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Disease on EC 3.6.4.13 - RNA helicase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Connecting Replication and Repair: YoaA, a Helicase-Related Protein, Promotes Azidothymidine Tolerance through Association with Chi, an Accessory Clamp Loader Protein.
Escherichia coli DbpA is a 3' --> 5' RNA helicase.
Helicase and polymerase move together close to the fork junction and copy DNA in one-nucleotide steps.
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing.
Structural Insights into a Unique Dimeric DEAD-Box Helicase CshA that Promotes RNA Decay.
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acro-Osteolysis
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
Acute Lung Injury
?-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.
Addison Disease
Polymorphisms in the Interferon-Induced Helicase (IFIH1) locus and susceptibility to Addison's disease.
Adenocarcinoma
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I.
Poly(I:C) exhibits an anti-cancer effect in human gastric adenocarcinoma cells which is dependent on RLRs.
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
Adenoviridae Infections
Adenovirus Virus-Associated RNAs Induce Type I Interferon Expression through a RIG-I-Mediated Pathway.
African Horse Sickness
Characterization of the nucleic acid binding activity of inner core protein VP6 of African horse sickness virus.
Targeted mutational analysis to unravel the complexity of African horse sickness virus NS3 function in mammalian cells.
African Swine Fever
The identification of an African swine fever gene with conserved helicase motifs and a striking homology to herpes virus origin binding protein, UL9.
Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.
Three African swine fever virus genes encoding proteins with homology to putative helicases of vaccinia virus.
alpha-Thalassemia
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Alveolitis, Extrinsic Allergic
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Alzheimer Disease
Borrowing nuclear DNA helicases to protect mitochondrial DNA.
Decreased base excision repair and increased helicase activity in Alzheimer's disease brain.
eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.
Genetic variations in chromodomain helicase DNA-binding protein 5, gene-environment interactions and risk of sporadic Alzheimer's disease in Chinese population.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Werner helicase polymorphism is not associated with Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4).
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Androgen-Insensitivity Syndrome
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Anemia, Diamond-Blackfan
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Anemia, Hypochromic
Chlorosis caused by two recessively interacting genes reveals a role of RNA helicase in hybrid breakdown in Arabidopsis thaliana.
Identification and regulation of host genes related to Rice stripe virus symptom production.
Leaf chlorosis in Arabidopsis thaliana hybrids is associated with transgenerational decline and imbalanced ribosome number.
Aortic Aneurysm, Abdominal
Endovascular abdominal aortic aneurysm sizing and case planning using the TeraRecon Aquarius workstation.
Apraxias
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2.
Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Arenaviridae Infections
Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells.
Arteriosclerosis
Chromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.
Arteritis
Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases.
Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure.
ORF1a-encoded replicase subunits are involved in the membrane association of the arterivirus replication complex.
Processing of the equine arteritis virus replicase ORF1b protein: identification of cleavage products containing the putative viral polymerase and helicase domains.
Arthritis
[Damage-associated molecular patterns and chronic diseases]
Arthritis, Rheumatoid
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes.
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
Asthma
Genetic associations with viral respiratory illnesses and asthma control in children.
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Astrocytoma
Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA.
RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.
Ataxia
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2.
Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
Tight expression regulation of senataxin, linked to motor neuron disease and ataxia, is required to avert cell-cycle block and nucleolus disassembly.
Ataxia Telangiectasia
A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23.
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Genetic testing for hereditary prostate cancer: Current status and limitations.
Germline genetic variants in men with prostate cancer and one or more additional cancers.
Klotho suppresses RIG-I-mediated senescence-associated inflammation.
Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.
Atherosclerosis
Endothelial RIG-I activation impairs endothelial function.
Expression of retinoic acid-inducible gene-I (RIG-I) in macrophages: possible involvement of RIG-I in atherosclerosis.
Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.
[Damage-associated molecular patterns and chronic diseases]
Autoimmune Diseases
A female autoimmunity gene exists: DDX3X.
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.
DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy.
Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.
Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes.
Global expression and CpG methylation analysis of primary endothelial cells before and after TNFa stimulation reveals gene modules enriched in inflammatory and infectious diseases and associated DMRs.
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk.
Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review.
Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant.
Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CC chemokine ligand (CCL) 5 in human mesangial cells.
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
RNA binding activates RIG-I by releasing an autorepressed signaling domain.
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
UV radiation regulates Mi-2 through protein translation and stability.
Azoospermia
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Complex transcriptional control of the AZFa gene DDX3Y in human testis.
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.
Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia.
Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation.
Progress in understanding the molecular functions of DDX3Y (DBY) in male germ cell development and maintenance.
Translational control of the AZFa gene DDX3Y by 5'UTR exon-T extension.
Bacterial Infections
Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators.
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells.
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Blepharophimosis
De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome.
Bloom Syndrome
A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.
A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.
A role for the amino terminus of human topoisomerase I.
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.
Absence of p53 enhances growth defects and etoposide sensitivity of human cells lacking the Bloom syndrome helicase BLM.
Accumulation of FFA-1, the Xenopus homolog of Werner helicase, and DNA polymerase delta on chromatin in response to replication fork arrest.
Atm is a negative regulator of intestinal neoplasia.
Augmented cell death with Bloom syndrome helicase deficiency.
Binding and melting of D-loops by the Bloom syndrome helicase.
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells.
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks.
Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein.
Bloom Syndrome Helicase Promotes Meiotic Crossover Patterning and Homolog Disjunction.
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.
Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells.
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Bloom syndrome.
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Cellular defects caused by hypomorphic variants of the Bloom syndrome helicase gene BLM.
Centromere-Proximal Meiotic Crossovers in Drosophila melanogaster Are Suppressed by Both Highly Repetitive Heterochromatin and Proximity to the Centromere.
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.
Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation.
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.
Contribution of domain structure to the RNA 3' end processing and degradation functions of the nuclear exosome subunit Rrp6p.
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex.
Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.
Deficiency of bloom syndrome helicase activity is radiomimetic.
Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors.
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.
Disease-causing missense mutations in human DNA helicase disorders.
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
DNA strand displacement, strand annealing and strand swapping by the Drosophila Bloom's syndrome helicase.
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.
Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Enhanced tumor formation in mice heterozygous for Blm mutation.
Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.
Evolution of an MCM complex in flies that promotes meiotic crossovers by blocking BLM helicase.
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.
Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage.
High BLM Expression Predicts Poor Clinical Outcome and Contributes to Malignant Progression in Human Cholangiocarcinoma.
Holliday Junction Processing Activity of the BLM-Topo III{alpha}-BLAP75 Complex.
Human Bloom protein stimulates flap endonuclease 1 activity by resolving DNA secondary structure.
Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.
Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening.
Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.
Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks.
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.
Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Mechanism of RecQ helicase mechanoenzymatic coupling reveals that the DNA interactions of the ADP-bound enzyme control translocation run terminations.
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability.
Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
Oligomeric ring structure of the Bloom's syndrome helicase.
Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination.
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution.
PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA.
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Processive translocation mechanism of the human Bloom's syndrome helicase along single-stranded DNA.
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Recognition and Unfolding of c-MYC and Telomeric G-Quadruplex DNAs by the RecQ C-Terminal Domain of Human Bloom Syndrome Helicase.
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Regulation of BLM Nucleolar Localization.
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
Resolution of ROS-induced G-quadruplexes and R-loops at transcriptionally active sites is dependent on BLM helicase.
Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication.
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
RMI1 deficiency in mice protects from diet and genetic-induced obesity.
Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks.
Role of the Bloom's syndrome helicase in maintenance of genome stability.
Roles of the Bloom's syndrome helicase in the maintenance of genome stability.
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
RPA Phosphorylation Inhibits DNA Resection.
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase.
Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain.
Structural Insight into BLM Recognition by TopBP1.
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Super-resolution mapping of cellular double-strand break resection complexes during homologous recombination.
Super-sized deletions: Improved transposon excision screens using a mus309 mutant background.
Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.
The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.
The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis.
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase.
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
The Bloom's syndrome helicase can promote the regression of a model replication fork.
The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6.
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
The Bloom's syndrome helicase unwinds G4 DNA.
The Bloom's syndrome helicase: keeping cancer at bay.
The catalytic core of Leishmania donovani RECQ helicase unwinds a wide spectrum of DNA substrates and is stimulated by replication protein A.
The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling.
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over.
The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis.
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation.
The Werner syndrome protein is a DNA helicase.
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.
Time to bloom.
TopBP1 controls BLM protein level to maintain genome stability.
TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.
Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination.
Unwinding forward and sliding back: an intermittent unwinding mode of the BLM helicase.
Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.
Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
Werner syndrome: entering the helicase era.
Bluetongue
A coiled-coil motif in non-structural protein 3 (NS3) of bluetongue virus forms an oligomer.
A DIVA system based on the detection of antibodies to non-structural protein 3 (NS3) of bluetongue virus.
Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type ? interferon signaling by targeting STAT1.
Bluetongue virus VP6 acts early in the replication cycle and can form the basis of chimeric virus formation.
Bluetongue virus VP6 protein binds ATP and exhibits an RNA-dependent ATPase function and a helicase activity that catalyze the unwinding of double-stranded RNA substrates.
Defining the structure-function relationships of bluetongue virus helicase protein VP6.
Identification of four novel group-specific bluetongue virus NS3 protein B-cell epitopes.
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Structure based modification of Bluetongue virus helicase protein VP6 to produce a viable VP6-truncated BTV.
Bone Cysts, Aneurysmal
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.
Bone Marrow Failure Disorders
ATP-dependent helicase activity is dispensable for the physiological functions of Recql4.
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility.
Borna Disease
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Brain Diseases
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
CHD2 myoclonic encephalopathy is frequently associated with self-induced seizures.
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Brain Ischemia
RIG-I contributes to the innate immune response after cerebral ischemia.
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Brain Neoplasms
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Breast Neoplasms
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.
A requirement of FancL and FancD2 monoubiquitination in DNA repair.
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases.
BACH1 Ser919Pro variant and breast cancer risk.
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.
BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of northern China.
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors.
Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer.
Combined Use of Immunoreactivities of RIG-I with Efp/TRIM25 for Predicting Prognosis of Patients With Estrogen Receptor-positive Breast Cancer.
Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis.
DDX17 (P72), a Sox2 binding partner, promotes stem-like features conferred by Sox2 in a small cell population in estrogen receptor-positive breast cancer.
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
DEAD-box RNA Helicase 39 Promotes Invasiveness and Chemoresistance of ER-positive Breast Cancer.
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells.
Disease-causing missense mutations in human DNA helicase disorders.
eIF4F suppression in breast cancer affects maintenance and progression.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Expression of the BRCA1-interacting protein Brip1/BACH1/FANCJ is driven by E2F and correlates with human breast cancer malignancy.
Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Functional interplay between BRCA2/FancD1 and FancC in DNA repair.
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
G-Quadruplex Helicase DHX36/G4R1 Engages Nuclear Lamina Proteins in Quiescent Breast Cancer Cells.
Genetic testing for hereditary prostate cancer: Current status and limitations.
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
HAGE, the helicase antigen as a biomarker for breast cancer prognosis (WO2013144616).
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3.
Induction of Apoptosis in Metastatic Breast Cancer Cells: XV. Downregulation of DNA Polymerase-? - Helicase Complex (Replisomes) and Glyco-Genes.
Induction of hemeoxygenase-1 expression after inhibition of hemeoxygenase activity promotes inflammation and worsens ischemic brain damage in mice.
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand.
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.
Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion.
NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
Prevalence of RECQL germline variants in Pakistani early-onset and familial breast cancer patients.
Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells.
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97).
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells.
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
RNA helicase DDX5 regulates microRNA expression and contributes to cytoskeletal reorganization in basal breast cancer cells.
RNAi screens identify CHD4 as an essential gene in breast cancer growth.
SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.
SMARCAD1 in Breast Cancer Progression.
SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.
The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells.
The CXCR4-LASP1-eIF4F Axis Promotes Translation of Oncogenic Proteins in Triple-Negative Breast Cancer Cells.
The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
The functions of the multi-tasking Pfh1(Pif1) helicase.
The RNA helicase p68 modulates expression and function of the Delta133 isoform(s) of p53, and is inversely associated with Delta133p53 expression in breast cancer.
The role of DEAD-box RNA helicase p68 (DDX5) in the development and treatment of breast cancer.
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles.
Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer.
Bronchitis
An arginine-to-proline mutation in a domain with undefined functions within the helicase protein (Nsp13) is lethal to the coronavirus infectious bronchitis virus in cultured cells.
Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus.
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Bunyaviridae Infections
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Burkitt Lymphoma
EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Caliciviridae Infections
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages.
Candidiasis
The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections.
Carcinogenesis
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.
Biochemical quantification of ATPase activities during liver carcinogenesis.
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Cell biology of cancer: BRCA1 and sister chromatid pairing reactions?
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines.
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.
DDX3X: structure, physiologic functions and cancer.
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication.
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
DNA helicases associated with genetic instability, cancer, and aging.
Downregulation of MCM8 expression restrains the malignant progression of cholangiocarcinoma.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis.
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis.
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer.
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription.
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.
Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review.
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma.
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase.
Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis.
Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.
RecQL4 helicase amplification is involved in human breast tumorigenesis.
RIG-I Is a Tumor Suppressor and Biomarker of IFN-? Efficacy in HCC.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
RNAi screens identify CHD4 as an essential gene in breast cancer growth.
Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis.
Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Severe gastrointestinal symptoms caused by a novel DDX3X variant.
Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1.
Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase.
Structural characterization of ?-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation.
Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set.
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
The RNA helicase DDX3 is required for ovarian development and oocyte maturation in Locusta migratoria.
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness.
Tumor suppressor activity of RIG-I.
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
[Mechanisms of Epstein-Barr Virus-Mediated Oncogenesis].
Carcinoma
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
Analysis of the RNA helicase A gene in human lung cancer.
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Corrigendum to "Decreased expression of DEAD-Box Helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy".
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Decreased expression of DEAD-Box helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy.
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Key contribution of eIF4H-mediated translational control in tumor promotion.
Overexpression of RNA helicase p68 protein in cutaneous squamous cell carcinoma.
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells.
Small-molecule inhibitors targeting eIF4A in leukemia.
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
The DEAD-box RNA helicase DDX41 is a novel repressor of p21
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
[RNA-dependent ATPase from the cells of a Krebs 2 ascitic carcinoma]
Carcinoma in Situ
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Carcinoma, Embryonal
Imsnc761 and DDX6 synergistically suppress cell proliferation and promote apoptosis via p53 in testicular embryonal carcinoma cells.
Carcinoma, Hepatocellular
Characterization of HCV interactions with Toll-like receptors and RIG-I in liver cells.
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
CHD1L protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival.
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling.
DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity.
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
Enhancement of interferon induction by ORF3 product of hepatitis E virus.
Ftx non coding RNA-derived miR-545 promotes cell proliferation by targeting RIG-I in hepatocellular carcinoma.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Non-Homologous End Joining.
Hepatitis E virus inhibits type I interferon induction by ORF1 products.
Increased susceptibility of Huh7 cells to HCV replication does not require mutations in RIG-I.
Knockdown of terminal differentiation induced ncRNA (TINCR) suppresses proliferation and invasion in hepatocellular carcinoma by targeting the miR-218-5p/DEAD-box helicase 5 (DDX5) axis.
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Overexpression and clinical relevance of the RNA helicase DHX15 in hepatocellular carcinoma.
Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors.
Proteomic analysis of human hepatoma cells expressing methionine adenosyltransferase I/III Characterization of DDX3X as a target of S-adenosylmethionine.
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma.
Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma.
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-?B Pathway.
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
Tumor suppressor activity of RIG-I.
Carcinoma, Non-Small-Cell Lung
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of ?-catenin.
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways.
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
Carcinoma, Renal Cell
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity.
Carcinoma, Squamous Cell
Corrigendum to "Decreased expression of DEAD-Box Helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy".
Decreased expression of DEAD-Box helicase 5 inhibits esophageal squamous cell carcinomas by regulating endoplasmic reticulum stress and autophagy.
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Overexpression of RNA helicase p68 protein in cutaneous squamous cell carcinoma.
Cardiotoxicity
Amidinoanthracyclines - a new group of potential anti-hepatitis C virus compounds.
Castleman Disease
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Cataract
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
Central Nervous System Viral Diseases
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
Cerebellar Ataxia
Ataxia with oculomotor apraxia type 2 fibroblasts exhibit increased susceptibility to oxidative DNA damage.
Cerebellar Neoplasms
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.
Cerebral Cortical Thinning
Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Cerebral Palsy
A child with a novel DDX3X variant mimicking cerebral palsy: a case report.
Charcot-Marie-Tooth Disease
Clinical diversity caused by novel IGHMBP2 variants.
CHARGE Syndrome
8q12.1q12.3 de novo microdeletion involving the CHD7 gene in a patient without the major features of CHARGE syndrome: case report and critical review of the literature.
A case of CHARGE syndrome associated with hyperinsulinemic hypoglycemia in infancy.
A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay.
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Atypical phenotypes associated with pathogenic CHD7 variants and a proposal for broadening CHARGE syndrome clinical diagnostic criteria.
Cerebellar vermis hypoplasia in CHARGE syndrome: clinical and molecular characterization of 18 unrelated Korean patients.
CHARGE and Kabuki syndromes: A phenotypic and molecular link.
CHARGE syndrome associated with de novo (I1460Rfs*15) frameshift mutation of CHD7 gene in a patient with arteria lusoria and horseshoe kidney.
CHARGE syndrome gastrointestinal involvement: from mouth to anus.
CHARGE syndrome.
CHARGEd with neural crest defects.
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.
CHD7 cooperates with PBAF to control multipotent neural crest formation.
Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.
CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment.
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.
CHD7 mutation spectrum in 28 Swedish patients diagnosed with CHARGE syndrome.
CHD7 promotes glioblastoma cell motility and invasiveness through transcriptional modulation of an invasion signature.
CHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression.
CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance.
Chromatin remodeler CHD7 is critical for cochlear morphogenesis and neurosensory patterning.
Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.
Clinical and Genetic Analysis of CHD7 Expands the Genotype and Phenotype of CHARGE Syndrome.
Clinical genetics of Kallmann syndrome.
Congenital heart defects in CHARGE: The molecular role of CHD7 and effects on cardiac phenotype and clinical outcomes.
Congenital T cell deficiency in a patient with CHARGE syndrome.
Embryonic expression profile of chicken CHD7, the ortholog of the causative gene for CHARGE syndrome.
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Familial CHARGE syndrome because of CHD7 mutation: clinical intra- and interfamilial variability.
Feeding difficulty is the dominant feature in 12 Chinese newborns with CHD7 pathogenic variants.
Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome.
Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency.
Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.
Identification of a novel mutation in the CHD7 gene in a patient with CHARGE syndrome.
Identification of one novel CHD7 mutation in a patient from China with atypical CHARGE syndrome.
Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome.
Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome.
Mutations in the CHD7 gene: the experience of a commercial laboratory.
Non-homologous end joining repair mechanism-mediated deletion of CHD7 gene in a patient with typical CHARGE syndrome.
Novel CHD7 mutations contributing to the mutation spectrum in patients with CHARGE syndrome.
Novel Frameshift CHD7 Mutation Related to CHARGE Syndrome.
Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome.
Screening for CHARGE syndrome mutations in the CHD7 gene using denaturing high-performance liquid chromatography.
Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome.
Spectrum of CHD7 Mutations in 110 Individuals with CHARGE Syndrome and Genotype-Phenotype Correlation.
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
Terminal 4q deletion and 8q duplication in a patient with CHARGE-like features.
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
Three novel mutations of CHD7 gene in two turkish patients with charge syndrome; A double point mutation and an insertion.
Choanal Atresia
A novel CHD7 mutation in an adolescent presenting with growth and pubertal delay.
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Discovery of a novel CHD7 CHARGE syndrome variant by integrated omics analyses.
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Cholesteatoma
Expression of pattern recognition receptors in cholesteatoma.
Chorioamnionitis
Hierarchical Maturation of Innate Immune Defences in Very Preterm Neonates.
Placental and intra-amniotic inflammation are associated with altered fetal immune responses at birth.
Choriocarcinoma
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Classical Swine Fever
Autocatalytic Cleavage within Classical Swine Fever Virus NS3 Leads to a Functional Separation of Protease and Helicase.
Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase.
Characterization of interaction of classical swine fever virus NS3 helicase with 3' untranslated region.
Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-kappaB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages.
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
RNA helicase is involved in the expression and replication of classical swine fever virus and interacts with untranslated region.
TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication.
What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Coccidioidomycosis
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation.
Cockayne Syndrome
A role for the Cockayne Syndrome B (CSB)-Elongin ubiquitin ligase complex in signal-dependent RNA polymerase II transcription.
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum.
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
Novel missense mutations in a conserved loop between ERCC6 (CSB) helicase motifs V and VI: Insights into Cockayne syndrome.
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Werner syndrome: entering the helicase era.
Coinfection
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
In vitro and ex vivo analyses of co-infections with swine influenza and porcine reproductive and respiratory syndrome viruses.
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.
Colitis
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
RIG-I has guts: identification of a role for RIG-I in colitis development.
Role of DDX3 in the pathogenesis of inflammatory bowel disease.
Colitis-Associated Neoplasms
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Coloboma
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
The role of CHD7 and the newly identified WDR11 gene in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
Colonic Neoplasms
BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.
DEAD-box RNA helicase p68 is not required for nuclear transloction of beta-catenin in colon cancer cells.
Delivery of 5'-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Fascin1 Suppresses RIG-I-like Receptor Signaling and Interferon-? Production by Associating with I?B Kinase ? (IKK ?) in Colon Cancer.
Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage.
