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Information on EC 3.6.1.8 - ATP diphosphatase for references in articles please use BRENDA:EC3.6.1.8
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EC Tree
The enzyme appears in viruses and cellular organisms
Synonyms
adenosine triphosphate pyrophosphatase, ATP pyrophosphatase, ATP pyrophosphohydrolase, ATPase, ATPDase, ATPdiphosphohydrolase,
Pk-rec , pyrophosphatase, adenosine triphosphate,
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adenosine triphosphate pyrophosphatase
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ATP pyrophosphatase
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ATP pyrophosphohydrolase
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ATPdiphosphohydrolase
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pyrophosphatase, adenosine triphosphate
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ATP + H2O = AMP + diphosphate
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phosphorous acid anhydride hydrolysis
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ATP diphosphohydrolase (diphosphate-forming)
Also acts on ITP, GTP, CTP and UTP.
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ATP + H2O
AMP + diphosphate
beta, gamma-imido ATP + H2O
AMP + imido diphosphate
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?
beta,gamma-methylene ATP + H2O
AMP + methylene diphosphate
CTP + H2O
CMP + diphosphate
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?
dATP + H2O
dAMP + diphosphate
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?
GTP + H2O
GMP + diphosphate
ITP + H2O
IMP + diphosphate
ATP + H2O
AMP + diphosphate
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?
ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
the enzyme shows DNase activity on both single- and double-stranded DNAs along with the ATPase activity. ATPase activity is independent of both single-stranded and double-stranded DNAs
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beta,gamma-methylene ATP + H2O
AMP + methylene diphosphate
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beta,gamma-methylene ATP + H2O
AMP + methylene diphosphate
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?
GTP + H2O
GMP + diphosphate
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?
GTP + H2O
GMP + diphosphate
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ITP + H2O
IMP + diphosphate
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?
ITP + H2O
IMP + diphosphate
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?
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ATP + H2O
AMP + diphosphate
CTP + H2O
CMP + diphosphate
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?
GTP + H2O
GMP + diphosphate
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?
ITP + H2O
IMP + diphosphate
ATP + H2O
AMP + diphosphate
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?
ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ATP + H2O
AMP + diphosphate
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ITP + H2O
IMP + diphosphate
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?
ITP + H2O
IMP + diphosphate
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?
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Ba2+
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no effect
Ba2+
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weak inhibition in absence of Mg2+
Ca2+
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no effect
Ca2+
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required for activity
Ca2+
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required for activity
Ca2+
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required for activity
Co2+
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activating
Mg2+
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no effect
Mn2+
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no effect
Sr2+
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no effect
Sr2+
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partial substitution for Ca2+
Sr2+
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weak inhibition in absence of Mg2+
Zn2+
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activating
Zn2+
preferable divalent cation for ATPase activity
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15-desoxybludein
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0.065 mg/ml, 11% inhibition
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Caffeine
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25% inhibition at 3 mM
cAMP
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20% inhibition at 3 mM
eremantolide C
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0.065 mg/ml, 17% inhibition
glaucolide A
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0.065 mg/ml, 11% inhibition
glaucolide B
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0.065 mg/ml, 16% inhibition
GMP
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competitive inhibition with Ki: 0.001 mM
goyazensolide
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0.065 mg/ml, 10% inhibition
isogoyazensolide
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0.065 mg/ml, 11% inhibition
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licnofolide
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0.065 mg/ml, 22% inhibition
thapsigargicin
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0.065 mg/ml, 57% inhibition
thapsigargin
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inhibits ATP hydrolysis, 70% inhibition at 0.065 mg/ml, mixed type inhibition, little or not affected by changes in free Ca2+ or Mg2+ concentrations, hydrolysis of ADP is not inhibited
