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7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
dATP + H2O
dAMP + diphosphate
-
-
-
?
additional information
?
-
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the enzyme is far more active against dGTP, 8-oxo-GTP, dTTP, and other nucleoside and deoxynucleoside 3'-triphosphates than against 7,8-dihydroneopterin 3'-triphosphate
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
catalytic efficiency of the enzyme is far higher for dGTP
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
-
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
-
-
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
-
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
committed step of folate synthesis in bacteria
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
key enzyme in the folate pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the enzyme participates in a folate biosynthesis pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the second step in the pterin branch of the folate synthesis pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
no activity against deoxynucleoside triphosphates
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
no detectable activity with GTP, ATP, TTP, CTP, the corresponding deoxynucleoside triphosphates, 8-oxo-dGTP, NADH, NAD, diadenosine tri- or tetraphosphate, ADP-ribose, UDP-glucose, or coenzyme A (the detection limit is less than 1% of the activity with 7,8-dihydroneopterin 3'-triphosphate)
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the second step in the pterin branch of the folate synthesis pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
no activity against deoxynucleoside triphosphates
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
no detectable activity with GTP, ATP, TTP, CTP, the corresponding deoxynucleoside triphosphates, 8-oxo-dGTP, NADH, NAD, diadenosine tri- or tetraphosphate, ADP-ribose, UDP-glucose, or coenzyme A (the detection limit is less than 1% of the activity with 7,8-dihydroneopterin 3'-triphosphate)
-
-
?
additional information
?
-
-
no activity with ATP, GTP, dihydroneopterin phosphate, 4-nitrophenyl hosphate or diphosphate
-
-
?
additional information
?
-
no activity with ATP, GTP, dihydroneopterin phosphate, 4-nitrophenyl hosphate or diphosphate
-
-
?
additional information
?
-
the enzyme also catalyzes the hydrolysis of dATP, 8-hydroxy-dATP, dADP, and 8-hydroxy-dADP
-
-
?
additional information
?
-
-
the enzyme also catalyzes the hydrolysis of dATP, 8-hydroxy-dATP, dADP, and 8-hydroxy-dADP
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
-
-
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
committed step of folate synthesis in bacteria
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
key enzyme in the folate pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the enzyme participates in a folate biosynthesis pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the second step in the pterin branch of the folate synthesis pathway
-
-
?
7,8-dihydroneopterin 3'-triphosphate + H2O
7,8-dihydroneopterin 3'-phosphate + diphosphate
the second step in the pterin branch of the folate synthesis pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Hori, M.; Fujikawa, K.; Kasai, H.; Harashima, H.; Kamiya, H.
Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme
DNA Repair
4
33-39
2005
Escherichia coli (P0AFC0), Escherichia coli
brenda
Suzuki, Y.; Brown, G.M.
The biosynthesis of folic acid. XII. Purification and properties of dihydroneopterin triphosphate pyrophosphohydrolase
J. Biol. Chem.
249
2405-2410
1974
Escherichia coli, Escherichia coli (P0AFC0)
brenda
Klaus, S.M.; Wegkamp, A.; Sybesma, W.; Hugenholtz, J.; Gregory, J.F. 3rd, Hanson, A.D.
A nudix enzyme removes pyrophosphate from dihydroneopterin triphosphate in the folate synthesis pathway of bacteria and plants
J. Biol. Chem.
280
5274-5280
2004
Lactococcus lactis (D8KIT5), Lactococcus lactis, Arabidopsis thaliana (Q9CA40), Lactococcus lactis NZ9000 (D8KIT5)
brenda
Gabelli, S.B.; Bianchet, M.A.; Xu, W.; Dunn, C.A.; Niu, Z.D.; Amzel, L.M.; Bessman, M.J.
Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis
Structure
15
1014-1022
2007
Escherichia coli (P0AFC0), Escherichia coli
brenda
OHandley, S.; Frick, D.; Bullions, L.; Mildvan, A.; Bessman, M.
Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme
J. Biol. Chem.
271
24649-24654
1996
Escherichia coli (P0AFC0), Escherichia coli
brenda
Hill, S.E.; Nguyen, E.; Ukachukwu, C.U.; Freeman, D.M.; Quirk, S.; Lieberman, R.L.
Metal ion coordination in the E. coli Nudix hydrolase dihydroneopterin triphosphate pyrophosphatase New clues into catalytic mechanism
PLoS ONE
12
e0180241
2017
Escherichia coli
brenda