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Disease on EC 3.6.1.5 - apyrase and Organism(s) Homo sapiens

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis following ischemia reperfusion injury.
Alveolar Bone Loss
P2X4 is up-regulated in gingival fibroblasts after periodontal surgery.
Amebiasis
Ectonucleotide diphosphohydrolase activities in Entamoeba histolytica.
Anaplasia
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Anemia
Dual-perspective analysis of vascular formations in sickle cell retinopathy.
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
Anemia, Sickle Cell
Dual-perspective analysis of vascular formations in sickle cell retinopathy.
Aortic Aneurysm
Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPAR?.
Aortic Valve Stenosis
Simultaneous accurate quantification of HO-1, CD39, and CD73 in human calcified aortic valves using multiple enzyme digestion - filter aided sample pretreatment (MED-FASP) method and targeted proteomics.
apyrase deficiency
Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. A biochemical basis for thymidine sensitivity.
Ecto-ATPase deficiency in glia of seizure-prone mice.
Arteriosclerosis
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Arthritis
Effect of quercetin on E-NTPDase/E-ADA activities and cytokine secretion of complete Freund adjuvant-induced arthritic rats.
Free and nanoencapsulated vitamin D3 : effects on E-NTPDase and E-ADA activities in an animal model with induced arthritis.
Arthritis, Rheumatoid
Activities of enzymes that hydrolyze adenine nucleotides in lymphocytes from patients with rheumatoid arthritis.
Asthma
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells.
Astrocytoma
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes.
Ataxia
A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene.
Atherosclerosis
ADPase activity of normal and atherosclerotic human aorta intima.
The anatomical distribution of ADPase activity in the rabbit aorta.
Bacterial Infections
Apyrase Elicits Host Antimicrobial Responses and Resolves Infection in Burns.
The role of Langerhans cells in Pseudomonas aeruginosa infection.
Bluetongue
Apyrase activity and adenosine diphosphate induced platelet aggregation inhibition by the salivary gland proteins of Culicoides variipennis, the North American vector of bluetongue viruses.
Brain Diseases
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Brain Ischemia
Brain ischemia alters platelet ATP diphosphohydrolase and 5'-nucleotidase activities in naive and preconditioned rats.
Breast Neoplasms
AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments.
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis.
Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients.
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
P2Y2 nucleotide receptor-mediated extracellular signal-regulated kinases and protein kinase C activation induces the invasion of highly metastatic breast cancer cells.
Carcinogenesis
Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance.
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
PSMC2 is up-regulated in osteosarcoma and regulates osteosarcoma cell proliferation, apoptosis and migration.
PSMC2 is Up-regulated in Pancreatic Cancer and Promotes Cancer Cell Proliferation and Inhibits Apoptosis.
Carcinoma
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
Prevalence of the mercurial-sensitive EctoATPase in human small cell lung carcinoma: characterization and partial purification.
Carcinoma, Hepatocellular
A novel response to dioxin. Induction of ecto-ATPase gene expression.
Accessibility and activity of the promoter for a dioxin-inducible ecto-ATPase gene.
Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Enzymatic and transcriptional regulation of human ecto-ATPase/E-NTPDase 2.
Evidence for an ATP-dependent bile acid transport protein other than the canalicular liver ecto-ATPase in rats.
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
The rat liver ecto-ATPase/C-CAM cDNA detects induction of carcinoembryonic antigen but not the mercurial-insensitive ecto-ATPase in human hepatoma Li-7A cells treated by epidermal growth factor and cholera toxin.
[Adenosinetriphosphate content and apyrase activity in normal rat liver and rat hepatoma.]
Carcinoma, Squamous Cell
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca(2+) ATPase 2 heterozygote mice keratinocytes.
Cardiomegaly
Extracellular signal-regulated kinase activation during cardiac hypertrophy reduces sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) transcription.
Cerebral Infarction
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.
Chagas Disease
E-NTPDase and E-ADA activities are altered in lymphocytes of patients with indeterminate form of Chagas' disease.
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Triatoma infestans apyrases belong to the 5'-nucleotidase family.
