Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.6.1.72 - DNA-3'-diphospho-5'-guanosine diphosphatase

for references in articles please use BRENDA:EC3.6.1.72
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8, 3'-phosphate/5'-hydroxy nucleic acid ligase) . The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release. The enzyme also possesses the activity of EC 3.6.1.71, adenosine-5'-diphospho-5'-[DNA] diphosphatase, and EC 3.6.1.70, guanosine-5'-diphospho-5'-[DNA] diphosphatase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The enzyme appears in viruses and cellular organisms
Reaction Schemes
[DNA]-3'-diphospho-5'-guanosine
+
=
[DNA]-3'-phosphate
+
Synonyms
aprataxin, APTX, DNA-3'pp5'G guanylate hydrolase, EC 3.1.12.2, HNT3, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[DNA]-3'-diphospho-5'-guanosine + H2O = [DNA]-3'-phosphate + GMP
show the reaction diagram
-
-
-
-
Select items on the left to see more content.