Disease on EC 3.6.1.5 - apyrase and Organism(s) Homo sapiens
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Acute Kidney Injury
The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis following ischemia reperfusion injury.
Anaplasia
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Anemia
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Anemia
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Anemia, Sickle Cell
Dual-perspective analysis of vascular formations in sickle cell retinopathy.
Aortic Aneurysm
Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPAR?.
Aortic Valve Stenosis
Simultaneous accurate quantification of HO-1, CD39, and CD73 in human calcified aortic valves using multiple enzyme digestion - filter aided sample pretreatment (MED-FASP) method and targeted proteomics.
apyrase deficiency
Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. A biochemical basis for thymidine sensitivity.
Arteriosclerosis
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Arthritis
Effect of quercetin on E-NTPDase/E-ADA activities and cytokine secretion of complete Freund adjuvant-induced arthritic rats.
Arthritis
Free and nanoencapsulated vitamin D3 : effects on E-NTPDase and E-ADA activities in an animal model with induced arthritis.
Arthritis, Rheumatoid
Activities of enzymes that hydrolyze adenine nucleotides in lymphocytes from patients with rheumatoid arthritis.
Asthma
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Astrocytoma
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
Ataxia
A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene.
Bacterial Infections
Apyrase Elicits Host Antimicrobial Responses and Resolves Infection in Burns.
Bluetongue
Apyrase activity and adenosine diphosphate induced platelet aggregation inhibition by the salivary gland proteins of Culicoides variipennis, the North American vector of bluetongue viruses.
Brain Diseases
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Brain Ischemia
Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats.
Breast Neoplasms
AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments.
Breast Neoplasms
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Breast Neoplasms
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Breast Neoplasms
Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis.
Breast Neoplasms
Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients.
Breast Neoplasms
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Breast Neoplasms
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
Breast Neoplasms
P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.
Carcinogenesis
Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance.
Carcinogenesis
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Carcinogenesis
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Carcinogenesis
PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration.
Carcinogenesis
PSMC2 is Up-regulated in Pancreatic Cancer and Promotes Cancer Cell Proliferation and Inhibits Apoptosis.
Carcinoma
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Carcinoma
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
Carcinoma
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
Carcinoma
Prevalence of the mercurial-sensitive EctoATPase in human small cell lung carcinoma: characterization and partial purification.
Carcinoma, Hepatocellular
A novel response to dioxin. Induction of ecto-ATPase gene expression.
Carcinoma, Hepatocellular
Accessibility and activity of the promoter for a dioxin-inducible ecto-ATPase gene.
Carcinoma, Hepatocellular
Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Carcinoma, Hepatocellular
Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2.
Carcinoma, Hepatocellular
Evidence for an ATP-dependent bile acid transport protein other than the canalicular liver ecto-ATPase in rats.
Carcinoma, Hepatocellular
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.
Carcinoma, Hepatocellular
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Carcinoma, Hepatocellular
The rat liver ecto-ATPase/C-CAM cDNA detects induction of carcinoembryonic antigen but not the mercurial-insensitive ecto-ATPase in human hepatoma Li-7A cells treated by epidermal growth factor and cholera toxin.
Carcinoma, Hepatocellular
[Adenosinetriphosphate content and apyrase activity in normal rat liver and rat hepatoma.]
Carcinoma, Squamous Cell
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
Cardiomegaly
Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.
Cerebral Infarction
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.
Chagas Disease
E-NTPDase and E-ADA activities are altered in lymphocytes of patients with indeterminate form of Chagas' disease.
Chagas Disease
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Cholera
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
Cholera
The rat liver ecto-ATPase/C-CAM cDNA detects induction of carcinoembryonic antigen but not the mercurial-insensitive ecto-ATPase in human hepatoma Li-7A cells treated by epidermal growth factor and cholera toxin.
Cholestasis
Differential expression of canalicular membrane Ca2+/Mg(2+)-ecto-ATPase in estrogen-induced and obstructive cholestasis in the rat.