Cholera
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
The rat liver ecto-ATPase/C-CAM cDNA detects induction of carcinoembryonic antigen but not the mercurial-insensitive ecto-ATPase in human hepatoma Li-7A cells treated by epidermal growth factor and cholera toxin.
Cholestasis
Differential expression of canalicular membrane Ca2+/Mg(2+)-ecto-ATPase in estrogen-induced and obstructive cholestasis in the rat.
Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis.
Cholestasis, Intrahepatic
Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis.
Chromoblastomycosis
Characterization of an ecto-ATPase activity in Fonsecaea pedrosoi.
Colic
Evaluation of the genes encoding CD39/NTPDase-1 and CD39L1/NTPDase-2 in horses with and without abnormal hemorrhage and in horses with pathologic evidence of exercise-induced pulmonary hemorrhage.
Colitis
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Extracellular ATP mediates inflammatory responses in colitis via P2?×?7 receptor signaling.
Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn's disease.
NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD.
Colorectal Neoplasms
Novel role of Sarco/endoplasmic reticulum calcium ATPase 2 in development of colorectal cancer and its regulation by F36, a curcumin analog.
Silencing of Proteasome 26S Subunit ATPase 2 Regulates Colorectal Cancer Cell Proliferation, Apoptosis, and Migration.
Coronary Artery Disease
ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease.
Crohn Disease
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Modulation of CD39 and exogenous APT102 correct immune dysfunction in experimental colitis and Crohn's disease.
Cystic Fibrosis
CYSTIC FIBROSIS REMODELS THE REGULATION OF PURINERGIC SIGNALING BY NTPDASE1 (CD39) AND NTPDASE3.
Cystic fibrosis transmembrane conductance regulator in human and mouse red blood cell membranes and its interaction with ecto-apyrase.
Cysts
Antagonism of endogenous putative P2Y receptors reduces the growth of MDCK-derived cysts cultured in vitro.
Formation of cysts by principal-like MDCK cells depends on the synergy of cAMP- and ATP-mediated fluid secretion.
Cytomegalovirus Infections
Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5'nucleotidase (CD73) on endothelial cells.
Darier Disease
Loss of function mutations in ATP2A2 and psychoses: A case report and literature survey.
Metabolic phenotype in Darier disease: a cross-sectional clinical study.
Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes.
Up-Regulation of Transient Receptor Potential Canonical 1 (TRPC1) following Sarco(endo)plasmic Reticulum Ca2+ ATPase 2 Gene Silencing Promotes Cell Survival: A Potential Role for TRPC1 in Darier's Disease.
[Detection and analysis of an ATP2A2 mutation in a family with Darier-White disease].
Demyelinating Diseases
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Apyrase and 5'-nucleotidase Activities in Synaptosomes from the Cerebral Cortex of Rats Experimentally Demyelinated with Ethidium Bromide and Treated with Interferon-beta.
Apyrase and 5'-nucleotidase activities in synaptosomes from the cerebral cortex of rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Diabetes Mellitus
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Diabetes Mellitus, Type 2
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Diabetic Nephropathies
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy.
Diabetic Retinopathy
Phosphatase enzyme histochemistry for studying vascular hierarchy, pathology, and endothelial cell dysfunction in retina and choroid.
Vascular endothelial growth factor and vascular permeability changes in human diabetic retinopathy.
Encephalomyelitis
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Temporal pattern of plasma membrane calcium ATPase 2 expression in the spinal cord correlates with the course of clinical symptoms in two rodent models of autoimmune encephalomyelitis.
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis.
Endotoxemia
Experimental endotoxemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity.
Epilepsies, Partial
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Epilepsy
Changes in nucleotide hydrolysis in rat blood serum induced by pentylenetetrazol-kindling.
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Epilepsy, Temporal Lobe
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Erectile Dysfunction
Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model.
Glioblastoma
Differing platelet aggregating effects by two tumor cell lines: absence of role for platelet-derived ADP.
Identifying small molecule probes of ENTPD5 through high throughput screening.
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Selective chemical modification of plasma membrane ectoenzymes.
Glioma
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Inhibition of ecto-ATPase by PPADS, suramin and reactive blue in endothelial cells, C6 glioma cells and RAW 264.7 macrophages.
