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Disease on EC 3.6.5.3 - protein-synthesizing GTPase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole.
Acidosis
Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro.
Acquired Immunodeficiency Syndrome
Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription.
Elongation factor-P at the crossroads of the host-endosymbiont interface.
In vivo biochemical analyses reveal distinct roles of ?-importins and eEF1A in tRNA subcellular traffic.
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Acute Lung Injury
Eukaryotic Translation Initiation Factor 5A Small Interference RNA-Liposome Complexes Reduce Inflammation and Increase Survival in Murine Models of Severe Sepsis and Acute Lung Injury.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay.
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.
Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.
Differential screening of a human pancreatic adenocarcinoma lambda gt11 expression library has identified increased transcription of elongation factor EF-1 alpha in tumour cells.
Digital morphometry of cytologic aspirate endometrial samples.
eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.
Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon.
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis.
N1-guanyl-1, 7-diaminoheptane enhances the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine via the inhibition of eukaryotic translation initiation factor 5A2.
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
RASAL2 Plays Inconsistent Roles in Different Cancers.
The effect of miR-496 on eIF3h in lung invasive adenocarcinoma.
[Expression of eukaryotic translation initiation factor 5A2 in pancreatic adenocarcinoma and its correlation with the prognosis].
Adenocarcinoma of Lung
Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells.
eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.
Expression and prognostic analysis of Rho GTPase-activating protein 11A in lung adenocarcinoma.
p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells.
[Rho GTPase-activating protein 11A (ARHGAP11A) is up-regulated in lung adenocarcinoma and positively associated with poor prognosis].
Adenoma
Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
The value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland.
Adenomatous Polyposis Coli
Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins.
IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli.
Adenomyosis
RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
The Possible Role of Eukaryotic Translation Initiation Factor 3 Subunit e (eIF3e) in the Epithelial-Mesenchymal Transition in Adenomyosis.
Adrenoleukodystrophy
ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.
African Swine Fever
Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2? and inhibiting activation of pro-apoptotic CHOP.
Promoter analysis of an African swine fever virus gene encoding a putative elongation factor.
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
Albuminuria
MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.
Alzheimer Disease
Activation of eukaryotic initiation factor-2 alpha-kinases in okadaic acid-treated neurons.
Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.
Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease.
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE-/- mice.
Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.
Genetic inhibition of phosphorylation of the translation initiation factor eIF2? does not block A?-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease.
Limited effects of an eIF2?S51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.
Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pathogenesis and promising therapeutics of Alzheimer disease through eIF2? pathway and correspondent kinases.
Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity.
Ameloblastoma
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma.
Amyotrophic Lateral Sclerosis
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Validation of reference genes for real-time polymerase chain reaction studies in atlantic salmon.
Anemia, Diamond-Blackfan
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Angiomyolipoma
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
Arthritis
Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12.
Arthritis, Rheumatoid
Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Astrocytoma
RASAL2 Plays Inconsistent Roles in Different Cancers.
Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner.
Ataxia
A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy.
A new function and complexity for protein translation initiation factor eIF2B.
A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation.
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
Dominant form of vanishing white matter-like leukoencephalopathy.
Drosophila histone locus bodies form by hierarchical recruitment of components.
eIF2B, a mediator of general and gene-specific translational control.
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish.
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Leukoencephalopathy with vanishing white matter due to homozygous EIF2B2 gene mutation. First Polish cases.
Membrane phospholipids and high-energy metabolites in childhood ataxia with CNS hypomyelination.
Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy.
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Ovarian failure related to eukaryotic initiation factor 2B mutations.
Profile of Indian Children with Childhood Ataxia and Central Nervous System Hypomyelination/Vanishing White Matter Disease: A Single Center Experience from Southern India.
The effect of genotype on the natural history of eIF2B-related leukodystrophies.
The large spectrum of eIF2B-related diseases.
The spectrum of mutations for the diagnosis of vanishing white matter disease.
Ataxia Telangiectasia
Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
Atherosclerosis
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE-/- mice.
Atrial Fibrillation
Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses.
Atypical Squamous Cells of the Cervix
MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Azoospermia
Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.
Babesiosis
Characterization and gene expression of Babesia bovis elongation factor-1alpha.
Bacteremia
Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization.
Bacterial Infections
Evaluation of candidate reference genes for quantitative expression studies in Asian seabass (Lates calcarifer) during ontogenesis and in tissues of healthy and infected fishes.
Evaluation of potential internal references for quantitative real-time RT-PCR normalization of gene expression in red drum (Sciaenops ocellatus).
Blast Crisis
Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency.
Blister
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Bone Marrow Failure Disorders
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Brain Diseases
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene.
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Mutation in subdomain G' of mitochondrial elongation factor G1 is associated with combined OXPHOS deficiency in fibroblasts but not in muscle.
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Recessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy.
Successful treatment of choreo-athetotic movements in a patient with an EEF1A2 gene variant.
The latest on leukodystrophies.
The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex.
Brain Injuries
Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Brain Injuries, Traumatic
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury.
Brain Ischemia
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.
Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion.
Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha.
PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2alpha) phosphatase, under ischemic reperfusion and tolerance.
Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins.
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat.
Brain Neoplasms
Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
Breast Neoplasms
4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis.
A transcriptional complex composed of ER(?), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells.
Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.
Activation of the PERK-eIF2? Pathway Is Associated with Tumor-infiltrating Lymphocytes in HER2-Positive Breast Cancer.
Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer.
Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
Decreased microRNA-768-3p expression indicates a poor prognosis in patients with breast cancer and promotes breast cancer cell viability, migration and invasion.
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Droplet digital PCR using HER2/EIF2C1 ratio for detection of HER2 amplification in breast cancer tissues.
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility.
Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer.
Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.
Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer.
Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.
Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors.
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Inflammatory breast cancer cells are constitutively adapted to hypoxia.
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.
LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1.
Long non-coding RNA NORAD inhibition upregulates microRNA-323a-3p to suppress tumorigenesis and development of breast cancer through the PUM1/eIF2 axis.
mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network.
N1-Guanyl-1,7-Diaminoheptane Sensitizes Estrogen Receptor Negative Breast Cancer Cells to Doxorubicin by Preventing Epithelial-Mesenchymal Transition through Inhibition of Eukaryotic Translation Initiation Factor 5A2 Activation.
Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.
Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1? and FOXO3a by AMPK signaling.
Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor ??-?1 expression.
PERK-Phosphorylated eIF2? Pathway Suppresses Tumor Metastasis Through Downregulating Expression of Programmed Death Ligand 1 and CXCL5 in Triple-Negative Breast Cancer.
Plitidepsin to treat multiple myeloma.
PRMT7 Methylates Eukaryotic Translation Initiation Factor 2? and Regulates its Role in Stress Granule Formation.
RAS protein activator-like 1 is functionally involved in hypoxia resistance in breast cancer cells by targeting hypoxia inducible factor-1?.
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.
SPA-1 controls the invasion and metastasis of human prostate cancer.
Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy.
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours.
Bronchitis
Inhibition of PKR Activation and Up-regulation of GADD34 Expression Play a Synergistic Role in Facilitating Coronavirus Replication by Maintaining de novo Protein Synthesis in Virus-Infected Cells.
Burkholderia Infections
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Burkitt Lymphoma
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response.
Buruli Ulcer
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Carcinogenesis
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis.
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
ACAP4 interacts with CrkII to promote the recycling of integrin ?1.
Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice.
An oncogenic role of eIF3e/INT6 in human breast cancer.
An RNA polymerase II elongation factor encoded by the human ELL gene.
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1? signaling pathways.
Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and risk of colon and rectal cancer: additional support for a TGF-{beta}-signaling pathway.
Characterization of novel calmodulin binding domains within IQ motifs of IQGAP1.
Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells.
Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.
Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.
Different Oligomeric Properties and Stability of Highly Homologous A1 and Proto-Oncogenic A2 Variants of Mammalian Translation Elongation Factor eEF1.
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
eEF1A2 as a putative oncogene.
Effect on the Ras/Raf signaling pathway of post-translational modifications of neurofibromin: In silico study of protein modification responsible for regulatory pathways.
EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells.
eIF4E-mediated translational control of cancer incidence.
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.
Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.
Eukaryotic translation initiation factor 3H suppression inhibits osteocarcinoma cell growth and tumorigenesis.
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancer.
Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer.
Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC.
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade.
High expression of eukaryotic initiation factor 3M predicts poor prognosis in colon adenocarcinoma patients.
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Human INT6/eIF3e is required for nonsense-mediated mRNA decay.
Imbalanced splicing in MAPK signaling sustains Ras-induced transformation.
Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism.
Increased expression of stathmin and elongation factor 1? in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
Increased HE4 mRNA Expression Correlates with High Level Of eIF3a mRNA And Better Survival in Women with Epithelial Ovarian Cancer.
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous cell carcinoma cells.
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells.
Knockdown of IRE1? inhibits colonic tumorigenesis through decreasing ?-catenin and IRE1? targeting suppresses colon cancer cells.
KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/?-catenin and PI3K/AKT signaling pathways.
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
miR-939-5p Contributes to the Migration and Invasion of Pancreatic Cancer by Targeting ARHGAP4.
Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.
Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
mTOR signaling: implications for cancer and anticancer therapy.
Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
Overexpression of NELFE contributes to gastric cancer progression via Wnt/?-catenin signaling-mediated activation of CSNK2B expression.
Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes.
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
p53-dependent translational control of senescence and transformation via 4E-BPs.
Phosphorylation of eEF1A1 at Ser300 by T?R-I results in inhibition of mRNA translation.
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Role of IQGAP1 in Carcinogenesis.
Spectrin Domain of Eukaryotic Initiation Factor 3a Is the Docking Site for Formation of the a:b:i:g Subcomplex.
Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.
Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma.
Targeting the eukaryotic translation initiation factor 4E for cancer therapy.
The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections.
The eIF2{alpha} Kinases PERK and PKR Activate Glycogen Synthase Kinase 3 to Promote the Proteasomal Degradation of p53.
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
The role of eukaryotic translation initiation factor 6 in tumors.
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3.
Translational control and cancer therapy.
Translational control: the cancer connection.
TUFM-knockdown inhibits the migration and proliferation of gastrointestinal stromal tumor cells.
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
[Expression change of TIF3 p36 at different stages of human bronchial epithelial cells transformed and induced by cadmium chloride]
Carcinoma
A fibroblast elongation factor purified from colon carcinoma cells shares sequence identity with TIMP-1.
Aberrant expression and phosphorylation of 4E-BP1, a main target of mTOR signaling, in rat mammary carcinomas: an association with etiology.
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation.
Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells.
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Differential expression of translation-associated genes in benign and malignant human breast tumours.
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Elongation factor 1 gamma mRNA expression in oesophageal carcinoma.
Eukaryotic polypeptide elongation system and its sensitivity to the inhibitory substances of plant origin.
Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating ?-catenin signaling pathway.
Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma.
Eukaryotic translation initiation factor 5A-2 involves in doxorubicin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells.
Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.
Growth factor-independent expression of the gene encoding eukaryotic translation initiation factor 4E in transformed cell lines.
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.
High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2.
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.
Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity.
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Independent roles of eIF5A and polyamines in cell proliferation.
Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma.
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.
Interactome Mapping of eIF3A in a Colon Cancer and an Immortalized Embryonic Cell Line Using Proximity-Dependent Biotin Identification.
Isolation and properties of the subunit form EF-1C of elongation factor 1 from Guerin epithelioma cells.
Key contribution of eIF4H-mediated translational control in tumor promotion.
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
Monoclonal antibodies to elongation factor-1alpha inhibit in vitro translation in lysates of Sf21 cells.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma.
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.
Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma.
Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer (†).
Purification and properties of the heterogeneous subunits of elongation factor EF-1 from Guerin epithelioma cells.
Rac GTPase-Activating Protein 1 (RACGAP1) as an Oncogenic Enhancer in Esophageal Carcinoma.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.
Small-molecule inhibitors targeting eIF4A in leukemia.
The eIF3a Arg803Lys genetic polymorphism is associated with susceptibility to and chemoradiotherapy efficacy in cervical carcinoma.
The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
The phosphorylation of elongation factor EF-1 isolated from Guerin epithelioma.
The value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland.
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma.
Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma.
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma]
Carcinoma, Ductal
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
Carcinoma, Ehrlich Tumor
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
Differential phosphorylation of soluble versus ribosome-bound eukaryotic initiation factor 2 in the Ehrlich ascites tumor cell.
Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells.