Cholestasis
Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis.
Cholestasis, Intrahepatic
Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis.
Colic
Evaluation of the genes encoding CD39/NTPDase-1 and CD39L1/NTPDase-2 in horses with and without abnormal hemorrhage and in horses with pathologic evidence of exercise-induced pulmonary hemorrhage.
Colitis
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Colitis
Extracellular ATP mediates inflammatory responses in colitis via P2?×?7 receptor signaling.
Colitis
Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn's disease.
Colitis
NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.
Colitis
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
Colorectal Neoplasms
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.
Colorectal Neoplasms
Silencing of Proteasome 26S Subunit ATPase 2 Regulates Colorectal Cancer Cell Proliferation, Apoptosis, and Migration.
Coronary Artery Disease
ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease.
Crohn Disease
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Crohn Disease
Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn's disease.
Cystic Fibrosis
CYSTIC FIBROSIS REMODELS THE REGULATION OF PURINERGIC SIGNALING BY NTPDASE1 (CD39) AND NTPDASE3.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator in human and mouse red blood cell membranes and its interaction with ecto-apyrase.
Cysts
Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro.
Cysts
Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion.
Cytomegalovirus Infections
Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5'nucleotidase (CD73) on endothelial cells.
Darier Disease
Loss of function mutations in ATP2A2 and psychoses: A case report and literature survey.
Darier Disease
Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.
Darier Disease
Up-Regulation of Transient Receptor Potential Canonical 1 (TRPC1) following Sarco(endo)plasmic Reticulum Ca2+ ATPase 2 Gene Silencing Promotes Cell Survival: A Potential Role for TRPC1 in Darier's Disease.
Darier Disease
[Detection and analysis of an ATP2A2 mutation in a family with Darier-White disease].
Demyelinating Diseases
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Demyelinating Diseases
Apyrase and 5'-nucleotidase Activities in Synaptosomes from the Cerebral Cortex of Rats Experimentally Demyelinated with Ethidium Bromide and Treated with Interferon-beta.
Demyelinating Diseases
Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Diabetes Mellitus
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Diabetes Mellitus, Type 2
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Diabetic Nephropathies
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Diabetic Nephropathies
The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy.
Diabetic Retinopathy
Phosphatase enzyme histochemistry for studying vascular hierarchy, pathology, and endothelial cell dysfunction in retina and choroid.
Diabetic Retinopathy
Vascular endothelial growth factor and vascular permeability changes in human diabetic retinopathy.
Encephalomyelitis
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis
Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis.
Encephalomyelitis
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Endotoxemia
Experimental endotoxemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity.
Epilepsies, Partial
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Epilepsy
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Epilepsy
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Epilepsy, Temporal Lobe
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Erectile Dysfunction
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.
Glioblastoma
Differing platelet aggregating effects by two tumor cell lines: absence of role for platelet-derived ADP.
Glioblastoma
Identifying small molecule probes of ENTPD5 through high throughput screening.
Glioblastoma
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Glioma
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
Glioma
Neuroblasts-glia interaction. The effect of co-cultivation upon ecto-ATPase activity of neuroblastoma and glioma cells.
Glioma
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Glioma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Glomerulonephritis
Intraglomerular thrombotic tendency and glomerular ADPase. Unilateral impairment of ADPase elicits a proaggregatory microenvironment in experimental glomerulonephritis.
Glomerulonephritis
Modulation of anti-Thy1 nephritis in the rat by adenine nucleotides. Evidence for an anti-inflammatory role for nucleotidases.
Glucose Intolerance
Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
Graft vs Host Disease
A single nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanised mouse model.
Gray Platelet Syndrome
Immunocytochemical localization of fibrinogen during thrombin-induced aggregation of washed human platelets.
Heart Diseases
ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease.
Hemoglobinopathies
Histopathologic features of neovascularization in sickle cell retinopathy.
Hyperalgesia
Free and nanoencapsulated vitamin D3 : effects on E-NTPDase and E-ADA activities in an animal model with induced arthritis.