Neuroblasts-glia interaction. The effect of co-cultivation upon ecto-ATPase activity of neuroblastoma and glioma cells.
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Purinergic signaling in glioma progression.
Purinergic Signaling in Glioma Progression.
Selective NTPDase2 expression modulates in vivo rat glioma growth.
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Glomerulonephritis
Intraglomerular thrombotic tendency and glomerular ADPase. Unilateral impairment of ADPase elicits a proaggregatory microenvironment in experimental glomerulonephritis.
Modulation of anti-Thy1 nephritis in the rat by adenine nucleotides. Evidence for an anti-inflammatory role for nucleotidases.
Glucose Intolerance
Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
Graft vs Host Disease
A single nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanised mouse model.
Gray Platelet Syndrome
Immunocytochemical localization of fibrinogen during thrombin-induced aggregation of washed human platelets.
Heart Diseases
ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease.
Hemoglobinopathies
Histopathologic features of neovascularization in sickle cell retinopathy.
Hyperalgesia
Free and nanoencapsulated vitamin D3 : effects on E-NTPDase and E-ADA activities in an animal model with induced arthritis.
Hyperemia
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
[Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review]
Hyperhomocysteinemia
[Effect of thiolactone homocysteine loading on adenosine metabolism in rats: relationship with platelet hyper-reactivity, correction of this metabolism disorders by vitamin-microelement complex]
Hypersensitivity
Apyrase activity and adenosine diphosphate induced platelet aggregation inhibition by the salivary gland proteins of Culicoides variipennis, the North American vector of bluetongue viruses.
The role of Langerhans cells in Pseudomonas aeruginosa infection.
Hypertension
Identification of differential gene expression profile from peripheral blood cells of military pilots with hypertension by RNA sequencing analysis.
Swimming training prevents alterations in ecto-NTPDase and adenosine deaminase activities in lymphocytes from N?-nitro-L-arginine methyl ester hydrochloride induced hypertension rats.
hypoxanthine phosphoribosyltransferase deficiency
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Infections
Age alters ADPase positive dendritic (Langerhans) cell response to P. aeruginosa ocular challenge.
Antibody reactivity against potato apyrase, a protein that shares epitopes with Schistosoma mansoni ATP diphosphohydrolase isoforms, in acute and chronically infected mice, after chemotherapy and reinfection.
Antibody Responses Against Anopheles darlingi Immunogenic Peptides in Plasmodium Infected Humans.
Apyrase Elicits Host Antimicrobial Responses and Resolves Infection in Burns.
Characterisation of the secreted apyrase family of Heligmosomoides polygyrus.
Cross-immunoreactivity between anti-potato apyrase antibodies and mammalian ATP diphosphohydrolases: potential use of the vegetal protein in experimental schistosomiasis.
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
Enzymatic Activity of the Soybean Ecto-Apyrase GS52 Is Essential for Stimulation of Nodulation.
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
GS52 ecto-apyrase plays a critical role during soybean nodulation.
Inhibition of ecto-ATPase activities impairs HIV-1 infection of macrophages.
Leishmania infantum ecto-nucleoside triphosphate diphosphohydrolase-2 is an apyrase involved in macrophage infection and expressed in infected dogs.
Malaria load affects the activity of mosquito salivary apyrase.
Multiple ecto-nucleoside triphosphate diphosphohydrolases facilitate intracellular replication of Legionella pneumophila.
OppA, the ecto-ATPase of Mycoplasma hominis induces ATP release and cell death in HeLa cells.
Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells.
Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries.
Influenza, Human
The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.
Insulin Resistance
Extracellular ATP Increases Glucose Metabolism in Skeletal Muscle Cells in a P2 Receptor Dependent Manner but Does Not Contribute to Palmitate-Induced Insulin Resistance.
Intestinal Volvulus
Salivary apyrase in New World blackflies (Diptera: Simuliidae) and its relationship to onchocerciasis vector status.
Ischemic Stroke
Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats.
Kidney Failure, Chronic
Enzymes that hydrolyze adenine nucleotides in chronic renal failure: relationship between hemostatic defects and renal failure severity.
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Leishmaniasis
A Leishmania (L.) amazonensis ATP diphosphohydrolase isoform and potato apyrase share epitopes: antigenicity and correlation with disease progression.