Carcinoma, Hepatocellular
Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.
ASAP3 is a downstream target of HIF-1? and is critical for progression of lung adenocarcinoma.
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma.
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy.
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.
Dissecting the role of the elongation factor 1A isoforms in hepatocellular carcinoma cells by liposome-mediated delivery of siRNAs.
DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.
eIF-2 initiation factor activity in Yoshida ascites hepatoma AH 130 cells and in 4-dimethylaminoazobenzene-induced liver tumor tissue during growth.
Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma.
Erythropoietin enhancer stimulates production of a recombinant protein by Chinese hamster ovary (CHO) cells under hypoxic condition.
Eukaryotic elongation factor-1? 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-?B signaling.
Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions.
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translation elongat ion factor 1 alpha 1.
Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines.
Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma.
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
Inhibition of eIF2? dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells.
Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
Knockdown of eukaryotic translation initiation factor 5A2 enhances the therapeutic efficiency of doxorubicin in hepatocellular carcinoma cells by triggering lethal autophagy.
Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma.
MEK Signaling Is Required for Phosphorylation of eIF2{alpha} following Amino Acid Limitation of HepG2 Human Hepatoma Cells.
MicroRNA-383 inhibits doxorubicin resistance in hepatocellular carcinoma by targeting eukaryotic translation initiation factor 5A2.
MicroRNA-9 enhances sensitivity to cetuximab in epithelial phenotype hepatocellular carcinoma cells through regulation of the eukaryotic translation initiation factor 5A-2.
MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells.
Opposing roles of C/EBP? and eEF1A1 in Sp1-regulated miR-122 transcription.
Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma.
PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma.
RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Suppression of Vascular Endothelial Growth Factor via Inactivation of Eukaryotic Elongation Factor 2 by Alkaloids in Coptidis rhizoma in Hepatocellular Carcinoma.
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Up-regulation of Rac GTPase activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.
[Eukaryotic translation elongation factor 1A1 positively regulates NOB1 expression to promote invasion and metastasis of hepatocellular carcinoma cells in vitro].
Carcinoma, Intraductal, Noninfiltrating
Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer.
Carcinoma, Merkel Cell
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma.
Carcinoma, Non-Small-Cell Lung
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.
MicroRNA-9 regulates non-small cell lung cancer cell invasion and migration by targeting eukaryotic translation initiation factor 5A2.
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
The prognostic significance of eukaryotic elongation factor 1 alpha-2 in non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
Carcinoma, Renal Cell
Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma.
High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma.
Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Carcinoma, Squamous Cell
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity.
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
The role of eukaryotic translation initiation factor 5A-1 (eIF5A-1) gene in HPV 16 E6 induces cell growth in human cervical squamous carcinoma cells.
Carcinosarcoma
RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma.
Cardiomegaly
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Cardiomyopathies
Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.
Novel compound mutations in the mitochondrial translation elongation factor (TSFM) gene cause severe cardiomyopathy with myocardial fibro-adipose replacement.
Cardiomyopathy, Dilated
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Cardiomyopathy, Hypertrophic
Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy.
Cardiovascular Diseases
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
Cerebellar Ataxia
From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.
Psychotic syndrome associated with anti-Ca/ARHGAP26 and voltage-gated potassium channel antibodies.
Cholangiocarcinoma
Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival.
Cholera
Transport of the cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1.
Choriocarcinoma
A protein kinase C-independent pathway leading to c-Jun-dependent expression of 100-kDa Ras GTPase-activating protein in JEG-3 human choriocarcinoma cells.
Classical Swine Fever
eEF1A Interacts with the NS5A Protein and Inhibits the Growth of Classical Swine Fever Virus.
eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.
Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.
The eukaryotic translation initiation factor 3 subunit E binds to classical swine fever virus NS5A and facilitates viral replication.
Viral strategies for triggering and manipulating mitophagy.
Cleft Lip
Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
Clostridium Infections
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Cockayne Syndrome
A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair.
Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage.
Coinfection
Activation of dsRNA Dependent Protein Kinase PKR in Karpas299 Does Not Lead to Cell Death.
Colitis
DNA microarray technology reveals similar gene expression patterns in rats with vitamin a deficiency and chemically induced colitis.
Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.
Regulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity.
The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
Colitis, Ulcerative
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colonic Neoplasms
Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.
Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma.
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.
Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.
Muscarinic acetylcholine receptors regulate the dephosphorylation of eukaryotic translation elongation factor 2 in SNU-407 colon cancer cells.
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.
Overexpression of p150, a part of the large subunit of the eukaryotic translation initiation factor 3, in colon cancer.
Overexpression of ribosomal proteins L4 and L5 and the putative alternative elongation factor PTI-1 in the doxorubicin resistant human colon cancer cell line LoVoDxR.
RNA interference-mediated silencing of eukaryotic translation initiation factor 3, subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells.
Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.
TBC1D8B, a GTPase-activating protein, is a novel apoptosis inducer.
Colorectal Neoplasms
A MYC-GCN2-eIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53.
Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy.
Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia.
Eukaryotic translation initiation factor 3 subunit G promotes human colorectal cancer.
Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition.
Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia.
High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
How autophagy controls the intestinal epithelial barrier.
Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1.
Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion.
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation.
Targeting MYC Translation in Colorectal Cancer.
The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression.
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Coronavirus Infections
COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges.
Crohn Disease
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.
Cystic Fibrosis
Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in elongation factor, fusA1.
How autophagy controls the intestinal epithelial barrier.
Cysts
Cyst morphology and sequence analysis of the small subunit rDNA and ef1 alpha identifies a novel Giardia genotype in a quenda (Isoodon obesulus) from Western Australia.
Distribution of the low molecular weight form of eukaryotic elongation factor 1 in various tissues.
Elongation factor 1 beta gamma from Artemia. Purification and properties of its subunits.
Molecular cloning and analysis of cDNA sequences for two ribosomal proteins from Artemia. The coordinate expression of genes for ribosomal proteins and elongation factor 1 during embryogenesis of Artemia.
Sequence homology between EF-1 alpha, the alpha-chain of elongation factor 1 from Artemia salina and elongation factor EF-Tu from Escherichia coli.
TgIF2K-B Is an eIF2? Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity.
The role of guanine nucleotides in the interaction between aminoacyl-tRNA and elongation factor 1 of Artemia salina.
Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii.
Dehydration
Expression analysis of genes encoding translation initiation factor 3 subunit g (TaeIF3g) and vesicle-associated membrane protein-associated protein (TaVAP) in drought tolerant and susceptible cultivars of wheat
Selection of Reference Genes for qRT-PCR Analysis in Medicinal Plant Glycyrrhiza under Abiotic Stresses and Hormonal Treatments.
Dementia
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Demyelinating Diseases
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Dengue
Interaction between the cellular protein eEF1A and the 3'-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis.
Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA.
Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells.
Viral strategies for triggering and manipulating mitophagy.
Diabetes Mellitus
Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions.
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Diabetes Mellitus, Type 1
Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus.
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Diabetes Mellitus, Type 2
A self-defeating anabolic program leads to ?-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.
DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.
EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families.
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Diabetic Nephropathies
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.
Diphtheria
1-N6-Etheno-ADP-ribosylation of elongation factor-2 by diphtheria toxin.
A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin a and diphtheria toxin.
A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.
Actin--an inhibitor of eukaryotic elongation factor activities.
ADP-ribosylatable content of elongation factor-2 changes during cell cycle of normal and cancerous human cells.
ADP-ribosylation of Translation Elongation Factor 2 by Diphtheria Toxin in Yeast Inhibits Translation and Cell Separation.
ADP-ribosyltransferase from beef liver which ADP-ribosylates elongation factor-2.
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Archaebacterial elongation factor is ADP-ribosylated by diphtheria toxin.
Bacterial toxins.
Characterization of Cholix toxin-induced apoptosis in HeLa cells.
Comparison of the frequency of diphtheria toxin and thioguanine resistance induced by a series of carcinogens to analyze their mutational specificities in diploid human fibroblasts.
Cytotoxic properties of DAB486EGF and DAB389EGF, epidermal growth factor (EGF) receptor-targeted fusion toxins.
Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders.
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity.
Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha.
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.
Diphtheria-toxin-resistant mutants of CHO cells affected in protein synthesis: a novel phenotype.
Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.
Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions.
Endogenous ADP-ribosylation of eukaryotic elongation factor 2 and its 32 kDa tryptic fragment.
Entry of diphtheria toxin into cells: possible existence of cellular factor(s) for entry of diphtheria toxin into cells was studied in somatic cell hybrids and hybrid toxins.
Estimating the amounts of ADP-ribosylatable active elongation factor-2 in mammalian cell-free extracts.
Expression of a biologically active diphtheria toxin fragment B in Escherichia coli.
Gene for the diphtheria toxin-susceptible elongation factor 2 from Methanococcus vannielii.
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
Immobilization of reticulocyte elongation factor EF-2.
Inhibition of metabolic cooperation by phorbol esters in a cell culture system based on adenosine kinase deficient mutants of V79 cells.
Insights into diphthamide, key diphtheria toxin effector.
Loss of diphthamide pre-activates NF-?B and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis.
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
Novel cholix toxin variants, ADP-ribosylating toxins in Vibrio cholerae non-O1/non-O139 strains, and their pathogenicity.
On diphtheria toxin fragment A release into the cytosol-Cytochalasin D effect and involvement of actin filaments and eukaryotic elongation factor 2.
Production of exoenzyme S by clinical isolates of Pseudomonas aeruginosa.
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.
Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II.
Reconstitution of Diphthine Synthase Activity in Vitro.
Reduced levels of ADP-ribosylatable elongation factor-2 in aged and SV40-transformed human cell cultures.
Role of CypA and Hsp90 in membrane translocation mediated by anthrax Protective Antigen.
Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin.
Structures of two archaeal diphthine synthases: insights into the post-translational modification of elongation factor 2.
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network.
The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis.
The cytotoxic effect of diphtheria toxin on the actin cytoskeleton.
The Hidden Nature of Protein Translational Control by Diphthamide - the secrets under the leather.
The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A.
Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin.
Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin.
Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.
Two elongation factors from the extremely halophilic archaebacterium Halobacterium cutirubrum. Assay systems and purification at high salt concentrations.
Utilization of 2'-deoxynad for ADP-ribose transfer reactions.
YBR246W is required for the third step of diphthamide biosynthesis.
[Effect of cytochalasin D, diphtheria toxin, and ricin on the localization of eukaryotic elongation factor 2 along actin filament bundles in fibroblasts]
Diverticular Diseases
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Diverticulitis
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Down Syndrome
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.
Drug-Related Side Effects and Adverse Reactions
ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.
Dysentery, Amebic
Cloning and characterization of Entamoeba histolytica antigens recognized by human secretory IgA antibodies.
Dysplastic Nevus Syndrome
eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion.
Dystonia
EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia.
Linking Penetrance and Transcription in DYT-THAP1: Insights From a Human iPSC-Derived Cortical Model.
Echinococcosis
Elongation factor 1 beta/delta of Echinococcus granulosus and allergic manifestations in human cystic echinococcosis.
Encephalitis
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Encephalitis, Japanese
MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Encephalomyelitis, Autoimmune, Experimental
Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Expression profile of eukaryotic translation initiation factor and matrix metalloproteinase 9 in endometrial cancer tissue.
Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/ ?-catenin signaling pathway.
MicroRNA-182 Promotes Tumor Cell Growth by Targeting Transcription Elongation Factor A-like 7 in Endometrial Carcinoma.
Endometriosis
Reduced Expression of Eukaryotic Translation Initiation Factor 3 Subunit e and Its Possible Involvement in the Epithelial-Mesenchymal Transition in Endometriosis.
Enterovirus Infections
Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E.
Enzootic Bovine Leukosis
Isolation and characterisation of a bovine cDNA encoding eukaryotic initiation factor 2 alpha.
Epilepsy
Cellular compartmentalization of phosphorylated eIF2alpha and neuronal NOS in human temporal lobe epilepsy with hippocampal sclerosis.
Clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy and their effects on EF-Tumt and EF-Tsmt expression.
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy.
Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy.
Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain.
Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability.
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations.
Epilepsy, Temporal Lobe
Cellular compartmentalization of phosphorylated eIF2alpha and neuronal NOS in human temporal lobe epilepsy with hippocampal sclerosis.
Clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy and their effects on EF-Tumt and EF-Tsmt expression.
Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy.
Equine Infectious Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Esophageal Neoplasms
Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer.