additional information
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no inhibition by 0.065 mg/ml 15-desoxygoyazensolide
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3-isobutyl-1-methylxanthine
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activation in preincubation
glucose
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activation in preincubation
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0.0022
GTP
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with 0.1 mM free Ca2+, pH 8
0.00032
ATP
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with 0.1 mM free Ca2+, pH 8
0.0173
ATP
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37°C, pH 7.4
0.076
ATP
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in presence of ZnCl2 and CaCl2
0.18
ATP
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in presence of 2 mM ZnCl2
0.2
ATP
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without added metal ions
0.83
ATP
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vesicle associated enzyme at pH 7.3
1.28
ATP
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vesicle associated enzyme at pH 9.9
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0.001
GMP
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competitive inhibition
0.02
thapsigargin
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37°C, pH 7.4, inhibition of ATP hydrolysis
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0.03 - 0.04
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with ATP as substrate
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6 - 10
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20% activity at pH 6, 50% activity at pH 10
7.4 - 8.8
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much higher activity at pH 8.8
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snake
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acellular slime mold
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SwissProt
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additional information
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18 tissues examined
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two different localisations found
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human erythrocyte membrane
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human erythrocyte membrane
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Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
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127000
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SDS-PAGE, sedimentable enzyme
28000
2 * 28000, SDS-PAGE
61000
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SDS-PAGE, soluble enzyme
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dimer
2 * 28000, SDS-PAGE
tetramer
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4 * 56000, SDS-PAGE and gel filtration
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60
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30 min at 60°C causes no loss of activity
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partial purification
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expression in Escherichia coli
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Heppel, L.A.; Hilmoe, R.J.
Mechanism of enzymatic hydrolysis of adenosinetriphosphate
J. Biol. Chem.
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217-226
1953
Bos taurus, Crotalus adamanteus, Oryctolagus cuniculus, Rattus norvegicus
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Kawamura, M.; Nagano, K.
A calcium ion-dependent ATP pyrophosphohydrolase in Physarum polycephalum
Biochim. Biophys. Acta
397
207-219
1975
Physarum polycephalum
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Kawamura, M.; Tonotsuka, N.; Nagano, K.
Change in ATP-pyrophosphohydrolase activity during spherule formation of Physarum polycephalum
Biochim. Biophys. Acta
421
195-202
1976
Physarum polycephalum
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Flodgaard, H.; Torp-Pedersen, C.
A calcium ion-dependent adenosine triphosphate pyrophosphohydrolase in plasma membrane from rat liver. Demonstration that the adenosine triphosphate analogues adenosine 5-[betagamma-imido]triphosphate and adenosine 5-[betagamma-methylene]-triphosphate are substrates for the enzyme
Biochem. J.
171
817-820
1978
Rattus norvegicus
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Torp-Pedersen, C.; Flodgaard, H.; Saermark, T.
Studies on a Ca2+-dependent nucleoside triphosphate pyrophosphohydrolase in rat liver plasma membranes
Biochim. Biophys. Acta
571
94-104
1979
Rattus norvegicus
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Capito, K.; Hansen, S.E.; Hedeskov, C.J.; Thams, D.
Presence of ATP-pyrophosphohydrolase in mouse pancreatic islets
Diabetes
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1096-1100
1986
Mus musculus
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Masuda, I.; Hamada, J.; Haas, A.L.; Ryan, L.M.; McCarthy, D.J.
A unique ectonucleotide pyrophosphohyrolase associated with porcine chondrocyte-derived vesicels
J. Clin. Invest.
95
699-704
1995
Sus scrofa
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Martins, S.M.; Torres, C.R.; Ferreira, S.T.
Inhibition of the ecto-ATPdiphosphohydrolase of Schistosoma mansoni by thapsigargin
Biosci. Rep.
20
369-381
2000
Schistosoma mansoni
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Rashid, N.; Morikawa, M.; Nagahisa, K.; Kanaya, S.; Imanaka, T.
Characterization of a RecA/RAD51 homologue from the hyperthermophilic archaeon Pyrococcus sp. KOD1
Nucleic Acids Res.
25
719-726
1997
Thermococcus kodakarensis (P95547)
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