Canine Antibodies against Salivary Recombinant Proteins of Phlebotomus perniciosus: A Longitudinal Study in an Endemic Focus of Canine Leishmaniasis.
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
No recent adaptive selection on the apyrase of Mediterranean Phlebotomus: implications for using salivary peptides to vaccinate against canine leishmaniasis.
Phlebotomus perniciosus Recombinant Salivary Proteins Polarize Murine Macrophages Toward the Anti-Inflammatory Phenotype.
Leishmaniasis, Cutaneous
Cytochemical localization of ATP diphosphohydrolase from Leishmania (Viannia) braziliensis promastigotes and identification of an antigenic and catalytically active isoform.
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Phlebotomus papatasi Yellow-Related and Apyrase Salivary Proteins Are Candidates for Vaccination against Human Cutaneous Leishmaniasis.
Leishmaniasis, Visceral
An antigenic domain within a catalytically active Leishmania infantum nucleoside triphosphate diphosphohydrolase (NTPDase 1) is a target of inhibitory antibodies.
Leukemia
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, B-Cell
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Cell membrane fluidity in chronic lymphocytic leukemia (CLL) lymphocytes and its relation to membrane receptor expression.
The kinetic properties of the ecto-ATPase of human peripheral blood lymphocytes and of chronic lymphatic leukemia cells.
Leukemia, Myeloid, Acute
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML.
Liver Diseases
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Purinergic signalling in liver diseases: Pathological functions and therapeutic opportunities.
Liver Failure, Acute
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Lung Injury
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.
Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury.
Lung Neoplasms
ENTPD5 induces apoptosis in lung cancer cells via regulating caspase 3 expression.
Establishment and validation of a prognostic signature for lung adenocarcinoma based on metabolism-related genes.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Malaria
Antibody Responses Against Anopheles darlingi Immunogenic Peptides in Plasmodium Infected Humans.
Characterization of apyrase-like activity in Ochlerotatus triseriatus, Ochlerotatus hendersoni, and Aedes aegypti.
Malaria load affects the activity of mosquito salivary apyrase.
Salivary apyrase in African and New World vectors of Plasmodium species and its relationship to malaria transmission.
Malnutrition
Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats.
Medulloblastoma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Melanoma
1?, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
The immunogenic properties of human melanomas and melanoma-associated antigens recognized by cytotoxic T lymphocytes.
MELAS Syndrome
Salivary apyrase in African and New World vectors of Plasmodium species and its relationship to malaria transmission.
Metabolic Syndrome
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease.
Movement Disorders
Naringin attenuates Bisphenol-A mediated neurotoxicity in hypertensive rats by abrogation of cerebral nucleotide depletion, oxidative damage and neuroinflammation.
Multiple Sclerosis
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Myocardial Infarction
Apyrase treatment of myocardial infarction according to a clinically applicable protocol fails to reduce myocardial injury in a porcine model.
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Biochemical analysis of ectonucleotidases on primary rat vascular smooth muscle cells and in silico investigation of their role in vascular diseases.
Myocardial Ischemia
CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury.
Platelet aggregation induced by the endoperoxide analogue U46619 is inhibited by polymorphonuclear leukocyte ADPase activity.
Myocardial Reperfusion Injury
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Neoplasm Metastasis
AMP hydrolysis reduction in blood plasma of breast cancer elderly patients after different treatments.
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Neoplasms
A new tetraphenylethylene based AIE sensor with light-up and tunable measuring range for adenosine triphosphate in aqueous solution and in living cells.
A tumor-cell biomimetic nanoplatform embedding biological enzymes for enhanced metabolic therapy.
Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis.
Altered purinergic signalling in CD73 deficient mice inhibits tumor progression.
APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice.
Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance.
Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling.
Characterisation of platelet aggregation induced by PC-3 human prostate adenocarcinoma cells and inhibited by venom peptides, trigramin and rhodostomin.
Characterization of platelet aggregation induced by human breast carcinoma and its inhibition by snake venom peptides, trigramin and rhodostomin.
