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Information on EC 3.6.1.44 - oligosaccharide-diphosphodolichol diphosphatase
for references in articles please use BRENDA:EC3.6.1.44
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EC Tree 3 Hydrolases
3.6 Acting on acid anhydrides
3.6.1 In phosphorus-containing anhydrides
3.6.1.44 oligosaccharide-diphosphodolichol diphosphatase
The enzyme appears in viruses and cellular organisms
Reaction Schemes
showSynonyms
dlodp, dlo diphosphatase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
oligosaccharide-diphosphodolichol pyrophosphatase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
oligosaccharide-diphosphodolichol + H2O = oligosaccharide phosphate + dolichyl phosphate
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of diphosphate bonds
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
oligosaccharide-diphosphodolichol phosphodolichohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
117698-28-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dolichyl diphosphate + H2O
dolichyl phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
Glc2Man5GlcNAc2-diphosphodolichol + H2O
Glc2Man5GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
Glc2Man9GlcNAc2-diphosphodolichol + H2O
Glc2Man9GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
Glc3Man5GlcNAc2-diphosphodolichol + H2O
Glc3Man5GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
Glc3Man9GlcNAc2-diphosphodolichol + H2O
Glc3Man9GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
GlcMan5GlcNAc2-diphosphodolichol + H2O
GlcMan5GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
GlcMan9GlcNAc2-diphosphodolichol + H2O
GlcMan9GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
GlcNAc2-PP-solanesol + H2O
GlcNAc2-phosphate + solanesyl phosphate
-
Substrates: -
Products: -
Products: -
?
Man5GlcNAc2-diphosphodolichol + H2O
Man5GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
Man7GlcNAc2-diphosphodolichol + H2O
Man7GlcNAc2 phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
Man9GlcNAc2-diphosphodolichol + H2O
Man9GlcNAc2-phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
oligosaccharide-diphosphodolichol + H2O
oligosaccharide phosphate + dolichyl phosphate
-
Substrates: oligosaccharide-diphosphodolichol from mouse splenocytes
Products: -
Products: -
?
oligosaccharide-diphosphodolichol + H2O
oligosaccharide phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dolichyl diphosphate + H2O
dolichyl phosphate + phosphate
-
Substrates: -
Products: -
Products: -
?
oligosaccharide-diphosphodolichol + H2O
oligosaccharide phosphate + dolichyl phosphate
-
Substrates: -
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
-
preincubation for 10 min, half-life at 62°C 1 hour, activity lost after incubation at 70°C
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Belard, M.; Cacan, R.; Verbert,A.
Characterization of an oligosaccharide-pyrophosphodolichol pyrophosphatase activity in yeast
Biochem. J.
255
235-242
1988
Saccharomyces cerevisiae
brenda
Massarweh, A.; Bosco, M.E.; Iatmanen-Harbi, S.; Tessier, C.; Amana, L.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S.E.
Brefeldin A promotes the appearance of oligosaccharyl phosphates (OSP) derived from Glc3Man9GlcNAc2-PP-dolichol within the endomembrane system of HepG2 cells
J. Lipid Res.
57
1477-1491
2016
Homo sapiens
brenda
Massarweh, A.; Bosco, M.; Iatmanen-Harbi, S.; Tessier, C.; Auberger, N.; Busca, P.; Chantret, I.; Gravier-Pelletier, C.; Moore, S.E.
Demonstration of an oligosaccharide-diphosphodolichol diphosphatase activity whose subcellular localization is different than those of dolichyl-phosphate-dependent enzymes of the dolichol cycle
J. Lipid Res.
57
1029-1042
2016
Homo sapiens
brenda
EXTERNAL LINKS (specific for EC-Number 3.6.1.44)
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