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Phosphorylation of p68 RNA helicase by p38 MAP kinase contributes to colon cancer cells apoptosis induced by oxaliplatin.
PUM1 Is Overexpressed in Colon Cancer Cells With Acquired Resistance to Cetuximab.
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
RNA helicase and colon cancer.
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration.
Colorectal Neoplasms
Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines.
DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer.
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
DEAD-box RNA helicase protein DDX21 as a prognosis marker for early stage colorectal cancer with microsatellite instability.
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Downregulation of the Helicase Lymphoid-Specific (HELLS) Gene Impairs Cell Proliferation and Induces Cell Cycle Arrest in Colorectal Cancer Cells.
Genetic and expressional alterations of CHD genes in gastric and colorectal cancers.
Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.
In Vivo Selection Against Human Colorectal Cancer Xenografts Identifies an Aptamer That Targets RNA Helicase Protein DHX9.
In vivo selection of tumor-targeting RNA motifs.
Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
O-GlcNAcylation promotes colorectal cancer progression by regulating protein stability and potential catcinogenic function of DDX5.
Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer.
Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours.
Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling.
Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients.
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Targeting MYC Translation in Colorectal Cancer.
Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families.
The Significance of Circular RNA DDX17 in Prostate Cancer.
Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Communicable Diseases
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Communicable Diseases, Emerging
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Confusion
RNA binding activates RIG-I by releasing an autorepressed signaling domain.
The molecular cloning of the gene encoding the Escherichia coli 75-kDa helicase and the determination of its nucleotide sequence and gentic map position.
Congenital Abnormalities
CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis.
SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome.
Connective Tissue Diseases
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Coronary Artery Disease
Coronary artery disease: AQUARIUS findings do not support the use of aliskiren in patients with CAD and prehypertension.
Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS.
Coronary Disease
Effect of aliskiren on progression of coronary disease in patients with prehypertension: the AQUARIUS randomized clinical trial.
Coronavirus Infections
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.
Crystal structure of Middle East respiratory syndrome coronavirus helicase.
Deducing the Crystal Structure of MERS-CoV Helicase.
Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES.
Middle East Respiratory Syndrome Coronavirus 4a Protein Is a Double-Stranded RNA-Binding Protein That Suppresses PACT-Induced Activation of RIG-I and MDA5 in the Innate Antiviral Response.
Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon Induction by Targeting RIG-I Signaling.
NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
COVID-19
A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice.
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-? with in-vitro effective drug ivermectin.
Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents.
Differential roles of RIG-I like receptors in SARS-CoV-2 infection.
Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase.
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase.
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase.
Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3.
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters.
Molecular targets for COVID-19 drug development: Enlightening Nigerians about the pandemic and future treatment.
Potential of Flavonoid-Inspired Phytomedicines against COVID-19.
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children.
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection.
Proteomic signature of host response to SARS-CoV-2 infection in the nasopharynx.
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.
Should We Try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy?
The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19.
Craniosynostoses
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Cryptococcosis
Unlocking the DEAD-box: a key to cryptococcal virulence?
Cytomegalovirus Infections
Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis.
De Lange Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Deafness
Complete screening of 50 patients with CHARGE syndrome for anomalies in the CHD7 gene using a denaturing high-performance liquid chromatography-based protocol: new guidelines and a proposal for routine diagnosis.
Dehydration
A new DEAD-box helicase ATP-binding protein (OsABP) from rice is responsive to abiotic stress.
Dementia
RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders.
Dengue
A comparative retrospective study of RT-PCR-based liquid hybridization assay for early, definitive diagnosis of dengue.
A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.
Activation of dengue virus-specific T cells modulates vascular endothelial growth factor receptor 2 expression.
Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations.
An In-Silico Investigation of Phytochemicals as Antiviral Agents against Dengue Fever.
Analysis of the domain interactions between the protease and helicase of NS3 in dengue and hepatitis C virus.
Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein.
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery.
Automated type specific ELISA probe detection of amplified NS3 gene products of dengue viruses.
C5a receptor targeting of partial non-structural protein 3 of dengue virus promotes antigen-specific IFN-?-producing T-cell responses in a mucosal dengue vaccine model.
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain.
Dengue neurovirulence in mice: identification of molecular signatures in the E and NS3 helicase domains.
Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.
Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.
Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant.
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.
Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3.
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Downregulation of Aedes aegypti chromodomain helicase DNA binding protein 7/Kismet by Wolbachia and its effect on dengue virus replication.
Essential role of RIG-I in the activation of endothelial cells by dengue virus.
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.
Generation and characterization of a rat monoclonal antibody against the RNA polymerase protein from Dengue Virus-2.
Global Consensus Sequence Development and Analysis of Dengue NS3 Conserved Domains.
Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors.
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Identification of Potential Inhibitors for Targets Involved in Dengue Fever.
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein.
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Modulation of enzymatic activity of dengue virus nonstructural protein NS3 nucleoside triphosphatase/helicase by poly(U).
Modulation of the nucleoside triphosphatase/RNA helicase and 5'-RNA triphosphatase activities of Dengue virus type 2 nonstructural protein 3 (NS3) by interaction with NS5, the RNA-dependent RNA polymerase.
Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA.
Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.
Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase.
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.
Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
Novel Insights into the Molecular Interaction of a Panduratin A Derivative with the Non Structural Protein (NS3) of Dengue Serotypes: A Molecular Dynamics Study.
NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.
Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection.
Nucleotide-dependent dynamics of the Dengue NS3 helicase.
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Production and characterization of a monoclonal antibody specific for NS3 protease and the ATPase region of Dengue-2 virus.
Recombinant Dengue 2 Virus NS3 Helicase Protein Enhances Antibody and T-Cell Response of Purified Inactivated Vaccine.
Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes.
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes.
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.
RNA binding property and RNA chaperone activity of dengue virus core protein and other viral RNA-interacting proteins.
RNA Helicase A Is an Important Host Factor Involved in Dengue Virus Replication.
RNA sensors enable human mast cell anti-viral chemokine production and IFN-mediated protection in response to antibody-enhanced dengue virus infection.
Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I IFN response.
Specific Interaction of DDX6 with an RNA Hairpin in the 3'?UTR of the Dengue Virus Genome Mediates G1 Phase Arrest.
Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin.
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A.
Structure of the NS3 helicase from Zika virus.
Structure-based mutational analysis of the NS3 helicase from dengue virus.
Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format.
Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening.
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals.
The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
The role of surface basic amino acids of dengue virus NS3 helicase in viral RNA replication and enzyme activities.
The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids.
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA.
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses.
Use of NS3 consensus primers for the polymerase chain reaction amplification and sequencing of dengue viruses and other flaviviruses.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Dermatomyositis
Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes.
Influence of UV radiation on immunological system and occurrence of autoimmune diseases.
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.
The immunopathologic and inflammatory differences between dermatomyositis, polymyositis and sporadic inclusion body myositis.
The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis.
Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform.
UV radiation regulates Mi-2 through protein translation and stability.
Diabetes Mellitus
Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus IFIH1 polymorphism and type 1 diabetes onset.
Does diabetes mellitus as a comorbid condition affect the health-related quality of life in prostate cancer survivors? Results of a population-based observational study Mols F, Aquarius AE, Essink-Bot ML, Aaronson NK, Kil PJ, van de Poll-Franse LV, CoRPS-Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands.
The A allele of the rs1990760 polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells.
The genetic basis of graves' disease.
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.
Diabetes Mellitus, Type 1
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes.
Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.
Association between interferon-induced helicase (IFIH1) rs1990760 polymorphism and seasonal variation in the onset of type 1 diabetes mellitus IFIH1 polymorphism and type 1 diabetes onset.
Cesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes risk.
Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1.
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in Chinese Han population.
Interferon induced with helicase C domain 1 (IFIH1): trends on helicase domain and type 1 diabetes onset.
The A allele of the rs1990760 polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells.
The genetic basis of graves' disease.
The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis.
The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations.
The role of interferon induced with helicase C domain 1 (IFIH1) in the development of type 1 diabetes mellitus.
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
Unique pathological changes in the pancreas of fulminant type 1 diabetes.
Diabetes Mellitus, Type 2
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Diffuse Cerebral Sclerosis of Schilder
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
DiGeorge Syndrome
'Black sheep' that don't leave the double-stranded RNA-binding domain fold.
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
Disorders of Sex Development
Variant analysis of the chromodomain helicase DNA-binding protein 7 in pediatric disorders of sex development.
DNA Virus Infections
A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-?B-mediated innate immunity against DNA virus infection.
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
Drug Hypersensitivity
DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects.
Ductus Arteriosus, Patent
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Dyskeratosis Congenita
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome.
Dystonia
Ataxia with oculomotor apraxia type 2: clinical, biological and genotype/phenotype correlation study of a cohort of 90 patients.
Walker-A threonine couples nucleotide occupancy with the chaperone activity of the AAA+ ATPase ClpB.
Encephalitis
Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.
Theoretical study of the Usutu virus helicase 3D structure, by means of computer-aided homology modelling.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Encephalitis, Japanese
Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein.
Conserved amino acids 193-324 of non-structural protein 3 are a dominant source of peptide determinants for CD4+ and CD8+ T cells in a healthy Japanese encephalitis virus-endemic cohort.
Crystal structure of the catalytic domain of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase at a resolution of 1.8 A.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Human DDX3X Unwinds Japanese Encephalitis and Zika Viral 5' Terminal Regions.
Identification and characterization of the RNA helicase activity of Japanese encephalitis virus NS3 protein.
Ilheus virus (Flaviviridae, Flavivirus) is closely related to Japanese encephalitis virus complex.
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.
Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities.
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis.
RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection.
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection.
Structure-based discovery of two antiviral inhibitors targeting the NS3 helicase of Japanese encephalitis virus.
Structure-based virtual screening for novel inhibitors of Japanese encephalitis virus NS3 helicase/nucleoside triphosphatase.
The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR.
The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase?dependent and ?independent pathways.
Encephalitis, Tick-Borne
Corrigendum to "Crystal structure of the NS3 helicase of tick-borne encephalitis virus" [Biochem. Biophys. Res. Commun. 528(3) (2020) 601-606].
Crystal structure of the NS3 helicase of tick-borne encephalitis virus.
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Structural modeling of the NS 3 helicase of Tick-borne encephalitis virus and their virtual screening of potent drugs using molecular docking.
[Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus]
Encephalomyelitis
Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.
Encephalomyelitis, Venezuelan Equine
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3.
Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
Enteritis
Duck RIG-I restricts duck enteritis virus infection.
Enterovirus Infections
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Unique pathological changes in the pancreas of fulminant type 1 diabetes.
Epilepsy
Absence epilepsy and the CHD2 gene: an adolescent male with moderate intellectual disability, short-lasting psychoses, and an interstitial deletion in 15q26.1-q26.2.
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
CHD2-related epilepsy: novel mutations and new phenotypes.
In-Frame Deletion and Missense Mutations of the C-Terminal Helicase Domain of SMARCA2 in Three Patients with Nicolaides-Baraitser Syndrome.
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Smartphones in Epilepsy: The New Age of Aquarius.
The first reported case of an inherited pathogenic CHD2 variant in a clinically affected mother and daughter.
Epilepsy, Generalized
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
Epilepsy, Reflex
Photosensitivity and CHD2 Variants.
Epileptic Syndromes
Juvenile myoclonic epilepsy mimic associated with CHD2 gene mutation.
Epstein-Barr Virus Infections
Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway.
Exanthema
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
Fanconi Anemia
A requirement of FancL and FancD2 monoubiquitination in DNA repair.
Biochemical characterization of Warsaw breakage syndrome helicase.
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Disease-causing missense mutations in human DNA helicase disorders.
DNA Helicase Mph1FANCM Ensures Meiotic Recombination between Parental Chromosomes by Dissociating Precocious Displacement Loops.
Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells.
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction.
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Fanconi anemia Group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes.
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.
Helicase-inactivating mutations as a basis for dominant negative phenotypes.
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair.
Multiple mechanisms limit meiotic crossovers: TOP3? and two BLM homologs antagonize crossovers in parallel to FANCM.
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple negative breast and serous ovarian cancers.
Protein degradation pathways regulate the functions of helicases in the DNA damage response and maintenance of genomic stability.
Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression.
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461.
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.
Fasciitis
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions.
Fatty Liver
Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice.
Fetal Growth Retardation
Whole-transcriptome analysis delineates the human placenta gene network and its associations with fetal growth.
Flavivirus Infections
How flaviviruses activate and suppress the interferon response.
Foot-and-Mouth Disease
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
Foot-and-Mouth Disease Virus 3B Protein Interacts with Pattern Recognition Receptor RIG-I to Block RIG-I-Mediated Immune Signaling and Inhibit Host Antiviral Response.
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells.
Identification of RNA helicase A as a new host factor in the replication cycle of foot-and-mouth disease virus.
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: Role of Jumonji C-domain containing protein 6 in RHA demethylation.
Ribosomal Protein L13 Promotes IRES-Driven Translation of Foot-and-Mouth Disease Virus in a Helicase DDX3-Dependent Manner.
STING1 is essential for an RNA-virus triggered autophagy.
Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation.
The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication.
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate.
Fowlpox
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Gallbladder Neoplasms
Targeting eIF4A using rocaglate CR?1?31B sensitizes gallbladder cancer cells to TRAIL?mediated apoptosis through the translational downregulation of c?FLIP.
Gastric Antral Vascular Ectasia
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression.
Unique epitopes in RNA helicase II/Gu protein recognized by serum from a watermelon stomach patient.
Gastroenteritis
Cellular RNA Helicase DDX1 Is Involved in Transmissible Gastroenteritis Virus nsp14-Induced Interferon-Beta Production.
Identification of protease and ADP-ribose 1''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3.
Gastrointestinal Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Gastrointestinal Stromal Tumors
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour.
Genetic Diseases, Inborn
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Bloom syndrome.
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
DNA helicases associated with genetic instability, cancer, and aging.
DNA helicases involved in DNA repair and their roles in cancer.
DNA repair helicases as targets for anti-cancer therapy.
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges.
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Overview: what are helicases?
Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Unique and important consequences of RECQ1 deficiency in mammalian cells.
WRN mutations in Werner syndrome.
Glaucoma
Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome.
Glioblastoma
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.
Harnessing the Activation of RIG-I Like Receptors to Inhibit Glioblastoma Tumorigenesis.
MiR?500a?5p promotes glioblastoma cell proliferation, migration and invasion by targeting chromodomain helicase DNA binding protein 5.
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12.
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
Glioma
Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells.
Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population.
Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma.
Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3?-E2F1 Axis Linking Reversely with Survival in Gliomas.
CK2 induced RIG-I drives metabolic adaptations in IFN?-treated glioma cells.
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1?-RIG-I axis in IFN? treated glioma cells.
Cysteine-rich 61-associated gene expression profile alterations in human glioma cells.
DDX3X Biomarker Correlates with Poor Survival in Human Gliomas.
DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis.
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
Nucleoside transporter subtype expression: effects on potency of adenosine kinase inhibitors.
p68 RNA helicase promotes glioma cell proliferation in vitro and in vivo via direct regulation of NF-?B transcription factor p50.
P68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5.
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
RNA helicase DHX15 acts as a tumour suppressor in glioma.
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
Gonadal Dysgenesis
Expanding DSD Phenotypes Associated with Variants in the DEAH-Box RNA Helicase DHX37.
Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum.
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome.
Gonadal Dysgenesis, Mixed
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Gonadoblastoma
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Graves Disease
Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.
The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population.
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
Hantavirus Infections
New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells.
Head and Neck Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Hearing Loss
Aggressive-like behavior and increased glycine transporters in a zebrafish model of CHARGE syndrome.
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Endocrinological Characteristics of 25 Japanese Patients with CHARGE Syndrome.
Heart Defects, Congenital
Discovery of a novel CHD7 CHARGE syndrome variant by integrated omics analyses.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Failure
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Rupture
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Heart Septal Defects, Atrial
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Heart Septal Defects, Ventricular
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Hemangioma
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
Hematologic Neoplasms
Ddx41 inhibition of DNA damage signaling permits erythroid progenitor expansion in zebrafish.
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
Hemorrhagic Fever, Crimean
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus.
Hemorrhagic Septicemia, Viral
A20 (tnfaip3) is a negative feedback regulator of RIG-I-Mediated IFN induction in teleost.
Henipavirus Infections
Differential Innate Immune Responses Elicited by Nipah Virus and Cedar Virus Correlate with Disparate In Vivo Pathogenesis in Hamsters.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
Hepatitis
Association between fulminant hepatic failure and a strain of GBV virus C.
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
Detection of hepatitis G virus RNA in patients with acute non-A-E hepatitis.
Expression and characterization of the hepatitis G virus helicase.
GB virus C/hepatitis G virus infection in Saudi Arabian blood donors and patients with cryptogenic hepatitis.
Host mechanisms in viral hepatitis.
Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro.
New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling.
New variant groups identified from HGV isolates.
Persistent hepatitis G virus infection after neonatal transfusion.
Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase.
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3.
The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis.
Treatment options in patients with chronic hepatitis C.
X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.
Hepatitis B
Antiviral immunity. Dual attack by RIG-I.
DDX3 DEAD-Box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into nucleocapsids.
DDX3 DEAD-box RNA helicase is a host factor that restricts hepatitis B virus replication at the transcriptional level.
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways.
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity.
Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma.
RNA Helicase DDX17 Inhibits Hepatitis B Virus Replication by Blocking Viral Pregenomic RNA Encapsidation.
RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes.
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
Single lysophosphatidylcholine components exhibit adjuvant activities in vitro and in vivo.
Stimulation of DDX3 expression by ginsenoside Rg3 through the Akt/p53 pathway activates the innate immune response via TBK1/IKK?/IRF3 signalling.
Suppression of hepatitis B virus through therapeutic activation of RIG-I and IRF3 signaling in hepatocytes.
The catcher in the RIG-I.
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus.
Use of alpha-N,N-bis[carboxymethyl]lysine-modified peroxidase in immunoassays.
Hepatitis B, Chronic
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
RIG-I enhances interferon-? response by promoting antiviral protein expression in patients with chronic hepatitis B.
Toll-like receptors, long non-coding RNA NEAT1, and RIG-I expression are associated with HBeAg-positive chronic hepatitis B patients in the active phase.
Hepatitis C
A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.
A fluorescence-based screening assay for identification of hepatitis C virus NS3 helicase inhibitors and characterization of their inhibitory mechanism.
A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique.
A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities.
A novel high throughput screening assay for HCV NS3 helicase activity.
A novel recombinant single-chain hepatitis C virus NS3-NS4A protein with improved helicase activity.
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein.
A single amino acid is critical for the expression of B-cell epitopes on the helicase domain of the pestivirus NS3 protein.
A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain.
A synthetic peptide derived from the non-structural protein 3 of hepatitis C virus serves as a specific substrate for PKC.
Abrogation of hepatitis C virus NS3 helicase enzymatic activity by recombinant human antibodies.
Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth.
Amantadine and rimantadine have no direct inhibitory effects against hepatitis C viral protease, helicase, ATPase, polymerase, and internal ribosomal entry site-mediated translation.
An ELISA for RNA helicase activity: application as an assay of the NS3 helicase of hepatitis C virus.
An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities.
Analysis of aptamer binding site for HCV-NS3 protease by alanine scanning mutagenesis.
Analysis of interaction between RNA aptamer and protein using nucleotide analogs.
Analysis of protein conformational transitions using elastic network model.
Analysis of the domain interactions between the protease and helicase of NS3 in dengue and hepatitis C virus.
Antigenicity of a recombinant NS3 protein representative of ATPase/helicase domain from hepatitis C virus.
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors.
Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway.
Artificial neural network for prediction of antigenic activity for a major conformational epitope in the hepatitis C virus NS3 protein.
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase.
ATP dependent NS3 helicase interaction with RNA: insights from molecular simulations.
Aurintricarboxylic Acid Modulates the Affinity of Hepatitis C Virus NS3 Helicase for Both Nucleic Acid and ATP.
Backbone 1H, 15N and 13C resonance assignments of the NTPase subdomain of the hepatitis C virus NS3 RNA helicase.
Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.
Binding by the Hepatitis C Virus NS3 Helicase Partially Melts Duplex DNA.
Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus.
Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.
Biological evaluation of hepatitis C virus helicase inhibitors.
Bis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.
C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity.
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Cell Transformation and Proteome Alteration in QSG7701 Cells Transfected with Hepatitis C Virus Non-structural Protein 3.
Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication.
Characterisation of non-structural protein 3 of hepatitis C virus as modulator of protein phosphorylation mediated by PKA and PKC: evidences for action on the level of substrate and enzyme.
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.
Characterization of a monoclonal antibody and its single-chain antibody fragment recognizing the nucleoside Triphosphatase/Helicase domain of the hepatitis C virus nonstructural 3 protein.
Characterization of ATPase activity of a hepatitis C virus NS3 helicase domain, and analysis involving mercuric reagents.
Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase.
Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein.
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.
Chronic hepatitis C and no response to antiviral therapy: potential current and future therapeutic options.
Circular dichroism analysis for multidomain proteins: studies of the irreversible unfolding of Hepatitis C virus helicase.
Classification Models of HCV NS3 Protease Inhibitors Based on Support Vector Machine (SVM).
Cloning and expression of NS3 helicase fragment of hepatitis C virus and the study of its immunoreactivity in HCV infected patients.
Cloning and expression of retinoic acid-induced gene-I and its effect on hepatitis C virus replication.
Cloning and molecular characterization of human high affinity antibody fragments against Hepatitis C virus NS3 helicase.
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases.
Comparisons of RNAi approaches for validation of human RNA helicase A as an essential factor in hepatitis C virus replication.