Characterization of platelet aggregation induced by human colon adenocarcinoma cells and its inhibition by snake venom peptides, trigramin and rhodostomin.
Characterization of tumor-induced platelet aggregation: the role of immunorelated GPIb and GPIIb/IIIa expression by MCF-7 breast cancer cells.
Comparative studies of the cytotoxic T lymphocyte-mediated cytotoxicity and of extracellular ATP-induced cell lysis. Different requirements in extracellular Mg2+ and pH.
Differences in the mode of action of 1-oleoyl-2-acetyl-glycerol and phorbol ester in platelet activation.
Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.
Differentiation of platelet-aggregating effects of human tumor cell lines based on inhibition studies with apyrase, hirudin, and phospholipase.
Disruption of the interaction between PMCA2 and calcineurin triggers apoptosis and enhances paclitaxel-induced cytotoxicity in breast cancer cells.
Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas.
Ectonucleoside triphosphate diphosphohydrolase type 5 (entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
EL-4 tumor cell-induced human and rabbit platelet aggregations.
Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells.
ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.
ENTPD5-mediated modulation of ATP results in altered metabolism and decreased survival in gliomablastoma multiforme.
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts.
Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells.
Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling.
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma.
GATA Binding Protein 3 Boosts Extracellular ATP Hydrolysis and Inhibits Metastasis of Breast Cancer by Up-regulating Ectonucleoside Triphosphate Diphosphohydrolase 3.
High expression of CD39 in gastric cancer reduces patient outcome following radical resection.
Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity.
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Identifying small molecule probes of ENTPD5 through high throughput screening.
In vitro interaction between cultured cells and human blood platelets.
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Inhibition of the interactions between metastatic human breast cancer cells and platelets by ?-nitrostyrene derivatives.
Interleukin-10 expression in lipopolysaccharide-activated microglia is mediated by extracellular ATP in an autocrine fashion.
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues.
Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner.
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Optimization of a Luminescence-Based High-Throughput Screening Assay for Detecting Apyrase Activity.
Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU).
p53 gain-of-function mutations promote metastasis via ENTPD5 upregulation and enhanced N-glycoprotein folding.
Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.
Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death.
Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical-characteristics.
PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma.
Purification, cloning, and expression of an apyrase from the bed bug Cimex lectularius. A new type of nucleotide-binding enzyme.
Purinergic signaling in glioma progression.
Purinergic Signaling in Glioma Progression.
Role of ADP receptors on platelets in the growth of ovarian cancer.
Silencing of Proteasome 26S Subunit ATPase 2 Regulates Colorectal Cancer Cell Proliferation, Apoptosis, and Migration.
Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer.
The Arg-Gly-Asp-containing peptide, rhodostomin, inhibits in vitro cell adhesion to extracellular matrices and platelet aggregation caused by saos-2 human osteosarcoma cells.
The DC electrical-field-induced Ca(2+) response and growth stimulation of multicellular tumor spheroids are mediated by ATP release and purinergic receptor stimulation.
The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor.
The P2RY2 Receptor Induces Carcinoma Cell Migration and EMT Through Cross-Talk With Epidermal Growth Factor Receptor.
Thromboxane production by platelets during tumor cell-induced platelet activation.
TOX is a critical regulator of tumour-specific T cell differentiation.
V?9V?2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Nephritis
Intraglomerular thrombotic tendency and glomerular ADPase. Unilateral impairment of ADPase elicits a proaggregatory microenvironment in experimental glomerulonephritis.
Nephrosis, Lipoid
Oxygen-dependent injury by a human plasma factor associated with minimal change disease.
Nephrotic Syndrome
Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro.
Neuralgia
Enhancement of purinergic signalling by excessive endogenous ATP in resiniferatoxin (RTX) neuropathy.
Neuronal NTPDase3 Mediates Extracellular ATP Degradation in Trigeminal Nociceptive Pathway.
Neuroblastoma
Neuroblasts-glia interaction in tissue culture as evidenced by the study of ectoenzymes. Ecto-ATPase activity of mouse neuroblastoma cells.
Neuroblasts-glia interaction. The effect of co-cultivation upon ecto-ATPase activity of neuroblastoma and glioma cells.
On the activation of plasma membrane ecto-enzymes by treatment with neuraminidase.
