Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.6.1.56 - 2-hydroxy-dATP diphosphatase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
2-hydroxy-datp diphosphatase deficiency
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
Adenoma
HMTH1 induces the metastasis and recurrence of the parotid adenoma by repairing DNA damage.
Alzheimer Disease
Expression of hMTH1 in the hippocampi of control and Alzheimer's disease.
Brain Neoplasms
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Breast Neoplasms
Biological characterisation and application of human MTH1 and monoclonal antibody preparation.
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Carcinogenesis
Mutation analysis of the hMTH1 gene in sporadic human ovarian cancer.
Carcinoma
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer.
Carcinoma, Hepatocellular
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
[Potential role of human DNA-repair enzymes hMTH1, hOGG1 and hMYHalpha in the hepatocarcinogenesis]
Carcinoma, Non-Small-Cell Lung
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Carcinoma, Renal Cell
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Colorectal Neoplasms
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells.
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
Diabetes Mellitus, Type 2
Combined analysis of polymorphism variants in hMTH1, hOGG1 and MUTYH genes on the risk of type 2 diabetes in the Chinese population.
Dystonia
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
Glioma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Huntington Disease
A role for oxidized DNA precursors in Huntington's disease-like striatal neurodegeneration.
Oxidized purine nucleotides, genome instability and neurodegeneration.
Idiopathic Pulmonary Fibrosis
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.
Leukemia
Inhibition of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity of the antimutagenic human MTH1 protein by nucleoside 5'-diphosphates.
Lung Diseases, Interstitial
Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.
Lung Neoplasms
Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients.
Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells.
Lymphatic Metastasis
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
Meningioma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Neoplasm Metastasis
Great potential of a panel of multiple hMTH1, SPD, ITGA11 and COL11A1 markers for diagnosis of patients with non-small cell lung cancer.
HMTH1 induces the metastasis and recurrence of the parotid adenoma by repairing DNA damage.
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
Neoplasms
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients.
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Bacterial DNA repair genes and their eukaryotic homologues: 2. Role of bacterial mutator gene homologues in human disease. Overview of nucleotide pool sanitization and mismatch repair systems.
Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung DNA of non-small-cell lung cancer patients.
Development of Damaged Nucleoside Mimics for Inhibition of Their Repair Enzymes.
Expression of DNA repair enzyme hMTH1 mRNA and protein in hepatocellular carcinoma.
Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers.
Hexabromocyclododecane-induced Genotoxicity in Cultured Human Breast Cells through DNA Damage.
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Inhibitory Effect of 8-Halogenated 7-Deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.
Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma: evidence of persistent oxidative stress in cancer.
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.
Neoplasms, Neuroepithelial
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Neurilemmoma
Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors.
Ovarian Neoplasms
Mutation analysis of the hMTH1 gene in sporadic human ovarian cancer.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Stomach Neoplasms
A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients.
Thyroid Neoplasms
hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage.
hMTH1 is required for maintaining migration and invasion potential of human thyroid cancer cells.