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x * 60000, calculated for full-length protein, x * 38000, SDS-PAGE and calculated for motor domain
additional information
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interaction of KIF18A with estrogen receptor ERalpha
additional information
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interaction of kinesin heavy chain KIF5C with gamma-aminobutyric acid type A receptor interacting factor-1 GRIF-1. Direct association between the two proteins at the KIF5C C-terminal and GRIF-1 N-terminal regions. GRIF-1 can bind to the tetrameric kinesin light chain/kinesin heavy-chain complex
additional information
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isoform KIF14 interacts with microtubule-bundling protein PRC1 and targets to the central spindle via this interaction
additional information
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Ran-binding protein 2 associates selectively with kinesins KIF5B and KIF5C, but not KIF5A. A single residue conserved in KIF5B and KIF5C, but not KIF5A, confers KIF5-isotype-specific association with RanBP2. Interaction is also mediated by a conserved leucine-like heptad motif present in KIF5s and KBD of RanBP2. Selective inhibition of the interaction between kinesin-bindiing domain of RanBP2 and KIF5B/KIF5C in cell lines causes perinuclear clustering of mitochondria, but not of lysosomes, deficits inmitochondrialmembrane potential and cell shrinkage
additional information
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contrary to Oryza sativa, modification of brain or skeletal muscle K16 with photoreactive ATP derivative, 2'(3')-O-(4-benzoylbenzoyl)-1,N6-etheno-ATP and UV-irradiation does not result in intermolecular cross-linking
additional information
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interaction of KIF18A with estrogen receptor ERalpha
additional information
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KIFC5A interacts with nucleotide-binding proteins 1 and 2. Knockdown of nucleotide-binding protein 1 or double knockdown of nucleotide-binding proteins 1 and 2 both phenocopy the KIFC5A silencing effect
additional information
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modification of K16 with photoreactive ATP derivative, 2'(3')-O-(4-benzoylbenzoyl)-1,N6-etheno-ATP and UV-irradiation results in intermolecular cross-linking in presence of ADP or ATP. No cross-linking is observed in absence of nucleotide
additional information
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in kinesin-like calmodulin binding protein, calmodulin binds to helix alpha4 and inserts itself between the motor and the microtubule. Positioning of the calmodulin binding helix is not decided by crystal packing forces but is determined by the conformational state of the motor
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Preuss, M.L.; Kovar, D.R.; Lee, Y.R.; Staiger, C.J.; Delmer, D.P.; Liu, B.
A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers
Plant Physiol.
136
3945-3955
2004
Gossypium hirsutum
brenda
Dathe, V.; Proels, F.; Brand-Saberi, B.
Expression of kinesin kif5c during chick development
Anat. Embryol.
207
475-480
2004
Gallus gallus
brenda
Zhang, Y.; Sperry, A.O.
Comparative analysis of two C-terminal kinesin motor proteins: KIFC1 and KIFC5A
Cell Motil. Cytoskeleton
58
213-230
2004
Mus musculus
brenda
Peden, E.M.; Barr, M.M.
The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans
Curr. Biol.
15
394-404
2005
Caenorhabditis elegans
brenda
Lee, Y.M.; Kim, W.
Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells
Exp. Mol. Med.
36
93-97
2004
Homo sapiens
brenda
Jimeno, D.; Feiner, L.; Lillo, C.; Teofilo, K.; Goldstein, L.S.; Pierce, E.A.; Williams, D.S.
Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre
Invest. Ophthalmol. Vis. Sci.
47
5039-5046
2006
Gallus gallus
brenda
Umeki, N.; Mitsui, T.; Umezu, N.; Kondo, K.; Maruta, S.
Preparation and characterization of a novel rice plant-specific kinesin
J. Biochem.
139
645-654
2006
Oryza sativa
brenda
Vinogradova, M.V.; Reddy, V.S.; Reddy, A.S.; Sablin, E.P.; Fletterick, R.J.