Computational biology approach to uncover hepatitis C virus helicase operation.
Computer modeling of helicases using elastic network model.
Construction and Immunogenicity Analysis of Hepatitis C Virus (HCV) Truncated Non-Structural Protein 3 (NS3) Plasmid Vaccine.
Construction of the dual-functional RNA ligand against HCV NS3 protease and helicase.
Control of Innate Immune Signaling and Membrane Targeting by the Hepatitis C Virus NS3/4A Protease Are Governed by the NS3 Helix ?0.
Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein.
Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA.
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Crystal structure of the NS3 protease-helicase from dengue virus.
Crystallization and preliminary X-ray crystallographic analysis of the helicase domain of hepatitis C virus NS3 protein.
Current and evolving therapies for hepatitis C.
DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication.
DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control.
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies.
Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.
Detection of hepatitis C virus helicase activity using the scintillation proximity assay system.
Development of a hepatitis C virus RNA helicase high throughput assay.
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.
Dimerization-driven interaction of hepatitis c virus core protein with NS3 helicase.
Direct fluorometric measurement of hepatitis C virus helicase activity.
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.
Discovery of hepatitis C virus NS3 helicase inhibitors by a multiplexed, high-throughput helicase activity assay based on graphene oxide.
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
DNA helicase activity of the hepatitis C virus nonstructural protein 3.
DNA immunization efficiently targets conserved functional domains of protease and ATPase/helicase of nonstructural 3 protein (NS3) of human hepatitis C virus.
Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target.
Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
Dynamic Interconversions of HCV Helicase Binding Modes on the Nucleic Acid Substrate.
Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.
Effects of a Fixed-Dose Co-Formulation of Daclatasvir, Asunaprevir, and Beclabuvir on the Pharmacokinetics of a Cocktail of Cytochrome P450 and Drug Transporter Substrates in Healthy Subjects.
Effects on protease inhibition by modifying of helicase residues in hepatitis C virus nonstructural protein 3.
Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations.
Engineering of the hepatitis C virus helicase for enhanced seroreactivity.
Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding.
Enhanced RIG-I expression is mediated by interferon regulatory factor-2 in peripheral blood B cells from hepatitis C virus-infected patients.
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system.
Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli.
Enzymatic properties of hepatitis C virus NS3-associated helicase.
Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase.
Evolutionary relationship of hepatitis C, pesti-, flavi-, plantviruses, and newly discovered GB hepatitis agents.
Experimental and emerging therapies for chronic hepatitis C virus infection.
Expression and purification of a hepatitis C virus NS3/4A complex, and characterization of its helicase activity with the Scintillation Proximity Assay system.
Expression and purification of an active, full-length hepatitis C viral NS4A.
Expression of human single-chain variable fragment antibody against non-structural protein 3 of hepatitis C virus antigen in e.coli.
Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV.
Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase.
Five new or recently discovered (GBV-A) virus species are indigenous to New World monkeys and may constitute a separate genus of the Flaviviridae.
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.
Fluorometric assay of hepatitis C virus NS3 helicase activity.
Fuel specificity of the hepatitis C virus NS3 helicase.
Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.
Future trends in managing hepatitis C.
GB hepatitis agent in cadaver organ donors and their recipients.
Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3.
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
HCV NS3Ag: a reliable and clinically useful predictor of antiviral outcomes in genotype 1b hepatitis C virus-infected patients.
Helicase from hepatitis C virus, energetics of DNA binding.
Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C.
Helicase structure and mechanism.
Helicase, a target for novel inhibitors of hepatitis C virus.
Hepatitis C NS3 helicase unwinds RNA in leaps and bounds.
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase.
Hepatitis C virus controls interferon production through PKR activation.
Hepatitis C virus core protein binds to a DEAD box RNA helicase.
Hepatitis C virus core protein interacts with cellular putative RNA helicase.
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.
Hepatitis C Virus Helicase Binding Activity Monitored through Site-Specific Labeling Using an Expanded Genetic Code.
Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target.
Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity.
Hepatitis C virus non-structural protein 3-specific cellular immune responses following single or combined immunization with DNA or recombinant Semliki Forest virus particles.
Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites.
Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties.
Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.
Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (Amphimedon) ?Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling.
Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors.
Hepatitis C Virus NS3 Protein Plays a Dual Role in WRN-Mediated Repair of Non-Homologous End Joining.
Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
Hepatitis C virus reveals a novel early control in acute immune response.
Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase.
Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis.
High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon.
Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein.
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.
Humanized-VH/VHH that inhibit HCV replication by interfering with the virus helicase activity.
Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.
Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase.
Identification and Analysis of Novel Inhibitors against NS3 Helicase and NS5B RNA-Dependent RNA Polymerase from Hepatitis C Virus 1b (Con1).
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.
Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.
Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.
Identification of conserved nucleotide sequences within the GB virus C 5'-untranslated region: design of PCR primers for detection of viral RNA.
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.
Immunogenicity and antigenicity of the ATPase/helicase domain of the hepatitis C virus non-structural 3 protein.
In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.
In trans interaction of hepatitis C virus helicase domains mediates protease activity critical for internal NS3 cleavage and cell transformation.
In Vitro Assessment of Re-treatment Options for Patients with Hepatitis C Virus Genotype 1b Infection Resistant to Daclatasvir Plus Asunaprevir.
In vitro selection of RNA aptamers against the HCV NS3 helicase domain.
Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.
Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation.
Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior.
Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Amphimedon sp.
Inhibition of HCV NS3 protease by RNA aptamers in cells.
Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone.
Inhibition of Hepatitis C Virus NS3 Helicase by Manoalide.
Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.
Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.
Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor.
Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP, NaF, MgCl2, and poly(rU). Two ADP binding sites on the enzyme-nucleic acid complex.
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Inhibitory mechanism of 5-bromo-3-indoleacetic acid for non-structural-3 helicase hepatitis C virus with dynamics correlation network analysis.
Innate Immune Responses against Viral Infection and Its Suppression by Viral Proteins.
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
Internal cleavage of hepatitis C virus NS3 protein is dependent on the activity of NS34A protease.
Internal processing of hepatitis C virus NS3 protein.
Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone.
Investigation of translocation, DNA unwinding, and protein displacement by NS3h, the helicase domain from the hepatitis C virus helicase.
Isolation of novel virus-like sequences associated with human hepatitis.
Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity.
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe.
Letter to the editor: Sequence-specific 1H, 15N and 13C resonance assignments for an engineered arginine-rich domain of the hepatitis C virus NS3 RNA helicase.
Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.
Mechanism of flexibility control for ATP access of hepatitis C virus NS3 helicase.
Mechanisms of HCV NS3 helicase monitored by optical tweezers.
Minimal T-cell-stimulatory sequences and spectrum of HLA restriction of immunodominant CD4+ T-cell epitopes within hepatitis C virus NS3 and NS4 proteins.
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A.
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.
Molecular docking investigation of the binding interactions of macrocyclic inhibitors with HCV NS3 protease and its mutants (R155K, D168A and A156V).
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase.
Monitoring helicase activity with molecular beacons.
Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.
Multilayer fluorescence optically encoded beads for protein detection.
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.
Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Mutational analysis of hepatitis C virus NS3-associated helicase.
Mutational analysis of the hepatitis C virus RNA helicase.
Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase.
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Nanomechanical microcantilever operated in vibration modes with use of RNA aptamer as receptor molecules for label-free detection of HCV helicase.
Neuregulin 1 discovered as a cleavage target for the HCV NS3/4A protease by a microfluidic membrane protein array.
New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection.
New drug targets for HIV and hepatitis C virus coinfection.
New therapies on the horizon for hepatitis C: are we close?
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients.
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.
NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.
NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.
NS3 helicase domains involved in infectious intracellular hepatitis C virus particle assembly.
NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
NS3 Peptide, a novel potent hepatitis C virus NS3 helicase inhibitor: its mechanism of action and antiviral activity in the replicon system.
Nucleic acid unwinding by hepatitis C virus and bacteriophage t7 helicases is sensitive to base pair stability.
Optimization for the detection of hepatitis C virus antigens in the liver.
Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline.
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Overview of interferon therapy for chronic hepatitis C.
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase.
Peptidic inhibitors of the hepatitis C virus serine protease within non-structural protein 3.
Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase.
Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase.
Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase.
Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase.
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells.
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.
Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA.
Production and characterization of monoclonal antibody specific for NS3 helicase of hepatitis C virus.
Protease and helicase activities of hepatitis C virus genotype 4, 5, and 6 NS3-NS4A proteins.
Protease inhibitors block multiple functions of the NS3/4A protease-helicase during the hepatitis C virus life cycle.
Psammaplin A inhibits hepatitis C virus NS3 helicase.
Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.
Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3.
Rational design of modular allosteric aptamer sensor for label-free protein detection.
Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro.
Recombinant ovine atadenovirus induces a strong and sustained T cell response against the hepatitis C virus NS3 antigen in mice.
Redesigning the substrate specificity of the hepatitis C virus NS3 protease.
Refolding of a recombinant full-length non-structural (NS3) protein from hepatitis C virus by chromatographic procedures.
Refolding of the full-length non-structural protein 3 of hepatitis C virus.
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Regulation of RIG-I Activation by K63-Linked Polyubiquitination.
Relationship between sex hormones and RIG-I signaling in peripheral blood mononuclear cells of patients infected with hepatitis C virus.
Restoration of the Activated Rig-I Pathway in Hepatitis C Virus (HCV) Replicon Cells by HCV Protease, Polymerase, and NS5A Inhibitors In Vitro at Clinically Relevant Concentrations.
RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells.
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.
RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase.
RNA unwinding by NS3 helicase: a statistical approach.
RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP.
Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.
Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding.
Role of the Conserved DECH-Box Cysteine in Coupling Hepatitis C Virus Helicase-Catalyzed ATP Hydrolysis to RNA Unwinding.
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity.
Screening and identification of bioactive compounds from citrus against non-structural protein 3 protease of hepatitis C virus genotype 3a by fluorescence resonance energy transfer assay and mass spectrometry.
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Sequence analysis of hepatitis GB virus C (GBV-C) isolates from 14 patients.
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic Acid unwinding of the viral helicase.
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus.
Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody.
Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.
Single lysophosphatidylcholine components exhibit adjuvant activities in vitro and in vivo.
Single strand binding proteins increase the processivity of DNA unwinding by the hepatitis C virus helicase.
Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase.
Single-molecule imaging reveals the translocation and DNA looping dynamics of hepatitis C virus NS3 helicase.
Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase.
Step-by-step progress toward understanding the hepatitis C virus RNA helicase.
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase.
Strand-separating activity of hepatitis C virus helicase in the absence of ATP.
Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus.
Structural basis for DNA duplex separation by a superfamily-2 helicase.
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
Structural studies of Helicase NS3 variants from Hepatitis C virus genotype 3 in virological sustained responder and non-responder patients.
Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.
Structure and function of hepatitis C virus NS3 helicase.
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A.
Structure of the hepatitis C virus RNA helicase domain.
Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.
Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.
Structure-based mutagenesis study of hepatitis C virus NS3 helicase.
Structure-based mutational analysis of the hepatitis C virus NS3 helicase.
Structure-based simulations of the translocation mechanism of the hepatitis C virus NS3 helicase along single-stranded nucleic acid.
Subcellular localisation of NS3 in HCV-infected hepatocytes.
Suppression of Hepatitis C Virus Genome Replication in Cells with RNA-Cleaving DNA Enzymes and Short-Hairpin RNA.
Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication.
The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly.
The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.
The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
The effects of hepatitis C virus non-structural protein 3 on cell growth mediated by extracellular signal-related kinase cascades in human hepatocytes in vitro.
The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity.
The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3).
The helicase from hepatitis C virus is active as an oligomer.
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.
The mitochondrial targeting chaperone 14-3-3? regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently.
The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells.
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities.
The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity.
The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
The RNA-unwinding activity of hepatitis C virus non-structural protein 3 (NS3) is positively modulated by its protease domain.
The scavenger receptors SRA-1 and SREC-I cooperate with TLR2 in the recognition of the hepatitis C virus non-structural protein 3 by dendritic cells.
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
The Spring ?-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action.
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Toward the mechanism of dynamical couplings and translocation in hepatitis C virus NS3 helicase using elastic network model.
Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.
Tracing entire operation cycles of molecular motor hepatitis C virus helicase in structurally resolved dynamical simulations.
Tropolone and its derivatives as inhibitors of the helicase activity of hepatitis C virus nucleotide triphosphatase/helicase.
Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action.
Two-state model for helicase translocation and unwinding of nucleic acids.
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis.
Unmasking the active helicase conformation of NS3 from Hepatitis C Virus.
Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex.
Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1.
Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I.
Use of alpha-N,N-bis[carboxymethyl]lysine-modified peroxidase in immunoassays.
Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.
Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity.
Viral and cellular RNA helicases as antiviral targets.
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection.
Viral immune surveillance: Toward a TH17/TH9 gate to the central nervous system.
[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs]
[Characterization of a panel of monoclonal antibodies to hepatitis C NS3 recombinant protein ]
[Inducible expression of non-structural protein 3 of hepatitis C virus in E. coli]
[Molecular evolutionary analysis of GB viruses and hepatitis G virus]
[The combined application of nucleotide and amino acid sequences of NS3 hepatitis C virus protein, DNA encoding granulocyte macrophage colony-stimulating factor and inhibitor of regulatory T cells induces effective immune response against hepatitis C virus].
Hepatitis C, Chronic
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
New therapies for the treatment of chronic hepatitis C.
Overview of interferon therapy for chronic hepatitis C.
Responsiveness to interferon alpha treatment in patients with chronic hepatitis C coinfected with hepatitis G virus.
Hepatitis E
A novel mycovirus that is related to the human pathogen hepatitis E virus and rubi-like viruses.
Analysis of complete genome sequences and a V239A substitution in the helicase domain of swine hepatitis E virus strains isolated in Canada.
Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication.
Analysis of the helicase gene of Korean swine hepatitis E virus isolates and trends in viral infection.
Avian hepatitis E virus in an outbreak of hepatitis-splenomegaly syndrome and fatty liver haemorrhage syndrome in two flaxseed-fed layer flocks in Ontario.
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease.
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.
Genotyping of hepatitis E virus in clinical specimens by restriction endonuclease analysis.
Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.
Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I.
Hepatitis E virus ORF1 encoded non structural protein-host protein interaction network.
Hepatitis E Virus ORF2 Inhibits RIG-I Mediated Interferon Response.
Identification and genetic characterization of a porcine hepe-astrovirus (bastrovirus) in the United States.
Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening.
Mutagenesis of hepatitis E virus helicase motifs: effects on enzyme activity.
NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain.
Phylogenetic analysis of avian hepatitis E virus samples from European and Australian chicken flocks supports the existence of a different genus within the Hepeviridae comprising at least three different genotypes.
RIG-I Is A Key Antiviral Interferon-Stimulated Gene Against Hepatitis E Virus Dispensable Of Interferon Production.
RNA 5'-triphosphatase activity of the hepatitis E virus helicase domain.
RNA Strand Displacement Assay for Hepatitis E Virus Helicase.
Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus.
Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication.
Viral Macro Domains Reverse Protein ADP-Ribosylation.
Hepatitis, Chronic
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways.
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Herpes Simplex
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
Combined transcriptomic/proteomic analysis of crucian carp Carassius auratus gibelio in cyprinid herpesvirus 2 infection.
Direct interaction between the N- and C-terminal portions of the herpes simplex virus type 1 origin binding protein UL9 implies the formation of a head-to-tail dimer.
Effect of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum (II) on the activity of a helicase essential for DNA replication, the herpes simplex virus type-1 origin-binding protein.
Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: enhancement of UL9 helicase activity.
Helicase motif Ia is involved in single-strand DNA-binding and helicase activities of the herpes simplex virus type 1 origin-binding protein, UL9.
Helicase primase: targeting the Achilles heel of herpes simplex viruses.
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5.
Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.
High-throughput screening assay for helicase enzymes.
Induction of interferon-? contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells.
Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex.
Inhibition of herpes simplex virus type 1 replication by adeno-associated virus rep proteins depends on their combined DNA-binding and ATPase/helicase activities.
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.
New antiviral drugs that target herpesvirus helicase primase enzymes.
Physical interaction between the herpes simplex virus 1 origin-binding protein and single-stranded DNA-binding protein ICP8.
Replacement of gly815 in helicase motif V alters the single-stranded DNA-dependent ATPase activity of the herpes simplex virus type 1 helicase-primase.
Residues within the conserved helicase motifs of UL9, the origin-binding protein of herpes simplex virus-1, are essential for helicase activity but not for dimerization or origin binding activity.
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
RIG-I Mediated STING Up-Regulation Restricts HSV-1 Infection.
Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication.
Suppression of PACT-induced type I interferon production by herpes simplex virus type 1 Us11 protein.
The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.
The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.
The herpes simplex virus type 1 helicase-primase. Analysis of helicase activity.
The herpes simplex virus type-1 origin binding protein. DNA helicase activity.
The herpes simplex virus type-1 single-strand DNA-binding protein (ICP8) promotes strand invasion.
The herpesvirus accessory protein ?134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I.
The human cytomegalovirus genes and proteins required for DNA synthesis.
The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function.
trans-acting requirements for replication of Epstein-Barr virus ori-Lyt.
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
[Inhibition of herpes simplex virus helicase UL9 by netropsin derivatives and antiviral activities of bis-netropsins].
Herpesviridae Infections
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
Hirschsprung Disease
Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression.
HIV Infections
Differential expression of Werner and Bloom syndrome genes in the peripheral blood of HIV-1 infected patients.
State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2.
Hodgkin Disease
Association of DDX58 177 C?>?T polymorphism with decreased risk of Epstein-Barr virus-related nodular sclerosis classical Hodgkin lymphoma.
Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Hyperpigmentation
Genomic analysis of GBS data reveals genes associated with facial pigmentation in Xinyang blue-shelled layers.
Hypersensitivity
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
Hypertension
Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.
Hypogonadism
Anosmia Predicts Hypogonadotropic Hypogonadism in CHARGE Syndrome.
Hypoparathyroidism
Successful cord blood transplantation for a CHARGE syndrome with CHD7 mutation showing DiGeorge sequence including hypoparathyroidism.
hypoxanthine phosphoribosyltransferase deficiency
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Ichthyosis
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Suppression of UV-induced apoptosis by the human DNA repair protein XPG.
The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes.
Idiopathic Interstitial Pneumonias
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Idiopathic Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Infarction, Middle Cerebral Artery
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Infections
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
A mutation in helicase motif IV of HSV-1 UL5 that results in reduced growth in vitro and lower virulence in a murine infection model is related to predicted helicase structure.
A necrosis-inducing elicitor domain encoded by both symptomatic and asymptomatic Plantago asiatica mosaic virus isolates, whose expression is modulated by virus replication.
A novel chicken lung epithelial cell line: characterization and response to low pathogenicity avian influenza virus.
A rapid and transient innate immune response to avian influenza infection in mallards.
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant.
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
Activation and regulation of pathogen sensor RIG-I.
Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins.
Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death.
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
An important role for MAVS in the KSHV lifecycle.
An RNA-Binding Protein Secreted by a Bacterial Pathogen Modulates RIG-I Signaling.
Analysis of Global Transcriptome Change in Mouse Embryonic Fibroblasts After dsDNA and dsRNA Viral Mimic Stimulation.
Analysis of oral infection and helicase gene of the nucleopolyhedroviruses isolated from Philosamia cynthia ricini and Antheraea pernyi.
Annexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3-IFNAR-STAT1-IFIT1 pathway in A549 lung epithelial cells.
Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
Association of RIG-I with innate immunity of ducks to influenza.
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVS.
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
Bacteriophage T4 gene 41 protein, required for the synthesis of RNA primers, is also a DNA helicase.
Bacteriophage T4 gene 59 helicase assembly protein binds replication fork DNA. The 1.45 A resolution crystal structure reveals a novel alpha-helical two-domain fold.
Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo.
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Beet necrotic yellow vein virus 42 kDa triple gene block protein binds nucleic acid in vitro.
Cell type-specific involvement of RIG-I in antiviral response.
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein.
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Characterization of mimotopes mimicking an immunodominant conformational epitope on the hepatitis C virus NS3 helicase.
Characterization of the immune response following in vitro mayaro and chikungunya viruses (Alphavirus, Togaviridae) infection of mononuclear cells.
Chicken cells sense influenza A virus infection through MDA5 and CARDIF signaling involving LGP2.
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.
Cloning and expression of NS3 helicase fragment of hepatitis C virus and the study of its immunoreactivity in HCV infected patients.
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.
Combined transcriptomic/proteomic analysis of crucian carp Carassius auratus gibelio in cyprinid herpesvirus 2 infection.
Comparative Analysis of the Liver and Spleen Transcriptomes between Holstein and Yunnan Humped Cattle.
Comparative analysis of viral RNA signatures on different RIG-I-like receptors.
Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase.
Control of Innate Immune Signaling and Membrane Targeting by the Hepatitis C Virus NS3/4A Protease Are Governed by the NS3 Helix ?0.
Control of the induction of type I interferon by Peste des petits ruminants virus.
Conventional protein kinase C-? (PKC-?) and PKC-? negatively regulate RIG-I antiviral signal transduction.
COVID-19: An Update on Pathogenesis and Treatment.
Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.
Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo.
Current Findings Regarding Natural Components With Potential Anti-2019-nCoV Activity.
Cytokine-independent upregulation of MDA5 in viral infection.
Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.
DANCING WITH CHEMICAL FORMULAE OF ANTIVIRALS: A PANORAMIC VIEW (part 2).
ddPCR increases detection of SARS-CoV-2 RNA in patients with low viral loads.
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
DDX3 directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signalling complexes downstream from MAVS.
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells.
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection.
DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathway.