Selective chemical modification of plasma membrane ectoenzymes.
Obesity
Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism.
Onchocerciasis
Salivary apyrase in New World blackflies (Diptera: Simuliidae) and its relationship to onchocerciasis vector status.
Osteoarthritis
Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis.
Osteoporosis, Postmenopausal
Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.
Osteosarcoma
H(2)O(2) modulates purinergic-dependent calcium signalling in osteoblast-like cells.
Ovarian Neoplasms
Role of ADP receptors on platelets in the growth of ovarian cancer.
The ecto-ATPDase CD39 is involved in the acquisition of the immunoregulatory phenotype by M-CSF-macrophages and ovarian cancer tumor-associated macrophages: Regulatory role of IL-27.
Pancreatic Neoplasms
Identification of ENTPD8 and cytidine in pancreatic cancer by metabolomic and transcriptomic conjoint analysis.
Paraplegia
A new case of spastic paraplegia type 64 due to a missense mutation in the ENTPD1 gene.
Parasitic Diseases
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Peripheral Vascular Diseases
Assay, kinetics and properties of plasma adenosine diphosphatase. The relationship to acid and alkaline phosphatase and variations in disease.
Peritonitis
Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.
Phenylketonurias
ATP diphosphohydrolase activity in synaptosomes from cerebral cortex of rats subjected to chemically induced phenylketonuria.
Proteinuria
Induction of experimental proteinuria in vivo following infusion of human plasma hemopexin.
Pulmonary Disease, Chronic Obstructive
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.
Pulmonary Edema
Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.
Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts.
Reperfusion Injury
Apyrase administration prolongs discordant xenograft survival.
Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts.
Human recombinant apyrase therapy protects against canine pulmonary ischemia-reperfusion injury.
Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice.
Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions.
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury: Erratum.
The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis following ischemia reperfusion injury.
Retinal Detachment
Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon).
Retinal Neovascularization
??elemene inhibits oxygen?induced retinal neovascularization via promoting miR?27a and reducing VEGF expression.
CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Effects of green tea fractions on oxygen-induced retinal neovascularization in the neonatal rat.
Effects of microRNA-29a on retinopathy of prematurity by targeting AGT in a mouse model.
Effects of the phosphatidylinositol 3-kinase inhibitor in a mouse model of retinal neovascularization.
Genetic inactivation of the adenosine A2A receptor attenuates pathological but not developmental angiogenesis in mouse retina.
Influence of the difference of breastfeeding volume on a rat model of oxygen-induced retinopathy.
Oxygen-induced retinopathy in the rat: relationship of retinal nonperfusion to subsequent neovascularization.
Pentoxifylline inhibition of vasculogenesis in the neonatal rat retina.
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.
Retinopathy of Prematurity
Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity.
Neovascularization grading methods in a rat model of retinopathy of prematurity.
Phosphatase enzyme histochemistry for studying vascular hierarchy, pathology, and endothelial cell dysfunction in retina and choroid.
Retinoschisis
Senile retinoschisis versus retinal detachment, the additional value of peripheral retinal OCT scans (SL SCAN-1, Topcon).
Sarcoma
The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes.
Schistosomiasis
Cross-immunoreactivity between anti-potato apyrase antibodies and mammalian ATP diphosphohydrolases: potential use of the vegetal protein in experimental schistosomiasis.
Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients.
IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase.
Inhibition of the ecto-ATPdiphosphohydrolase of Schistosoma mansoni by thapsigargin.
Mapping of the conserved antigenic domains shared between potato apyrase and parasite ATP diphosphohydrolases: potential application in human parasitic diseases.
Potato apyrase reduces granulomatous area and increases presence of multinucleated giant cells in murine schistosomiasis.
Seizures
Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene.
Sepsis
CD39 improves survival in microbial sepsis by attenuating systemic inflammation.
Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro.
Identification of key pathogenic genes of sepsis based on the Gene Expression Omnibus database.
Increased NTPDase activity in lymphocytes during experimental sepsis.
Skin Diseases
Metabolic phenotype in Darier disease: a cross-sectional clinical study.