Hyperemia
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
Hyperemia
[Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review]
Hyperhomocysteinemia
[Effect of thiolactone homocysteine loading on adenosine metabolism in rats: relationship with platelet hyper-reactivity, correction of this metabolism disorders by vitamin-microelement complex]
Hypersensitivity
Apyrase activity and adenosine diphosphate induced platelet aggregation inhibition by the salivary gland proteins of Culicoides variipennis, the North American vector of bluetongue viruses.
Hypertension
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Hypertension
Swimming training prevents alterations in ecto-NTPDase and adenosine deaminase activities in lymphocytes from N?-nitro-L-arginine methyl ester hydrochloride induced hypertension rats.
hypoxanthine phosphoribosyltransferase deficiency
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Infections
Age alters ADPase positive dendritic (Langerhans) cell response to P. aeruginosa ocular challenge.
Infections
Antibody reactivity against potato apyrase, a protein that shares epitopes with Schistosoma mansoni ATP diphosphohydrolase isoforms, in acute and chronically infected mice, after chemotherapy and reinfection.
Infections
Antibody Responses Against Anopheles darlingi Immunogenic Peptides in Plasmodium Infected Humans.
Infections
Cross-immunoreactivity between anti-potato apyrase antibodies and mammalian ATP diphosphohydrolases: potential use of the vegetal protein in experimental schistosomiasis.
Infections
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
Infections
Enzymatic Activity of the Soybean Ecto-Apyrase GS52 Is Essential for Stimulation of Nodulation.
Infections
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
Infections
Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apyrase involved in macrophage infection and expressed in infected dogs.
Infections
Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.
Infections
OppA, the ecto-ATPase of Mycoplasma hominis induces ATP release and cell death in HeLa cells.
Infections
Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells.
Infections
Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries.
Influenza, Human
The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.
Insulin Resistance
Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance.
Intestinal Volvulus
Salivary apyrase in New World blackflies (Diptera: Simuliidae) and its relationship to onchocerciasis vector status.
Ischemic Stroke
Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats.
Kidney Failure, Chronic
Enzymes that hydrolyze adenine nucleotides in chronic renal failure: relationship between hemostatic defects and renal failure severity.
Kidney Failure, Chronic
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Leishmaniasis
A Leishmania (L.) amazonensis ATP diphosphohydrolase isoform and potato apyrase share epitopes: antigenicity and correlation with disease progression.
Leishmaniasis
Canine Antibodies against Salivary Recombinant Proteins of Phlebotomus perniciosus: A Longitudinal Study in an Endemic Focus of Canine Leishmaniasis.
Leishmaniasis
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
Leishmaniasis
No recent adaptive selection on the apyrase of Mediterranean Phlebotomus: implications for using salivary peptides to vaccinate against canine leishmaniasis.
Leishmaniasis
Phlebotomus perniciosus Recombinant Salivary Proteins Polarize Murine Macrophages Toward the Anti-Inflammatory Phenotype.
Leishmaniasis, Cutaneous
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
Leishmaniasis, Cutaneous
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Leishmaniasis, Cutaneous
Phlebotomus papatasi Yellow-Related and Apyrase Salivary Proteins Are Candidates for Vaccination against Human Cutaneous Leishmaniasis.
Leishmaniasis, Visceral
An antigenic domain within a catalytically active Leishmania infantum nucleoside triphosphate diphosphohydrolase (NTPDase 1) is a target of inhibitory antibodies.
Leukemia
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, B-Cell
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Cell membrane fluidity in chronic lymphocytic leukemia (CLL) lymphocytes and its relation to membrane receptor expression.
Leukemia, Lymphocytic, Chronic, B-Cell
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, Myeloid, Acute
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML.
Liver Diseases
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Liver Diseases
Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities.
Liver Failure, Acute
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Lung Injury
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.
Lung Injury
Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.