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
Defining New Therapeutics Using a More Immunocompetent Mouse Model of Antibody-Enhanced Dengue Virus Infection.
Degradation of RIG-I following cytomegalovirus infection is independent of apoptosis.
Dengue Virus Capsid Interacts with DDX3X-A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection.
Dengue virus induces interferon-? by activating RNA sensing pathways in megakaryocytes.
Dengue virus-induced regulation of the host cell translational machinery.
Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.
Dicodon monitoring of protein synthesis (DiCoMPS) reveals levels of synthesis of a viral protein in single cells.
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.
Differential recognition of viral RNA by RIG-I.
Direct, interferon-independent activation of the CXCL10 promoter by NF-?B and interferon regulatory factor 3 during hepatitis C virus infection.
Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.
Dissecting the Role of DDX21 in Regulating Human Cytomegalovirus Replication.
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Downregulation of Aedes aegypti chromodomain helicase DNA binding protein 7/Kismet by Wolbachia and its effect on dengue virus replication.
Duck RIG-I restricts duck enteritis virus infection.
Duckling short beak and dwarfism syndrome virus infection activates host innate immune response involving both DNA and RNA sensors.
Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
Duox2-derived Reactive Oxygen Species Induce Pattern Recognition Receptors' Expression Against Influenza A Virus in Nasal Mucosa.
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.
Effective treatment of respiratory alphaherpesvirus infection using RNA interference.
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.
Elevation of Alanine Aminotransferase Activity Occurs after Activation of the Cell-Death Signaling Initiated by Pattern-Recognition Receptors ?but before Activation of Cytolytic Effectors in NK or CD8+ T Cells in the Liver During Acute HCV Infection.
Emerging therapies for herpes viral infections (types 1 - 8).
Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.
Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant.
Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.
Enterovirus 2Apro targets MDA5 and MAVS in infected cells.
Enterovirus 71 inhibits cellular type I interferon signaling by inhibiting host RIG-I ubiquitination.
Essential role for the Legionella pneumophila rep helicase homologue in intracellular infection of mammalian cells.
Essential role of RIG-I in the activation of endothelial cells by dengue virus.
Existence of transdominant and potentiating mutants of UL9, the herpes simplex virus type 1 origin-binding protein, suggests that levels of UL9 protein may be regulated during infection.
Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor.
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.
Expression and Functional Characterization of Retinoic Acid-Inducible Gene-I-Like Receptors of Mast Cells in Response to Viral Infection.
Expression of immune genes RIG-I and Mx in mallard ducks infected with low pathogenic avian influenza (LPAI): A dataset.
Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus.
Expression profiles of carp IRF-3/-7 correlate with the up-regulation of RIG-I/MAVS/TRAF3/TBK1, four pivotal molecules in RIG-I signaling pathway.
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection.
First Report of Little cherry virus 2 in Flowering and Sweet Cherry Trees in China.
FKBP5 Regulates RIG-I-Mediated NF-?B Activation and Influenza A Virus Infection.
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells.
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense.
Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity.
Fusobacterium nucleatum activates the immune response through retinoic acid-inducible gene I.
GB hepatitis agent in cadaver organ donors and their recipients.
Gene Expression Analysis During Dengue Virus Infection In Hepg2 Cells Reveals Virus Control of Innate Immune Response.
Gene expression profile after activation of RIG-I in 5'ppp-dsRNA challenged DF1.
Genetic Control of Human Infection with SARS-CoV-2.
Genetic determinants of host immunity against human rhinovirus infections.
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection.
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Hantaan virus triggers TLR3-dependent innate immune responses.
HCV NS3Ag: a reliable and clinically useful predictor of antiviral outcomes in genotype 1b hepatitis C virus-infected patients.
Helicase Domain Encoded by Cucumber mosaic virus RNA1 Determines Systemic Infection of Cmr1 in Pepper.
Helicases as antiviral drug targets.
Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.
Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity.
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
Hepatitis C virus reveals a novel early control in acute immune response.
Hepatitis E virus from India exhibits significant amino acid mutations in fulminant hepatic failure patients.
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5.
Herpes simplex virus type 2 virion host shutoff protein suppresses innate dsRNA antiviral pathways in human vaginal epithelial cells.
High-mobility group box 1 protein (HMGB1) from Cherry Valley duck mediates signaling pathways and antiviral activity.
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3.
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
Host Innate Immune Responses of Ducks Infected with Newcastle Disease Viruses of Different Pathogenicities.
Host innate immune responses of geese infected with goose origin nephrotic astrovirus.
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.
How RIG-I like receptors activate MAVS.
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling.
Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.
Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA.
Identification and rapid diagnosis of the pathogen responsible for haemorrhagic disease of the gill of Allogynogenetic crucian carp.
Identification of a retinoic acid-inducible gene I from grass carp (Ctenopharyngodon idella) and expression analysis in vivo and in vitro.
Identification of avian RIG-I responsive genes during influenza infection.
Identification of DDX58 and CXCL10 as Potential Biomarkers in Acute Respiratory Distress Syndrome.
Identification of multiple RIG-I-specific pathogen associated molecular patterns within the West Nile virus genome and antigenome.
Identification of Potential Inhibitors for Targets Involved in Dengue Fever.
Identification of several key genes by microarray data analysis of bovine mammary gland epithelial cells challenged with Escherichia coli and Staphylococcus aureus.
Identification of the RNA Pseudoknot within the 3' End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3.
IFN-?-inducing, unusual viral RNA species produced by paramyxovirus infection accumulated into distinct cytoplasmic structures in an RNA-type-dependent manner.
IFN? Influences Epithelial Anti-viral Responses via Histone Methylation of the Rig-I Promoter.
IFN? Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I.
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus.
Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus.
In vivo cellular and molecular study on duck spleen infected by duck Tembusu virus.
Incoming RNA Virus Nucleocapsids Containing a 5'-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling.
Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes.
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Induction of cell-mediated immune responses in mice by DNA vaccines that express hepatitis C virus NS3 mutants lacking serine protease and NTPase/RNA helicase activities.
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-?-dependent induction of pro-apoptotic Noxa.
Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling.
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Influenza PB1-F2 Inhibits Avian MAVS Signaling.
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
Inhibition of H9N2 Virus Invasion into Dendritic Cells by the S-Layer Protein from L. acidophilus ATCC 4356.
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
Inhibition of RIG-I mediated signaling by Kaposi's sarcoma-associated herpesvirus-encoded deubiquitinase ORF64.
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.
Innate Immune Responses to Avian Influenza Viruses in Ducks and Chickens.
Innate immune responses to rotavirus infection in macrophages depend on MAVS but involve neither the NLRP3 inflammasome nor JNK and p38 signaling pathways.
Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.
Innate sensing of viruses by pattern recognition receptors in birds.
Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection.
Interaction between SARS-CoV helicase and a multifunctional cellular protein (Ddx5) revealed by yeast and mammalian cell two-hybrid systems.
Interaction of the bacteriophage T4 gene 59 helicase loading protein and gene 41 helicase with each other and with fork, flap, and cruciform DNA.
Interactions of the TGB1 protein during cell-to-cell movement of Barley stripe mosaic virus.
Interferon stimulated genes, CXCR4 and immune cell responses in peripheral blood mononuclear cells infected with bovine viral diarrhea virus.
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
Intracytoplasmic stable expression of IgG1 antibody targeting NS3 helicase inhibits replication of highly efficient hepatitis C Virus 2a clone.
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia.
Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.
Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner.
Lack of evidence of mimivirus replication in human PBMCs.
Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection.
LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV.
Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
Long-term HIV-1 infection induces an antiviral state in primary macrophages.
Loss of Sendai virus C protein leads to accumulation of RIG-I immunostimulatory defective interfering RNA.
MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.
MDA-5 is cleaved in poliovirus-infected cells.
MDA5 Induces a Stronger Interferon Response than RIG-I to GCRV Infection through a Mechanism Involving the Phosphorylation and Dimerization of IRF3 and IRF7 in CIK Cells.
MDA5 plays a critical role in interferon response during hepatitis C virus infection.
Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Mechanism of interaction between virus and host is inferred from the changes of gene expression in macrophages infected with African swine fever virus CN/GS/2018 strain.
Melanoma differentiation-associated gene 5 senses hepatitis B virus and activates innate immune signaling to suppress virus replication.
Microplitis bicoloratus bracovirus modulates innate immune suppression through the eIF4E-eIF4A axis in the insect Spodoptera litura.
Micropterus salmoides rhabdovirus (MSRV) infection induced apoptosis and activated interferon signaling pathway in largemouth bass skin cells.
MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125.
MiR-202-5p Inhibits RIG-I-Dependent Innate Immune Responses to RGNNV Infection by Targeting TRIM25 to Mediate RIG-I Ubiquitination.
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro.
Molecular cloning, characterization and expression analysis of woodchuck retinoic acid-inducible gene I.
Molecular cloning, functional characterization and antiviral activity of porcine DDX3X.
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition.
Molecular modeling and pharmacophore elucidation study of the Classical Swine Fever virus helicase as a promising pharmacological target.
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection.
mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A.
Murine Coronavirus Induces Type I Interferon in Oligodendrocytes Through Recognition by RIG-I and MDA5.
Muscovy duck reovirus infection rapidly activates host innate immune signaling and induces an effective antiviral immune response involving critical interferons.
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections.
Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity.
Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome.
Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
N1L Is an Ectromelia Virus Virulence Factor and Essential for In Vivo Spread upon Respiratory Infection.
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Natural chemical entities from Arisaema genus might be a promising break-through against Japanese encephalitis virus infection: a molecular docking and dynamics approach.
Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1.
Nicotiana benthamiana plants transformed with the plum pox virus helicase gene are resistant to virus infection.
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-?B signaling pathways.
Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells.
O'nyong nyong virus molecular determinants of unique vector specificity reside in non-structural protein 3.
Origin activation requires both replicative and accessory helicases during T4 infection.
Oropouche virus infection and pathogenesis is restricted by MAVS, IRF-3, IRF-7, and type I IFN signaling pathways in non-myeloid cells.
OsBIRH1, a DEAD-box RNA helicase with functions in modulating defence responses against pathogen infection and oxidative stress.
Osteoblasts from osteoarthritis patients show enhanced to Ross River virus infection associated with delayed type I interferon responses.
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
p53 mediated IFN-? signaling to affect viral replication upon TGEV infection.
Pangolins Lack IFIH1/MDA5, a Cytoplasmic RNA Sensor That Initiates Innate Immune Defense Upon Coronavirus Infection.
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV.
Piscine orthoreovirus (PRV) replicates in Atlantic salmon (Salmo salar L.) erythrocytes ex vivo.
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus.
Poly(dA:dT) Suppresses HSV-2 Infection of Human Cervical Epithelial Cells Through RIG-I Activation.
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Porcine circovirus 2 infection induces IFN? expression through increased expression of genes involved in RIG-I and IRF7 signaling pathways.
Porcine deltacoronavirus (PDCoV) infection antagonizes interferon-?1 production.
Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-? production.
Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-? production by impairing dsRNA and PACT binding to RIG-I.
Porcine epidemic diarrhea virus infection induces NF-?B activation through the TLR2, TLR3 and TLR9 pathways in porcine intestinal epithelial cells.
Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway.
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Promoter analysis of the Chilo iridescent virus DNA polymerase and major capsid protein genes.
Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice.
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
Recent patents relating to HCV molecules like putative targets for therapeutic intervention.
Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus.
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I.
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6.
Relationship between sex hormones and RIG-I signaling in peripheral blood mononuclear cells of patients infected with hepatitis C virus.
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Requirements for eIF4A and eIF2 during translation of Sindbis virus subgenomic mRNA in vertebrate and invertebrate host cells.
Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling.
Respiratory syncytial virus infection of microglia exacerbates SH-SY5Y neuronal cell injury by inducing the secretion of inflammatory cytokines: A Transwell in vitro study.
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection.
Retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 are induced but not essential for dengue virus induced type I interferon response.
Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells.
Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Down-regulation of the Very Low Density Lipoprotein Receptor.
Rhabdovirus evasion of the interferon system.
Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes.
Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
RIG-I and dsRNA-induced IFNbeta activation.
RIG-I and MDA5 RNA Helicases Both Contribute to the Induction of Interferon-{alpha}/{beta} in Measles Virus-Infected Human Cells.
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
RIG-I detects HIV-1 infection and mediates type I interferon response in human macrophages from patients with HIV-1-associated neurocognitive disorders.
RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
RIG-I detects triphosphorylated RNA of Listeria monocytogenes during infection in non-immune cells.
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
RIG-I in RNA virus recognition.
RIG-I Is A Key Antiviral Interferon-Stimulated Gene Against Hepatitis E Virus Dispensable Of Interferon Production.
RIG-I is cleaved during picornavirus infection.
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids.
RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication.
RIG-I knockdown impedes neurogenesis in a murine model of Japanese encephalitis.
RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection.
RIG-I Mediated STING Up-Regulation Restricts HSV-1 Infection.
RIG-I Mediates an Antiviral Response to Crimean-Congo Hemorrhagic Fever Virus.
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
RIG-I Recognizes the 5' Region of Dengue and Zika Virus Genomes.
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells.
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi.
RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.
RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation.
RIG-I-mediated Activation of p38 MAPK Is Essential for Viral Induction of Interferon and Activation of Dendritic Cells: DEPENDENCE ON TRAF2 AND TAK1.
RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.
RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
RNA helicase signaling is critical for type I interferon production and protection against Rift Valley fever virus during mucosal challenge.
RNA helicases in infection and disease.
RNA Sequencing of Murine Norovirus-Infected Cells Reveals Transcriptional Alteration of Genes Important to Viral Recognition and Antigen Presentation.
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling.
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.
SARS-CoV-2 sensing by RIG-I and MDA5 links epithelial infection to macrophage inflammation.
Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression.
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Sensing Adenovirus infection: activation of IRF3 in RAW264.7 cells.
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus.
Silvestrol Inhibits Chikungunya Virus Replication.
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
SNAP-tagged Chikungunya Virus Replicons Improve Visualisation of Non-Structural Protein 3 by Fluorescence Microscopy.
SOCS1 and pattern recognition receptors: TLR9 and RIG-I; novel haplotype associations in Egyptian fibrotic/cirrhotic patients with HCV genotype 4.
Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.
Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.
STING Mediates Neuronal Innate Immune Response Following Japanese Encephalitis Virus Infection.
STING1 is essential for an RNA-virus triggered autophagy.
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.
Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA.
Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1.
Sustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.
SVCV infection triggers fish IFN response through RLR signaling pathway.
Targeted mutational analysis to unravel the complexity of African horse sickness virus NS3 function in mammalian cells.
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
The adenovirus E1b55K/E4orf6 complex induces degradation of the Bloom helicase during infection.
The Antiviral Molecule 5-Pyridoxolactone Identified Post BmNPV Infection of the Silkworm, Bombyx mori.
The Antiviral RNA Interference Response Provides Resistance to Lethal Arbovirus Infection and Vertical Transmission in Caenorhabditis elegans.
The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene Expression.
The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing.
The Autophagy Protein ATG16L1 Is Required for Sindbis Virus-Induced eIF2? Phosphorylation and Stress Granule Formation.
The C-terminal domain of Salmonid Alphavirus nonstructural protein 2 (nsP2) is essential and sufficient to block RIG-I pathway induction and interferon-mediated antiviral response.
The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection.
The cellular immune responses induced in the follow-up of interferon-alpha treated patients with chronic hepatitis C may determine the therapy outcome.
The core promoter controls basal and inducible expression of duck retinoic acid inducible gene-I (RIG-I).
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.
The DEAH-box RNA helicase DHX15 activates NF-?B and MAPK signaling downstream of MAVS during antiviral responses.
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
The Effect of the Hepatitis B Virus Surface Protein Truncated sC69? Mutation on Viral Infectivity and the Host Innate Immune Response.
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
The innate immunity of guinea pigs against highly pathogenic avian influenza virus infection.
The insertion of a mitochondrial selfish element into the nuclear genome and its consequences.
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.
The Long Noncoding RNA NEAT1 Exerts Anti-Hantaviral Effects by Acting as a Positive Feedback for RIG-I Signaling.
The Microtubule-Associated Innate Immune Sensor GEF-H1 Does Not Influence Mouse Norovirus Replication in Murine Macrophages.
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
The regulation of type I interferon production by paramyxoviruses.
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon.
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity.
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon.
The tyrosine kinase c-Src enhances retinoic acid inducible gene-I (RIG-I)-elicited antiviral signaling.
The U-Rich Untranslated Region of the Hepatitis E Virus Induces Differential Type I and Type III Interferon Responses in a Host Cell-Dependent Manner.
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5.
Toll-like receptors, long non-coding RNA NEAT1, and RIG-I expression are associated with HBeAg-positive chronic hepatitis B patients in the active phase.
Transcriptome profiling of influenza A virus-infected lung epithelial (A549) cells with lariciresinol-4-?-D-glucopyranoside treatment.
Transmissible gastroenteritis virus infection induces NF-?B activation through RLR-mediated signaling.
TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus.
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
UntRIG(er)ing lncRNAs.
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I.
Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp.
Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling.
Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.
Zebrafish TRIM25 Promotes Innate Immune Response to RGNNV Infection by Targeting 2CARD and RD Regions of RIG-I for K63-Linked Ubiquitination.
[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs]
[Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus]
[Cell type specific involvement of RIG-I in antiviral responses]
[Establishment of RIG-I knockout 293T cell line and its effect on the replication of influenza B virus].
[RIG-I mediated hepatic innate immune signaling that controls HCV infection]
Infertility
Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe.
Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.
RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes.
Infertility, Female
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
Infertility, Male
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility.
DDX3X and DDX3Y are redundant in protein synthesis.
Downregulation of miR-322 promotes apoptosis of GC-2 cell by targeting Ddx3x.
Gonadotropin-Regulated Testicular RNA helicase (GRTH/DDX25) a Multifunctional Protein Essential for Spermatogenesis.
Human Y chromosome microdeletion analysis by PCR multiplex protocols identifying only clinically relevant AZF microdeletions.
Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia.
Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Influenza in Birds
A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance.
Association of RIG-I with innate immunity of ducks to influenza.
Avian Influenza A Virus Polymerase Recruits Cellular RNA Helicase eIF4A3 to Promote Viral mRNA Splicing and Spliced mRNA Nuclear Export.
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
Expression of immune genes RIG-I and Mx in mallard ducks infected with low pathogenic avian influenza (LPAI): A dataset.
Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells.
Gene expression profile after activation of RIG-I in 5'ppp-dsRNA challenged DF1.
Identification of avian RIG-I responsive genes during influenza infection.
Muscovy duck retinoic acid-induced gene I (MdRIG-I) functions in innate immunity against H9N2 avian influenza viruses (AIV) infections.
Influenza, Human
5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity.
5'-Triphosphate-Short Interfering RNA: Potent Inhibition of Influenza A Virus Infection by Gene Silencing and RIG-I Activation.
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.
?-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.
A Dual-Functioning 5'-PPP-NS1shRNA that Activates a RIG-I Antiviral Pathway and Suppresses Influenza NS1.
A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection.
Activation of duck RIG-I by TRIM25 is independent of anchored ubiquitin.
Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity.
Apigenin suppresses influenza A virus-induced RIG-I activation and viral replication.
Association of RIG-I with innate immunity of ducks to influenza.
Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro.
CEACAM1-Mediated Inhibition of Virus Production.
Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein.
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken.
Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models.
Cigarette Smoke Extract Suppresses the RIG-I Initiated Innate Immune Response To Influenza Virus In Human Lung.
Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine.
Combined Intranasal Nanoemulsion and RIG-I Activating RNA Adjuvants Enhance Mucosal, Humoral, and Cellular Immunity to Influenza Virus.
Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.
DANCING WITH CHEMICAL FORMULAE OF ANTIVIRALS: A PANORAMIC VIEW (part 2).
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response.
De novo replication of the influenza virus RNA genome is regulated by DNA replicative helicase, MCM.
Deciphering interactions used by the influenza virus NS1 protein to silence the host antiviral sensor protein RIG-I using a bacterial reverse two-hybrid system.
Defective RNA sensing by RIG-I in severe influenza virus infection.
Differential recognition of viral RNA by RIG-I.
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes.
Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant.
Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses.
Ergosterol peroxide suppresses influenza A virus-induced pro-inflammatory response and apoptosis by blocking RIG-I signaling.
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Expression, purification, crystallization and preliminary X-ray analysis of full-length human RIG-I.
Function of duck RIG-I in induction of antiviral response against IBDV and avian influenza virus on chicken cells.
Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation.
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Hardy-Weinberg Equilibrium in the Large Scale Genomic Sequencing Era.
Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.
Human Eosinophils Reduce Viral Titer, Secrete IL-8, and Increase RIG-I Expression in Response to Influenza A H1N1 pdm09.
Human interactome of the influenza B virus NS1 protein.
Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.
Identification of avian RIG-I responsive genes during influenza infection.
Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle.
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
IFN-? suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis.
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus.
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction.
Influenza A Virus Polymerase Recruits the RNA Helicase DDX19 to Promote the Nuclear Export of Viral mRNAs.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Influenza A virus TRIMs the type I interferon response.
Influenza A(H1N1)pdm09 virus suppresses RIG-I initiated innate antiviral responses in the human lung.
Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30.
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Influenza PB1-F2 Inhibits Avian MAVS Signaling.
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.
Influenza virus NS1- C/EBP? gene regulatory complex inhibits RIG-I transcription.
Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus.
Innate sensing of viruses by pattern recognition receptors in birds.
Interactions between the influenza A virus RNA polymerase components and retinoic acid-inducible gene I.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication.
MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG-I expression in lung epithelial cells.
Mini viral RNAs act as innate immune agonists during influenza virus infection.
NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-?B signaling pathways.
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity.
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens.
Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Phosphorylation of TRIM28 Enhances the Expression of IFN-? and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.
Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.
Regulation of RIG-I Activation by K63-Linked Polyubiquitination.
Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.
Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines.
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
RIG-I and TLR3 are both required for maximum interferon induction by influenza virus in human lung alveolar epithelial cells.
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
RIG-I from waterfowl and mammals differ in their abilities to induce antiviral responses against influenza A viruses.
RIG-I is cleaved during picornavirus infection.
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression.
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Role of the chaperone protein 14-3-3? in the regulation of influenza A virus-activated beta interferon.
Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages.
Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding.
Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Small RNA Plays Important Roles in Virus-Host Interactions.
Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
Standing on three legs: antiviral activities of RIG-I against influenza viruses.
Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.
Structural and biophysical properties of RIG-I bound to dsRNA with G-U wobble base pairs.
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Structural features of influenza A virus panhandle RNA enabling the activation of RIG-I independently of 5'-triphosphate.
Subcellular Localizations of RIG-I, TRIM25, and MAVS Complexes.
Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection.
Systematic editing of synthetic RIG-I ligands to produce effective antiviral and anti-tumor RNA immunotherapies.
The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I.
The catcher in the RIG-I.
The Cellular DExD/H-Box RNA Helicase UAP56 Co-localizes With the Influenza A Virus NS1 Protein.
The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection.
The core promoter controls basal and inducible expression of duck retinoic acid inducible gene-I (RIG-I).
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I.
The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling.
The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
Threonine 80 phosphorylation of non-structural protein 1 regulates the replication of influenza A virus by reducing the binding affinity with RIG-I.
TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination.
Transcriptome profiling of influenza A virus-infected lung epithelial (A549) cells with lariciresinol-4-?-D-glucopyranoside treatment.
TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.
Tumor Necrosis Factor Alpha Enhances Influenza A Virus-Induced Expression of Antiviral Cytokines by Activating RIG-I Gene Expression.
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity.
[Establishment of RIG-I knockout 293T cell line and its effect on the replication of influenza B virus].
[Mechanisms underlying interferon-mediated host innate immunity during influenza A virus infection].
Intellectual Disability
A de novo DDX3X Variant Is Associated With Syndromic Intellectual Disability: Case Report and Literature Review.
A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features.
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Absence epilepsy and the CHD2 gene: an adolescent male with moderate intellectual disability, short-lasting psychoses, and an interstitial deletion in 15q26.1-q26.2.
Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.
CHD2 is Required for Embryonic Neurogenesis in the Developing Cerebral Cortex.
CHD2 mutations are a rare cause of generalized epilepsy with myoclonic-atonic seizures.
DDX3 Modulates Neurite Development via Translationally Activating an RNA Regulon Involved in Rac1 Activation.
DDX3X mutations in two girls with a phenotype overlapping Toriello-Carey syndrome.
DDX3X: structure, physiologic functions and cancer.
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
De novo SMARCA2 variants clustered outside the helicase domain cause a new recognizable syndrome with intellectual disability and blepharophimosis distinct from Nicolaides-Baraitser syndrome.
Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Expansion of phenotype of DDX3X syndrome: six new cases.
Genotype-phenotype correlations and novel molecular insights into the DHX30-associated neurodevelopmental disorders.
In-Frame Deletion and Missense Mutations of the C-Terminal Helicase Domain of SMARCA2 in Three Patients with Nicolaides-Baraitser Syndrome.
JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse.
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Paralog Studies Augment Gene Discovery: DDX and DHX Genes.
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Phenotypic expansion in DDX3X - a common cause of intellectual disability in females.
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation.
Severe gastrointestinal symptoms caused by a novel DDX3X variant.
The clinical presentation caused by truncating CHD8 variants.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
The first reported case of an inherited pathogenic CHD2 variant in a clinically affected mother and daughter.
The RNA helicase DDX3 induces neural crest by promoting AKT activity.
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Intestinal Pseudo-Obstruction
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Iron Deficiencies
Loss of mitochondrial localization of human FANCG causes defective FANCJ helicase.
The Cth2 ARE-binding Protein Recruits the Dhh1 Helicase to Promote the Decay of Succinate Dehydrogenase SDH4 mRNA in Response to Iron Deficiency.
Keratitis
TLR3/TRIF signalling pathway regulates IL-32 and IFN-? secretion through activation of RIP-1 and TRAF in the human cornea.
Kidney Diseases
Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum.
Klatskin Tumor
Narrowing of the remnant portal vein diameter and decreased portal vein angle are risk factors for portal vein thrombosis after perihilar cholangiocarcinoma surgery.
Kyphosis
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Lactose Intolerance
The molecular basis of lactose intolerance.
Language Development Disorders
A de novo variant of CHD8 in a patient with autism spectrum disorder.
Prospective and detailed behavioral phenotyping in DDX3X syndrome.
Leishmaniasis
Leishmania infantum LeIF protein is an ATP-dependent RNA helicase and an eIF4A-like factor that inhibits translation in yeast.
Leishmaniasis, Visceral
DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis.
Leukemia
BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
EBV in T-/NK-Cell Tumorigenesis.
Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells.
Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition.
Mixture models and wavelet transforms reveal high confidence RNA-protein interaction sites in MOV10 PAR-CLIP data.
Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.
Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.
MOV10 Provides Antiviral Activity against RNA Viruses by Enhancing RIG-I-MAVS-Independent IFN Induction.
Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.
New dead/H-box helicase gene (ddx41) mutation in an Italian family with recurrent leukemia.
Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.
RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness.
RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation.
RNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA Pathway.
Small-molecule inhibitors targeting eIF4A in leukemia.
Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study.
The FMRP-MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes.
The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.
The role of Moloney leukemia virus 10 in hepatitis B virus expression in hepatoma cells.
TLR ligands upregulate RIG-I expression in human plasmacytoid dendritic cells in a type I IFN-independent manner.
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Leukemia, Erythroblastic, Acute
Prevention of anthracycline-induced cytotoxicity in hemopoietic cells by hemin.
Leukemia, Lymphocytic, Chronic, B-Cell
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia.
Leukemia, Myeloid, Acute
Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.
Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies.
Gene expression of helicase antigen in patients with acute and chronic myeloid leukemia.
Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia.
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
RIG-I plays a critical role in negatively regulating granulocytic proliferation.
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
Leukemia, T-Cell
RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1.
Leukemia-Lymphoma, Adult T-Cell
Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia.
Listeriosis
Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I.
Liver Diseases
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism.
Liver Failure, Acute
Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication.
Liver Neoplasms
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a.
RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis.
Loeys-Dietz Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Lung Diseases, Interstitial
Clinically amyopathic dermatomyositis.
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
Lung Neoplasms
Analysis of the RNA helicase A gene in human lung cancer.
Chromatin remodeling factor lymphoid-specific helicase inhibits ferroptosis through lipid metabolic genes in lung cancer progression.
DDX10 promotes human lung carcinoma proliferation by U3 small nucleolar ribonucleoprotein IMP4.
DDX17 nucleocytoplasmic shuttling promotes acquired gefitinib resistance in non-small cell lung cancer cells via activation of ?-catenin.
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
EGFR and Ras regulate DDX59 during lung cancer development.
Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.
Identification and validation of HELLS (Helicase, Lymphoid-Specific) and ICAM1 (Intercellular adhesion molecule 1) as potential diagnostic biomarkers of lung cancer.
Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
Lead DEAD/H box helicase biomarkers with the therapeutic potential identified by integrated bioinformatic approaches in lung cancer.
Long Noncoding RNA Urothelial Carcinoma Associated 1 Promotes the Proliferation and Metastasis of Human Lung Tumor Cells by Regulating MicroRNA-144.
Radon Exposure-induced Genetic Variations in Lung Cancers among Never Smokers.
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
RNA helicase DHX9 may be a therapeutic target in lung cancer and inhibited by enoxacin.
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
The DEAD-box RNA helicase 51 controls non-small cell lung cancer proliferation by regulating cell cycle progression via multiple pathways.
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer.
Lupus Erythematosus, Systemic
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients.
Association of IFIH1 and pro-inflammatory mediators: Potential new clues in SLE-associated pathogenesis.
Association of interferon-induced helicase C domain (IFIH1) gene polymorphisms with systemic lupus erythematosus and a relevant updated meta-analysis.
Dysregulation of antiviral helicase pathways in systemic lupus erythematosus.
Evaluation of Impact of Interferon-Induced Helicase C Domain-Containing Protein 1 Gene in Egyptian Systemic Lupus Erythematosus Patients and its Relationship With Vascular Manifestations of the Disease.
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus.
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
Novel interferonopathies associated with mutations in RIG-I like receptors.
Lupus Nephritis
Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.
Retinoic acid-inducible gene-I (RIG-I) is induced by IFN- in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis.
Lyme Disease
Homologues of helicase genes priA and ruvAB of Borrelia burgdorferi, the Lyme borreliosis agent.
HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete.
HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete.
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
Lymphatic Metastasis
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Lymphocytic Choriomeningitis
Host mechanisms in viral hepatitis.
Z proteins of New World arenaviruses bind RIG-I and interfere with type I interferon induction.
Lymphoma
Carcinogenic heavy metals replace Ca2+ for DNA binding and annealing activities of mono-ubiquitinated annexin A1 homodimer.
Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas.
DDX3X Is the Most Frequently Mutated Gene in Natural Killer/T-cell Lymphoma.
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
EBV in T-/NK-Cell Tumorigenesis.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.
Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A.
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase.
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells.
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Xp54, the Xenopus homologue of human RNA helicase p54, is an integral component of stored mRNP particles in oocytes.
Lymphoma, Large B-Cell, Diffuse
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Lymphoma, Non-Hodgkin
HCV non-structural protein 3 and HCV RNA genome in non-Hodgkin lymphoma and transition of the serum HCV RNA level: a retrospective analysis in one institution.
Lymphoma, Primary Effusion
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Lymphopenia
The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis.
Lymphoproliferative Disorders
Chronic Active Epstein-Barr Virus Infection of T/NK-Cell Type Mimicking Classic Hodgkin Lymphoma: Clinicopathologic and Genetic Features of 8 Cases Supporting a Variant With "Hodgkin/Reed-Sternberg-like" Cells of NK Phenotype.
Macroglossia
A novel de novo DDX3X missense variant in a female with brachycephaly and intellectual disability: a case report.
Malaria
'DEAD-box' helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific.
Bipolar, Dual Plasmodium falciparum Helicase 45 Expressed in the Intraerythrocytic Developmental Cycle Is Required for Parasite Growth.
Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase.
Mandibular Fractures
A novel computer algorithm for modeling and treating mandibular fractures: A pilot study.
Mandibulofacial Dysostosis
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Marfan Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Massive Hepatic Necrosis
Infection with GB virus C (GBV-C) in patients with fulminant hepatitis.
Measles
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2.
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
Measles virus C protein interferes with Beta interferon transcription in the nucleus.
Measles virus interaction with host cells and impact on innate immunity.
Non-encapsidated 5' copy-back defective-interfering genomes produced by recombinant measles viruses are recognized by RIG-I and LGP2 but not MDA5.
PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.
Polymorphisms in key innate immune genes and their effects on measles vaccine responses and vaccine failure in children from Mozambique.
RIG-I and MDA5 RNA Helicases Both Contribute to the Induction of Interferon-{alpha}/{beta} in Measles Virus-Infected Human Cells.
RIG-I Is Required for the Inhibition of Measles Virus by Retinoids.
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.
The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines.
TLR3 and RIG-I gene variants: associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants.
Medulloblastoma
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Cancer-Associated Mutants of RNA Helicase DDX3X Are Defective in RNA-Stimulated ATP Hydrolysis.
CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma.
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42.
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.
Medulloblastoma-associated mutations in the DEAD-box RNA helicase DDX3X/DED1 cause specific defects in translation.
Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33.
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
Megalencephaly
A de novo variant of CHD8 in a patient with autism spectrum disorder.
Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.
Chromatin Remodeler CHD8 in Autism and Brain Development.
Melanoma
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome.
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-?.
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5.
Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Anti-cancer function of polyinosinic-polycytidylic acid.
Anti-pyroptotic function of TGF-? is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.
Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects.
Apoptosis induced by synthetic retinoic acid CD437 on human melanoma A375 cells involves RIG-I pathway.
Astrogliosis involves activation of retinoic acid-inducible gene-like signaling in the innate immune response after spinal cord injury.
Cardiac-specific overexpression of melanoma differentiation-associated gene-5 protects mice from lethal viral myocarditis.
Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus.
Clinically amyopathic dermatomyositis.
Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi-Goutières Syndrome and Singleton-Merten Syndrome.
Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection.
Critical role of MDA5 in the interferon response induced by human metapneumovirus infection in dendritic cells and in vivo.
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease.
Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells.
Cytoplasmic nucleic acid sensors in antiviral immunity.
Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
Defining the functional determinants for RNA surveillance by RIG-I.
Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity towards autologous melanoma cells.
Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-?-induced apoptosis in tumor-repopulating cells of melanoma.
Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors.
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Enteroviral pathogenesis of type 1 diabetes: queries and answers.
Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.
Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss).
Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7.
Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense.
Functional RIG-I-like receptors control the survival of mesenchymal stem cells.
Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2.
Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III IFN gene expression.
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS.
Inflammatory chemokine expression via Toll-like receptor 3 signaling in normal human mesangial cells.
Influenza A Virus PA Antagonizes Interferon-? by Interacting with Interferon Regulatory Factor 3.
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance.
Innate sensing of viruses by pattern recognition receptors in birds.
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.
Interaction between Interferon-Stimulated Gene 56 and Melanoma Differentiation-Associated Gene 5 in Toll-Like Receptor 3 Signaling in Normal Human Mesangial Cells.
KAP1-Mediated Epigenetic Suppression in Anti-RNA Viral Responses by Direct Targeting RIG-I and MDA5.
Knockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc.
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes.
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.
MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.
Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-?-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.
Melanoma Differentiation-Associated Gene 5 Regulates the Expression of a Chemokine CXCL10 in Human Mesangial Cells: Implications for Chronic Inflammatory Renal Diseases.
Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling.
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
Negative regulation of cytoplasmic RNA-mediated antiviral signaling.
Oligomerization of RIG-I and MDA5 2CARD domains.
Oncostatin M induces RIG-I and MDA5 expression and enhances the double-stranded RNA response in fibroblasts.
Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells.
Pigeon RIG-I Function in Innate Immunity against H9N2 IAV and IBDV.
Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors.
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome.
Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: a potential serum biomarker for melanoma metastasis.
Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation.
Reduced expression of the MDA5 gene IFIH1 prevents autoimmune diabetes.
Regulation of antiviral innate immune signaling by stress-induced RNA granules.
Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors.
RIG-I activation induces the release of extracellular vesicles with antitumor activity.
RIG-I activation is critical for responsiveness to checkpoint blockade.
RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1.
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis.
Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.
Sensing Adenovirus infection: activation of IRF3 in RAW264.7 cells.
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells.
Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines.
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy.
The antiviral signaling mediated by black carp MDA5 is positively regulated by LGP2.
The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas.
The E3 Ubiquitin Ligase TRIM40 Attenuates Antiviral Immune Responses by Targeting MDA5 and RIG-I.
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1.
The laboratory of genetics and physiology 2: emerging insights into the controversial functions of this RIG-I-like receptor.
The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
TRIM25 in the Regulation of the Antiviral Innate Immunity.
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response.
Utility of the RIG-I agonist triphosphate RNA for melanoma therapy.
Viral RNA detection by RIG-I-like receptors.
West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5.
ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling.
Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.
[DDX10 promotes AIM2-inflammasome activation by maintaining AIM2 protein stability].
Meningeal Neoplasms
Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray.
Meningioma
Applying DDX3X Biomarker to Discriminate Atypical from Benign Meningiomas in Tissue Microarray.
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.
Meningitis
Comparison of real-time florescence quantitative PCR measurements of VAD1 mRNA with three conventional methods in diagnosis and follow-up treatment of Cryptococcus neoformans infection.
The effect of the expression of virulence-associated DEAD-box RNA helicase mRNA on the imbalance of Th1-Th2 cytokines in the CSF of patients with Cryptococcus neoformans meningitis.
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Mental Retardation, X-Linked
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons.
Mesothelioma
Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas.
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Mesothelioma, Malignant
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Microcephaly
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Mitochondrial Diseases
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Mitochondrial Myopathies
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Motor Neuron Disease
Senataxin, A Novel Helicase at the Interface of RNA Transcriptome Regulation and Neurobiology: From Normal Function to Pathological Roles in Motor Neuron Disease and Cerebellar Degeneration.
Mouth Neoplasms
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
Movement Disorders
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Multiple Myeloma
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Multiple Sclerosis
Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies.
Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1.
Mumps
A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2.
Muscle Cramp
Mast cell phenotypic plasticity and their activity under the influence of cathelicidin-related antimicrobial peptide (CRAMP) and IL-33 alarmins.
Muscle Hypotonia
A de novo DDX3X Variant Is Associated With Syndromic Intellectual Disability: Case Report and Literature Review.
De novo DDX3X missense variants in males appear viable and contribute to syndromic intellectual disability.
Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling.
Muscular Atrophy
Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation.
Muscular Atrophy, Spinal
Biochemical and genetic evidence for a role of IGHMBP2 in the translational machinery.
Clinical diversity caused by novel IGHMBP2 variants.
Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ.
Muscular Diseases
Mild ocular myopathy associated with a novel mutation in mitochondrial twinkle helicase.
Muscular Dystrophies
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Musculoskeletal Pain
Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3.
Myasthenic Syndromes, Congenital
A spontaneous missense mutation in the chromodomain helicase DNA-binding protein 8 (CHD8) gene: a novel association with congenital myasthenic syndrome.
Mycoses
Evaluation of Reference Genes for Reverse Transcription Quantitative PCR Studies of Physiological Responses in the Ghost Moth, Thitarodes armoricanus (Lepidoptera, Hepialidae).
Myelodysplastic Syndromes
Erratum for Fusion of the Nucleoporin Gene, NUP98, and the Putative RNA Helicase Gene, DZXX10, by Inversion 11 (p15q22) Chromosome Translocation in a Patient with Etoposide-related Myelodysplastic Syndrome.
Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.
Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in Caenorhabditis elegans.
Myeloproliferative Disorders
RIG-I plays a critical role in negatively regulating granulocytic proliferation.
Myocardial Infarction
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population.
Myocarditis
Inhibition of RNA Helicase Activity Prevents Coxsackievirus B3-Induced Myocarditis in Human iPS Cardiomyocytes.
Myoclonic Epilepsy, Juvenile
Juvenile myoclonic epilepsy mimic associated with CHD2 gene mutation.
Myositis
Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease.
Myositis specific autoantibodies.
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
[Expression of retinoic acid-I nducible gene I in the muscle tissues of idiopathic inflammatory myopathies].
Myositis, Inclusion Body
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Myotonic Dystrophy
Reduction of toxic RNAs in myotonic dystrophies type 1 and type 2 by the RNA helicase p68/DDX5.
Myxoma
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells.
Nasopharyngeal Carcinoma
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver.
Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
RIG-I promotes IFN/JAK2 expression and the endoplasmic reticulum stress response to inhibit chemoradiation resistance in nasopharyngeal carcinoma.
Tumour inflammasome-derived IL-1? recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma.
Neoplasm Metastasis
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.
DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG.
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
DEAD-Box Helicase 3 X-Linked Promotes Metastasis by Inducing Epithelial-Mesenchymal Transition via p62/Sequestosome-1.
Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability.
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
eIF4F suppression in breast cancer affects maintenance and progression.
Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.
Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer.
Helicase antigen (HAGE)-derived vaccines induce immunity to HAGE and ImmunoBody®-HAGE DNA vaccine delays the growth and metastasis of HAGE-expressing tumors in vivo.
Identification of Prognostic and Metastatic Alternative Splicing Signatures in Kidney Renal Clear Cell Carcinoma.
Interaction between p68 RNA helicase and Ca2+-calmodulin promotes cell migration and metastasis.
Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia.
Mitochondria Autoimmunity and MNRR1 in Breast Carcinogenesis: A Review.
Molecular testing in metastatic basal cell carcinoma.
Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Quantitative measurement of circulating lymphoid-specific helicase (HELLS) gene transcript: a potential serum biomarker for melanoma metastasis.
RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer.
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
SMARCAD1 in Breast Cancer Progression.
SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis.
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
The prognostic effect of DDX3 upregulation in distant breast cancer metastases.
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Neoplasms
(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma.
A computational analysis of ATP binding of SV40 large tumor antigen helicase motor.
A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines.
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
A double on the Rocs with a twist: Rocaglamide A targets multiple DEAD-box helicases to inhibit translation initiation.
A double-negative feedback loop between DEAD-box protein DDX21 and Snail regulates epithelial-mesenchymal transition and metastasis in breast cancer.
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types.
A Genomewide Screen for Suppressors of Alu-Mediated Rearrangements Reveals a Role for PIF1.
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance.
A role for WRN in telomere-based DNA damage responses.
A specific docking site for DNA polymerase {alpha}-primase on the SV40 helicase is required for viral primosome activity, but helicase activity is dispensable.
Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases.
Activation of RIG-I signaling to increase the pro-inflammatory phenotype of a tumor.
AML-specific cytotoxic antibodies in patients with durable graft-versus-leukemia responses.
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
An essential role of alternative splicing of c-myc suppressor FUSE-binding protein-interacting repressor in carcinogenesis.
An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA.
An Integrative Approach Identified Genes Associated with Drug Response in Gastric Cancer.
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation.
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Analysis of the RNA helicase p68 (Ddx5) as a transcriptional regulator.