Small Cell Lung Carcinoma
Prevalence of the mercurial-sensitive EctoATPase in human small cell lung carcinoma: characterization and partial purification.
Spinal Cord Injuries
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).
Status Epilepticus
Altered residual ATP content in rat brain cortex subcellular fractions following status epilepticus induced by lithium and pilocarpine.
Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy.
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Stroke
Combination treatment of r-tPA and an optimized human apyrase reduces mortality rate and hemorrhagic transformation 6h after ischemic stroke in aged female rats.
Testicular Neoplasms
Ectonucleoside triphosphate diphosphohydrolase 6 expression in testis and testicular cancer and its implication in cisplatin resistance.
Tetanus
ATP released by electrical stimuli elicits calcium transients in skeletal muscle.
Thrombocytosis
Platelet aggregation in platelet-rich plasma and whole blood in 120 patients with myeloproliferative disorders.
Thromboembolism
The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Thrombosis
Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo.
Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture.
Ectonucleotidase tri(di)phosphohydrolase-1 (ENTPD-1) disrupts inflammasome/interleukin 1?-driven venous thrombosis.
Effect of 300- and 450-mg clopidogrel loading doses on membrane and soluble P-selectin in patients undergoing coronary stent implantation.
Experimental endotoxemia in pregnancy: in situ glomerular microthrombus formation associated with impaired glomerular adenosine diphosphatase activity.
Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor.
Full activation of mouse platelets requires ADP secretion regulated by SERCA3 ATPase-dependent calcium stores.
Human Placental Ectonucleoside Triphosphate Diphosphohydrolase Gene Transfer via Gelatin-Coated Stents Prevents In-Stent Thrombosis.
Intraglomerular platelet aggregation and experimental glomerulonephritis.
Intravenous apyrase administration reduces arterial thrombosis in a rabbit model of endothelial denudation in vivo.
Loss of ATP diphosphohydrolase activity with endothelial cell activation.
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk.
Oral L-arginine administration does not inhibit thrombosis on an experimental model of arterial thrombosis: the effect on the apyrasic activity of the arterial wall.
P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
Recombinant soluble apyrase APT102 inhibits thrombosis and intimal hyperplasia in vein grafts without adversely affecting hemostasis or re-endothelialization.
Reduced thrombogenicity of artificial materials by coating with ADPase.
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Thyroid Neoplasms
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma.
Tonsillitis
Localisation of ecto-5'-nucleotidase and divalent cation-activated ecto-ATPase in chronic tonsillitis.
Urinary Bladder Neoplasms
NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.
Vascular Diseases
Biochemical analysis of ectonucleotidases on primary rat vascular smooth muscle cells and in silico investigation of their role in vascular diseases.
Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation.
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.
Vascular Ring
Platelets enhance anoxic contraction of rat aortic rings through platelet-activating factor-dependent mechanism.
Vascular System Injuries
Ectonucleotide triphosphate diphosphohydrolase-1 (CD39) mediates resistance to occlusive arterial thrombus formation after vascular injury in mice.
Loss of ATP diphosphohydrolase activity with endothelial cell activation.
Loss of rat glomerular ATP diphosphohydrolase activity during reperfusion injury is associated with oxidative stress reactions.
Venous Thromboembolism
The ENTPD1 promoter polymorphism -860 A > G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.
Vitreous Hemorrhage
Clinical and histopathologic features of canine oxygen-induced proliferative retinopathy.
von Willebrand Diseases
The effect of apyrase on platelet retention in normal subjects and in patients with abnormal cardiac valves or with von Willebrand's disease.
Whooping Cough
Hyperosmolar solution effects in guinea pig airways. III. Studies on the identity of epithelium-derived relaxing factor in isolated perfused trachea using pharmacological agents.
Secretion of Matrix Metalloproteinase-9 from Astrocytes by Inhibition of Tonic P2Y(14)-Receptor-Mediated Signal(s).
Yellow Fever
Promoter sequences of the putative Anopheles gambiae apyrase confer salivary gland expression in Drosophila melanogaster.
Salivary gland-specific gene expression in the malaria vector Anopheles gambiae.
The Apyrase gene of the vector mosquito, Aedes aegypti, is expressed specifically in the adult female salivary glands.