Lung Neoplasms
ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
Lung Neoplasms
Establishment and validation of a prognostic signature for lung adenocarcinoma based on metabolism-related genes.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Malaria
Antibody Responses Against Anopheles darlingi Immunogenic Peptides in Plasmodium Infected Humans.
Malaria
Characterization of apyrase-like activity in Ochlerotatus triseriatus, Ochlerotatus hendersoni, and Aedes aegypti.
Malaria
Salivary apyrase in African and New World vectors of Plasmodium species and its relationship to malaria transmission.
Malnutrition
Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats.
Medulloblastoma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Melanoma
1?, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.
Melanoma
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Melanoma
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
Melanoma
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
Melanoma
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Melanoma
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Melanoma
The immunogenic properties of human melanomas and melanoma-associated antigens recognized by cytotoxic T lymphocytes.
MELAS Syndrome
Salivary apyrase in African and New World vectors of Plasmodium species and its relationship to malaria transmission.
Metabolic Syndrome
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Movement Disorders
Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation.
Multiple Sclerosis
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Myocardial Infarction
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
Myocardial Infarction
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Myocardial Infarction
Biochemical analysis of ectonucleotidases on primary rat vascular smooth muscle cells and in silico investigation of their role in vascular diseases.
Myocardial Ischemia
CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury.
Myocardial Ischemia
Platelet aggregation induced by the endoperoxide analogue U46619 is inhibited by polymorphonuclear leukocyte ADPase activity.
Myocardial Reperfusion Injury
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Neoplasm Metastasis
AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments.
Neoplasm Metastasis
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Neoplasm Metastasis
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Neoplasm Metastasis
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Neoplasm Metastasis
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
Neoplasm Metastasis
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
Neoplasm Metastasis
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Neoplasm Metastasis
p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.
Neoplasm Metastasis
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Neoplasms
A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells.
Neoplasms
A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy.
Neoplasms
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Neoplasms
Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance.
Neoplasms
Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling.
Neoplasms
Characterisation of platelet aggregation induced by PC-3 human prostate adenocarcinoma cells and inhibited by venom peptides, trigramin and rhodostomin.
Neoplasms
Characterization of platelet aggregation induced by human breast carcinoma and its inhibition by snake venom peptides, trigramin and rhodostomin.
Neoplasms
Characterization of platelet aggregation induced by human colon adenocarcinoma cells and its inhibition by snake venom peptides, trigramin and rhodostomin.
Neoplasms
Characterization of tumor-induced platelet aggregation: the role of immunorelated GPIb and GPIIb/IIIa expression by MCF-7 breast cancer cells.
Neoplasms
Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH.
Neoplasms
Differences in the mode of action of 1-oleoyl-2-acetyl-glycerol and phorbol ester in platelet activation.
Neoplasms
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Neoplasms
Differentiation of platelet-aggregating effects of human tumor cell lines based on inhibition studies with apyrase, hirudin, and phospholipase.
Neoplasms
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.
Neoplasms
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
Neoplasms
Ectonucleoside triphosphate diphosphohydrolase type 5 (entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
Neoplasms
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
Neoplasms
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Neoplasms
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
Neoplasms
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Neoplasms
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Neoplasms
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
Neoplasms
Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling.
Neoplasms
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma.
Neoplasms
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
Neoplasms
High expression of CD39 in gastric cancer reduces patient outcome following radical resection.
Neoplasms
Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity.
Neoplasms
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
Neoplasms
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.
Neoplasms
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Neoplasms
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Neoplasms
Inhibition of the interactions between metastatic human breast cancer cells and platelets by ?-nitrostyrene derivatives.
Neoplasms
Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion.
Neoplasms
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Neoplasms
Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner.
Neoplasms
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
Neoplasms
New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.
Neoplasms
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.
Neoplasms
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Neoplasms
Optimization of a Luminescence-Based High-Throughput Screening Assay for Detecting Apyrase Activity.
Neoplasms
Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU).
Neoplasms
p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.
Neoplasms
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Neoplasms
Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death.
Neoplasms
Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical-characteristics.
Neoplasms
PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma.