Aneuploidy and improved growth are coincident but not causal in a yeast cancer model.
Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs.
Anti-pyroptotic function of TGF-? is suppressed by a synthetic dsRNA analogue in triple negative breast cancer cells.
Anticancer activity of RecQL1 helicase siRNA in mouse xenograft models.
Application of dsRNA in cancer immunotherapy: current status and future trends.
Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.
Association of the chromodomain helicase DNA-binding protein 4 (CHD4) missense variation p.D140E with cancer: potential interaction with smoking.
Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma.
Atm is a negative regulator of intestinal neoplasia.
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
BACH1 is a DNA repair protein supporting BRCA1 damage response.
Bargain with the tooth fairy - The savings accounts for dental stem cells.
Being Small and Intronic: miRNAs That Count!
Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer.
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells.
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.
BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex.
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
BRIP-1 germline mutation and its role in colon cancer: presentation of two case reports and review of literature.
c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy.
Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation.
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein.
Canine keratinocytes upregulate type I interferons and proinflammatory cytokines in response to poly(dA:dT) but not to canine papillomavirus.
Cell-type-specific innate immune response to oncolytic newcastle disease virus.
Cellular studies of MrDb (DDX18).
Central role of interferon regulatory factor-1 (IRF-1) in controlling retinoic acid inducible gene-I (RIG-I) expression.
Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1.
Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes.
CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A.
CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma.
CHD5 is a tumor suppressor at human 1p36.
CHD5 is down-regulated through promoter hypermethylation in gastric cancer.
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
CHD5, a tumor suppressor that is epigenetically silenced in lung cancer.
Chromatin remodeling factor LSH affects fumarate hydratase as a cancer driver.
Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.
Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis.
Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer.
Chromodomain Helicase DNA-Binding Protein 5 Inhibits Renal Cell Carcinoma Tumorigenesis by Activation of the p53 and RB Pathways.
Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction.
circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.
CircDDX42 Accelerates the Development of Pancreatic Cancer via miR-613/ID4/PI3K/AKT Axis.
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.
Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor.
Clinical significance of chromatin remodeling factor CHD5 expression in gastric cancer.
Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Conformational rearrangements of SV40 large T antigen during early replication events.
Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.
CRISPR Screens Single Out WRN.
Crystal structure of the eIF4A-PDCD4 complex.
Cysteine-rich 61-associated gene expression profile alterations in human glioma cells.
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
Cytokine-independent upregulation of MDA5 in viral infection.
Cytoplasmic DDX3 as prognosticator in male breast cancer.
DDX17 promotes hepatocellular carcinoma progression via inhibiting Klf4 transcriptional activity.
DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG.
DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor.
DDX39, Upregulated in Lung Squamous Cell Cancer, Displays RNA Helicase Activities and Promotes Cancer Cell Growth.
DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations.
DDX3X is Epigenetically Repressed in Renal Cell Carcinoma and Serves as a Prognostic Indicator and Therapeutic Target in Cancer Progression.
DDX3X Multifunctionally Modulates Tumor Progression and Serves as a Prognostic Indicator to Predict Cancer Outcomes.
DDX3X promotes the biogenesis of a subset of miRNAs and the potential roles they played in cancer development.
DDX3X RNA helicase affects breast cancer cell cycle progression by regulating expression of KLF4.
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma.
DDX3X: structure, physiologic functions and cancer.
DDX41 regulates the expression and alternative splicing of genes involved in tumorigenesis and immune response.
DDX5 promotes gastric cancer cell proliferation in vitro and in vivo through mTOR signaling pathway.
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
DDX5 promotes proliferation and tumorigenesis of non-small-cell lung cancer cells by activating ?-catenin signaling pathway.
DDX54 Plays a Cancerous Role Through Activating P65 and AKT Signaling Pathway in Colorectal Cancer.
De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms.
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
DEAD box RNA helicase functions in cancer.
DEAD-box helicase 27 enhances stem cell-like properties with poor prognosis in breast cancer.
DEAD-box helicase 27 plays a tumor-promoter role by regulating the stem cell-like activity of human colorectal cancer cells.
DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.
DEAD-Box Helicase 4 (Ddx4)+ Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.
DEAD-box helicase DP103 defines metastatic potential of human breast cancers.
DEAD-box proteins, like Leishmania eIF4A, modulate interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production by human monocytes.
DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis.
DEAD-box RNA helicase protein DDX21 as a prognosis marker for early stage colorectal cancer with microsatellite instability.
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells.
Decreased expression of chromodomain helicase DNA-binding protein 5 is an unfavorable prognostic marker in patients with primary gallbladder carcinoma.
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Decreased expression of the CHD5 gene and its clinicopathological significance in breast cancer: Correlation with aberrant DNA methylation.
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Delivery of 5'-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy.
Design, synthesis, in vitro and in vivo anti-respiratory syncytial virus (RSV) activity of novel oxizine fused benzimidazole derivatives.
DHX33 Interacts with AP-2? To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival.
DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription.
DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration.
Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity towards autologous melanoma cells.
Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors.
DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss.
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
DNA helicases and their roles in cancer.
DNA helicases as targets for anti-cancer drugs.
DNA helicases associated with genetic instability, cancer, and aging.
DNA helicases involved in DNA repair and their roles in cancer.
DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism.
DNA repair gene expression level in peripheral blood and tumour tissue from non-small cell lung cancer and head and neck squamous cell cancer patients.
DNA repair helicases as targets for anti-cancer therapy.
DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease.
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Downregulation of p68 RNA Helicase (DDX5) Activates a Survival Pathway Involving mTOR and MDM2 Signals.
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor.
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A.
Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle.
eIF4A alleviates the translational repression mediated by classical secondary structures more than by G-quadruplexes.
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
eIF4A inhibitors suppress cell cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer.
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Endogenous Retroelement Activation by Epigenetic Therapy Reverses the Warburg Effect and Elicits Mitochondrial-Mediated Cancer Cell Death.
Enhanced tumor formation in mice heterozygous for Blm mutation.
Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs.
Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs.
Epigenome-wide data collection in a case of gliofibroma.
Epstein-Barr virus-encoded circular RNA circBART2.2 promotes immune escape of nasopharyngeal carcinoma by regulating PD-L1.
Escherichia coli replication terminator protein impedes simian virus 40 (SV40) DNA replication fork movement and SV40 large tumor antigen helicase activity in vitro at a prokaryotic terminus sequence.
Eukaryotic initiation factor 4F: a vulnerability of tumor cells.
Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation.
Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer.
Expression of CHD5 may serve as an independent biomarker of prognosis in colorectal cancer via immunohistochemical staining.
Expression of minichromosome maintenance 8 in chronic myelogenous leukemia.
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
FGFR1-Activated Translation of WNT Pathway Components with Structured 5' UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation.
Forced Expression of miR-143 Represses ERK5/c-Myc and p68/p72 Signaling in Concert with miR-145 in Gut Tumors of Apc(Min) Mice.
Frequent Mutations in Natural Killer/T Cell Lymphoma.
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes.
Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies.
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.
Global analysis of metastasis-associated gene expression in primary cultures from clinical specimens of clear-cell renal-cell carcinoma.
Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades.
Harnessing RIG-I and intrinsic immunity in the tumor microenvironment for therapeutic cancer treatment.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Helicase antigen (HAGE)-derived vaccines induce immunity to HAGE and ImmunoBody®-HAGE DNA vaccine delays the growth and metastasis of HAGE-expressing tumors in vivo.
Helicases as antiviral and anticancer drug targets.
Helicases as prospective targets for anti-cancer therapy.
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
High expression of ALDOA and DDX5 are associated with poor prognosis in human colorectal cancer.
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.
Host-Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis.
Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity.
Human Cancer Cells Sense Cytosolic Nucleic Acids Through the RIG-I-MAVS Pathway and cGAS-STING Pathway.
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3.
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes.
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster.
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
Identification of candidate targets for the diagnosis and treatment of atherosclerosis by bioinformatics analysis.
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Identification of genes associated with tumorigenesis of meibomian cell carcinoma by microarray analysis.
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen.
Immune- and miRNA-response to recombinant interferon beta-1a: a biomarker evaluation study to guide the development of novel type I interferon- based therapies.
Implementing combinatorial immunotherapeutic regimens against cancer: The concept of immunological conditioning.
Importance of retinoic acid-inducible gene I and of receptor for type I interferon for cellular resistance to infection by Newcastle disease virus.
Increased error-prone non homologous DNA end-joining--a proposed mechanism of chromosomal instability in Bloom's syndrome.
Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation.
Induction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicase.
Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.
Inhibitors of translation initiation as cancer therapeutics.
Innate RIG-I signaling restores antigen presentation in tumors and overcomes T cell resistance.
Insights into the oligomeric states, conformational changes, and helicase activities of SV40 large tumor antigen.
Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma.
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.
Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.
Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.
Involvement of Schizosaccharomyces pombe Srs2 in cellular responses to DNA damage.
Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer.
Knockdown of DDX46 Inhibits the Invasion and Tumorigenesis in Osteosarcoma Cells.
Knockdown of DDX46 inhibits trophoblast cell proliferation and migration through the PI3K/Akt/mTOR signaling pathway in preeclampsia.
Knockdown of DDX46 suppresses the proliferation and invasion of gastric cancer through inactivating Akt/GSK-3?/?-catenin pathway.
Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells.
Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo.
Known Inhibitors of RNA Helicases and Their Therapeutic Potential.
Label-Free Semiquantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics Analysis of Laryngeal/Hypopharyngeal Squamous Cell Carcinoma on Formalin-Fixed, Paraffin-Embedded Tissue Samples - a Pilot Study.
Landscape of BRIP1 molecular lesions in gastrointestinal cancers from published genomic studies.
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
Level of Murine DDX3 RNA Helicase Determines Phenotype Changes of Hepatocytes In Vitro and In Vivo.
LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.
Lymphoid-specific helicase in epigenetics, DNA repair and cancer.
Lymphoid-specific helicase promotes the growth and invasion of hepatocellular carcinoma by transcriptional regulation of centromere protein F expression.
Malignant and nonmalignant brain tissues differ in their messenger RNA expression patterns for ERCC1 and ERCC2.
Mammalian DNA topoisomerase I activity and poisoning by camptothecin are inhibited by simian virus 40 large T antigen.
MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.
Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.
Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen.
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.
Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation.
MicroRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.
Modulation of the expression of bloom helicase by estrogenic agents.
Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Molecular pathogenesis of Fanconi anemia: recent progress.
Molecular testing in metastatic basal cell carcinoma.
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells.
Morphine may act via DDX49 to inhibit hepatocellular carcinoma cell growth.
Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17).
Multiple genes identified as targets for 20q13.12-13.33 gain contributing to unfavorable clinical outcomes in patients with hepatocellular carcinoma.
Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5.
Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer.
Mutation screening of CHD5 in melanoma-prone families linked to 1p36 revealed no deleterious coding or splice site changes.
Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.
MYC-driven tumorigenesis is inhibited by WRN syndrome gene deficiency.
NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer.
NanoLC-MS coupling of liquid microjunction microextraction for on-tissue proteomic analysis.
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathway.
New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.
Next-Generation Sequencing of DDX41 in Myeloid Neoplasms Leads to Increased Detection of Germline Alterations.
Novel blood biomarkers of human urinary bladder cancer.
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy.
Nucleic Acid Sensing Machinery: Targeting Innate Immune System for Cancer Therapy.
OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis.
Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer.
Optimization of Potent Hepatitis C Virus NS3 Helicase Inhibitors Isolated from the Yellow Dyes Thioflavine S and Primuline.
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis.
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
P68 RNA helicase as a molecular target for cancer therapy.
p97 Promotes a Conserved Mechanism of Helicase Unloading During DNA Crosslink Repair.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Patient gender is associated with distinct patterns of chromosomal abnormalities and sex chromosome linked gene-expression profiles in meningiomas.
PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Pharmacokinetic Characterization of Supinoxin and Its Physiologically Based Pharmacokinetic Modeling in Rats.
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Phosphorylation-dependent interactions of BLM and 53BP1 are required for their anti-recombinogenic roles during homologous recombination.
Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation.
Pif1 helicase and Pol? promote recombination-coupled DNA synthesis via bubble migration.
Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.
Premature aging and predisposition to cancers caused by mutations in RecQ family helicases.
Prevalence of RECQL germline variants in Pakistani early-onset and familial breast cancer patients.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells.
Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.
Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin.
Proteomic Analysis of Zeb1 Interactome in Breast Carcinoma Cells.
Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents.
Radiation Induced Upregulation of DNA Sensing Pathways is Cell-Type Dependent and Can Mediate the Off-Target Effects.
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling.
RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions.
RecQ DNA Helicase Rqh1 Promotes Rad3ATR Kinase Signaling in the DNA Replication Checkpoint Pathway of Fission Yeast.
RECQ1 Helicase in Genomic Stability and Cancer.
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
RecQL1 DNA repair helicase: A potential tumor marker and therapeutic target against hepatocellular carcinoma.
RECQL4 helicase has oncogenic potential in sporadic breast cancers.
RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Regulation of MCM2-7 function.
Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features.
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1.
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.
RIG-I activation is critical for responsiveness to checkpoint blockade.
RIG-I Is a Tumor Suppressor and Biomarker of IFN-? Efficacy in HCC.
RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-?B Pathway.
RIG-I promotes IFN/JAK2 expression and the endoplasmic reticulum stress response to inhibit chemoradiation resistance in nasopharyngeal carcinoma.
RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation.
RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMP9.
RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade.
RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
RIG-I: a multifunctional protein beyond a pattern recognition receptor.
RIG-like Helicase Regulation of Chitinase 3-like 1 Axis and Pulmonary Metastasis.
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells.
RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells.
RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune Signaling.
RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation.
RNA helicase DHX15 acts as a tumour suppressor in glioma.
RNA helicase DP103 and TAK1: a new connection in cancer.
RNA helicase p68 deploys ?-catenin in regulating RelA/p65 gene expression: implications in colon cancer.
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1? mRNA is translated.
RNA helicases in infection and disease.
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
Role of SIRT1 in homologous recombination.
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Roles of DNA helicases in the maintenance of genome integrity.
Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.
Sequence determination of the Crimean-Congo hemorrhagic fever virus L segment.
Sequence independent duplex DNA opening reaction catalysed by SV40 large tumor antigen.
Serpin-derived peptides are antiangiogenic and suppress breast tumor xenograft growth.
Silencing of CHD5 gene by promoter methylation in leukemia.
Silencing of p68 and STAT3 synergistically diminishes cancer progression.
Simulating the electrostatic guidance of the vectorial translocations in hexameric helicases and translocases.
SLFN11 expression in advanced prostate cancer and response to platinum-based chemotherapy.
SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.
Small-molecule inhibitors targeting eIF4A in leukemia.
SNF2 histone linker PHD RING helicase related Has_circ_0001649 as a diagnostic and prognostic biomarker in solid cancer: A PRISMA-compliant meta-analysis based on the Chinese population.
Spleen cells from young but not old immunized mice eradicate large established cancers.
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
Stopping trouble before it starts.
Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
Structural basis for translational inhibition by the tumour suppressor Pdcd4.
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Structural characterization of ?-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation.
Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists.
Structure and expression of the human p68 RNA helicase gene.
Structure and function of DEAH-box helicase 32 and its role in cancer.
Structure of Rad5 provides insights into its role in tolerance to replication stress.
Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A.
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen.
Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein.
Structure of the tandem MA-3 region of Pdcd4 and characterisation of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumour suppressor.
Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts.
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway.
Susceptibility of polar cod (Boreogadus saida) to a model carcinogen.
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
Synergistic effects of eIF4A and MEK inhibitors on proliferation of NRAS-mutant melanoma cell lines.
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Systematic Analysis of Intronic miRNAs Reveals Cooperativity within the Multicomponent FTX Locus to Promote Colon Cancer Development.
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells.
Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA.
Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Targeting MYC Translation in Colorectal Cancer.
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.
Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein.
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy.
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
Targeting Translation of mRNA as a Therapeutic Strategy in Cancer.
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.
The anticancer functions of RIG-I-like receptors, RIG-I and MDA5, and their applications in cancer therapy.
The Bloom's syndrome helicase: keeping cancer at bay.
The chase for the RIG-I ligand--recent advances.
The chromodomain helicase CHD4 regulates ERBB2 signaling pathway and autophagy in ERBB2+ breast cancer cells.
The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer.
The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties.
The dark side of RNA:DNA hybrids.
The DDX5/Dbp2 subfamily of DEAD-box RNA helicases.
The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.
The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.
The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells.
The DNA fibre technique - tracking helicases at work.
The DNA2 nuclease/helicase is an estrogen-dependent gene mutated in breast and ovarian cancers.
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy.
The enigmatic helicase DHX9 and its association with the hallmarks of cancer.
The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.
The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas.
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
The G4 Resolvase DHX36 Possesses a Prognosis Significance and Exerts Tumour Suppressing Function Through Multiple Causal Regulations in Non-Small Cell Lung Cancer.
The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation In Vivo.
The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1.
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.
The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
The Innate Immune Signalling Pathways: Turning RIG-I Sensor Activation Against Cancer.
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
The involvement of CHD5 hypermethylation in laryngeal squamous cell carcinoma.
The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape.
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest.
The multifaceted functions of RNA helicases in the adaptive cellular response to hypoxia: From mechanisms to therapeutics.
The Multiple Facets of ATRX Protein.
The natural compound silvestrol is a potent inhibitor of Ebola virus replication.
The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.
The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.
The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3? and decreasing the expression of cyclinD1.
The prognostic effect of DDX3 upregulation in distant breast cancer metastases.
The Promoter-Associated Noncoding RNA pncCCND1_B Assembles a Protein-RNA Complex to Regulate Cyclin D1 Transcription in Ewing Sarcoma.
The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.
The quest for the 1p36 tumor suppressor.
The Regulation of Homologous Recombination by Helicases.
The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.
The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.
The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers.
The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I.
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype.
The Role of LncRNAs in Translation.
The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness.
The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma.
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
The Significance of Circular RNA DDX17 in Prostate Cancer.
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
The Tumor Suppressor Chromodomain Helicase DNA-binding Protein 5 (CHD5) Remodels Nucleosomes by Unwrapping.
The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma.
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
Three de novo DDX3X variants associated with distinctive brain developmental abnormalities and brain tumor in intellectually disabled females.
TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection.
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma.
Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence.
Tumor cell survival dependence on the DHX9 DExH-box helicase.
Tumor cell-intrinsic RIG-I signaling governs synergistic effects of immunogenic cancer therapies and checkpoint inhibitors in mice.
Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.
Tumor Necrosis Factor Alpha Enhances Influenza A Virus-Induced Expression of Antiviral Cytokines by Activating RIG-I Gene Expression.
Tumor Necrosis Factor-?-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
Tumor suppressor activity of RIG-I.
Tumor suppressor p53 represses transcription of RECQ4 helicase.
Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.
Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.
Tumour inflammasome-derived IL-1? recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma.
Unwinding the mechanisms of a DEAD-box RNA helicase in cancer.
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Up-regulation of TLK1B by eIF4E overexpression predicts cancer recurrence in irradiated patients with breast cancer.
Upregulation of DEAD box helicase 5 and 17 are correlated with the progression and poor prognosis in gliomas.
Utility of the RIG-I agonist triphosphate RNA for melanoma therapy.
Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour.
VEGFR-2 kinase domain inhibition as a scaffold for anti-angiogenesis: Validation of the anti-angiogenic effects of carotenoids from Spondias mombin in DMBA model of breast carcinoma in Wistar rats.
Virtual liver resection and volumetric analysis of the future liver remnant using open source image processing software.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Wnt/?-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-?B-dependent innate immune response.
WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
[Damage-associated molecular patterns and chronic diseases]
[DNA helicases and human diseases]
[Preparation of the gene targeted knockout mice for human premature aging diseases, Werner syndrome, and Rothmund-Thomson syndrome caused by the mutation of DNA helicases]
Neoplasms, Germ Cell and Embryonal
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Neoplasms, Squamous Cell
DDX39, Upregulated in Lung Squamous Cell Cancer, Displays RNA Helicase Activities and Promotes Cancer Cell Growth.
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Nervous System Diseases
RNA helicases in infection and disease.
Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations.
SETX sumoylation: A link between DNA damage and RNA surveillance disrupted in AOA2.
Neurilemmoma
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor.
Neuroblastoma
Amplification of a DEAD box gene (DDX1) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus.
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans.
EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma.
Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.
MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma.
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Small non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.
The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.
The tumor suppressor Chd5 is induced during neuronal differentiation in the developing mouse brain.
The tumour suppressor CHD5 forms a NuRD-type chromatin remodelling complex.
Two microRNAs encoded within the bovine herpesvirus 1 latency-related gene promote cell survival by interacting with RIG-I and stimulating NF-?B-dependent transcription and beta interferon signaling pathways.
Neurodegenerative Diseases
Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis.
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Translation termination depends on the sequential ribosomal entry of eRF1 and eRF3.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibrosarcoma
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor.
Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.
Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.
Neuronal Ceroid-Lipofuscinoses
The visual assignment of genes by fiber-fish: BTF3 protein homologue gene (BTF3) and a novel pseudogene of human RNA helicase A (DDX9P) on 13q22.
Newcastle Disease
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Antiviral response dictated by choreographed cascade of transcription factors.
Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus.
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1.
Signaling through RIG-I and type I interferon receptor: Immune activation by Newcastle disease virus in man versus immune evasion by Ebola virus (Review).
The rinderpest virus non-structural C protein blocks the induction of type 1 interferon.
Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
Validation of efficient high-throughput plasmid and siRNA transfection of human monocyte-derived dendritic cells without cell maturation.
Non-alcoholic Fatty Liver Disease
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death.
