Reference on EC 3.6.5.4 - signal-recognition-particle GTPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Conolly, T.; Gilmore, R.
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide
Cell
57
599-610
1989
Canis lupus familiaris
Conolly, T.; Rapiejko, P.J.; Gilmore, R.
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor
Science
252
1171-1173
1991
Triticum aestivum
Samuelsson, T.; Olsson, M.
GTPase activity of a bacterial SRP-like complex
Nucleic Acids Res.
21
847-853
1993
Mycoplasma mycoides, Mycoplasma mycoides SRPM54
Miller, J.D.; Wilhelm, H.; Gierasch, L.; Gilmore, R.; Walter, P.
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation
Nature
366
351-354
1993
Escherichia coli
Conolly, T.; Gilmore, R.
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor
J. Cell Biol.
123
799-807
1993
Canis lupus familiaris
Zopf, D.; Bernstein, H.D.; Walter, P.
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding
J. Cell Biol.
120
1113-1121
1993
Canis lupus familiaris
Miller, J.D.; Tajima, S.; Lauffer, L.; Walter, P.
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alph subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane
J. Cell Biol.
128
273-282
1995
Canis lupus familiaris
Kusters, R.; Lentzen, G.; Eppens, E.; van Geel, A.; van der Weijden, C.C.; Wintermeyer, W.; Luirink, J.
The functioning of the SRP receptor FtsY in protein-targeting in E.coli is correlated with its ability to bind and hydrolyse GTP
FEBS Lett.
372
253-258
1995
Escherichia coli
Bacher, G.; Lutcke, H.; Jungnickel, B.; Rapoport, T.A.; Dobberstein, B.
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting
Nature
381
248-251
1996
Triticum aestivum
Macao, B.; Luirink, J.; Samuelsson, T.
Ffh and FtsY in a Mycoplasma mycoides signal-recognition particle pathway: SRP RNA and M domain of Ffh are not required for stimulation of GTPase activity in vitro
Mol. Microbiol.
24
523-534
1997
Mycoplasma mycoides, Mycoplasma mycoides MmFtsY
Freymann, D.M.; Keenan, R.J.; Stroud, R.M.; Walter, P.
Structure of the conserved GTPase domain of the signal recognition particle
Nature
385
361-364
1997
Thermus aquaticus
Moll, R.; Schmidtke, S.; Petersen, A.; Schfer, G.
The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity
Biochim. Biophys. Acta
1335
218-230
1997
Acidianus ambivalens
Farmery, M.; Macao, B.; Larsson, T.; Samuelsson, T.
Binding of GTP and GDP induces a significant conformational change in the GTPase domain of Ffh, a bacterial homologue of the SRP 54 kDa subunit
Biochim. Biophys. Acta
1385
61-68
1998
Mycoplasma mycoides, Mycoplasma mycoides Ffh
Ogg, S.C.; Barz, W.P.; Walter, P.
A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit
J. Cell Biol.
142
341-354
1998
Saccharomyces cerevisiae
Bacher, G.; Pool, M.; Dobberstein, B.
The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor
J. Cell Biol.
146
723-730
1999
Canis lupus familiaris
Montoya, G.; te Kaat, K.; Moll, R.; Schfer, G.; Sinning, I.
Crystallization and preliminary x-ray diffraction studies on the conserved GTPase domain of the signal recognition particle from Acidianus ambivalens
Acta Crystallogr. Sect. D
55
1949-1951
1999
Acidianus ambivalens, Acidianus ambivalens Ffh
Moll, R.; Schmidtke, S.; Schfer, G.
Domain structure, GTP-hydrolyzing activity and 7S RNA binding of Acidianus ambivalens Ffh-homologous protein suggest an SRP-like complex in archaea
Eur. J. Biochem.
259
441-448
1999
Acidianus ambivalens, Acidianus ambivalens Ffh
Legate, K.R.; Falcone, D.; Andrews, D.W.
Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit
J. Biol. Chem.
275
27439-27446
2000
Canis lupus familiaris
Peluso, P.; Shan, S.O.; Nock, S.; Herschlag, D.; Walter, P.
Role of SRP RNA in the GTPase cycles of Ffh and FtsY
Biochemistry
40
15224-15233
2001
Escherichia coli
Lu, Y.; Qi, H.Y.; Hyndman, J.B.; Ulbrandt, N.D.; Teplyakov, A.; Tomasevic, N.; Bernstein, H.D.
Evidence for a novel GTPase priming step in the SRP protein targeting pathway
EMBO J.
20
6724-6734
2001
Escherichia coli, Escherichia coli WAM121
Zanen, G.; Antelmann, H.; Westers, H.; Hecker, M.; van Dijl, J.M.; Quax, W.J.
FlhF, the third signal recognition particle-GTPase of Bacillus subtilis, is dispensable for protein secretion
J. Bacteriol.
186
5956-5960
2004
Bacillus subtilis, Bacillus subtilis 168
Swain, J.F.; Gierasch, L.M.
Signal peptides bind and aggregate RNA. An alternative explanation for GTPase inhibition in the signal recognition particle
J. Biol. Chem.
276
12222-12227
2001
Escherichia coli
Egea, P.F.; Shan, S.O.; Napetschnig, J.; Savage, D.F.; Walter, P.; Stroud, R.M.
Substrate twinning activates the signal recognition particle and its receptor
Nature
427
215-221
2004
Thermus aquaticus
Rosendal, K.R.; Wild, K.; Montoya, G.; Sinning, I.
Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication
Proc. Natl. Acad. Sci. USA
100
14701-14706
2003
Saccharolobus solfataricus
Shan, S.O.; Walter, P.
Induced nucleotide specificity in a GTPase
Proc. Natl. Acad. Sci. USA
100
4480-4485
2003
Escherichia coli
Shan, S.O.; Walter, P.
Molecular crosstalk between the nucleotide specificity determinant of the SRP GTPase and the SRP receptor
Biochemistry
44
6214-6222
2005
Escherichia coli
Schuenemann, D.
Structure and function of the chloroplast signal recognition particle
Curr. Genet.
44
295-304
2004
Arabidopsis thaliana, Escherichia coli
Shan, S.O.; Walter, P.
Co-translational protein targeting by the signal recognition particle
FEBS Lett.
579
921-926
2005
Thermus aquaticus
Crowley, P.J.; Svensater, G.; Snoep, J.L.; Bleiweis, A.S.; Brady, L.J.
An ffh mutant of Streptococcus mutans is viable and able to physiologically adapt to low pH in continuous culture
FEMS Microbiol. Lett.
234
315-324
2004
Streptococcus mutans
Yurist, S.; Dahan, I.; Eichler, J.
SRP19 is a dispensable component of the signal recognition particle in Archaea
J. Bacteriol.
189
276-279
2007
Haloferax volcanii
Sivaraja, V.; Kumar, T.K.; Leena, P.S.; Chang, A.N.; Vidya, C.; Goforth, R.L.; Rajalingam, D.; Arvind, K.; Ye, J.L.; Chou, J.; Henry, R.; Yu, C.
Three-dimensional solution structures of the chromodomains of cpSRP43
J. Biol. Chem.
280
41465-41471
2005
Arabidopsis thaliana
Schlenker, O.; Hendricks, A.; Sinning, I.; Wild, K.
The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains
J. Biol. Chem.
281
8898-8906
2006
Homo sapiens, Mus musculus
Dani, H.M.; Singh, J.; Singh, S.
Advances in the structure and functions of signal recognition particle in protein targeting
J. Biol. Regul. Homeost. Agents
17
303-307
2004
Saccharomyces cerevisiae, Escherichia coli, Pyrococcus furiosus
Lustig, Y.; Goldshmidt, H.; Uliel, S.; Michaeli, S.
The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAi
J. Cell Sci.
118
4551-4562
2005
Trypanosoma brucei
Gariani, T.; Samuelsson, T.; Sauer-Eriksson, A.E.