Crystal structure of kinesin regulated by Ca(2+)-calmodulin
J. Biol. Chem.
279
23504-23509
2004
Solanum tuberosum
brenda
Kotaja, N.; Lin, H.; Parvinen, M.; Sassone-Corsi, P.
Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells
J. Cell Sci.
119
2819-2825
2006
Mus musculus
brenda
Luboshits, G.; Benayahu, D.
MS-KIF18A, a kinesin, is associated with estrogen receptor
J. Cell. Biochem.
100
693-702
2006
Homo sapiens, Mus musculus
brenda
Pan, R.; Lee, Y.R.; Liu, B.
Localization of two homologous Arabidopsis kinesin-related proteins in the phragmoplast
Planta
220
156-164
2004
Arabidopsis thaliana
brenda
Saade, M.; Irla, M.; Govin, J.; Victorero, G.; Samson, M.; Nguyen, C.
Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b
Exp. Cell Res.
313
614-626
2007
Mus musculus
brenda
Umeki, N.; Mitsui, T.; Koike, Y.; Maruta, S.
Intermolecular cross-linking of a novel rice kinesin K16 motor domain with a photoreactive ATP derivative
J. Biochem.
139
831-836
2006
Mus musculus, Oryza sativa
brenda
Umeki, N.; Mitsui, T.; Kondo, K.; Maruta, S.
Conformational change of the loop L5 in rice kinesin motor domain induced by nucleotide binding
J. Biochem.
139
857-864
2006
Oryza sativa
brenda
Smith, M.J.; Pozo, K.; Brickley, K.; Stephenson, F.A.
Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes
J. Biol. Chem.
281
27216-27228
2006
Homo sapiens
brenda
Gruneberg, U.; Neef, R.; Li, X.; Chan, E.H.; Chalamalasetty, R.B.; Nigg, E.A.; Barr, F.A.
KIF14 and citron kinase act together to promote efficient cytokinesis
J. Cell Biol.
172
363-372
2006
Homo sapiens
brenda
Christodoulou, A.; Lederer, C.W.; Surrey, T.; Vernos, I.; Santama, N.
Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication
J. Cell Sci.
119
2035-2047
2006
Mus musculus
brenda
Dunn, S.; Morrison, E.E.; Liverpool, T.B.; Molina-Paris, C.; Cross, R.A.; Alonso, M.C.; Peckham, M.
Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells
J. Cell Sci.
121
1085-1095
2008
Rattus norvegicus
brenda
Bernasconi, P.; Cappelletti, C.; Navone, F.; Nessi, V.; Baggi, F.; Vernos, I.; Romaggi, S.; Confalonieri, P.; Mora, M.; Morandi, L.; Mantegazza, R.
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies
J. Neuropathol. Exp. Neurol.
67
624-632
2008
Homo sapiens
brenda
Vinogradova, M.V.; Malanina, G.G.; Reddy, V.S.; Reddy, A.S.; Fletterick, R.J.
Structural dynamics of the microtubule binding and regulatory elements in the kinesin-like calmodulin binding protein
J. Struct. Biol.
163
76-83
2008
Solanum tuberosum
brenda
Cho, K.I.; Cai, Y.; Yi, H.; Yeh, A.; Aslanukov, A.; Ferreira, P.A.
Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function
Traffic
8
1722-1735
2007
Homo sapiens
brenda
Cho, K.I.; Yi, H.; Desai, R.; Hand, A.R.; Haas, A.L.; Ferreira, P.A.
RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system
EMBO Rep.
10
480-486
2009
Drosophila melanogaster
brenda
Tanaka, K.; Umeki, N.; Toshiaki, M.; Fujimoto, Z.; Maruta, S.
Crystallographic analysis reveals a unique conformation of the ADP-bound novel rice kinesin K16
Biochem. Biophys. Res. Commun.
401
251-256
2010
Oryza sativa
brenda