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
Esophageal Squamous Cell Carcinoma
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating ?-catenin signaling pathway.
Familial Primary Pulmonary Hypertension
A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype.
Fasciculation
Exposure to cypermethrin and mancozeb alters the expression profile of THBS1, SPP1, FEZ1 and GPNMB in human peripheral blood mononuclear cells.
Fatty Liver
Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.
Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Fibroadenoma
Differential expression of translation-associated genes in benign and malignant human breast tumours.
Fibrosarcoma
Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics.
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Folic Acid Deficiency
Folic acid deficiency damages male reproduction via endoplasmic reticulum stress-associated PERK pathway induced by Caveolin-1 in mice.
Foot-and-Mouth Disease
Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G.
Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site.
Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.
Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease.
Interaction of eukaryotic initiation factor eIF4B with the internal ribosome entry site of foot-and-mouth disease virus is independent of the polypyrimidine tract-binding protein.
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo.
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
STING1 is essential for an RNA-virus triggered autophagy.
Vaccinia virus protein synthesis has a low requirement for the intact translation initiation factor eIF4F, the cap-binding complex, within infected cells.
Fragile X Syndrome
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
Control of the eIF4E activity: structural insights and pharmacological implications.
Frontotemporal Dementia
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Frontotemporal Lobar Degeneration
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Fuchs' Endothelial Dystrophy
Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway?
Fusariosis
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.
Gallbladder Neoplasms
Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
Gastroenteritis
Viral strategies for triggering and manipulating mitophagy.
Gastrointestinal Neoplasms
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
gelatinase b deficiency
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.
Genetic Diseases, Inborn
LEUKOENCEPHALOPATHY WITH EVANESCENT WHITE MATTER: A CASE REPORT.
Peptidomics and proteomics studies of transformed lymphocytes from patients mutated for the eukaryotic initiation factor 2B.
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Regulation of translation initiation factor eIF2B at the hub of the integrated stress response.
Role of oculocerebrorenal syndrome of Lowe (OCRL) protein in megakaryocyte maturation, platelet production and functions: a study in patients with Lowe syndrome.
Glioblastoma
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration.
ATF4 links ER stress with reticulophagy in glioblastoma cells.
Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.
Growth factor-independent expression of the gene encoding eukaryotic translation initiation factor 4E in transformed cell lines.
Inhibition of eukaryotic initiation factor 3B suppresses proliferation and promotes apoptosis of chronic myeloid leukemia cells.
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Glioma
A GTPase-activating protein for the G protein Galphaz. Identification, purification, and mechanism of action.
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.
Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206.
Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function.
Eukaryotic translation initiation factor 3, subunit C is overexpressed and promotes cell proliferation in human glioma U-87 MG cells.
Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents.
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
The effect of miR-7 on behavior and global protein expression in glioma cell lines.
The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo.
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway.
Glomerulonephritis, Membranous
Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury.
Glycogen Storage Disease Type II
Isolation and characterisation of a recombinant, precursor form of lysosomal acid alpha-glucosidase.
Granuloma
Induction of ER stress in macrophages of tuberculosis granulomas.
Head and Neck Neoplasms
eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
Hearing Loss
An Alteration in ELMOD3, an Arl2 GTPase-Activating Protein, Is Associated with Hearing Impairment in Humans.
Elmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia.
Heart Failure
Reduced endoplasmic reticulum stress might alter the course of heart failure via caspase-12 and JNK pathways.
[Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis].
Hemangiosarcoma
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics.
Hematologic Neoplasms
Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.
Hemolytic-Uremic Syndrome
Demonstration of RNA N-glycosidase activity of a Vero toxin (VT2 variant) produced by Escherichia coli O91:H21 from a patient with the hemolytic uremic syndrome.
Hemophilia A
Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response.
Restoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs.
Hepatitis
Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells.
Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II.
Eukaryotic elongation factor 2 controls TNF-? translation in LPS-induced hepatitis.
Foreign gene expression and induction of antibody response by recombinant fowl adenovirus-9-based vectors with exogenous promoters.
Highly efficient lentiviral gene transfer in CD34+ and CD34+/38-/lin- cells from mobilized peripheral blood after cytokine prestimulation.
The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells.
Hepatitis A
Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G.
Hepatitis B
Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene (EFTUD2) Polymorphism with the Risk of Hepatitis B Virus Infection.
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Incorporation of eukaryotic translation initiation factor eIF4E into viral nucleocapsids via interaction with hepatitis B viral polymerase.
Increased expression of stathmin and elongation factor 1? in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis.
Hepatitis B, Chronic
Appropriate use of interferon for treatment of chronic hepatitis B.
Hepatitis C
A conserved RNA structure within the HCV IRES eIF3-binding site.
A single immunization with a plasmid encoding hepatitis C virus (HCV) structural proteins under the elongation factor 1-alpha promoter elicits HCV-specific cytotoxic T-lymphocytes (CTL).
Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy.
Cap-dependent and hepatitis C virus internal ribosome entry site-mediated translation are modulated by phosphorylation of eIF2alpha under oxidative stress.
Cross-correlation of common lines: a novel approach for single-particle reconstruction of a structure containing a flexible domain.
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.
eIF2A mediates translation of hepatitis C viral mRNA under stress conditions.
Establishment and Application of a High Throughput Screening System Targeting the Interaction between HCV Internal Ribosome Entry Site and Human Eukaryotic Translation Initiation Factor 3.
Eukaryotic translation initiation factor 4AII contributes to microRNA-122 regulation of hepatitis C virus replication.
Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2.
Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes.
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.
Human eIF3: from 'blobology' to biological insight.
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3.
La protein is a potent regulator of replication of hepatitis C virus in patients with chronic hepatitis C through internal ribosomal entry site-directed translation.
Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.
Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.
Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA.
TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site.
Unlike for cellular mRNAs and other viral internal ribosome entry sites (IRESs), the eIF3 subunit e is not required for the translational activity of the HCV IRES.
Hepatitis E
Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication.
Hepatitis, Autoimmune
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Chronic
Identification of hepatocellular-carcinoma-associated antigens and autoantibodies by serological proteome analysis combined with protein microarray.
Herpes Simplex
A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells.
A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA.
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses.
Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta.
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice.
Dephosphorylation of eIF2{alpha} Mediated by the {gamma}134.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion.
Epstein-Barr virus-encoded protein kinase BGLF4 mediates hyperphosphorylation of cellular elongation factor 1delta (EF-1delta): EF-1delta is universally modified by conserved protein kinases of herpesviruses in mammalian cells.
Eukaryotic elongation factor 1delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1.
Evolution of GADD34 expression after focal cerebral ischaemia.
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.
Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery.
Neutralizing innate host defenses to control viral translation in HSV-1 infected cells.
Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase.
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.
Viral strategies for triggering and manipulating mitophagy.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Connecting the dots in Huntington's disease with protein interaction networks.
Hydatidiform Mole
Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.
Expression of Ras GTPase-activating protein (GAP) in human normal chorionic villi and hydatidiform mole.
Hydrocephalus
Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
Hyperalgesia
The RhoA GTPase-Activating Protein DLC2 Modulates RhoA Activity and Hyperalgesia to Noxious Thermal and Inflammatory Stimuli.
Hyperferritinemia
Repression of ferritin light chain translation by human eIF3.
Hypersensitivity
Allergenic and antigenic determinants of latex allergen Hev b 1: peptide mapping of epitopes recognized by human, murine and rabbit antibodies.
Translational control by eIF2? phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2?.
Hypertension
A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype.
Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants.
Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways.
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Hypertension, Pulmonary
Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.
Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension.
Hypoglycemia
Initiation of protein synthesis and heat-shock protein-72 expression in the rat brain following severe insulin-induced hypoglycemia.
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
Hypothyroidism
Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells.
Ileitis
Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
Infarction, Middle Cerebral Artery
Dynamic mislocalizations of nuclear pore complex proteins after focal cerebral ischemia in rat.
Infections
A host RNA helicase-like protein, AtRH8, interacts with the potyviral genome-linked protein, VPg, associates with the virus accumulation complex, and is essential for infection.
A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells.
A negative elongation factor E inhibits white spot syndrome virus replication by suppressing promoter activity of the viral immediate early genes in red claw crayfish Cherax quadricarinatus.
Activating Ras Mutations Fail to Ensure Efficient Replication of Adenovirus Mutants Lacking VA-RNA.
Activation of double-stranded RNA-activated protein kinase in HeLa cells after poliovirus infection does not result in increased phosphorylation of eucaryotic initiation factor-2.
Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.
Allele mining in the pepper gene pool provided new complementation effects between pvr2-eIF4E and pvr6-eIF(iso)4E alleles for resistance to pepper veinal mottle virus.
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.
Binding between elongation factor 1A and the 3'-UTR of Chinese wheat mosaic virus is crucial for virus infection.
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
Bisifusarium Delphinoides, an Emerging Opportunistic Pathogen in a Burn Patient with Diabetes Mellitus.
Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infection.
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses.
Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection.
Characterizing Cellular Responses During Oncolytic Maraba Virus Infection.
Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1.
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes.
Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases.
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro.
Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae.
Contribution of MX dynamin, oligoadenylate synthetase, and protein kinase R to anti-paramyxovirus activity of type 1 interferons in vitro.
Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.
Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells.
Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Cryptosporidium parvum elongation factor 1? (CpEF1?) participates in the formation of base structure at the infection site during invasion.
Deficiency of the eIF4E isoform nCBP limits the cell-to-cell movement of a plant virus encoding triple-gene-block proteins in Arabidopsis thaliana.
Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.
Double-stranded RNA binding by human cytomegalovirus pTRS1.
Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection.
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.
Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells.
Effect of T4 infection on initiation of protein synthesis and messenger specificity of initiation factor 3.
Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in han Chinese population.
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease.
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
eIF2A mediates translation of hepatitis C viral mRNA under stress conditions.
Elongation factor 1 (EF1alpha) promoter in a lentiviral backbone improves expression of the CD20 suicide gene in primary T lymphocytes allowing efficient rituximab-mediated lysis.
Endoplasmic reticulum stress is induced and modulated by enterovirus 71.
Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.
Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors.
Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA-dependent RNA polymerase and VPg-Pro in virus-induced vesicles.
Evasion of cellular antiviral responses by human cytomegalovirus TRS1 and IRS1.
Evolution of plant eukaryotic initiation factor 4E (eIF4E) and potyvirus genome-linked protein (VPg): A game of mirrors impacting resistance spectrum and durability.
First Comprehensive Report of Clinical Fusarium Strains Isolated in the State of Sao Paulo (Brazil) and Identified by MALDI-TOF MS and Molecular Biology.
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.
Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins.
Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus.
Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response.
Fusarium musae as cause of superficial and deep-seated human infections.
Genotype 2 strains of porcine reproductive and respiratory syndrome virus dysregulate alveolar macrophage cytokine production via the unfolded protein response.
Global protein profiling studies of chikungunya virus infection identify different proteins but common biological processes.
Helicobacter pylori Antigens Inducing Early Immune Response in Infants.
Helicobacter pylori in a Korean Isolate Expressed Proteins Differentially in Human Gastric Epithelial Cells.
Helper component proteinase of the genus Potyvirus is an interaction partner of translation initiation factors eIF(iso)4E and eIF4E and contains a 4E binding motif.
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation.
Hepatitis C virus controls interferon production through PKR activation.
Hepatitis C virus hijacks P-body and stress granule components around lipid droplets.
Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors.
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
Host and viral translational mechanisms during cricket paralysis virus infection.
Human cytomegalovirus infection activates and regulates the unfolded protein response.
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death.
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Human herpesvirus 6A (HHV-6A) exhibits restrictive propagation with limited activation of PKR-eIF2? stress pathway.
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection.
Human papillomaviruses target the double-stranded RNA protein kinase pathway.
Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A.
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.
Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21).
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.
Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.
Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity.
Lentiviral gene transfer into the dorsal root ganglion of adult rats.
Lentiviral Transfection of Ependymal Primary Cultures Facilitates the Characterisation of Kinocilia-specific Promoters.
Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection.
Modulation of PKR activity in cells infected by bovine viral diarrhea virus.
Molecular analysis of fusidic acid resistance in Staphylococcus aureus.
Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells.
Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation.
Mycoplasma hyopneumoniae Inhibits Porcine Beta-Defensin 2 Production by Blocking the Unfolded Protein Response To Facilitate Epithelial Adhesion and Infection.
NF-?B Activation Promotes Alphavirus Replication in Mature Neurons.
Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2? phosphorylation in virus infected cells.