Obesity
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Oligospermia
Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation.
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
Ophthalmoplegia, Chronic Progressive External
A novel variation in the Twinkle linker region causing late-onset dementia.
Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells.
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations.
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Orchitis
CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways.
Orofaciodigital Syndromes
Confirmation that mutations in DDX59 cause an autosomal recessive form of oral-facial-digital syndrome: Further delineation of the DDX59 phenotype in two new families.
Copy Number Variations of Four Y-Linked Genes in Swamp Buffaloes.
Mutations in DDX59 Implicate RNA Helicase in the Pathogenesis of Orofaciodigital Syndrome.
Orthomyxoviridae Infections
The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages.
Osteoarthritis
Identification of
Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes.
Osteosarcoma
Anti-oncogene product p53 binds DNA helicase.
DEAD-Box Helicase 5 Interacts With Transcription Factor 12 and Promotes the Progression of Osteosarcoma by Stimulating Cell Cycle Progression.
Green fluorescent protein tag for studies of drug-induced translocation of nucleolar protein RH-II/Gu.
Identification of Prognostic RBPs in Osteosarcoma.
Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma.
Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis.
Retraction: DEAD-Box Helicase 5 Interacts With Transcription Factor 12 and Promotes the Progression of Osteosarcoma by Stimulating Cell Cycle Progression.
Rothmund-Thomson Syndrome: Insights from New Patients on the Genetic Variability Underpinning Clinical Presentation and Cancer Outcome.
Otitis Media
TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion.
Otitis Media with Effusion
TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion.
Ovarian Neoplasms
A surface topography assisted droplet manipulation platform for biomarker detection and pathogen identification.
circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade.
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
DEAD-Box Helicase 4 (Ddx4)+ Stem Cells Sustain Tumor Progression in Non-Serous Ovarian Cancers.
FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks.
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
Inhibition of poly(ADP-ribose) polymerase induces synthetic lethality in BRIP1 deficient ovarian epithelial cells.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells.
Rare BRIP1 Missense Alleles Confer Risk for Ovarian and Breast Cancer.
RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer.
Screening of HELQ in breast and ovarian cancer families.
Structure-function analysis of DNA helicase HELQ: A new diagnostic marker in ovarian cancer.
Targeted activation of RNA helicase retinoic acid-inducible gene-I induces proimmunogenic apoptosis of human ovarian cancer cells.
Vitamin D and DDX4 regulate the proliferation and invasion of ovarian cancer cells.
Pancreatic Neoplasms
eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer.
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer.
Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer.
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-?1 Silencing with RIG-I Activation in Pancreatic Cancer.
TRIM29 alters bioenergetics of pancreatic cancer cells via cooperation of miR-2355-3p and DDX3X recruitment to AK4 transcript.
Pancreatitis
Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data.
Papilloma
The bovine papilloma virus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells.
Papillomavirus Infections
HPV18 E1 Protein Plus ?-Galactosylceramide Elicit in Mice CD8+ T Cell Cross-Reactivity Against Cells Expressing E1 from Diverse Human Papillomavirus Types.
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
Vaccination with human papillomavirus-18 E1 protein plus ?-galactosyl-ceramide induces CD8+ cytotoxic response and impairs the growth of E1-expressing tumors.
Paralysis
Coupling of Translation Initiation and Termination Does Not Depend on the Mode of Initiation.
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Paramyxoviridae Infections
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity.
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
TLR3-dependent upregulation of RIG-I leads to enhanced cytokine production from cells infected with the parainfluenza virus SV5.
Paraplegia
A novel pathogenic variant p.Asp797Val in IFIH1 in a Japanese boy with overlapping Singleton-Merten syndrome and Aicardi-Goutières syndrome.
Parkinsonian Disorders
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Persistent Infection
Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.
Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.
IRF-3 activation by sendai virus infection is required for cellular apoptosis and avoidance of persistence.
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
Modulation of the cellular distribution of human cytomegalovirus helicase by cellular factor snapin.
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Peste-des-Petits-Ruminants
Caprine MAVS Is a RIG-I Interacting Type I Interferon Inducer Downregulated by Peste des Petits Ruminants Virus Infection.
Peste des petits ruminants virus non-structural C protein inhibits the induction of interferon-? by potentially interacting with MAVS and RIG-I.
Phlebotomus Fever
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Picornaviridae Infections
RIG-I is cleaved during picornavirus infection.
The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection.
Plague
Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague.
Plant Diseases
Elicitor-mediated oligomerization of the tobacco N disease resistance protein.
Pneumonia
DeaD contributes to Pseudomonas aeruginosa virulence in a mouse acute pneumonia model.
RIG-I Signaling via MAVS Is Dispensable for Survival in Lethal Influenza Infection In Vivo.
Poliomyelitis
Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides.
Polycystic Kidney, Autosomal Dominant
RNA helicase p68 inhibits the transcription and post-transcription of Pkd1 in ADPKD.
Polymicrogyria
Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.
Polymyositis
Interferon-induced helicase (IFIH1) polymorphism with systemic lupus erythematosus and dermatomyositis/polymyositis.
RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis.
Porcine Reproductive and Respiratory Syndrome
Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.
An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13.
Application of dsRNA in cancer immunotherapy: current status and future trends.
ATP-dependent effector-like functions of RIG-I-like receptors.
Cross-Talk between Human Dendritic Cell Subsets Influences Expression of RNA Sensors and Inhibits Picornavirus Infection.
Differential interferon system gene expression profiles in susceptible and resistant gynogenetic clones of gibel carp challenged with herpesvirus CaHV.
Enhanced expression of IFI16 and RIG-I in human third-trimester placentas following HSV-1 infection.
Expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with HBV and HCV.
Functional properties of the predicted helicase of porcine reproductive and respiratory syndrome virus.
Helicase of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Strain HV Reveals a Unique Structure.
Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.
Identification of an Intramolecular Switch That Controls the Interaction of Helicase nsp10 with Membrane-Associated nsp12 of Porcine Reproductive and Respiratory Syndrome Virus.
Identification of the RNA Pseudoknot within the 3' End of the Porcine Reproductive and Respiratory Syndrome Virus Genome as a Pathogen-Associated Molecular Pattern To Activate Antiviral Signaling via RIG-I and Toll-Like Receptor 3.
Identification of the strain-specifically truncated nonstructural protein 10 of porcine reproductive and respiratory syndrome virus in infected cells.
IFN? Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I.
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8? T cell responses to influenza A virus.
Induction of IFN-? through TLR-3- and RIG-I-Mediated Signaling Pathways in Canine Respiratory Epithelial Cells Infected with H3N2 Canine Influenza Virus.
Involvement of Innate Immune Receptors in the Resolution of Acute Hepatitis B in Woodchucks.
Matrix metalloproteinase-13 expression in response to double-stranded RNA in human chondrocytes.
Molecular cloning, functional characterization and antiviral activity of porcine DDX3X.
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS.
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production.
Nucleic acid sensing pattern recognition receptors in the development of colorectal cancer and colitis.
Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination.
Parts, assembly and operation of the RIG-I family of motors.
Pattern Recognition Receptor Signaling and Innate Responses to Influenza A Viruses in the Mallard Duck, Compared to Humans and Chickens.
Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway.
Reading the viral signature by Toll-like receptors and other pattern recognition receptors.
Recognition of viruses by cytoplasmic sensors.
RNA sensors of the innate immune system and their detection of pathogens.
Role of Innate Immunity in Preeclampsia: A Systematic Review.
Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus.
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro.
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites.
TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro.
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons.
Visualisation of direct interaction of MDA5 and the dsRNA replicative intermediate form of positive strand RNA viruses.
Visualization of Double-Stranded RNA Colocalizing With Pattern Recognition Receptors in Arenavirus Infected Cells.
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of DHX32 in lymphoid tissues.
The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia.
Prehypertension
Coronary artery disease: AQUARIUS findings do not support the use of aliskiren in patients with CAD and prehypertension.
Effect of aliskiren on progression of coronary disease in patients with prehypertension: the AQUARIUS randomized clinical trial.
Primary Ovarian Insufficiency
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Progeria
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
No detectable mutations at Werner helicase locus in progeria.
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
Prostatic Neoplasms
Bloom helicase explicitly unwinds 3'-tailed G4DNA structure in prostate cancer cells.
CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.
CHD1 loss sensitizes prostate cancer to DNA damaging therapy by promoting error-prone double-strand break repair.
Construction of a lncRNA-PCG bipartite network and identification of cancer-related lncRNAs: a case study in prostate cancer.
Coupling transcription to RNA processing via the p68 DEAD box RNA helicase androgen receptor co-activator in prostate cancer.
DDX52 knockdown inhibits the growth of prostate cancer cells by regulating c-Myc signaling.
Does diabetes mellitus as a comorbid condition affect the health-related quality of life in prostate cancer survivors? Results of a population-based observational study Mols F, Aquarius AE, Essink-Bot ML, Aaronson NK, Kil PJ, van de Poll-Franse LV, CoRPS-Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg, The Netherlands.
Frequent disruption of chromodomain helicase DNA-binding protein 8 (CHD8) and functionally associated chromatin regulators in prostate cancer.
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Impact of abiraterone acetate plus prednisone or enzalutamide on fatigue and cognition in patients with metastatic castration-resistant prostate cancer: initial results from the observational AQUARiUS study.
Impact of Abiraterone Acetate plus Prednisone or Enzalutamide on Patient-reported Outcomes in Patients with Metastatic Castration-resistant Prostate Cancer: Final 12-mo Analysis from the Observational AQUARiUS Study.
Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.
Organ-specific regulation of CHD1 by acute PTEN and p53 loss in mice.
p68/DdX5 supports ?-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.
RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer.
RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively.
The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer.
The role of chromodomain helicase DNA binding protein 1 (CHD1) in promoting an invasive prostate cancer phenotype.
The Significance of Circular RNA DDX17 in Prostate Cancer.
Psoriasis
Candidate gene polymorphisms and risk of psoriasis: A pilot study.
Carriers of Rare Missense Variants in IFIH1 Are Protected from Psoriasis.
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis.
IFN-alpha enhances poly-IC responses in human keratinocytes by inducing expression of cytosolic innate RNA receptors: relevance for psoriasis.
Narrowband ultraviolet B inhibits innate cytosolic double-stranded RNA receptors in psoriatic skin and keratinocytes.
Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant.
RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.
SRSF1 Facilitates Cytosolic DNA-Induced Production of Type I Interferons Recognized by RIG-I.
Pulmonary Disease, Chronic Obstructive
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease.
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients.
BRIP1 rs10744996C>A variant increases the risk of chronic obstructive pulmonary disease in the Mongolian population of northern China.
Deficient pulmonary IFN-? expression in COPD patients.
Evaluation of Innate Immune Mediators Related to Respiratory Viruses in the Lung of Stable COPD Patients.
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway.
RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.
Small-Molecule Antagonists of the RIG-I Innate Immune Receptor.
Pulmonary Fibrosis
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.
Pythiosis
Differential diagnosis for pythiosis using thermophilic helicase DNA amplification and restriction fragment length polymorphism (tHDA-RFLP).
Rabies
Establishment of Myotis myotis cell lines--model for investigation of host-pathogen interaction in a natural host for emerging viruses.
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Respiratory Distress Syndrome
Identification of DDX58 and CXCL10 as Potential Biomarkers in Acute Respiratory Distress Syndrome.
Respiratory Insufficiency
RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.
Respiratory Syncytial Virus Infections
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Respiratory Tract Infections
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.
Retinal Diseases
Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200.
Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.
Retinitis
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome.
[Targeted sequencing identifies a hotspot mutation SNRNP200 p.S1087L correlates with novel phenotypes in retinitis pigmentosa].
Retinitis Pigmentosa
A Combined in silico, in vitro and Clinical Approach to Characterize Novel Pathogenic Missense Variants in PRPF31 in Retinitis Pigmentosa.
A novel missense SNRNP200 mutation associated with autosomal dominant retinitis pigmentosa in a Chinese family.
Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.
Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200.
Contribution of SNRNP200 sequence variations to retinitis pigmentosa.
Copy-number variation is an important contributor to the genetic causality of inherited retinal degenerations.
Genotype-Phenotype Analysis of a Novel Recessive and a Recurrent Dominant SNRNP200 Variant Causing Retinitis Pigmentosa.
Identification of a PRPF4 loss-of-function variant that abrogates U4/U6.U5 tri-snRNP integration and is associated with retinitis pigmentosa.
Mutation Analysis of Pre-mRNA Splicing Genes PRPF31, PRPF8, and SNRNP200 in Chinese Families with Autosomal Dominant Retinitis Pigmentosa.
Next generation sequencing of pooled samples reveals new SNRNP200 mutations associated with retinitis pigmentosa.
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.
Retinitis pigmentosa mutations of SNRNP200 enhance cryptic splice-site recognition.
SNRNP200 Mutations Cause Autosomal Dominant Retinitis Pigmentosa.
Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response.
Three Gene Targeted Mouse Models of RNA Splicing Factor RP Show Late Onset RPE and Retinal Degeneration.
Retinoblastoma
Amplification of a DEAD box gene (DDX1) with the MYCN gene in neuroblastomas as a result of cosegregation of sequences flanking the MYCN locus.
Differential expression of DNA polymerase alpha in normal and transformed human fibroblasts.
Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines.
Rhabdomyosarcoma, Alveolar
Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.
Rheumatic Diseases
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Rhinitis, Allergic
Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis.
Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.
Retracted: Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.
Rift Valley Fever
Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs.
Monitoring activation of the antiviral pattern recognition receptors RIG-I and PKR by limited protease digestion and native PAGE.
RNA helicase signaling is critical for type I interferon production and protection against Rift Valley fever virus during mucosal challenge.
Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.
rna helicase deficiency
A complex zinc finger controls the enzymatic activities of nidovirus helicases.
A GTPase-activating protein-binding protein (G3BP1)/antiviral protein relay conveys arteriosclerotic Wnt signals in aortic smooth muscle cells.
Augmented cell death with Bloom syndrome helicase deficiency.
Cellular Assays to Study the Functional Importance of Human DNA Repair Helicases.
DDX19 Inhibits Type I Interferon Production by Disrupting TBK1-IKK?-IRF3 Interactions and Promoting TBK1 and IKK? Degradation.
Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.
Functional deficit associated with a missense Werner syndrome mutation.
Hepatic RIG-I predicts survival and interferon-? therapeutic response in hepatocellular carcinoma.
Induction of tolerogenic dendritic cells by activated TGF-?/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells.
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin ?3/p38 MAPK pathway.
Rig-I-/- mice develop colitis associated with downregulation of G alpha i2.
RNA Virus Infections
Association of rs2111485 and rs1990760 Polymorphisms of Interferon Induced with Helicase C Domain 1 Gene with Hepatitis C Virus Clearance in Chinese Han Population.
Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs.
CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection.
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Defective RNA sensing by RIG-I in severe influenza virus infection.
DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation.
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.
FIP200 restricts RNA virus infection by facilitating RIG-I activation.
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
Immune signaling by RIG-I-like receptors.
Influenza C virus NS1 protein counteracts RIG-I-mediated IFN signalling.
Inhibition of Dengue and Chikungunya Virus Infections by RIG-I-Mediated Type I Interferon-Independent Stimulation of the Innate Antiviral Response.
IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.
Latent Membrane Protein 1 of Epstein-Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway.
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation.
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades.
MAVS self-association mediates antiviral innate immune signaling.
MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation.
Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-?B signaling by targeting MAVS complex.
Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses.
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor.
Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response.
Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking.
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6.
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
RIG-I is cleaved during picornavirus infection.
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Sequence-Specific Modifications Enhance the Broad-Spectrum Antiviral Response Activated by RIG-I Agonists.
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.
Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.
The mitochondrial targeting chaperone 14-3-3? regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
Rotavirus Infections
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.
The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.
Rothmund-Thomson Syndrome
A patient with Rothmund-Thomson syndrome and all features of RAPADILINO.
Chromosome alignment maintenance requires the MAP RECQL4, mutated in the Rothmund-Thomson syndrome.
Chronic tibial nonunion in a Rothmund-Thomson syndrome patient.
Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Disease-causing missense mutations in human DNA helicase disorders.
Dual DNA unwinding activities of the Rothmund-Thomson syndrome protein, RECQ4.
Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis.
Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion.
Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
RecQ4 Facilitates UV Light-induced DNA Damage Repair through Interaction with Nucleotide Excision Repair Factor Xeroderma Pigmentosum Group A (XPA).
RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress.
RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity.
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress.
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Variable presentation of Rothmund-Thomson syndrome.
[Rothmund-Thomson syndrome, trisomy 8 mosaicism and RECQ4 gene mutation]
Rubella
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein.
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.
Protease and helicase domains are related to the temperature sensitivity of wild-type rubella viruses.
Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.
Salmonella Infections
RIG-I detects mRNA of intracellular Salmonella enterica serovar Typhimurium during bacterial infection.
Sarcoma
A predictive coarse-grained model for position-specific effects of post-translational modifications.
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
Werner syndrome gene variants in human sarcomas.
Sarcoma, Ewing
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.
Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9.
RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.
Sarcoma, Kaposi
Opposing roles of RNA receptors TLR3 and RIG-I in the inflammatory response to double-stranded RNA in a Kaposi's sarcoma cell line.
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
Sarcopenia
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
Scleroderma, Systemic
Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.
Werner's syndrome: from clinics to genetics.
Scoliosis
CHD7 gene polymorphisms in female patients with idiopathic scoliosis.
Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis.
Sepsis
Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.
Sertoli Cell-Only Syndrome
Progress in understanding the molecular functions of DDX3Y (DBY) in male germ cell development and maintenance.
Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis.
Severe Acute Respiratory Syndrome
A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA.
Alternative screening approaches for discovery of Middle East respiratory syndrome coronavirus inhibitors.
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.
Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents.
Correction for Hu et al., "The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination".
Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase.
Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Identification of a Novel Small Molecule Inhibitor Against SARS Coronavirus Helicase.
Mechanism of nucleic acid unwinding by SARS-CoV helicase.
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase.
Potential of Flavonoid-Inspired Phytomedicines against COVID-19.
Selective Inhibition of Enzymatic Activities of Severe Acute Respiratory Syndrome Coronavirus Helicase with a Thioxopyrimidine Derivative.
Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic Acid unwinding of the viral helicase.
Structural and biochemical basis for the difference in the helicase activity of two different constructs of SARS-CoV helicase.
The envelope protein of severe acute respiratory syndrome coronavirus interacts with the non-structural protein 3 and is ubiquitinated.
The SARS-CoV-2 conserved macrodomain is a highly efficient ADP-ribosylhydrolase enzyme.
The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
Three dimensional model of severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain and molecular design of severe acute respiratory syndrome coronavirus helicase inhibitors.
Severe Dengue
Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
Severe Fever with Thrombocytopenia Syndrome
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Sick Sinus Syndrome
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Skin Abnormalities
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.
Skin Diseases
Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes.
IFN-alpha enhances poly-IC responses in human keratinocytes by inducing expression of cytosolic innate RNA receptors: relevance for psoriasis.
Microscopic and Molecular Evidence of the First Elasmobranch Adomavirus, the Cause of Skin Disease in a Giant Guitarfish, Rhynchobatus djiddensis.
RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.
Skin Neoplasms
Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence.
Small Cell Lung Carcinoma
The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer.
Spastic Paraplegia, Hereditary
A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.
Spinocerebellar Ataxias
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Identification of Potential Driver Genes Based on Multi-Genomic Data in Cervical Cancer.
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Spondylosis
A polymorphic variant at the Werner helicase (WRN) gene is associated with bone density, but not spondylosis, in postmenopausal women.
Squamous Cell Carcinoma of Head and Neck
Dose dependent activation of retinoic Acid-inducible gene-I promotes both proliferation and apoptosis signals in human head and neck squamous cell carcinoma.
Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis.
Interferon-alpha enhances the antitumour activity of EGFR-targeted therapies by upregulating RIG-I in head and neck squamous cell carcinoma.
Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma.
Subsite-specific association of DEAD box RNA helicase DDX60 with the development and prognosis of oral squamous cell carcinoma.
Starvation
Differential expression of the murine eukaryotic translation initiation factor isogenes eIF4A(I) and eIF4A(II) is dependent upon cellular growth status.
Essential role for the Legionella pneumophila rep helicase homologue in intracellular infection of mammalian cells.
Mitochondrial and nuclear localization of human Pif1 helicase.
The initiation factor eIF4A is involved in the response to lithium stress in Saccharomyces cerevisiae.
Stomach Diseases
A nucleolar RNA helicase recognized by autoimmune antibodies from a patient with watermelon stomach disease.
Mouse RNA helicase II/Gu: cDNA and genomic sequences, chromosomal localization, and regulation of expression.
Stomach Neoplasms
(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.
An Integrative Approach Identified Genes Associated with Drug Response in Gastric Cancer.
DDX21 promotes gastric cancer proliferation by regulating cell cycle.
DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer.
Decreased RIG-I expression is associated with poor prognosis and promotes cell invasion in human gastric cancer.
Downregulation of lncRNA HCP5 has inhibitory effects on gastric cancer cells by regulating DDX21 expression.
Expression of DDX27 contributes to colony-forming ability of gastric cancer cells and correlates with poor prognosis in gastric cancer.
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT-YB1-MDR1 signaling pathway.
lncRNA HOXC-AS1 promotes gastric cancer via binding eIF4AIII by activating Wnt/?-catenin signaling.
Low expression of RecQ-like helicase 5 is associated with poor prognosis in patients with gastric cancer.
Molecular Mechanism of 73HOXC-AS1-Activated Wnt?-Catenin Signaling and eIF4AIII in Promoting Progression of Gastric Cancer.
Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells.