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY
J. Struct. Biol.
153
85-96
2006
Mycoplasma mycoides
Wild Klemen, W.K.; Halic Mari, H.M.; Sinning Irmgar, S.I.; Beckmann Rolan, B.R.
SRP meets the ribosome
Nat. Struct. Mol. Biol.
11
1049-1053
2004
Escherichia coli, Saccharolobus solfataricus, Thermus aquaticus
Spanggord, R.J.; Siu, F.; Ke, A.; Doudna, J.A.
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle
Nat. Struct. Mol. Biol.
12
1116-1122
2005
Escherichia coli
Rosenblad, M.A.; Samuelsson, T.
Identification of chloroplast signal recognition particle RNA genes
Plant Cell Physiol.
45
1633-1639
2004
Arabidopsis thaliana, Chlamydomonas sp., Chlorella vulgaris, Cyanidioschyzon merolae, Cyanidium caldarium, Mesostigma viride, Trieres chinensis, Pisum sativum, Thalassiosira pseudonana, Epifagus virginiana, Porphyra purpurea, Guillardia theta, Nephroselmis olivacea
Fulton, L.A.; Cordum, H.S.; Wang, C.; Elliott, G.; Edwards, J.; Mardis, E.R.; Engstrand, L.G.; Gordon, J.I.
The complete genome sequence of a chronic atrophic gastritis Helicobacter pylori strain: evolution during disease progression
Proc. Natl. Acad. Sci. USA
103
9999-10004
2006
Helicobacter pylori (Q1CSB4), Helicobacter pylori (Q1CTA7), Helicobacter pylori (Q1CU93), Helicobacter pylori HPAG1 (Q1CSB4), Helicobacter pylori HPAG1 (Q1CTA7), Helicobacter pylori HPAG1 (Q1CU93)
Hainzl, T.; Huang, S.; Sauer-Eriksson, A.E.
Structural insights into SRP RNA: an induced fit mechanism for SRP assembly
RNA
11
1043-1050
2005
Methanocaldococcus jannaschii
Dong, H.J.; Tao, S.M.; Li, Y.Q.; Chan, S.H.; Shen, X.L.; Wang, C.X.; Guan, W.J.
Analysis of the GTPase activity and active sites of the NG domains of FtsY and Ffh from Streptomyces coelicolor
Acta Biochim. Biophys. Sin. (Shanghai)
38
467-476
2006
Streptomyces coelicolor
Ramirez, U.D.; Freymann, D.M.
Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh
Acta Crystallogr. Sect. D
D62
1520-1534
2006
Thermus aquaticus
Bange, G.; Wild, K.; Sinning, I.
Protein translocation: checkpoint role for SRP GTPase activation
Curr. Biol.
17
R980-R982
2007
Escherichia coli, Thermus aquaticus
Gras, S.; Chaumont, V.; Fernandez, B.; Carpentier, P.; Charrier-Savournin, F.; Schmitt, S.; Pineau, C.; Flament, D.; Hecker, A.; Forterre, P.; Armengaud, J.; Housset, D.
Structural insights into a new homodimeric self-activated GTPase family
EMBO Rep.
8
569-575
2007
Pyrococcus abyssi
Stengel, K.F.; Holdermann, I.; Wild, K.; Sinning, I.
The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site
FEBS Lett.
581
5671-5676
2007
Arabidopsis thaliana
Angelini, S.; Boy, D.; Schiltz, E.; Koch, H.G.
Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites
J. Cell Biol.
174
715-724
2006
Escherichia coli
Shan, S.O.; Chandrasekar, S.; Walter, P.
Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation
J. Cell Biol.
178
611-620
2007
Escherichia coli
Chandrasekar, S.; Chartron, J.; Jaru-Ampornpan, P.; Shan, S.O.
Structure of the chloroplast signal recognition particle (SRP) receptor: domain arrangement modulates SRP-receptor interaction
J. Mol. Biol.
375
425-436
2008
Arabidopsis thaliana, Escherichia coli
Gawronski-Salerno, J.; Freymann, D.M.
Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY
J. Struct. Biol.
158
122-128
2007
Thermus aquaticus
Salvetti, S.; Ghelardi, E.; Celandroni, F.; Ceragioli, M.; Giannessi, F.; Senesi, S.
FlhF, a signal recognition particle-like GTPase, is involved in the regulation of flagellar arrangement, motility behaviour and protein secretion in Bacillus cereus
Microbiology
153
2541-2552
2007
Bacillus cereus
Gawronski-Salerno, J.; Coon, J.S.; Focia, P.J.; Freymann, D.M.
X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases
Proteins
66
984-995
2007
Thermus aquaticus
Siu, F.Y.; Spanggord, R.J.; Doudna, J.A.
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting
RNA
13
240-250
2007
Escherichia coli
Brooks, M.A.; Ravelli, R.B.; McCarthy, A.A.; Strub, K.; Cusack, S.
Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle
Acta Crystallogr. Sect. D
65
421-433
2009
Schizosaccharomyces pombe, Schizosaccharomyces pombe (Q9P372)
Abe, K.; Hattori, T.; Isobe, T.; Kitagawa, K.; Oda, T.; Uchida, C.; Kitagawa, M.
Pirh2 interacts with and ubiquitylates signal recognition particle receptor beta subunit
Biomed. Res.
29
53-60
2008
Homo sapiens
Ananthamurthy, K.; Kathir, K.M.; Kumar, T.K.; Kight, A.; Goforth, R.L.; Henry, R.
1H, 13C and 15N resonance assignments of the C-terminal domain of the 43 kDa subunit of the chloroplast signal recognition particle
Biomol. NMR Assign.
2
37-39
2008
Arabidopsis thaliana
Rosch, J.W.; Vega, L.A.; Beyer, J.M.; Lin, A.; Caparon, M.G.
The signal recognition particle pathway is required for virulence in Streptococcus pyogenes
Infect. Immun.
76
2612-2619
2008
Streptococcus pyogenes, Streptococcus pyogenes HSC5
Marty, N.J.; Rajalingam, D.; Kight, A.D.; Lewis, N.E.; Fologea, D.; Kumar, T.K.; Henry, R.L.; Goforth, R.L.
The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity
J. Biol. Chem.
284
14891-14903
2009
Pisum sativum
Kathir, K.M.; Rajalingam, D.; Sivaraja, V.; Kight, A.; Goforth, R.L.; Yu, C.; Henry, R.; Kumar, T.K.
Assembly of chloroplast signal recognition particle involves structural rearrangement in cpSRP43
J. Mol. Biol.
381
49-60
2008
Arabidopsis thaliana
Dalley, J.A.; Selkirk, A.; Pool, M.R.
Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation
Mol. Biol. Cell
19
2876-2884
2008
Saccharomyces cerevisiae
Maier, K.S.; Hubich, S.; Liebhart, H.; Krauss, S.; Kuhn, A.; Facey, S.J.
An amphiphilic region in the cytoplasmic domain of KdpD is recognized by the signal recognition particle and targeted to the Escherichia coli membrane
Mol. Microbiol.
68
1471-1484
2008
Escherichia coli, Escherichia coli MC1061
Egea, P.F.; Napetschnig, J.; Walter, P.; Stroud, R.M.
Structures of SRP54 and SRP19, the two proteins that organize the ribonucleic core of the signal recognition particle from Pyrococcus furiosus
PLoS ONE
3
e3528
2008
Pyrococcus furiosus (Q8U070), Pyrococcus furiosus
Egea, P.F.; Tsuruta, H.; de Leon, G.P.; Napetschnig, J.; Walter, P.; Stroud, R.M.
Structures of the signal recognition particle receptor from the archaeon Pyrococcus furiosus: implications for the targeting step at the membrane
PLoS ONE
3
e3619
2008
Pyrococcus furiosus (Q8U051), Pyrococcus furiosus
van Nues, R.W.; Leung, E.; McDonald, J.C.; Dantuluru, I.; Brown, J.D.
Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle
RNA Biol.
5
73-83
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae JDY819
Buskiewicz, I.A.; Joeckel, J.; Rodnina, M.V.; Wintermeyer, W.
Conformation of the signal recognition particle in ribosomal targeting complexes
RNA
15
44-54
2009
Escherichia coli, Escherichia coli MRE 600
Stengel, K.F.; Holdermann, I.; Cain, P.; Robinson, C.; Wild, K.; Sinning, I.
Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43
Science
321
253-256
2008
Arabidopsis thaliana (O22265)
Nguyen, T.X.; Chandrasekar, S.; Neher, S.; Walter, P.; Shan, S.O.
Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle
Biochemistry
50
7208-7217
2011
Arabidopsis thaliana
Ataide, S.; Schmitz, N.; Shen, K.; Ke, A.; Shan, S.; Doudna, J.; Ban, N.
The crystal structure of the signal recognition particle in complex with its receptor
Science
331
881-886
2011
Escherichia coli
Shen, K.; Wang, Y.; Hwang Fu, Y.H.; Zhang, Q.; Feigon, J.; Shan, S.O.
Molecular mechanism of GTPase activation at the signal recognition particle (SRP) RNA distal end
J. Biol. Chem.
288
36385-36397
2013
Escherichia coli
Henderson, R.C.; Gao, F.; Jayanthi, S.; Kight, A.; Sharma, P.; Goforth, R.L.; Heyes, C.D.; Henry, R.L.; Suresh Kumar, T.K.
Domain organization in the 54-kDa subunit of the chloroplast signal recognition particle
Biophys. J.
111
1151-1162
2016
Arabidopsis thaliana (P37107)
Chandrasekar, S.; Sweredoski, M.J.; Sohn, C.H.; Hess, S.; Shan, S.O.
Co-evolution of two GTPases enables efficient protein targeting in an RNA-less chloroplast signal recognition particle pathway
J. Biol. Chem.
292
386-396
2017
Arabidopsis thaliana (P37107)
Wild, K.; Bange, G.; Motiejunas, D.; Kribelbauer, J.; Hendricks, A.; Segnitz, B.; Wade, R.C.; Sinning, I.
Structural basis for conserved regulation and adaptation of the signal recognition particle targeting complex
J. Mol. Biol.
428
2880-2897
2016
Canis lupus familiaris (P61010 AND P06625)
Faoro, C.; Ataide, S.
Structural insights into the G-loop dynamics of E. coli FtsY NG domain
J. Struct. Biol.
208
107387
2019
Escherichia coli (P0AGD7 AND P10121), Escherichia coli
Jadhav, B.; McKenna, M.; Johnson, N.; High, S.; Sinning, I.; Pool, M.R.
Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation
Nat. Commun.
6
10133
2015
Thermochaetoides thermophila (G0SD15), Homo sapiens (P08240 AND Q9Y5M8), Mus musculus (Q9DBG7 AND P47758), Thermochaetoides thermophila IMI 039719 (G0SD15), Thermochaetoides thermophila DSM 1495 (G0SD15), Thermochaetoides thermophila CBS 144.50 (G0SD15)
Wild, K.; Juaire, K.D.; Soni, K.; Shanmuganathan, V.; Hendricks, A.; Segnitz, B.; Beckmann, R.; Sinning, I.
Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions
Nucleic Acids Res.
47
3184-3196
2019
Homo sapiens (P08240 AND Q9Y5M8), Homo sapiens
Jadhav, B.; Wild, K.; Pool, M.R.; Sinning, I.
Structure and switch cycle of SRbeta as ancestral eukaryotic GTPase associated with secretory membranes
Structure
23
1838-1847
2015
Thermochaetoides thermophila (G0SD15), Thermochaetoides thermophila IMI 039719 (G0SD15), Thermochaetoides thermophila DSM 1495 (G0SD15), Thermochaetoides thermophila CBS 144.50 (G0SD15)
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