondria.
Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.
Stomatin-Like Protein-2: A Potential Target to Treat Mitochondrial Cardiomyopathy.
Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.
Structure, function, and regulation of mitofusin-2 in health and disease.
Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy.
T-Cell Intracellular Antigens and Hu Antigen R Antagonistically Modulate Mitochondrial Activity and Dynamics by Regulating Optic Atrophy 1 Gene Expression.
Tang Luo Ning, a Traditional Chinese Compound Prescription, Ameliorates Schwannopathy of Diabetic Peripheral Neuropathy Rats by Regulating Mitochondrial Dynamics In Vivo and In Vitro.
Targeted next-generation sequencing extends the mutational spectrums for OPA1 mutations in Chinese families with optic atrophy.
Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors.
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock.
The association of autosomal dominant optic atrophy and moderate deafness may be due to the R445H mutation in the OPA1 gene.
The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells.
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function.
The Differential DRP1 Phosphorylation and Mitochondrial Dynamics in the Regional Specific Astroglial Death Induced by Status Epilepticus.
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
The G401D mutation of OPA1 causes autosomal dominant optic atrophy and hearing loss in a Chinese family.
The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease.
The mitochondrial inner membrane GTPase, Optic Atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma.
The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage.
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.
The relationship between optic atrophy 1 polymorphism and normal tension glaucoma in Taiwan.
The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy.
The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease.
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
The Short Variant of the Mitochondrial Dynamin OPA1 Maintains Mitochondrial Energetics and Cristae Structure.
The vicious circle between mitochondrial oxidative stress and dynamic abnormality mediates triethylene glycol dimethacrylate-induced preodontoblast apoptosis.
Therapeutic potential of targeting mitochondrial dynamics in cancer.
Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice.
Transient Contraction of Mitochondria Induces Depolarization through the Inner Membrane Dynamin OPA1.
Triptolide induces toxicity in inner ear stem cells via promoting DNA damage.
Ultrastructural Characterization of Flashing Mitochondria.
Upregulation of OPA1 by carnosic acid is mediated through induction of IKK? ubiquitination by parkin and protects against neurotoxicity.
Valproic acid-induced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore opening dependent apoptotic sensitivity in an induced pluripotent stem cell model.
Variation in OPA1 does not explain the incomplete penetrance of Leber hereditary optic neuropathy.
Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival.
[Effect of Sailuotong capsule on mitochondrial dynamics in focal cerebral ischemia/reperfusion rats].
[Effects of electroacupuncture at "Zusanli"(ST36) on ultrastructure and mitochondrial dynamics of skeletal muscle in rats with spleen qi deficiency syndrome].
[Effects of heme oxygenase-1/carbon monoxide pathway on the mitochondrial fusion in rat alveolar epithelial type II cells stimulated by lipopolysaccharide].
Optic Atrophy, Hereditary, Leber
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2.
Optic Nerve Diseases
A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects.
Alu-element insertion in an OPA1 intron sequence associated with autosomal dominant optic atrophy.
Concurrent OPA1 mutation and chromosome 3q deletion leading to Behr syndrome: a case report.
Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data.
Mutation survey of the optic atrophy 1 gene in 193 Chinese families with suspected hereditary optic neuropathy.
OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.
OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database.
The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells.
Osteoarthritis
Mitophagy in degenerative joint diseases.
Osteoporosis
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Osteosarcoma
Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone.
VPS34 regulates dynamin to determine the endocytosis of mitochondria-targeted zinc oxide nanoparticles in human osteosarcoma cells.
Ovarian Neoplasms
Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis.
Guanylate-Binding Protein-1 protects ovarian cancer cell lines but not breast cancer cell lines from killing by paclitaxel.
Prognostic impact of Dynamin related protein 1 (Drp1) in epithelial ovarian cancer.
Pancreatic Neoplasms
A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells.
Dynamin 2 interacts with ?-actinin 4 to drive tumor cell invasion.
Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1.
Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis.
Pancreatitis
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis.
Papillomavirus Infections
Dynamin 2 expression as a biomarker in grading of cervical intraepithelial neoplasia.
Paralysis
A new technique to correct facial paralysis.
Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis.
Dual function C-terminal domain of dynamin-1: modulation of self-assembly by interaction of the assembly site with SH3 domains.
Dynamin II regulates hormone secretion in neuroendocrine cells.
Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling.
Unique biochemical and behavioral alterations in Drosophila shibire(ts1) mutants imply a conformational state affecting dynamin subcellular distribution and synaptic vesicle cycling.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Viral strategies for triggering and manipulating mitophagy.
Paraplegia
Adult-onset autosomal dominant spastic paraplegia linked to a GTPase-effector domain mutation of dynamin 2.
Atlastin-1, the dynamin-like GTPase responsible for spastic paraplegia SPG3A, remodels lipid membranes and may form tubules and vesicles in the endoplasmic reticulum.
Mutations in the SPG3A gene encoding the GTPase atlastin interfere with vesicle trafficking in the ER/Golgi interface and Golgi morphogenesis.
Parkinson Disease
?-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain.
Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice.
Alternative mitochondrial quality control mediated by extracellular release.
Astrocytic dynamin-like protein 1 regulates neuronal protection against excitotoxicity in Parkinson disease.
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Dopamine D1 receptor agonism induces dynamin related protein-1 inhibition to improve mitochondrial biogenesis and dopaminergic neurogenesis in rat model of Parkinson's disease.
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells.
Dynamin Functions and Ligands: Classical Mechanisms Behind.
Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases.
Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson's disease.
Inhibition of dynamin-related protein 1 ameliorates the mitochondrial ultrastructure via PINK1 and Parkin in the mice model of Parkinson's disease.
Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations.
Mitophagy in degenerative joint diseases.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Periodontitis
Crosstalk between reactive oxygen species and Dynamin-related protein 1 in periodontitis.
Peripheral Nervous System Diseases
Case Report: A Novel de novo Mutation in DNM1L Presenting With Developmental Delay, Ataxia, and Peripheral Neuropathy.
Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant.
Dynamin 2 and human diseases.
Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.
Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.
Mitofusin 2 builds a bridge between ER and mitochondria.
Protective effect of gliclazide on diabetic peripheral neuropathy through Drp-1 mediated-oxidative stress and apoptosis.
Peritonitis
Clathrin- and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin.
Peroxisomal Disorders
Biallelic Mutations in DNM1L are Associated with a Slowly Progressive Infantile Encephalopathy.
Pheochromocytoma
Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms.
Sweeping model of dynamin activity. Visualization of coupling between exocytosis and endocytosis under an evanescent wave microscope with green fluorescent proteins.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia.
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells.
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
Mitofusin 1 degradation is induced by a disruptor of mitochondrial calcium homeostasis, CGP37157: A role in apoptosis in prostate cancer cells.
Steroids from an Australian sponge Psammoclema sp.
The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.
protein acetyllysine n-acetyltransferase deficiency
Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.
Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer.
SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo.
Proteinuria
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
Increased dynamin expression precedes proteinuria in glomerular disease.
More expression, less function: cleaved dynamin in glomerular kidney disease.
Proteinuria: is it all in the foot?
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Role of cathepsin L in idiopathic nephrotic syndrome in children.
Psoriasis
Deciphering psoriasis. A bioinformatic approach.
Dynamin-related protein 1 expression correlates with psoriasis disease severity and regulates keratinocyte function.
Uncoupling protein 2 and dynamin-related protein 1 mRNA expressions as genetic markers for plaque psoriasis.
Pulmonary Arterial Hypertension
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment.
Rabies
A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.
Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus.
Renal Insufficiency, Chronic
Increased dynamin expression precedes proteinuria in glomerular disease.
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models.
Reperfusion Injury
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission.
Erratum to: Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice.
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Inhibition of dynamin-related protein 1 protects against myocardial ischemia-reperfusion injury in diabetic mice.
PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury.
Zinc-Induced SUMOylation of Dynamin-Related Protein 1 Protects the Heart against Ischemia-Reperfusion Injury.
Retinal Detachment
Inhibition of Mitochondrial Fission Preserves Photoreceptors after Retinal Detachment.
Rhinitis, Allergic
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Seizures
De novo DNM1L variant presenting with severe muscular atrophy, dystonia and sensory neuropathy.
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Disruption of Endocytosis with the Dynamin Mutant shibirets1 Suppresses Seizures in Drosophila.
Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy.
Novel and lethal case of cardiac involvement in DNM1L mitochondrial encephalopathy.
Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I.