Neoplasms
Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme.
Neoplasms
Silencing of Proteasome 26S Subunit ATPase 2 Regulates Colorectal Cancer Cell Proliferation, Apoptosis, and Migration.
Neoplasms
Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer.
Neoplasms
The Arg-Gly-Asp-containing peptide, rhodostomin, inhibits in vitro cell adhesion to extracellular matrices and platelet aggregation caused by saos-2 human osteosarcoma cells.
Neoplasms
The DC electrical-field-induced Ca(2+) response and growth stimulation of multicellular tumor spheroids are mediated by ATP release and purinergic receptor stimulation.
Neoplasms
The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor.
Neoplasms
The P2RY2 Receptor Induces Carcinoma Cell Migration and EMT Through Cross-Talk With Epidermal Growth Factor Receptor.
Neoplasms
Thromboxane production by platelets during tumor cell-induced platelet activation.
Neoplasms
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Nephritis
Intraglomerular thrombotic tendency and glomerular ADPase. Unilateral impairment of ADPase elicits a proaggregatory microenvironment in experimental glomerulonephritis.
Nephrosis, Lipoid
Oxygen-dependent injury by a human plasma factor associated with minimal change disease.
Nephrotic Syndrome
Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro.
Neuralgia
Enhancement of purinergic signalling by excessive endogenous ATP in resiniferatoxin (RTX) neuropathy.
Neuralgia
Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.
Neuroblastoma
Neuroblasts-glia interaction in tissue culture as evidenced by the study of ectoenzymes. Ecto-ATPase activity of mouse neuroblastoma cells.
Neuroblastoma
Neuroblasts-glia interaction. The effect of co-cultivation upon ecto-ATPase activity of neuroblastoma and glioma cells.
Neuroblastoma
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
Obesity
Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
Onchocerciasis
Salivary apyrase in New World blackflies (Diptera: Simuliidae) and its relationship to onchocerciasis vector status.
Osteoarthritis
Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.
Osteoporosis, Postmenopausal
Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
Osteosarcoma
H(2)O(2) modulates purinergic-dependent calcium signalling in osteoblast-like cells.
Ovarian Neoplasms
The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27.
Pancreatic Neoplasms
Identification of ENTPD8 and cytidine in pancreatic cancer by metabolomic and transcriptomic conjoint analysis.
Paraplegia
A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene.
Parasitic Diseases
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Peripheral Vascular Diseases
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Peritonitis
Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.
Phenylketonurias
ATP diphosphohydrolase activity in synaptosomes from cerebral cortex of rats subjected to chemically induced phenylketonuria.
Proteinuria
Induction of experimental proteinuria in vivo following infusion of human plasma hemopexin.
Pulmonary Disease, Chronic Obstructive
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.
Pulmonary Edema
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.
Pulmonary Edema
Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts.
Reperfusion Injury
Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts.
Reperfusion Injury
Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury.
Reperfusion Injury
Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice.
Reperfusion Injury
Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions.
Reperfusion Injury
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Reperfusion Injury
The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury: Erratum.
Reperfusion Injury
The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis following ischemia reperfusion injury.
Retinal Detachment
Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon).
Retinal Neovascularization
??elemene inhibits oxygen?induced retinal neovascularization via promoting miR?27a and reducing VEGF expression.
Retinal Neovascularization
CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Retinal Neovascularization
Effects of green tea fractions on oxygen-induced retinal neovascularization in the neonatal rat.
Retinal Neovascularization
Effects of microRNA-29a on retinopathy of prematurity by targeting AGT in a mouse model.
Retinal Neovascularization
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization.
Retinal Neovascularization
Genetic inactivation of the adenosine A2A receptor attenuates pathological but not developmental angiogenesis in mouse retina.
Retinal Neovascularization
Influence of the difference of breastfeeding volume on a rat model of oxygen-induced retinopathy.
Retinal Neovascularization
Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization.
Retinal Neovascularization
Pentoxifylline inhibition of vasculogenesis in the neonatal rat retina.