Synthetic miR-143 Inhibits Growth of HER2-Positive Gastric Cancer Cells by Suppressing KRAS Networks Including DDX6 RNA Helicase.
Stroke
Relative Telomere Length and Stroke Risk in a Chinese Han Population.
The RIG-I Signal Pathway Mediated Panax notoginseng Saponin Anti-Inflammatory Effect in Ischemia Stroke.
Superinfection
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
Telangiectasis
Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Teratoma
Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation.
Testicular Neoplasms
AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
Re: AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells.
Tetralogy of Fallot
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Thrombocytopenia
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination.
Thrombosis
A morphologic study of chronic type B aortic dissections and aneurysms after thoracic endovascular stent grafting.
Thyroid Diseases
Analysis of chosen polymorphisms rs2476601 a/G - PTPN22, rs1990760 C/T - IFIH1, rs179247 a/G - TSHR in pathogenesis of autoimmune thyroid diseases in children.
Genomic Polymorphism in the Interferon-induced Helicase (IFIH1) Gene does not Confer Susceptibility to Autoimmune Thyroid Disease in the Japanese Population.
Thyroid Neoplasms
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies.
Tongue Neoplasms
Backbone 1H, 13C, and 15N resonance assignments of the PRY-SPRY domain of RNF135.
Toxoplasmosis
Protective immunity induced by a DNA vaccine expressing eIF4A of Toxoplasma gondii against acute toxoplasmosis in mice.
Sequence variation in the Toxoplasma gondii eIF4A gene among strains from different hosts and geographical locations.
Trauma, Nervous System
Toscana virus non-structural protein NSs acts as E3 ubiquitin ligase promoting RIG-I degradation.
Trichothiodystrophy Syndromes
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.
Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Werner syndrome: entering the helicase era.
Triple Negative Breast Neoplasms
Identification of DHX36 as a tumour suppressor through modulating the activities of the stress-associated proteins and cyclin-dependent kinases in breast cancer.
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
Tuberculosis
A novel B cell epitope in cold-shock DEAD-box protein A from Mycobacterium tuberculosis.
Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
Characterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrD.
DHX36, BAX, and ARPC1B May Be Critical for the Diagnosis and Treatment of Tuberculosis.
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity.
Evidence for the role of Mycobacterium tuberculosis RecG helicase in DNA repair and recombination.
Expression, purification and characterization of UvrD2 helicase from Mycobacterium tuberculosis.
GenomegaMap: within-species genome-wide dN/dS estimation from over 10,000 genomes.
Monitoring RNA unwinding by the transcription termination factor Rho from Mycobacterium tuberculosis.
Mycobacterium tuberculosis DinG is a structure-specific helicase that unwinds G4 DNA: implications for targeting G4 DNA as a novel therapeutic approach.
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions.
Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
Primary macrophages and J774 cells respond differently to infection with Mycobacterium tuberculosis.
Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis.
Structural insights into the interaction of helicase and primase in Mycobacterium tuberculosis.
The mycobacterial PhoH2 proteins are type II toxin antitoxins coupled to RNA helicase domains.
Thermal lysis and isothermal amplification of Mycobacterium tuberculosis H37Rv in one tube.
UvrD2 Is Essential in Mycobacterium tuberculosis, but Its Helicase Activity Is Not Required.
Whole exome sequencing of patients who resolved Crohn's disease and complex regional pain syndrome following treatment for paratuberculosis.
Ureteral Obstruction
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Urinary Bladder Neoplasms
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.
ERCC2 Helicase Domain Mutations Confer Nucleotide Excision Repair Deficiency and Drive Cisplatin Sensitivity in Muscle-Invasive Bladder Cancer.
Genomic Profiling Identified ERCC2 E606Q Mutation in Helicase Domain Respond to Platinum-Based Neoadjuvant Therapy in Urothelial Bladder Cancer.
Novel blood biomarkers of human urinary bladder cancer.
Up-regulation of DDX39 in human pancreatic cancer cells with acquired gemcitabine resistance compared to gemcitabine-sensitive parental cells.
Viral Targeting of Non-Muscle-Invasive Bladder Cancer and Priming of Antitumor Immunity Following Intravesical Coxsackievirus A21.
Urinary Tract Infections
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma.
Urogenital Abnormalities
Mutations in PHD-like domain of the ATRX gene correlate with severe psychomotor impairment and severe urogenital abnormalities in patients with ATRX syndrome.
Uterine Cervical Neoplasms
Interactome analysis of gene expression profiles of cervical cancer reveals dysregulated mitotic gene clusters.
MicroRNA-34a-Upregulated Retinoic Acid-Inducible Gene-I Promotes Apoptosis and Delays Cell Cycle Transition in Cervical Cancer Cells.
Vaccinia
A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway.
Active disruption of an RNA-protein interaction by a DExH/D RNA helicase.
Are DEAD-box proteins becoming respectable helicases?
Domain organization of vaccinia virus helicase-primase D5.
Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase.
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline.
Preformed hexamers of SV40 T antigen are active in RNA and origin-DNA unwinding.
RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication.
RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis.
Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track.
The NPH-II helicase displays efficient DNA x RNA helicase activity and a pronounced purine sequence bias.
The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.
The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.
The vaccinia virus A18R gene product is a DNA-dependent ATPase.
Three adjacent genes of African swine fever virus with similarity to essential poxvirus genes.
Three African swine fever virus genes encoding proteins with homology to putative helicases of vaccinia virus.
Unwinding by Local Strand Separation Is Critical for the Function of DEAD-Box Proteins as RNA Chaperones.
Unwinding initiation by the viral RNA helicase NPH-II.
Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription.
Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription.
Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other.
Vaccinia virus RNA helicase. Directionality and substrate specificity.
Vaccinia virus RNA helicase: an essential enzyme related to the DE-H family of RNA-dependent NTPases.
Vaccinia virus RNA helicase: nucleic acid specificity in duplex unwinding.
Vascular Diseases
Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling.
Vector Borne Diseases
Development of a U-bent plastic optical fiber biosensor with plasmonic labels for the detection of chikungunya non-structural protein 3.
Vesicular Stomatitis
Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection.
Conventional protein kinase C-? (PKC-?) and PKC-? negatively regulate RIG-I antiviral signal transduction.
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference.
Impairment of the retinoic acid-inducible gene-I-IFN-? signaling pathway in chronic hepatitis B virus infection.
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.
Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.
RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1.
RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes.
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance IFN-? response.
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I.
ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
Viremia
A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3.
Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.
Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigen.
Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp.
Virus Diseases
5'-Triphosphate RNA is the ligand for RIG-I.
5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity.
5'-Triphosphate-Short Interfering RNA: Potent Inhibition of Influenza A Virus Infection by Gene Silencing and RIG-I Activation.
A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells.
A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses.
A Hierarchical Mechanism of RIG-I Ubiquitination Provides Sensitivity, Robustness and Synergy in Antiviral Immune Responses.
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand.
A tobacco CBL-interacting protein kinase homolog is involved in phosphorylation of the N-terminal domain of the cucumber mosaic virus polymerase 2a protein.
Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response.
Activation of IFN-β expression by a viral mRNA through RNase L and MDA5.
Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis.
Activation of the Beta Interferon Promoter by Unnatural Sendai Virus Infection Requires RIG-I and Is Inhibited by Viral C Proteins.
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response.
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation.
Analysis of the helicase gene of Korean swine hepatitis E virus isolates and trends in viral infection.
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.
Antiviral RNA recognition and assembly by RLR family innate immune sensors.
Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
ARF-like Protein 16 (ARL16) Inhibits RIG-I by Binding with Its C-terminal Domain in a GTP-dependent Manner.
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Astrocytes recognize intracellular polyinosinic-polycytidylic acid via MDA-5.
ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon.
Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I.
Brome mosaic virus capsid protein regulates accumulation of viral replication proteins by binding to the replicase assembly RNA element.
c-FLIP-Short reduces type I interferon production and increases viremia with coxsackievirus B3.
Caprine MAVS Is a RIG-I Interacting Type I Interferon Inducer Downregulated by Peste des Petits Ruminants Virus Infection.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity.
Cellular DEAD-box RNA helicase DDX6 modulates interaction of miR-122 with the 5' untranslated region of hepatitis C virus RNA.
Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication.
Characterization of Chicken Mda5 Activity: Regulation of IFN-{beta} in the Absence of RIG-I Functionality.
Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken.
Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium.
Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5.
Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity.
Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection.
Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses.
Cytokine-independent upregulation of MDA5 in viral infection.
Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.
DDX1 from Cherry valley duck mediates signaling pathways and anti-NDRV activity.
DDX21 translocates from nucleus to cytoplasm and stimulates the innate immune response due to dengue virus infection.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
DDX3X Links NLRP11 to the Regulation of Type I Interferon Responses and NLRP3 Inflammasome Activation.
DDX3X: structure, physiologic functions and cancer.
DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling.
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense.
DEAD-box RNA helicases: The driving forces behind RNA metabolism at the crossroad of viral replication and antiviral innate immunity.
Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response.
Defective RNA sensing by RIG-I in severe influenza virus infection.
DHX15 Is a Coreceptor for RLR Signaling That Promotes Antiviral Defense Against RNA Virus Infection.
DHX15 senses double-stranded RNA in myeloid dendritic cells.
Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.
Drosophila DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway.
Duck RIG-I restricts duck enteritis virus infection.
Duck Tembusu Virus Infection Promotes the Expression of Duck Interferon-Induced Protein 35 to Counteract RIG-I Antiviral Signaling in Duck Embryo Fibroblasts.
DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity.
Dynamic Changes in Host Gene Expression following
Dynamic Interaction of Stress Granule, DDX3X and IKK-? Mediates Multiple Functions in Hepatitis C Virus Infection.
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Efficient eradication of hormone-resistant human prostate cancers by inactivated Sendai virus particle.
Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity.
Establishment of Myotis myotis cell lines--model for investigation of host-pathogen interaction in a natural host for emerging viruses.
Evolution of MDA-5/RIG-I-dependent innate immunity: independent evolution by domain grafting.
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Expression and function of RIG-I in oral keratinocytes and fibroblasts.
Fascin1 Suppresses RIG-I-like Receptor Signaling and Interferon-? Production by Associating with I?B Kinase ? (IKK ?) in Colon Cancer.
Fish DDX3X exerts antiviral function against grouper nervous necrosis virus infection.
Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7.
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis.
Functional characterization of porcine LSm14A in IFN-? induction.
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases.
Genomic analysis and functional characterization of immune genes from the RIG-I- and MAVS-mediated antiviral signaling pathway in lamprey.
Goose RIG-I functions in innate immunity against Newcastle disease virus infections.
Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity.
Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
High-throughput virtual screening lead to discovery of non-peptidic inhibitors of West Nile virus NS3 protease.
Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses.
HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection.
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
Human papillomavirus and the landscape of secondary genetic alterations in oral cancers.
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein.
Immune response to cytosolic DNA via intercellular receptor modulation in oral keratinocytes and fibroblasts.
In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
Inflammatory Response of Mast Cells during Influenza A Virus Infection Is Mediated by Active Infection and RIG-I Signaling.
Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I.
Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting.
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families.
Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators.
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Interferon-? Stimulation Elicited by the Influenza Virus Is Regulated by the Histone Methylase Dot1L through the RIG-I-TRIM25 Signaling Axis.
Intracellular pathogen detection by RIG-I-like receptors.
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia.
iTRAQ-based quantitative subcellular proteomic analysis of Avibirnavirus-infected cells.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.
LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs.
Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes.
Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses.
Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer.
LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I.
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection.
MasterCARD: a priceless link to innate immunity.
MDA5 localizes to stress granules but this localization is not required for the induction of type I interferon.
Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors.
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Mini viral RNAs act as innate immune agonists during influenza virus infection.
MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation.
Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules.
Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto.
Molecular characterization, expression patterns, and subcellular localization of RIG-I in the Jinding Duck (Anas platyrhynchos domesticus).
Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I).
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein.
Negative regulation of the antiviral response by grouper LGP2 against fish viruses.
Negative role of RIG-I serine 8 phosphorylation in the regulation of IFN-{beta} production.
Nicotiana benthamiana plants transformed with the plum pox virus helicase gene are resistant to virus infection.
NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection.
NLRX1 is a regulator of mitochondrial antiviral immunity.
Nonstructural NS1 proteins of several mosquito-borne Flavivirus do not inhibit TLR3 signaling.
Novel Insights into the Biochemical Mechanism of CK1? and its Functional Interplay with DDX3X.
Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation.
Nuclear localization of non-structural protein 3 (NS3) during dengue virus infection.
Opposing forces fight over the same ground to regulate interferon signaling.
PAMPer and tRIGer: ligand-induced activation of RIG-I.
Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length.
Pattern Recognition Receptor MDA5 Modulates CD8+ T Cell-Dependent Clearance of West Nile Virus from the Central Nervous System.
Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly.
Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
Phosphorylation-mediated negative regulation of RIG-I antiviral activity.
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.
Poly I:C-induced tumor cell apoptosis mediated by pattern-recognition receptors.
Porcine RIG-I and MDA5 Signaling CARD Domains Exert Similar Antiviral Function Against Different Viruses.
Positive regulatory role of c-Src-mediated TRIM25 tyrosine phosphorylation on RIG-I ubiquitination and RIG-I-mediated antiviral signaling pathway.
Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection.
Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection.
Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing.
Pregnancy and Interferon Tau Regulate DDX58 and PLSCR1 in the Ovine Uterus During the Peri-Implantation Period.
Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS.
Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking.
Rabies virus nucleoprotein functions to evade activation of the RIG-I-mediated antiviral response.
RACK1 attenuates RLR antiviral signaling by targeting VISA-TRAF complexes.
Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus.
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: Role of Jumonji C-domain containing protein 6 in RHA demethylation.
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.
Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection.
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.
Regulation of interferon production by RIG-I and LGP2: a lesson in self-control.
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design.
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells.
Retinoic acid inducible gene-I slows down cellular senescence through negatively regulating the integrin ?3/p38 MAPK pathway.
Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA.
RIG-I Activation by a Designer Short RNA Ligand Protects Human Immune Cells against Dengue Virus Infection without Causing Cytotoxicity.
RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.
RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.
RIG-I enhanced interferon independent apoptosis upon Junin virus infection.
RIG-I is cleaved during picornavirus infection.
RIG-I Like Receptors and Their Signaling Crosstalk in the Regulation of Antiviral Immunity.
RIG-I mediates innate immune response in mouse neurons following Japanese encephalitis virus infection.
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection.
RIG-I RNA Helicase Activation of IRF3 Transcription Factor Is Negatively Regulated by Caspase-8-Mediated Cleavage of the RIP1 Protein.
RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection.
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.
RIG-I-like receptors: sensing and responding to RNA virus infection.
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses.
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease.
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.
RNase L and the NLRP3-inflammasome: An old merchant in a new trade.
Robust Lys63-Linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection.
Role of viral receptors TLR3, RIG-I and MDA5 in mesothelial tissue-type plasminogen activator and plasminogen activator inhibitor-1 synthesis.
Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Roles of TLR3 and RIG-I in mediating the inflammatory response in mouse microglia following Japanese encephalitis virus infection.
Sensing and control of Bluetongue virus infection in epithelial cells via RIG-I and MDA5 helicases.
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Spatiotemporal dynamics of innate immune signaling via RIG-I-like receptors.
Stimulation of the Internal Ribosome Entry Site (IRES)-Dependent Translation of Enterovirus 71 by DDX3X RNA Helicase and Viral 2A and 3C Proteases.
Structural Basis for a Novel Interaction between the NS1 Protein Derived from the 1918 Influenza Virus and RIG-I.
Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Structural insights into RNA recognition and activation of RIG-I-like receptors.
Structural, biophysical and biochemical elucidation of the SARS-CoV-2 nonstructural protein 3 macro domain.
Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response.
Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection.
Syndecan-4 negatively regulates antiviral signalling by mediating RIG-I deubiquitination via CYLD.
Synthetic Abortive HIV-1 RNAs Induce Potent Antiviral Immunity.
Synthetic double-stranded RNA induces retinoic acid-inducible gene-I in mouse osteoblastic cells.
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Targeting Casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health.
Targeting host DEAD-box RNA helicase DDX3X for treating viral infections.
The Association of OASL and Type I Interferons in the Pathogenesis and Survival of Intracellular Replicating Bacterial Species.
The Caenorhabditis elegans RIG-I Homolog DRH-1 Mediates the Intracellular Pathogen Response upon Viral Infection.
The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection.
The chase for the RIG-I ligand--recent advances.
The dark side of RNA:DNA hybrids.
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays.
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila.
The dynamic interacting landscape of MAPL reveals essential functions for SUMOylation in innate immunity.
The effects of H3N2 swine influenza virus infection on TLRs and RLRs signaling pathways in porcine alveolar macrophages.
The Endogenous RIG-I Ligand Is Generated in Influenza A-Virus Infected Cells.
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.
The interplay between viruses and innate immune signaling: recent insights and therapeutic opportunities.
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response.
The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication.
The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish.
The nucleolar protein GLTSCR2 is required for efficient viral replication.
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers.
The RNA helicase DDX46 inhibits innate immunity by entrapping m(6)A-demethylated antiviral transcripts in the nucleus.
The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NF?B transcripts to dampen antiviral innate immunity.
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.
Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells.
TLR3/TRIF signalling pathway regulates IL-32 and IFN-? secretion through activation of RIP-1 and TRAF in the human cornea.
Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells.
TRIM proteins: another class of viral victims.
Tumor suppressor activity of RIG-I.
Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.
Understanding the structural and energetic basis of inhibitor and substrate bound to the full-length NS3/4A: insights from molecular dynamics simulation, binding free energy calculation and network analysis.
Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.
Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight.
Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.
Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium.
Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I.
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.
Vitiligo
The role of IFIH1 gene rs1990760 and rs2111485 single-nucleotide polymorphisms in generalized vitiligo predisposition
Werner Syndrome
A novel splice-site mutation of WRN (c.IVS28+2T>C) identified in a consanguineous family with Werner Syndrome.
A role for WRN in telomere-based DNA damage responses.
Analysis of helicase gene mutations in Japanese Werner's syndrome patients.
Are There Different Kinds of Aging?
C. elegans orthologs MUT-7/CeWRN-1 of Werner syndrome protein regulate neuronal plasticity.
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA.
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Computational image analysis of nuclear morphology associated with various nuclear-specific aging disorders.
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Disease-causing missense mutations in human DNA helicase disorders.
Diverse dealings of the Werner helicase/nuclease.
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.
Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome.
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Functional deficit associated with a missense Werner syndrome mutation.
Genetic instability syndromes with progeroid features.
Homozygous and compound heterozygous mutations at the Werner syndrome locus.
Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.
Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Increased insulin, triglycerides, reactive oxygen species, and cardiac fibrosis in mice with a mutation in the helicase domain of the Werner syndrome gene homologue.
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A.
Instability of the fragile X syndrome repeat in mice: the effect of age, diet and mutations in genes that affect DNA replication, recombination and repair proficiency.
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Multiple RPAs make WRN syndrome protein a superhelicase.
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells.
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome.
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Recombinational DNA repair and human disease.
Regulation of WRN helicase activity in human base excision repair.
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
Resveratrol Improves Insulin Resistance Hyperglycemia and Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life Span in a Mouse Model for Werner Syndrome.
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging.
Syndrome-causing mutations in Werner syndrome.
The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. Mutations in brief no. 136. Online.
The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.
The Werner syndrome protein at the crossroads of DNA repair and apoptosis.
The Werner syndrome protein has separable recombination and survival functions.
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity.
Understanding Vascular Diseases: Lessons From Premature Aging Syndromes.
Way out/way in: How the relationship between WRN and CDK1 may change the fate of collapsed replication forks.
Werner helicase expression in human fetal and adult aortas.
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Werner helicase is localized to transcriptionally active nucleoli of cycling cells.
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner syndrome: entering the helicase era.
Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver.
Werner's syndrome: from clinics to genetics.
WRN mutations in Werner syndrome.
[Atypical Werner syndrome: Atypical progeroid syndrome: A case report]
West Nile Fever
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1.
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection.
MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis.
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection.
The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection.
West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells.
Whooping Cough
Polyethersulfone improves isothermal nucleic acid amplification compared to current paper-based diagnostics.
Xeroderma Pigmentosum
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
A temperature-sensitive disorder in basal transcription and DNA repair in humans.
A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
ARCH domain of XPD, an anchoring platform for CAK that conditions TFIIH DNA repair and transcription activities.
Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.
Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors.
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells.
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair.
Contribution of DNA Repair Xeroderma Pigmentosum Group D Genotypes to Colorectal Cancer Risk in Taiwan.
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II.
Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients.
KERA: analysis tool for multi-process, multi-state single-molecule data.
Mechanism of DNA loading by the DNA repair helicase XPD.
Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking.
Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
Restoration of nucleotide excision repair in a helicase-deficient XPD mutant from intragenic suppression by a trichothiodystrophy mutation.
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.
Switch-like control of helicase processivity by single-stranded DNA binding protein.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway.
The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair.
Werner syndrome: entering the helicase era.
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage.
Yellow Fever
KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.
Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.
RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to yellow fever virus.
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons.
Zika Virus Infection
Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses.
Comparative Analysis of African and Asian Lineage-Derived Zika Virus Strains Reveals Differences in Activation of and Sensitivity to Antiviral Innate Immunity.
Insights into ZIKV-Mediated Innate Immune Responses in Human Dermal Fibroblasts and Epidermal Keratinocytes.
Molecular mechanism of ATP and RNA binding to Zika virus NS3 helicase and identification of repurposed drugs using molecular dynamics simulations.
Zika virus noncoding sfRNAs sequester multiple host-derived RNA-binding proteins and modulate mRNA decay and splicing during infection.