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Information on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC3.6.1.55

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IUBMB Comments

This enzyme hydrolyses the phosphoanhydride bond between the α and β phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) . Requires Mg2+.

The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms

Synonyms
8-oxo-dgtpase, nudt1, mutt homolog 1, mutt2, mutt homologue 1, cimutt, 8-oxo-dgtp hydrolase, more

PATHWAY SOURCE
PATHWAYS
MetaCyc
8-oxo-(d)GTP detoxification I
SYSTEMATIC NAME
IUBMB Comments
8-oxo-dGTP diphosphohydrolase
This enzyme hydrolyses the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+.
Highest Expressing Human Cell Lines
Cell Line Links Gene Links
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A0C6FGT7_PSEAI
315
0
34069
TrEMBL
-
A0A0F6RUP6_PSEAI
315
0
34055
TrEMBL
-
A0A367M554_PSEAI
315
0
34007
TrEMBL
-
A0A3M5E942_PSEAI
137
0
15171
TrEMBL
-
A0A6A9K3J1_PSEAI
315
0
34031
TrEMBL
-
A0AAQ3R0A4_PSEAI
315
0
34041
TrEMBL
-
A0ABD7K0T8_PSEAI
315
0
34081
TrEMBL
-