Retinal Neovascularization
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Retinal Neovascularization
The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.
Retinopathy of Prematurity
Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity.
Retinopathy of Prematurity
Neovascularization grading methods in a rat model of retinopathy of prematurity.
Retinopathy of Prematurity
Phosphatase enzyme histochemistry for studying vascular hierarchy, pathology, and endothelial cell dysfunction in retina and choroid.
Retinoschisis
Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon).
Schistosomiasis
Cross-immunoreactivity between anti-potato apyrase antibodies and mammalian ATP diphosphohydrolases: potential use of the vegetal protein in experimental schistosomiasis.
Schistosomiasis
Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients.
Schistosomiasis
IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase.
Schistosomiasis
Inhibition of the ecto-ATPdiphosphohydrolase of Schistosoma mansoni by thapsigargin.
Schistosomiasis
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Schistosomiasis
Potato apyrase reduces granulomatous area and increases presence of multinucleated giant cells in murine schistosomiasis.
Seizures
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Sepsis
Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.
Sepsis
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database.
Small Cell Lung Carcinoma
Prevalence of the mercurial-sensitive EctoATPase in human small cell lung carcinoma: characterization and partial purification.
Spinal Cord Injuries
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Status Epilepticus
Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.
Status Epilepticus
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Status Epilepticus
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Stroke
Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats.
Testicular Neoplasms
Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance.
Thrombocytosis
Platelet aggregation in platelet-rich plasma and whole blood in 120 patients with myeloproliferative disorders.
Thromboembolism
The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.
Thromboembolism
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Thrombosis
Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo.
Thrombosis
Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture.
Thrombosis
Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1?-driven venous thrombosis.
Thrombosis
Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation.
Thrombosis
Experimental endotoxemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity.
Thrombosis
Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor.
Thrombosis
Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores.
Thrombosis
Human Placental Ectonucleoside Triphosphate Diphosphohydrolase Gene Transfer via Gelatin-Coated Stents Prevents In-Stent Thrombosis.
Thrombosis
Intravenous apyrase administration reduces arterial thrombosis in a rabbit model of endothelial denudation in vivo.
Thrombosis
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Thrombosis
Oral L-arginine administration does not inhibit thrombosis on an experimental model of arterial thrombosis: the effect on the apyrasic activity of the arterial wall.
Thrombosis
P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
Thrombosis
Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization.
Thrombosis
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Thyroid Neoplasms
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma.
Tonsillitis
Localisation of ecto-5'-nucleotidase and divalent cation-activated ecto-ATPase in chronic tonsillitis.
Urinary Bladder Neoplasms
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Vascular Diseases
Biochemical analysis of ectonucleotidases on primary rat vascular smooth muscle cells and in silico investigation of their role in vascular diseases.
Vascular Diseases
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.
Vascular Diseases
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Vascular Ring
Platelets enhance anoxic contraction of rat aortic rings through platelet-activating factor-dependent mechanism.
Vascular System Injuries
Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.
Vascular System Injuries
Loss of ATP diphosphohydrolase activity with endothelial cell activation.
Vascular System Injuries
Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions.
Venous Thromboembolism
The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.
Vitreous Hemorrhage
Clinical and histopathologic features of canine oxygen-induced proliferative retinopathy.
von Willebrand Diseases
The effect of apyrase on platelet retention in normal subjects and in patients with abnormal cardiac valves or with von Willebrand's disease.
Whooping Cough
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
Whooping Cough
Secretion of Matrix Metalloproteinase-9 from Astrocytes by Inhibition of Tonic P2Y(14)-Receptor-Mediated Signal(s).
Yellow Fever
Promoter sequences of the putative Anopheles gambiae apyrase confer salivary gland expression in Drosophila melanogaster.
Yellow Fever
Salivary gland-specific gene expression in the malaria vector Anopheles gambiae.
Yellow Fever
The Apyrase gene of the vector mosquito, Aedes aegypti, is expressed specifically in the adult female salivary glands.