Relationship between changes in mitochondrial function and hippocampal neuronal apoptosis after recurrent convulsion during developmental stage.
Upregulated dynamin 1 in an acute seizure model and in epileptic patients.
Sepsis
Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis.
Sleep Deprivation
Endocytosis at the Drosophila blood-brain barrier as a function for sleep.
Spasms, Infantile
Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
Spastic Paraplegia, Hereditary
Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias.
Targeted high-throughput sequencing identifies mutations in atlastin-1 as a cause of hereditary sensory neuropathy type I.
Spinal Cord Injuries
Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration.
Starvation
Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.
MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria.
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.
Status Epilepticus
A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy.
A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus.
De Novo DNM1L Variant in a Teenager With Progressive Paroxysmal Dystonia and Lethal Super-refractory Myoclonic Status Epilepticus.
Dynamin-Related Protein 1 Promotes Mitochondrial Fission and Contributes to The Hippocampal Neuronal Cell Death Following Experimental Status Epilepticus.
Stomach Neoplasms
DNM1L, a key prognostic predictor for gastric adenocarcinoma, is involved in cell proliferation, invasion, and apoptosis.
Stroke
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission.
Deletion of a neuronal Drp1 activator protects against cerebral ischemia.
Dynamin protein in stroke and vascular dementia.
Effects of drag factor on physiological aspects of rowing.
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury.
Hypothermia Identifies Dynamin as a Potential Therapeutic Target in Experimental Stroke.
[Effects of uncoupling protein 2 overexpression on myocardial mitochondrial dynamics in sepsis rats].
Synucleinopathies
Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy.
Tauopathies
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy.
Tetanus
Synaptic vesicle exocytosis and increased cytosolic calcium are both necessary but not sufficient for activity-dependent bulk endocytosis.
Thrombocytopenia
Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.
Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thyroid Cancer, Papillary
Dynamin 2 Is Correlated with Recurrence and Poor Prognosis of Papillary Thyroid Cancer.
Thyroid Neoplasms
S616-p-DRP1 associates with locally invasive behavior of follicular cell-derived thyroid carcinoma.
Tooth Diseases
Oligomerization of dynamin superfamily proteins in health and disease.
Tuberculosis
Mycobacterium tuberculosis Rv3034c regulates mTORC1 and PPAR-? dependant pexophagy mechanism to control redox levels in macrophages.
Typhoid Fever
Salmonella enterica delivers its genotoxin through outer membrane vesicles secreted from infected cells.
Urinary Bladder Neoplasms
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells.
Serum and tissue profiling in bladder cancer combining protein and tissue arrays.
Uterine Cervical Neoplasms
Dose-Volume Histogram Parameters and Local Tumor Control in Magnetic Resonance Image-Guided Cervical Cancer Brachytherapy.
Dynamin 2 Inhibitors as Novel Therapeutic Agents Against Cervical Cancer Cells.
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Vaccinia
Signal transduction, desensitization, and recovery of responses to thyrotropin-releasing hormone after inhibition of receptor internalization.
Vascular Diseases
Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
Vascular System Injuries
Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury.
Vesicular Stomatitis
Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF-?B pathways as well as Cox-2-mediated PGE2 /EP receptor signalling to enhance clathrin-mediated virus endocytosis.
Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.
Receptor-mediated Moloney murine leukemia virus entry can occur independently of the clathrin-coated-pit-mediated endocytic pathway.
The matrix protein of Vesicular Stomatitis Virus binds dynamin for efficient viral assembly.
Virus Diseases
Cellular uptake and infection by canine parvovirus involves rapid dynamin-regulated clathrin-mediated endocytosis, followed by slower intracellular trafficking.
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission.
Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells.
Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling.
Mx1 and Mx2 key antiviral proteins are surprisingly lost in toothed whales.
Myxovirus resistance protein A activates type I IFN signaling pathway to inhibit zika virus replication.
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.
Vision Disorders
The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling.
Whooping Cough
Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.
Wiskott-Aldrich Syndrome
Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.
Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes.
Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells.
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.
Syndapin - a membrane remodelling and endocytic F-BAR protein.
Syndapin isoforms participate in receptor-mediated endocytosis and actin organization.
Syndapin oligomers interconnect the machineries for endocytic vesicle formation and actin polymerization.
Transcriptional regulation of artemin is related to neurite outgrowth and actin polymerization in mature DRG neurons.