Nuclear factor kappa B is required for the production of infectious human herpesvirus 8 virions.
p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly.
Phosphorylation of elongation factor G and ribosomal protein S6 in bacteriophage T7-infected Escherichia coli.
PKR activation enhances replication of classical swine fever virus in PK-15 cells.
PKR is not required for interferon-gamma inhibition of VSV replication in neurons.
PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Plant Translation Elongation Factor 1B? Facilitates Potato Virus X (PVX) Infection and Interacts with PVX Triple Gene Block Protein 1.
Plant Translation Factors and Virus Resistance.
Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection.
Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2? signaling pathway in IPEC-J2 cells.
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection.
Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis.
Proteomic analysis of the secretome of Leishmania donovani.
Proteomics analysis of host cells infected with infectious bursal disease virus.
Proteomics unravels new candidate genes for Meloidogyne resistance in wild Arachis.
Purification and Analysis of Effector Glucosyltransferase Lgt1 from Legionella pneumophila.
Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.
Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung.
Reovirus induces and benefits from an integrated cellular stress response.
Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo.
Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells.
Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication.
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.
Selective Editing of Herpes Simplex Virus 1 Enables Interferon Induction and Viral Replication That Destroy Malignant Cells.
Selective Interaction of Sugarcane eIF4E with VPgs from Sugarcane Mosaic Pathogens.
Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation.
Species-specific inhibition of capripoxvirus replication by host antiviral protein kinase R.
Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143.
Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu.
STING1 is essential for an RNA-virus triggered autophagy.
Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation.
Successive synovial Mycoplasma hominis isolates exhibit apparent antigenic variation.
Synthesis and degradation of early mRNA in lambda phage.
The Absence of Eukaryotic Initiation Factor eIF(iso)4E Affects the Systemic Spread of a Tobacco etch virus Isolate in Arabidopsis thaliana.
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.
The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells.
The elongation factor Tu coded by the tufA gene of Escherichia coli K-12 is almost identical to that coded by the tufB gene.
The experimental analysis of mimivirus translation initiation factor 4a reveals its importance for viral proteins translation during infection of
The major head protein of bacteriophage T4 binds specifically to elongation factor Tu.
The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA.
The MyD116 African swine fever virus homologue interacts with the catalytic subunit of protein phosphatase 1 and activates its phosphatase activity.
The Potyviral P3 Protein Targets Eukaryotic Elongation Factor 1A to Promote the Unfolded Protein Response and Viral Pathogenesis.
The potyvirus recessive resistance gene, sbm1, identifies a novel role for translation initiation factor eIF4E in cell-to-cell trafficking.
The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5.
The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.
Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles.
Transcriptomic study of 39 ostreid herpesvirus 1 genes during an experimental infection.
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants.
Translation of both 5'TOP and non-TOP host mRNAs continues into the late phase of Baculovirus infection.
Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection.
Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D.
Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
Up-regulation of a cellular protein at the translational level by a retrovirus.
Vaccinia virus gene A18R DNA helicase is a transcript release factor.
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Viral host range factors C7 or K1 are essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit PKR-mediated eIF2{alpha} phosphorylation.
West Nile virus infection does not induce PKR activation in rodent cells.
Zika Virus Induces an Atypical Tripartite Unfolded Protein Response with Sustained Sensor and Transient Effector Activation and a Blunted BiP Response.
[Proteome Profiling of A549 Cells Infected with Influenza H7N9 Virus].
Infertility
TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis.
Infertility, Male
Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes.
Inflammatory Bowel Diseases
How autophagy controls the intestinal epithelial barrier.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Breast Neoplasms
Inflammatory breast cancer cells are constitutively adapted to hypoxia.
Influenza, Human
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Influenza Virus mRNA Translation Revisited: Is the eIF4E Cap-Binding Factor Required for Viral mRNA Translation?
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.
Modification of eukaryotic initiation factor 4F during infection by influenza virus.
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes.
Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.
Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins.
Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.
The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism.
The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes.
TRIM28 functions as a negative regulator of aggresome formation.
Viral strategies for triggering and manipulating mitophagy.
VSV replication in neurons is inhibited by type I IFN at multiple stages of infection.
[Proteome Profiling of A549 Cells Infected with Influenza H7N9 Virus].
Insulin Resistance
Aberrant islet unfolded protein response in type 2 diabetes.
Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin resistant skeletal muscle of the obese Zucker rat.
Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice.
The ABCG5 ABCG8 Sterol Transporter Opposes the Development of Fatty Liver Disease and Loss of Glycemic Control Independently of Phytosterol Accumulation.
Intellectual Disability
Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome.
Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy.
De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability.
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.
Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Successful treatment of choreo-athetotic movements in a patient with an EEF1A2 gene variant.
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations.
Intestinal Volvulus
Translational elongation factor 1 alpha (EF-1 alpha) of Onchocerca volvulus.
Ischemic Attack, Transient
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat.
Ischemic Contracture
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
Ischemic Stroke
Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
Keratitis
[Molecular identification and in vitro susceptibility of Fusarium from fungal keratitis in central China].
Ketosis
Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis.
Kidney Calculi
Elongation factor Tu on Escherichia coli isolated from urine of kidney stone patients promotes calcium oxalate crystal growth and aggregation.
Kidney Neoplasms
A miRNA- and mRNA-seq-Based Feature Selection Approach for Kidney Cancer Biomakers.
Langer-Giedion Syndrome
The EIF3S3 gene encoding the p40 subunit of the translation initiation factor eIF3 has eight exons and maps to the Langer-Giedion syndrome chromosome region on 8q24, but is not the TRPS1 gene.
Latent Infection
Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.
Latex Hypersensitivity
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy.
The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy.
Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy.
Leiomyomatosis
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
Leiomyosarcoma
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
Leishmaniasis
Analysis of the Antigenic and Prophylactic Properties of the Leishmania Translation Initiation Factors eIF2 and eIF2B in Natural and Experimental Leishmaniasis.
Leishmaniasis, Visceral
Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides.
Leukemia
1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells.
4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6.
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78.
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.
Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.
Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
Glucocorticoids Induce Cardiac Fibrosis via Mineralocorticoid Receptor in Oxidative Stress: Contribution of Elongation Factor Eleven-Nineteen Lysine-Rich Leukemia (ELL).
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Lentiviral vectors for enhanced gene expression in human hematopoietic cells.
Loss of gene expression in lentivirus- and retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord.
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53.
Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?
RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy.
Small-molecule inhibitors targeting eIF4A in leukemia.
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors.
The effect of fludrocortisone on the uterine receptivity partially mediated by ERK1/2-mTOR pathway.
The Eleven-Nineteen Lysine-rich Leukemia gene (ELL2) influences the histone H3 modifications accompanying the shift to secretory Immunoglobulin heavy chain mRNA production.
The elongation factor ELL (eleven-nineteen lysine-rich leukemia) is a selective coregulator for steroid receptor functions.
The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells.
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Leukemia, Erythroblastic, Acute
Regulation of the utilization of mRNA for eucaryotic elongation factor Tu in Friend erythroleukemia cells.
The stability of mRNA for eucaryotic elongation factor Tu in Friend erythroleukemia cells varies with growth rate.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Puncta intended: connecting the dots between autophagy and cell stress networks.
Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.
Leukemia, Myeloid
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
Leukemia, Myeloid, Acute
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.
Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia.
Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
Inhibitory effects of SEL201 in acute myeloid leukemia.
Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia.
Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo.
MicroRNA-33b regulates sensitivity to daunorubicin in acute myelocytic leukemia by regulating eukaryotic translation initiation factor 5A-2.
Molecular targeting of the oncogene eIF4E in AML: a proof-of-principle clinical trial with ribavirin.
Targeting the oncogene eIF4E in cancer: from the bench to clinical trials.
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-?B and is aberrantly regulated in Acute Myeloid Leukemia.
Leukemia, T-Cell
Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.
Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution.
[Effect of Knocking down eEF1A1 Gene on Proliferation and Apoptosis in Jurkat Cells and Its Mechanisms].
[Effects of eEF1A1 re-expression on proliferation and apoptosis of Jurkat cells with knocked down eEF1A1 gene and its mechanisms].
Leukoencephalopathies
A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy.
A new function and complexity for protein translation initiation factor eIF2B.
A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
Analysis of eIF2B bodies and their relationships with stress granules and P-bodies.
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease.
Defective glial maturation in vanishing white matter disease.
Different Eukaryotic Initiation Factor 2B? Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes.
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.
eIF2B: recent structural and functional insights into a key regulator of translation.
Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.
Epstein-Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by the Synechococcus phage.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Fifteen Novel EIF2B1-5 Mutations Identified in Chinese Children with Leukoencephalopathy with Vanishing White Matter and a Long Term Follow-Up.
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2B? (eIF2B?) identified in Chinese patients with vanishing white matter disease.
Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.
Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease.
Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation.
Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease.
Identification of ten novel mutations in patients with eIF2B-related disorders.
Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.
Leukoencephalopathy with vanishing white matter due to homozygous EIF2B2 gene mutation. First Polish cases.
Localization of the Translational Guanine Nucleotide Exchange Factor eIF2B: A Common Theme for GEFs?
Modeling vanishing white matter disease with patient-derived induced pluripotent stem cells reveals astrocytic dysfunction.
Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.
Mutations in the genes encoding eukaryotic translation initiation factor 2B in Japanese patients with vanishing white matter disease.
Novel mutation in EIF2B gene in a case of adult-onset leukoencephalopathy with vanishing white matter.
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis.
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Profile of Indian Children with Childhood Ataxia and Central Nervous System Hypomyelination/Vanishing White Matter Disease: A Single Center Experience from Southern India.
Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response.
Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions.
Severity of Vanishing White Matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.
Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.
The Energy Status of Astrocytes Is the Achilles' Heel of eIF2B-Leukodystrophy.
The life and death of oligodendrocytes in vanishing white matter disease.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
The spectrum of mutations for the diagnosis of vanishing white matter disease.
Vanishing white matter disease in French-Canadian patients from Quebec.
Vanishing white matter disease presenting as opsoclonus myoclonus syndrome in childhood--a case report and review of the literature.
Vanishing white matter disease with a novel EIF2B5 mutation: A 10-year follow-up.
[Advances in functional study of EIF2B mutations in leukoencephalopathy with vanishing white matter].
[Eukaryotic translation initiation factor 2B and leukoencephalopathy with vanishing white matter.]
Lewy Body Disease
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Lipodystrophy
Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues.
Lipodystrophy, Congenital Generalized
Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues.
Liver Diseases
Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Liver Failure
Mutation in the mitochondrial translation elongation factor EFTs results in severe infantile liver failure.
Liver Neoplasms
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.
Deleted in liver cancer protein family in human malignancies (Review).
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
DLC1 Activation Requires Lipid Interaction through a Polybasic Region Preceding the RhoGAP Domain.
Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation.
DLC1 Negatively Regulates Angiogenesis in a Paracrine Fashion.
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.
Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A.
Expression of eukaryotic translation initiation factor 3 subunit B in liver cancer and its prognostic significance.
Identification of p122RhoGAP (Deleted in Liver Cancer-1) Serine 322 as a Substrate for Protein Kinase B and Ribosomal S6 Kinase in Insulin-stimulated Cells.
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
The RhoA GTPase-Activating Protein DLC2 Modulates RhoA Activity and Hyperalgesia to Noxious Thermal and Inflammatory Stimuli.
The role of CUGBP1 in age-dependent changes of liver functions.
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function.
Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort.
Lung Neoplasms
Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).
Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice.
Antibiotic drug rifabutin is effective against lung cancer cells by targeting the eIF4E-?-catenin axis.
Antisense oligonucleotide targeting eukaryotic translation initiation factor 4E reduces growth and enhances chemosensitivity of non-small-cell lung cancer cells.
ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-P27 axis.
Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients.
C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Effect of docetaxel on expression of eIF3a in human lung cancer A549 cell line.
eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.
Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.
High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Identification of a 170-kDa protein over-expressed in lung cancers.
Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer.
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer.
MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.
MicroRNA-9 regulates non-small cell lung cancer cell invasion and migration by targeting eukaryotic translation initiation factor 5A2.
MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway.
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.
Nannocystin Ax, a natural elongation factor 1? inhibitor from Nannocystis sp., suppresses epithelial-mesenchymal transition, adhesion and migration in lung cancer cells.
Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.
Overexpression of eukaryotic translation initiation factor 4E-binding protein 1 induces the alteration of immune status in H1299 lung cancer cells.
Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
The prognostic significance of eukaryotic elongation factor 1 alpha-2 in non-small cell lung cancer.
Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling.
Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170.
Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway.
Lyme Disease
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Lymphatic Metastasis
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
Lymphoma
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Dissecting eIF4E action in tumorigenesis.
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21).
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?
Lymphoma, B-Cell
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Expression and Phosphorylation of Eukaryotic Translation Initiation Factor 4E Binding Protein 1 in B-Cell Lymphomas and Reactive Lymphoid Tissues.
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.
Novel urine biomarkers to distinguish UTI from culture-negative pyuria.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.
Lymphoma, Follicular
FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Relationship between eukaryotic translation initiation factor 4E and malignant angiogenesis in non-Hodgkin lymphoma.
Macular Degeneration
Molecular cloning of ELOVL4 gene from cynomolgus monkey (Macaca fascicularis).
Malaria
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparum.
Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2?) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum.
Characterization of two malaria parasite organelle translation elongation factor g proteins: the likely targets of the anti-malarial fusidic acid.
Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses.
Malaria parasites contain two identical copies of an elongation factor 1 alpha gene.
Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase.
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.
Malnutrition
Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient diet.
Malocclusion
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Mandibulofacial Dysostosis
Investigation of Genetic Causes in a Developmental Disorder: Oculoauriculovertebral Spectrum.
Novel De Novo EFTUD2 Mutations in 2 Cases With MFDM, Initially Suspected to Have Alternative Craniofacial Diagnoses.
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Measles
Viral strategies for triggering and manipulating mitophagy.
Medulloblastoma
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.
New insights into malignant cell survival mechanisms in medulloblastoma.
Melanoma
Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity.
CXCR7 promotes melanoma tumorigenesis via Src kinase signaling.
Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion.
Human elongation factor 1 alpha: a polymorphic and conserved multigene family with multiple chromosomal localizations.
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth.
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Knockdown of EIF3D suppresses proliferation of human melanoma cells through G2/M phase arrest.
MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR.
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma.
Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
Role of EIF5A2, a downstream target of Akt, in promoting melanoma cell invasion.
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma.
Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1.
Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro.
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Translational reprogramming marks adaptation to asparagine restriction in cancer.
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue.
Memory Disorders
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome.
Meningioma
Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.
Meningitis
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Meningitis, Pneumococcal
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Mental Retardation, X-Linked
Oligophrenin-1, a Rho GTPase-activating protein (RhoGAP) involved in X-linked mental retardation, is expressed in the enteric nervous system.
Metabolic Syndrome
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Metrorrhagia
The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
Microcephaly
Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Investigation of Genetic Causes in a Developmental Disorder: Oculoauriculovertebral Spectrum.
Novel De Novo EFTUD2 Mutations in 2 Cases With MFDM, Initially Suspected to Have Alternative Craniofacial Diagnoses.
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Microphthalmos
Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects.
Mitochondrial Diseases
Clinical and molecular findings in a family expressing a novel heterozygous variant of the G elongation factor mitochondrial 1 gene.
Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency.
Mouth Neoplasms
Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies - The potential role of p53 and eIF4E as predictive parameters.
Multiple Myeloma
Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.
Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma.
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.
Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation.
Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E.
Plitidepsin: a Repurposed Drug for the Treatment of COVID-19.
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma.
The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma.
Multiple Sclerosis
Arg113His mutation of vanishing white matter is not present in multiple sclerosis.
Epstein-Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by the Synechococcus phage.
Murine Acquired Immunodeficiency Syndrome
Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome.
Muscle Cramp
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
Muscle Hypotonia
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Muscular Atrophy
Are tumoral factors responsible for host tissue wasting in cancer cachexia?
Cancer cachexia.
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles.
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy.
Mechanism of induction of muscle protein loss by hyperglycaemia.
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Regulation of contractile proteins and protein translational signaling in disused muscle.
The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy.
Muscular Diseases
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy.
Muscular Dystrophy, Duchenne
WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65.
Mycetoma
Pleurostomophora ochracea, a Novel Agent of Human Eumycetoma with Yellow Grains.
Mycoses
Evolutionary divergence of an elongation factor 3 from Cryptococcus neoformans.
Myelodysplastic Syndromes
Ras-proximate-1 GTPase-activating protein and Rac2 may play pivotal roles in the initial development of myelodysplastic syndrome.
Myeloproliferative Disorders
Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency.
Myocardial Infarction
Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2?.
Myocardial Ischemia
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2.
Myositis
Identification of a novel autoantigen eukaryotic initiation factor 3 associated with polymyositis.
Myotonic Dystrophy
The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats.
Myxoma
Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.
Nasal Polyps
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Nasopharyngeal Carcinoma
Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
p53, MDM2, eIF4E and EGFR expression in nasopharyngeal carcinoma and their correlation with clinicopathological characteristics and prognosis: A retrospective study.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.
Suppression of oncogenic protein translation via targeting eukaryotic translation initiation factor 4E overcomes chemo-resistance in nasopharyngeal carcinoma.
The DLC-1 -29A/T polymorphism is not associated with nasopharyngeal carcinoma risk in Chinese population.
[Over-expressions of p-eIF4E and p-4EBP1 are associated with poor prognosis in nasopharyngeal carcinoma].
Neoplasm Metastasis
Bromodomain 4 activation predicts breast cancer survival.
Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.
Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy.
Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis.
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1? protein.
Development of Biochemical Assays for the Identification of eIF4E-Specific Inhibitors.
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-? signals.
Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas.
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer.
Expression of total and phospho 4EBP1 in metastatic and non-metastatic renal cell carcinoma.
FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis.
G3BP1 activates the TGF-?/Smad signaling pathway to promote gastric cancer.
Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis.
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
Kisspeptin inhibits cancer growth and metastasis via activation of EIF2AK2.
Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.
Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/?-catenin and PI3K/AKT signaling pathways.
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
Mapping nucleolar localization sequences of 1A6/DRIM.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Oncogenic signaling in uveal melanoma.
Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor ??-?1 expression.
PERK-Phosphorylated eIF2? Pathway Suppresses Tumor Metastasis Through Downregulating Expression of Programmed Death Ligand 1 and CXCL5 in Triple-Negative Breast Cancer.
Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial.
RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer.
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis.
SPA-1 controls the invasion and metastasis of human prostate cancer.
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Targeting translation: eIF4E as an emerging anticancer drug target.
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
The interplay between IQGAP1 and small GTPases in cancer metastasis.
The lethal prune/Killer-of-prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1).
The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART.
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
[Eukaryotic translation elongation factor 1A1 positively regulates NOB1 expression to promote invasion and metastasis of hepatocellular carcinoma cells in vitro].
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
Neoplasms
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
A bad rap: Rap1 signaling and oncogenesis.
A cancer gene therapy approach through translational control of a suicide gene.
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
A comparison between histological grade and nuclear morphometry for predicting the clinical outcome of localized renal cell carcinoma.
A deficiency or an excess of dietary threonine level affects weight gain, enzyme activity, immune response and immune-related gene expression in juvenile blunt snout bream (Megalobrama amblycephala).
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein.
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.
A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors.
A rapid and specific method to simultaneously quantify eukaryotic elongation factor 1A1 and A2 protein levels in cancer cells.
A role of the tuberous sclerosis gene-2 product during neuronal differentiation.
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
A tumor suppressor DLC1: The functions and signal pathways.
A tumour suppressor network relying on the polyamine-hypusine axis.
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide.
Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas.
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers.
Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas.
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival.
Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment.
Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation.
An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing ?v?3 integrin.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3.
An oncogenic role of eIF3e/INT6 in human breast cancer.
An RNA polymerase II elongation factor encoded by the human ELL gene.
Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.
Analysis of nickel-binding peptides in a human hepidermoid cancer cell line by Ni-NTA affinity chromatography and mass spectrometry.
Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid.
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.
Antiviral Drug Ribavirin Targets Thyroid Cancer Cells by Inhibiting the eIF4E-?-Catenin Axis.
Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell.
Aptameric GT oligomers need to be complexed to ethoxylated polyethylenimine as pre-paired duplexes to efficiently exert their cytotoxic activity in human lymphoblastic cancer cells.
Are tumoral factors responsible for host tissue wasting in cancer cachexia?
Arf GTPase-activating Protein AGAP2 Regulates Focal Adhesion Kinase Activity and Focal Adhesion Remodeling.
ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.
ARHGAP6 Promotes Apoptosis and Inhibits Glycolysis in Lung Adenocarcinoma Through STAT3 Signaling Pathway.
ASAP3 is a downstream target of HIF-1? and is critical for progression of lung adenocarcinoma.
Asymmetric Total Synthesis of Nannocystin A.
Autophagy in the physiological endometrium and cancer.
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity.
Between Scylla and Charibdis: eIF2a kinases as targets for cancer chemotherapy.
Bikunin target genes in ovarian cancer cells identified by microarray analysis.
Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival.
Biochemical and Structural Insights into the eukaryotic translation initiation factor eIF4E.
Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation.
BRDT is a novel regulator of eIF4EBP1 in renal cell carcinoma.
Cancer cachexia.
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Cap in hand: targeting eIF4E.
Cap-dependent translation and control of the cell cycle.
Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha.
CCL18-dependent translocation of AMAP1 is critical for epithelial to mesenchymal transition in breast cancer.
Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation.
Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.
Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications.
Cellular dynamics of the negative transcription elongation factor NELF.
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
Characterization of Hydration Properties in Structural Ensembles of Biomolecules.
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.
Clinical significance of eukaryotic translation initiation factor 5A2 in papillary thyroid cancer.
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.
Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.
Comparative proteomic analysis of anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-transformed and normal human bronchial epithelial G0/G1 cells.
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Comparison of the gene expression profiles of resistant and non-resistant Japanese black pine inoculated with pine wood nematode using a modified LongSAGE technique
Computer-assisted image analysis can aid the prognostication of advanced-stage neuroblastomas.
Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.
Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice.
Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia.
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress.
Control of the eIF4E activity: structural insights and pharmacological implications.
Cordycepin as a sensitizer to tumour necrosis factor (TNF)-?-induced apoptosis through eukaryotic translation initiation factor 2? (eIF2?)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-?B.
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
Could the eIF2?-Independent Translation Be the Achilles Heel of Cancer?
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Crystal structure of the eIF4A-PDCD4 complex.
Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition.
Cysteine Proteases from V. cundinamarcensis (C. candamarcensis) Inhibit Melanoma Metastasis and Modulate Expression of Proteins Related to Proliferation, Migration and Differentiation.
Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex.
Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice.
Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors.
Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Development of Biochemical Assays for the Identification of eIF4E-Specific Inhibitors.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Differential phosphorylation of soluble versus ribosome-bound eukaryotic initiation factor 2 in the Ehrlich ascites tumor cell.
Differential screening of a human pancreatic adenocarcinoma lambda gt11 expression library has identified increased transcription of elongation factor EF-1 alpha in tumour cells.
Differential Transcriptomic Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer.
Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha.
Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma.
Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking.
Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent Mnk2 inhibitors: design, synthesis, SAR analysis, and evaluation of in vitro anti-leukaemic activity.
Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases.
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
DLC-1:a Rho GTPase-activating protein and tumour suppressor.
DLC1 Activation Requires Lipid Interaction through a Polybasic Region Preceding the RhoGAP Domain.
Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation.
DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism.
DLC1 Negatively Regulates Angiogenesis in a Paracrine Fashion.
DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers.
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.
Down-regulation of RASA1 Is Associated with Poor Prognosis in Human Hepatocellular Carcinoma.
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.
Downregulation of eIF4G by microRNA-503 enhances drug sensitivity of MCF-7/ADR cells through suppressing the expression of ABC transport proteins.
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE-/- mice.
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
eEF1A is a novel component of the mammalian nuclear protein export machinery.
eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.
eEF1A2 as a putative oncogene.
EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
Effect of activation of the Akt/mTOR signaling pathway by EEF1A2 on the biological behavior of osteosarcoma.
Effect of branched-chain amino acids on muscle atrophy in cancer cachexia.
Effect of eukaryotic translation initiation factor 4A3 in malignant tumors.
Effects of eEF1A1 targeting by aptamer/siRNA in chronic lymphocytic leukaemia cells.
Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.
eIF-2 initiation factor activity in Yoshida ascites hepatoma AH 130 cells and in 4-dimethylaminoazobenzene-induced liver tumor tissue during growth.
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.
EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.
eIF3c: a potential therapeutic target for cancer.
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
EIF3m promotes the malignant phenotype of lung adenocarcinoma by the up-regulation of oncogene CAPRIN1.
eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.
eIF4E as a marker for cervical neoplasia.
EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.
EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.
eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-? signals.
EIF5A2 predicts outcome in localised invasive bladder cancer and promotes bladder cancer cell aggressiveness in vitro and in vivo.
eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function.
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells.
Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.
Elongation factor 1 from ascites tumor cells: interaction with ribosomes and elongation factor 2.
Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
Enhance tumor radiosensitivity by intracellular delivery of eukaryotic translation initiation factor 4E binding proteins.
Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides.
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
ER Stress, Hypoxia Tolerance and Tumor Progression.
ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.
Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.
Established and Emerging Regulatory Roles of Eukaryotic Translation Initiation Factor 5B (eIF5B).
Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2?) Protein.
Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.
Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells.
Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions.
Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.
Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.
Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer.
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?
Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor ? Early Protransforming Events in Breast Epithelial Cells.
Eukaryotic translation initiation factor 5A in the pathogenesis of cancers.
Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.
Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition.
Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis.
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
Evolutionarily Conserved Binding of Translationally-Controlled Tumor Protein to Eukaryotic Elongation Factor 1B.
Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase.
Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation.
Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via ?1-integrin inactivation.
Expression analysis of global gene response to chronic heat exposure in broiler chickens (Gallus gallus) reveals new reactive genes.
Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon.
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Expression of G3BP1 in benign and malignant human prostate tissues.
Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression.
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.
Expression of total and phospho 4EBP1 in metastatic and non-metastatic renal cell carcinoma.
Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
Expression of truncated eIF3e resulting from integration of MMTV causes a shift from Cap-dependent to Cap-independent translation.
Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.
FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.
First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.
Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.
Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Functional identity of the monomeric and multiple forms of elongation-factor 1 from Krebs-II mouse ascites-tumor cells.
Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC.
Further evidence that elongation factor 1 remains bound to ribosomes during peptide chain elongation.
Gastric cancer cells escape metabolic stress via the DLC3/MACC1 axis.
Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.
Gene expression profile analysis in response to ?1,2-fucosyl transferase (FUT1) gene transfection in epithelial ovarian carcinoma cells.
Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis.
Genomic selection of reference genes for real-time PCR in human myocardium.
Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.
Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis.
Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
HDM2-binding partners: interaction with translation elongation factor EF1alpha.
HE4 and eIF3a Expression Correlates with Surgical Outcome and Overall Survival in Ovarian Cancer Patients with Secondary Cytoreduction.
High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database.
High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
High expression of disabled homolog 2-interacting protein contributes to tumor development and proliferation in cutaneous squamous cell carcinoma.
High expression of eIF3d is associated with poor prognosis in patients with gastric cancer.
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
How autophagy controls the intestinal epithelial barrier.
HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
Hsp90 inhibitors and the reduction of anti-cancer drug resistance by non-genetic and genetic mechanisms.
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch.
Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells.
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines.
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA).
Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis.
Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation.
Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers.
Identification of elicitor-responsive proteins in rice leaves by a proteomic approach.
Identification of elongation factor g as the conserved cellular target of argyrin B.
Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.
Identification of genes regulated by oleic acid in Jurkat cells by suppressive subtractive hybridization analysis.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis.
Identification of novel cellular targets in biliary tract cancers using global gene expression technology.
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Identification of p122RhoGAP (Deleted in Liver Cancer-1) Serine 322 as a Substrate for Protein Kinase B and Ribosomal S6 Kinase in Insulin-stimulated Cells.
Identification of Potential Anticancer Protein Targets in Cytotoxicity Mediated by Tropical Medicinal Fern Extracts.
IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.
Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma.
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
In-depth proteome analysis of the rubber particle of Hevea brasiliensis (para rubber tree).
Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells.
Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients.
Increased HE4 mRNA Expression Correlates with High Level Of eIF3a mRNA And Better Survival in Women with Epithelial Ovarian Cancer.
Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines.
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide.
Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADPRibosylating Toxins.
Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition.
Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines.
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.
Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.
Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis.
Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.
Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.
Inhibition of proliferation, invasion, and migration of prostate cancer cells by down-regulating elongation factor-1 alpha expression.
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.
Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines.
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology.
Involvement of endoplasmic reticulum stress in capsaicin-induced apoptosis of human pancreatic cancer cells.
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.
Isolation and characterization of elongation factor EF-2 from Guerin tumour.
iTRAQ Identification of Candidate Serum Biomarkers Associated with Metastatic Progression of Human Prostate Cancer.
Kisspeptin inhibits cancer growth and metastasis via activation of EIF2AK2.
Knockdown of eIF3d inhibits cell proliferation through G2/M phase arrest in non-small cell lung cancer.
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells.
Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.
Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1.
Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.
Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.
Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma.
Low expression of DAB2IP predicts an unfavorable prognosis in human bladder carcinoma.
Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery.
Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
Mass spectrometric identification of ancient proteins as potential molecular biomarkers for a 2000-year-old osteogenic sarcoma.
MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
METTL21B is a prognostic biomarker and potential therapeutic target in low-grade gliomas.
MicroRNA-182 Promotes Tumor Cell Growth by Targeting Transcription Elongation Factor A-like 7 in Endometrial Carcinoma.
MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Minimum requirements for the function of eukaryotic translation initiation factor 2.
miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1.
MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.
Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-?B activity and tumor growth in murine models of multiple myeloma.
Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.
Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).
Molecular targeting of the oncogene eIF4E in AML: a proof-of-principle clinical trial with ribavirin.
Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma.
mRNA export and cancer.
Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers.
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of acute lymphoblastic leukemia cells to vincristine through inhibition of eif5a-2 activation.
Negative role of trihydrophobin 1 in breast cancer growth and migration.
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
NELFE promoted pancreatic cancer metastasis and the epithelial?to?mesenchymal transition by decreasing the stabilization of NDRG2 mRNA.
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
New HIF2? inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.
New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase.
New Type of Antitumor Agent Targeting the Cell Adhesion Molecule, Integrin.
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Nf1 and Gmcsf interact in myeloid leukemogenesis.
NF1 and Neurofibromin: Emerging Players in the Genetic Landscape of Desmoplastic Melanoma.
Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.
Novel mechanisms of eIF2B action and regulation by eIF2? phosphorylation.
Novel roles for elongin C in yeast.
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.
Oncogenic signaling in uveal melanoma.
Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma.
Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.
Overexpression of eEF1A1 regulates G1-phase progression to promote HCC proliferation through the STAT1-cyclin D1 pathway.
Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer.
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
p53-dependent translational control of senescence and transformation via 4E-BPs.
Parotid gland tumors correlation between routine cytology and cytomorphometry by digital image analysis using conventional and newly introduced cytomorphometric parameters.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Pharmacological suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers.
Phospho-eIF4E: a new target for acute myeloid leukemia.
Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.
Phosphorylated eIF2? predicts disease-free survival in triple-negative breast cancer patients.
Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.
Phosphorylated p70S6K expression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.
Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.
Poorly differentiated carcinoma of the thyroid gland: Current status and future prospects.
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
Prognostic score for patients with localized renal cell carcinoma treated by nephrectomy.
Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma.
Properties of elongation factor 1 from ascites tumor cells.
Protective effects of dioscin against alcohol-induced liver injury.
Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Protein expression of eIF4E and integrin ?v?6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2? pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
Protein synthesis in tumor host. II. Increased activity of peptide elongation factor 1 in experimental rat tumors and in host liver.
Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.
Proteins of the Nucleolus of Dictyostelium discoideum: Nucleolar Compartmentalization, Targeting Sequences, Protein Translocations and Binding Partners.
Proteomic Analysis of Cervical Cancer Cells Treated with Adenovirus-Mediated MDA-7.
Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
Protumorigenic role of Timeless in hepatocellular carcinoma.
Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting.
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Rac1-mediated sustained ?4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.
RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Raf kinases in signal transduction and interaction with translation machinery.
Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells.
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.
RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.
RASAL1 inhibits HepG2 cell growth via HIF-2? mediated gluconeogenesis.
RASAL2 Plays Inconsistent Roles in Different Cancers.
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway.
Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1.
Reduced expression of neurofibromin in the soft tissue tumours obtained from patients with neurofibromatosis type I.
Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts.
Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.
Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies.
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?
Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation.
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia.
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.
Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.
RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics.
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase.
Roles of eIF3m in the tumorigenesis of triple negative breast cancer.
Roles of P67/MetAP2 as a tumor suppressor.
Roles of the translation initiation factor eIF2? serine 51 phosphorylation in cancer formation and treatment.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Salubrinal Enhances Doxorubicin Sensitivity in Human Cholangiocarcinoma Cells Through Promoting DNA Damage.
SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
Screening and identification of interacting proteins with hepatitis B virus core protein in leukocytes and cloning of new gene C1.
Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation.
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Selective killing of cancer cells based on translational control of a suicide gene.
Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish.
Sensitivity of doxorubicin-resistant cells to sorafenib: possible role for inhibition of eukaryotic initiation factor-2alpha phosphorylation.
Sequential Interferon ?-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner.
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.
Serum anti-EIF3A autoantibody as a potential diagnostic marker for hepatocellular carcinoma.
Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts.
Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation.
Small-molecule inhibitors targeting eIF4A in leukemia.
SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis.
Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis.
SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B.
Structure and function of IQ-domain GTPase-activating protein 1 and its association with tumor progression (Review).
Structure and functions of the translation initiation factor eIF4E and its role in cancer development and treatment.
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
Suppression Of ?-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.
Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.
Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway.
Synthesis and evaluation of novel dual BRD4/HDAC inhibitors.
Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.
Systematic Investigation of mRNA N 6-Methyladenosine Machinery in Primary Prostate Cancer.
Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma.
Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma.
Taking aim at translation for tumor therapy.
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling.
Targeting eIF4E inhibits growth, survival and angiogenesis in retinoblastoma and enhances efficacy of chemotherapy.
Targeting eIF4E signaling with ribavirin as a sensitizing strategy for ovarian cancer.
Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer.
Targeting MYC Translation in Colorectal Cancer.
Targeting of MNK/eIF4E overcomes chemoresistance in cervical cancer.
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Targeting the eIF4F translation initiation complex for cancer therapy.
Targeting the eukaryotic translation initiation factor 4E for cancer therapy.
Targeting the oncogene eIF4E in cancer: from the bench to clinical trials.
Targeting the translation machinery in cancer.
Targeting translation: eIF4E as an emerging anticancer drug target.
TCEAL2 as a Tumor Suppressor in Renal Cell Carcinoma is Associated with the Good Prognosis of Patients.
The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients.
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
The Alpha Subunit of Eukaryotic Initiation Factor (eIF) 2B is Requisite for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus.
The Anticancer Peptide TAT-RasGAP317-326 Exerts Broad Antimicrobial Activity.
The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: a proteomic approach.
The DLC-1 -29A/T polymorphism is not associated with nasopharyngeal carcinoma risk in Chinese population.
The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression.
The EEF1A2 gene expression as risk predictor in localized prostate cancer.
The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-?B and is aberrantly regulated in Acute Myeloid Leukemia.
The expression and function of RASAL2 in renal cell carcinoma angiogenesis.
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
The expression profile and prognostic significance of eukaryotic translation elongation factors in different cancers.
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.
The interplay between IQGAP1 and small GTPases in cancer metastasis.
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
The lethal prune/Killer-of-prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1).
The more basic isoform of eEF1A relates to tumour cell phenotype and is modulated by hyper-proliferative/differentiating stimuli in normal lymphocytes and CCRF-CEM T-lymphoblasts.
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
The Oncogene eIF4E: Using Biochemical Insights to Target Cancer.
The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.
The prognostic significance of elongation factor eEF1A2 in ovarian cancer.
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity.
The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.
The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma.
The role of eukaryotic translation initiation factor 6 in tumors.
The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth.
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.
The translation elongation factor eEF2 is a novel tumor?associated antigen overexpressed in various types of cancers.
The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord.
The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.
The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner.
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Tissue targeting in cancer: eIF4E's tale.
Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1.
Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3.
Translation elongation factor eEF1B? is identified as a novel prognostic marker of gastric cancer.
Translation from unconventional 5' start sites drives tumour initiation.
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma.
Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization.
Translation initiation factor eIF4E is a target for tumor cell radiosensitization.
Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E.
Translational control and cancer therapy.
Translational control by 5'-untranslated regions of eukaryotic mRNAs.
Translational control by mTOR-independent routes: how eIF6 organizes metabolism.
Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.
Translational control: the cancer connection.
Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A.
Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP).
Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1.
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling.
Tumor suppressor p16INK4a inhibits cancer cell growth by down-regulating eEF1A2 through a direct interaction.
Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
Up-regulation of PDCD4 in senescent human diploid fibroblasts.
Upconversion nanoparticles loaded with eIF4E siRNA and platinum(iv) prodrug to sensitize platinum based chemotherapy for laryngeal cancer and bioimaging.
Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells.
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.
Vitronectin-?v?3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.
Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells.
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
[Searching for genes interacting with human PCIA1 gene by using the bacterial two-hybrid system]
Neoplasms, Germ Cell and Embryonal
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Neoplasms, Glandular and Epithelial
Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
Neoplasms, Squamous Cell
Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Nervous System Diseases
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Cellular dynamics of the negative transcription elongation factor NELF.
eIF2B: recent structural and functional insights into a key regulator of translation.
Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.
Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.
Identification of Residues That Underpin Interactions within the Eukaryotic Initiation Factor (eIF2) 2B Complex.
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Nervous System Neoplasms
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neuroblastoma
Cloning of a human antibody directed against human neuroblastoma cells and specific for human translation elongation factor 1alpha.
Computer-assisted image analysis can aid the prognostication of advanced-stage neuroblastomas.
Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure.
ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma.
Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration.
MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2.
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
PERK is activated differentially in peripheral organs following cardiac arrest and resuscitation.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.
Neurodegenerative Diseases
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Connecting the dots in Huntington's disease with protein interaction networks.
eIF2B and the Integrated Stress Response: A Structural and Mechanistic View.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Novel mechanisms of eIF2B action and regulation by eIF2? phosphorylation.
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells.
Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.
Regulation of antioxidant metabolism by translation initiation factor 2alpha.
Somatostatin, neuronal vulnerability and behavioral emotionality.
Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice.
The Integrated Stress Response and Phosphorylated Eukaryotic Initiation Factor 2? in Neurodegeneration.
The large spectrum of eIF2B-related diseases.
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Translational control by 5'-untranslated regions of eukaryotic mRNAs.
Neurofibromatoses
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section mRNA.
Analysis of the GAP-related domain of the neurofibromatosis type 1 (NF1) gene in childhood brain tumors.
Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene.
Catalytic properties, tissue and intracellular distribution of neurofibromin.
Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities.
Identification and characterization of the neurofibromatosis type 1 protein product.
Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.
Molecular cloning of a cDNA coding for neurofibromatosis type 1 protein isoform lacking the domain related to ras GTPase-activating protein.
Multiple transcripts of the neurofibromatosis type 1 gene in human brain and in brain tumours.
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
Purification of a novel ras GTPase-activating protein from rat brain.
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
[Molecular genetics of neurofibromatosis type 1]
Neurofibromatosis 1
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section mRNA.
Catalytic properties, tissue and intracellular distribution of neurofibromin.
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities.
Identification and characterization of the neurofibromatosis type 1 protein product.
Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.
Molecular cloning of a cDNA coding for neurofibromatosis type 1 protein isoform lacking the domain related to ras GTPase-activating protein.
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
Purification of a novel ras GTPase-activating protein from rat brain.
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Somatic mutations in the neurofibromatosis 1 gene in human tumors.
Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
[Molecular genetics of neurofibromatosis type 1]
Neurofibrosarcoma
Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.
Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants.
Reduced expression of neurofibromin in the soft tissue tumours obtained from patients with neurofibromatosis type I.
Neuroinflammatory Diseases
Immune and gene expression profiling during tacrolimus to everolimus conversion early after liver transplantation.
Nevus
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
Newcastle Disease
Genetic responses of inbred chicken lines illustrate importance of eIF2 family and immune-related genes in resistance to Newcastle disease virus.
Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.
Viral strategies for triggering and manipulating mitophagy.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Non-alcoholic Fatty Liver Disease
Jiang-Zhi granules decrease sensitivity to low-dose CCl4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice.
Obesity
Aberrant islet unfolded protein response in type 2 diabetes.
An animal model manifesting neurodegeneration and obesity.
Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice.
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Oculocerebrorenal Syndrome
Role of oculocerebrorenal syndrome of Lowe (OCRL) protein in megakaryocyte maturation, platelet production and functions: a study in patients with Lowe syndrome.
Onychomycosis
Translation elongation factor 1-alpha gene as a marker for diagnosing of candidal onychomycosis.
Optic Nerve Diseases
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Optic Nerve Injuries
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Osteoarthritis
CircRNA circ-IQGAP1 Knockdown Alleviates Interleukin-1?-Induced Osteoarthritis Progression via Targeting miR-671-5p/TCF4.
Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development.
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Osteoporosis
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Osteosarcoma
EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
Identification of valid reference housekeeping genes for gene expression analysis in tumor neovascularization studies.
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells.
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E.
Ovarian Neoplasms
Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2?) pathway protect ovarian cancer cells from metformin-induced apoptosis.
Characterization of a Putative Ovarian Oncogene, Elongation Factor 1{alpha}, Isolated by Panning a Synthetic Phage Display Single-Chain Variable Fragment Library with Cultured Human Ovarian Cancer Cells.
Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
eEF1A2 as a putative oncogene.
Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.
Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
Eukaryotic translation initiation factor 3 subunit D overexpression is associated with the occurrence and development of ovarian cancer.
Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.
Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Puncta intended: connecting the dots between autophagy and cell stress networks.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Targeting eIF4E signaling with ribavirin as a sensitizing strategy for ovarian cancer.
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.
The prognostic significance of elongation factor eEF1A2 in ovarian cancer.
The role of protein elongation factor eEF1A2 in ovarian cancer.
Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours.
[Correlation between eIF3a and HE4 expression and ovarian cancer].
Overweight
Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats.
Pancreatic Neoplasms
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-?/SMAD signalling.
EIF3B promotes cancer progression in pancreatic cancer.
Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer.
Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer.
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells.
MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART.
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.
Translational reprogramming marks adaptation to asparagine restriction in cancer.
Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling.
Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research.
Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the ?-catenin pathway.
Pancreatitis
Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.
Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis.
Phosphorylation of the MNK1 substrate eIF4E is not required for response to acute pancreatitis.
Pancreatitis, Acute Necrotizing
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection.
Papilloma
Persistent expression of foreign genes in cultured hepatocytes: expression vectors.
Repositioning of anti-viral drugs as therapy for cervical cancer.
Papillomavirus Infections
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.
TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
Paralysis
Genetic influences on cognition in progressive supranuclear palsy.
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Paramyxoviridae Infections
Viral strategies for triggering and manipulating mitophagy.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Analysis of EIF4G1 in ethnic Chinese.
Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease.
D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population.
EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.
EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa.
Eukaryotic translation initiation factor 4-?, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.
Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Possible involvement of a mitochondrial translation initiation factor 3 variant causing decreased mRNA levels in Parkinson's disease.
Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease.
VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians.
VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from Southwest China.
Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.
Parkinsonian Disorders
Advances in the Genetics of Parkinson's Disease: A Guide for the Clinician.
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Study of the genetic variability in a Parkinson's Disease gene: EIF4G1.
Persistent Infection
Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis.
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.
Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation.
Pheochromocytoma
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.
Phytoplasma Disease
Expression Stabilities of Candidate Reference Genes for RT-qPCR in Chinese Jujube (Ziziphus jujuba Mill.) under a Variety of Conditions.
Sequence and RFLP analysis of the elongation factor Tu gene used in differentiation and classification of phytoplasmas.
Picornaviridae Infections
Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infection.
Plasmacytoma
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Pneumococcal Infections
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Pneumonia
A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation.
Polycystic Kidney, Autosomal Dominant
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.
Polymicrogyria
The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex.
Polymyositis
Identification of a novel autoantigen eukaryotic initiation factor 3 associated with polymyositis.
Porcine Reproductive and Respiratory Syndrome
MAMP (microbe-associated molecular pattern) triggered immunity in plants.
Viral strategies for triggering and manipulating mitophagy.
Pre-Eclampsia
Int6/eIF3e Silencing Promotes Placenta Angiogenesis in a Rat Model of Pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Potential molecules implicated in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and phosphatidylinositol 3'-kinase.
Premature Birth
Common Genetic Variants Link the Abnormalities in the Gut-Brain Axis in Prematurity and Autism.
Primary Ovarian Insufficiency
Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure.
The latest on leukodystrophies.
Prion Diseases
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo.
Prostatic Hyperplasia
In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae).
Prostatic Neoplasms
Activation of the EIF2?/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.
Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the ? subunit of the translation initiation factor 2.
ASAP1, a gene at 8q24, is associated with prostate cancer metastasis.
Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2.
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.
eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.
Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis.
Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.
Fibroblast growth factor and ornithine decarboxylase 5'UTRs enable preferential expression in human prostate cancer cells and in prostate tumors of PTEN(-/-) transgenic mice.
Inhibition of eukaryotic initiation factor 3B suppresses proliferation and promotes apoptosis of chronic myeloid leukemia cells.
Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer.
Mapping and gene expression profile of the minimally overrepresented 8q24 region in prostate cancer.
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Targeting of protein translation as a new treatment paradigm for prostate cancer.
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
Protein Deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
protein-synthesizing gtpase deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Proteostasis Deficiencies
PPP1R15A-mediated dephosphorylation of eIF2? is unaffected by Sephin1 or Guanabenz.
Pseudorabies
The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2?.
Pterygium
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
Pulmonary Arterial Hypertension
Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants.
Pulmonary Disease, Chronic Obstructive
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Fibrosis
Fluorofenidone attenuates bleomycin-induced pulmonary fibrosis by inhibiting eukaryotic translation initiation factor 3a (eIF3a) in rats.
Knockdown of eIF3a attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-?1.
Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-?1/Smad signaling pathway.
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis.
Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis.
[Effects of calcitonin gene-related peptide on eIF3a and p27 expression in bleomycin-induced pulmonary fibrosis of rats].
Pulmonary Veno-Occlusive Disease
Genetics of pulmonary hypertension in the clinic.
Genetics of pulmonary hypertension.
Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease.
Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.
Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension.
Rabies
Interscience conference on antimicrobial agents and chemotherapy - 50th annual meeting - research on promising new agents: part 1.
receptor protein-tyrosine kinase deficiency
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Retinitis Pigmentosa
Membrane protein transport in photoreceptors: the function of PDE?: the Proctor lecture.
Mistrafficking of prenylated proteins causes retinitis pigmentosa 2.
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3.
Retinoblastoma
A novel cAMP-stimulated pathway in protein phosphatase 2A activation.
Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique.
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways.
Proteomic profiling of retinoblastoma by high resolution mass spectrometry.
Targeting eIF4E inhibits growth, survival and angiogenesis in retinoblastoma and enhances efficacy of chemotherapy.
Rhabdomyosarcoma
Endoplasmic reticulum stress is induced and modulated by enterovirus 71.
The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma.
Rickettsia Infections
Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii.
Rift Valley Fever
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.
Rotavirus Infections
Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection.
Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.
The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7.
Salmonella Infections
Elongation factor P controls translation of the mgtA gene encoding a Mg2+ transporter during Salmonella infection.
tRNA(Pro) -mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection.
Sarcoidosis
Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis.
Sarcoma
Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation.
Sarcoma, Avian
Cytolytic activity induced by intramuscular injection of plasmid DNA expressing the nucleocapsid protein of the JHM strain of mouse hepatitis virus into C57BL/6 mice.
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors.
Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.
Inducible high-level expression vector for mammalian cells, pEF-LAC carrying human elongation factor 1alpha promoter and lac operator.
Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v-src oncogene.
Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo.
Seminiferous tubule cannulation (STC): a new, sensitive technique for detecting gene transfer in developing sperm.
Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation.
Vargula hilgendorfii luciferase: a secreted reporter enzyme for monitoring gene expression in mammalian cells.
Sarcopenia
Sarcopenia: Ammonia metabolism and hepatic encephalopathy.
Scleroderma, Systemic
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Seizures
Deletion of Long Isoform of Eukaryotic Elongation Factor 1B? Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Phenotypic analysis of catastrophic childhood epilepsy genes.
Seizures, Febrile
Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway.
Seminoma
Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas.
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Sepsis
Bacterial sepsis triggers an antiviral response that causes translation shutdown.
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
Effect of sepsis on eIE4E availability in skeletal muscle.
Eukaryotic Translation Initiation Factor 5A Small Interference RNA-Liposome Complexes Reduce Inflammation and Increase Survival in Murine Models of Severe Sepsis and Acute Lung Injury.
Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis.
Regulation of eukaryotic initiation factor-2 expression during sepsis.
Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha.
Targeting protein translation to prevent septic kidney injury.
TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.
Shwachman-Diamond Syndrome
Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.
Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain.
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics.
Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions.
Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations.
Sleep Deprivation
Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.
Smallpox
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
Spasms, Infantile
West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1.
sphingosine kinase deficiency
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
Spinal Cord Ischemia
Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.
Spinal Dysraphism
Allergenic and antigenic determinants of latex allergen Hev b 1: peptide mapping of epitopes recognized by human, murine and rabbit antibodies.
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy.
Latex antigens: identification and use in clinical and experimental studies, including crossreactivity with food and pollen allergens.
The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy.
[Latex allergy. Diagnosis and therapeutic aspects]
Squamous Cell Carcinoma of Head and Neck
Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Eukaryotic translation initiation factor 5A-2 involves in doxorubicin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells.
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma]
Staphylococcal Infections
Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections.
Starvation
"Two out of three" codon reading leading to mistranslation in vivo.
A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Arabidopsis eIF2alpha kinase GCN2 is essential for growth in stress conditions and is activated by wounding.
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
Characterization of mammalian eIF2A and identification of the yeast homolog.
Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.
Coordinate regulation of eIF2? phosphorylation by dPPP1R15 and dGCN2 is required during development.
Dhh1 promotes autophagy-related protein translation during nitrogen starvation.
Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic.
Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition.
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
eIF2? is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.
Elongation factor Tu.guanosine 3'-diphosphate 5'-diphosphate complex increases the fidelity of proofreading in protein biosynthesis: mechanism for reducing translational errors introduced by amino acid starvation.
Evaluation of reference genes for real-time quantitative PCR analysis in southern corn rootworm, Diabrotica undecimpunctata howardi (Barber).
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells.
Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.
Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation.
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.
IfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size.
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.
Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.
Insights into the architecture of the eIF2B?/?/? regulatory subcomplex.
L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori.
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
Loss of translational control in yeast compromised for the major mRNA decay pathway.
Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM.
Overexpression of eukaryotic translation Elongation Factor 3 (eEF3) impairs GCN2 activation.
PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.
Promotion of viral IRES-mediated translation under amino acid starvation.
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans.
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame.
Repression of GCN4 mRNA translation by nitrogen starvation in Saccharomyces cerevisiae.
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Snf1 promotes eIF2{alpha} phosphorylation by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress.
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner.
Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.
Translational control of GCN4: an in vivo barometer of initiation-factor activity.
Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha.
Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.
Status Epilepticus
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Stomach Neoplasms
Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer.
Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin.
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancer.
Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.
Inhibition of mTOR signaling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation.
Overexpression of eukaryotic elongation factor 1 alpha-2 is associated with poorer prognosis in patients with gastric cancer.
Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer.
Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.
P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion.
RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1.
Thermo-chemotherapy inhibits the proliferation and metastasis of gastric cancer cells via suppression of EIF5A2 expression.
Translation elongation factor eEF1B? is identified as a novel prognostic marker of gastric cancer.
[Effects of eukaryotic translation initiation factor 5A2 down-regulation by small interfering RNA on aggressiveness of MKN28 human].
[Expression of elongation factor 1 gamma-related sequence in human gastric cancer: preliminary report]
[The effects of C2 gene on growth of gastric cancer cells]
Stroke
Elongation factor G initiates translocation through a power stroke.
Supranuclear Palsy, Progressive
Genetic influences on cognition in progressive supranuclear palsy.
Tauopathies
PERK activation mitigates tau pathology in vitro and in vivo.
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Teratozoospermia
Identification of candidate causal genes and their associated pathogenic mechanisms underlying teratozoospermia based on the spermatozoa transcript profiles.
Thymoma
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Differential chromatin looping regulates CD4 expression in immature thymocytes.
Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).
Transcriptomic differences of genes in the avian target of rapamycin (avTOR) pathway in a divergent line of meat-type chickens selected for feed efficiency.
Thyroid Cancer, Papillary
Clinical significance of eukaryotic translation initiation factor 5A2 in papillary thyroid cancer.
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases.
Thyroid Neoplasms
Antiviral Drug Ribavirin Targets Thyroid Cancer Cells by Inhibiting the eIF4E-?-Catenin Axis.
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
Effects of small interfering RNA-mediated silencing of susceptibility genes of non-syndromic cleft lip with or without cleft palate on cell proliferation and migration.
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.
Tick Infestations
Control of tick infestations in cattle vaccinated with bacterial membranes containing surface-exposed tick protective antigens.
Tinea
Assessment of a pan-dermatophyte nested-PCR compared with conventional methods for direct detection and identification of dermatophytosis agents in animals.
Multilocus differentiation of the related dermatophytes Microsporum canis, Microsporum ferrugineum and Microsporum audouinii.
Toxoplasmosis
Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1-alpha.
Toxoplasma gondii Elongation Factor 1-Alpha (TgEF-1?) Is a Novel Vaccine Candidate Antigen against Toxoplasmosis.
Triple Negative Breast Neoplasms
Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells.
Puncta intended: connecting the dots between autophagy and cell stress networks.
RASAL2 Plays Inconsistent Roles in Different Cancers.
Therapeutic targeting of transcriptional cyclin-dependent kinases.
Trypanosomiasis, African
Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.
Tuberculosis
Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.
BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy.
Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis.
Characterization of Mycobacterium tuberculosis ribosome recycling factor (RRF) and a mutant lacking six amino acids from the C-terminal end reveals that the C-terminal residues are important for its occupancy on the ribosome.
Crystal Structure of Mycobacterium tuberculosis Elongation Factor G1.
Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis.
Induction of ER stress in macrophages of tuberculosis granulomas.
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP is regulated by phosphorylation.
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.
Monoclonal antibodies specific for elongation factor Tu and complete nucleotide sequence of the tuf gene in Mycobacterium tuberculosis.
Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases.
Specific interaction between the ribosome recycling factor and the elongation factor G from Mycobacterium tuberculosis mediates peptidyl-tRNA release and ribosome recycling in Escherichia coli.
Structure of translation initiation factor 1 from Mycobacterium tuberculosis and inferred binding to the 30S ribosomal subunit.
Tuberous Sclerosis
A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2).
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle.
AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.
Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: A potential treatment for lymphangioleiomyomatosis.
Genetics and molecular biology of tuberous sclerosis complex.
Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process.
Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma.
Leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs.
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.
Proteomes analysis reveals the involvement of autophagy in AD-like neuropathology induced by noise exposure and ApoE4.
Significance of dynamic changes in gastric smooth muscle cell apoptosis, PI3K-AKT-mTOR and AMPK-mTOR signaling in a rat model of diabetic gastroparesis.
Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs.
Structural basis for the unique biological function of small GTPase RHEB.
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Urinary Bladder Neoplasms
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation.
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
RASAL2 Plays Inconsistent Roles in Different Cancers.
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Usher Syndromes
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.
Uterine Cervical Neoplasms
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
HPV18 E7 induces the over-transcription of eIF4E gene in cervical cancer.
Inhibiting MNK Selectively Targets Cervical Cancer via Suppressing eIF4E-Mediated ?-Catenin Activation.
Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer.
Targeting the eIF4E/?-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy.
Vaccinia
A targeted approach to identification of vaccinia virus postreplicative transcription elongation factors: genetic evidence for a role of the H5R gene in vaccinia transcription.
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.
Characterization of the interactions among vaccinia virus transcription factors G2R, A18R, and H5R.
Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway.
Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR).
Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.
Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.
Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.
In vivo regulation of protein synthesis by phosphorylation of the alpha subunit of wheat eukaryotic initiation factor 2.
Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase.
Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR.
Phenotypic characterization of mutants in vaccinia virus gene G2R, a putative transcription elongation factor.
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product.
Purification and identification of a vaccinia virus-encoded intermediate stage promoter-specific transcription factor that has homology to eukaryotic transcription factor SII (TFIIS) and an additional role as a viral RNA polymerase subunit.
Recognition of mRNA cap structures by viral and cellular proteins.
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase.
Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.
The effect of the vaccinia K1 protein on the PKR-eIF2alpha pathway in RK13 and HeLa cells.
The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication.
The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions.
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Transcription elongation activity of the vaccinia virus J3 protein in vivo is independent of poly(A) polymerase stimulation.
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Vaccinia virus gene A18R DNA helicase is a transcript release factor.
Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein.
Vaccinia virus protein synthesis has a low requirement for the intact translation initiation factor eIF4F, the cap-binding complex, within infected cells.
Vaccinia virus-mediated inhibition of host protein synthesis involves neither degradation nor underphosphorylation of components of the cap-binding eukaryotic translation initiation factor complex eIF-4F.
Viral host range factors C7 or K1 are essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit PKR-mediated eIF2{alpha} phosphorylation.
Varicose Veins
IQGAP1 promotes the phenotypic switch of vascular smooth muscle by myocardin pathway: a potential target for varicose vein.
Vascular System Injuries
The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.
Vesicular Stomatitis
Ciliary beating recovery in deficient human airway epithelial cells after lentivirus ex vivo gene therapy.
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors.
Human papillomaviruses target the double-stranded RNA protein kinase pathway.
Lentiviral gene transfer into the dorsal root ganglion of adult rats.
Lentiviral Transfection of Ependymal Primary Cultures Facilitates the Characterisation of Kinocilia-specific Promoters.
Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity.
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.
The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation.
Virus Diseases
A game of survival: herpesvirus strategies of autophagy manipulation.
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons.
An antiviral response directed by PKR phosphorylation of the RNA helicase A.
An Isoform of Eukaryotic Initiation Factor 4E from Chrysanthemum morifolium Interacts with Chrysanthemum Virus B Coat Protein.
Binding between elongation factor 1A and the 3'-UTR of Chinese wheat mosaic virus is crucial for virus infection.
Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.
Deep sequencing leads to the identification of eukaryotic translation initiation factor 5a as a key element in Rsv1-mediated lethal systemic hypersensitive response to Soybean mosaic virus infection in Soybean.
Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications.
Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE-/- mice.
dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.
eIF2? of Litopenaeus vannamei involved in shrimp immune response to WSSV infection.
Enhancement of osteoblastogenesis and suppression of osteoclastogenesis by inhibition of de-phosphorylation of eukaryotic translation initiation factor 2 alpha.
Eukaryotic initiation factor 2B (eIF2B).
Evidence of viral genome linked protein of banana bract mosaic virus interaction with translational eukaryotic initiation factor 4E of plantain cv. Nendran based on yeast two hybrid system study.
Evolution of GADD34 expression after focal cerebral ischaemia.
Functional analysis of the short isoform of orf virus protein OV20.0.
GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection.
GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis.
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.
HRI of Epinephelus coioides is a critical factor in the grouper immune response to RGNNV infection.
Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function.
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Inhibition of eIF2? Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.
Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).
Insights into the architecture of the eIF2B?/?/? regulatory subcomplex.
Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons.
Involvement of eIF2? of Epinephelus coioides in the fish immune response to virus infection.
Life as a Vector of Dengue Virus: The Antioxidant Strategy of Mosquito Cells to Survive Viral Infection.
LreEF1A4, a Translation Elongation Factor from Lilium regale, Is Pivotal for Cucumber Mosaic Virus and Tobacco Rattle Virus Infections and Tolerance to Salt and Drought.
Phosphorylation state of the cap-binding protein eIF4E during viral infection.
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.
PKR in innate immunity, cancer, and viral oncolysis.
Plant Translation Elongation Factor 1B? Facilitates Potato Virus X (PVX) Infection and Interacts with PVX Triple Gene Block Protein 1.
PmTBC1D20, a Rab GTPase-activating protein from the black tiger shrimp, Penaeus monodon, is involved in white spot syndrome virus infection.
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.
Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection.
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions.
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2.
Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.
Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.
Small molecule inhibitors of the RNA-dependent protein kinase.
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.
Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha.
Tellurium/Bovine Serum Albumin Nanocomposites Inducing the Formation of Stress Granules in a Protein Kinase R-Dependent Manner.
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinase R.
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.
The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.
The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections.
The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7.
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation.
Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants.
Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
Variola virus E3L Z? domain, but not its Z-DNA binding activity, is required for PKR inhibition.
Whooping Cough
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Xeroderma Pigmentosum
[Screening of binding proteins to interferon-alpha promoter DNA by phage display technique]
Yellow Fever
The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
Zika Virus Infection
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.
The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.