Reference on EC 3.6.1.17 - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Warner, A.H.; Finamore, F.J.
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs
Biochemistry
4
1568-1575
1965
Artemia salina
Vallejo, C.G.; Sillero, M.A.G.; Sillero, A.
Diguanosinetetraphosphate guanosylhydrolase in Artemia salina
Biochim. Biophys. Acta
358
117-125
1974
Artemia salina
Lobaton, C.D.; Vallejo, C.G.; Sillero, A.; Sillero, M.A.G.
Diguanosinetetraphosphatase from rat liver: Activity on diadenosine tetraphosphate and inhibition by adenosine tetraphosphate
Eur. J. Biochem.
50
495-501
1975
Rattus norvegicus
Vallejo, C.G.; Lobaton, C.D.; Quintanilla, M.; Sillero, A.; Sillero, M.A.G.
Dinucleosidasetetraphosphatase in rat liver and Artemia salina
Biochim. Biophys. Acta
438
304-309
1976
Artemia salina, Rattus norvegicus
Moreno, A.; Lobaton, C.D.; Sillero, M.A.G.; Sillero, A.
Dinucleosidetetraphosphatase from Ehrlich ascites tumour cells: inhibition by adenosine, guanosine and uridine 5-tetraphosphates
Int. J. Biochem.
14
629-634
1982
Mus musculus
Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.
Bis-(5-guanosyl) tetraphosphatase in rat tissues
Biochem. J.
201
405-410
1982
Rattus norvegicus
Costas, M.J.; Cameselle, J.C.; Sillero, A.
Mitochondrial location of rat liver dinucleoside triphosphatase
J. Biol. Chem.
261
2064-2067
1986
Rattus norvegicus
Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.
Dinucleosidetetraphosphatase inhibition by Zn(II)
Biochem. Biophys. Res. Commun.
113
717-722
1983
Rattus norvegicus
Cameselle, J.C.; Costas, M.J.; Sillero, M.A.G.; Sillero, A.
Two low Km hydrolytic activities on dinucleoside 5',5'''-P1,P4-tetraphosphates in rat liver. Characterization as the specific dinucleoside tetraphosphatase and a phosphodiesterase-I-like enzyme
J. Biol. Chem.
259
2879-2885
1984
Rattus norvegicus
Costas, M.J.; Cameselle, J.C.
Binding of zinc (II) to beta-D-fructose 2,6-bisphosphate
Biochem. Biophys. Res. Commun.
143
206-211
1987
Rattus norvegicus
Hause, B.; Feussner, K.; Wasternack, C.
Nuclear location of a diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) hydrolase in tomato cells grown in suspension cultures
Bot. Acta
110
452-457
1997
Solanum lycopersicum
-
Maksel, D.; Guranowski, A.; Ilgoutz, S.; Moir, A.; Blackburn, M.G.; Gayler, K.R.
Cloning and expression of diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L
Biochem. J.
329
313-319
1998
Lupinus sp.
McLennan, A.G.; Mayers, E.; Walker-Smith, I.; Chen, H.
Lanterns of firefly Photinus pyralis contain abundant diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity
J. Biol. Chem.
270
3706-3709
1995
Photinus pyralis
Pinto, R.M.; Costas, M.J.; Fernandez, A.; Canales, J.; Garcia-Agundez, J.A.; Camselle, J.C.
Dinucleoside tetraphosphatase from human blood cells: Purification and characterization as a high specific activity enzyme recognized by an anti-rat tetraphosphatase antibody
FEBS Lett.
287
85-88
1991
Homo sapiens, Rattus norvegicus
Guranowski, A.
Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases
FEBS Lett.
262
205-208
1990
Bos taurus, Saccharomyces cerevisiae, Cucurbita pepo, Helianthus sp., Lupinus sp.
Lazewska, D.; Starzynska, E.; Guranowski, A.
Human placental (asymmetrical) diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase: Purification to homogenity and some properties
Protein Expr. Purif.
4
45-51
1993
Homo sapiens
McLennan, A.G.; Mayers, E.; Hankin, S.; Thorne, N.M.; Prescott, M.; Powls, R.
The green alga Scenedesmus obliquus contains both diadenosine 5',5'''-P1,P4-tetraphosphate (asymmetrical) pyrophosphohyrolase and phosphorylase activities
Biochem. J.
300
183-189
1994
Chlorella vulgaris, Scenedesmus sp.
Guranowski, A.; Brown, P.; Ashton, P.A.; Blackburn, G.M.
Regiospecificity of the hydrolysis of diadenosine polyphosphates catalyzed by three specific pyrophosphohydrolases
Biochemistry
33
235-240
1994
Lupinus sp.
Feussner, K.; Guranowski, A.; Kostka, S.; Wasternack, C.
Diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) hydrolase from tomato (Lycopersicon esculentum cv. Lukullus): Purification, biochemical properties and behaviour during stress
Z. Naturforsch. C
51
477-486
1996
Solanum lycopersicum
Swarbrick, J.D.; Bashtannyk, T.; Maksel, D.; Pau, R.N.; Gayler, K.R.; Gooley, P.R.
1H, 13C and 15N backbone of the 19000 kDa diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from Lupinus angustifolius L.
J. Biomol. NMR
16
269-270
2000
Lupinus sp.
Robinson, A.K.; de la Pena C.E.; Barnes, L.D.
Isolation and charcterization of diadenosine tetraphosphate (Ap4A) hydrolase from Schizosaccharomyces pombe
Biochim. Biophys. Acta
1161
139-148
1993
Saccharomyces cerevisiae
Guranowski, A.; Galbas, M.; Hartmann, R.; Justesen, J.
Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap3A and Ap4A, by two specific human dinucleoside polyphosphate hydrolases
Arch. Biochem. Biophys.
373
218-224
2000
Homo sapiens
Maksel, D.; Gooley, P.R.; Swarbrick, J.D.; Guranowski, A.; Gange, C.; Blackburn, G.M.; Gayler, K.R.
Characterization of active-site residues in diadenosine tetraphosphate hydrolase from Lupinus angustifolius
Biochem. J.
357
399-405
2001
Lupinus angustifolius
Guranowski, A.; Starzynska, E.; McLennan, A.G.; Baraniak, J.; Stec, W.J.
Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases
Biochem. J.
373
635-640
2003
Homo sapiens, Lupinus angustifolius
Abdelghany, H.M.; Gasmi, L.; Cartwright, J.L.; Bailey, S.; Rafferty, J.B.; McLennan, A.G.
Cloning, characterisation and crystallization of a diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans
Biochim. Biophys. Acta
1550
27-36
2001
Caenorhabditis elegans
Abdelghany, H.M.; Bailey, S.; Blackburn, G.M.; Rafferty, J.B.; McLennan, A.G.
Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis
J. Biol. Chem.
278
4435-4439
2003
Caenorhabditis elegans
Minelli, A.; Allegrucci, C.; Liguori, L.; Ronquist, G.
Ecto-diadenosine polyphosphate hydrolase activity on human prostasomes
Prostate
51
1-9
2002
Homo sapiens
Swarbrick, J.D.; Buyya, S.; Gunawardana, D.; Gayler, K.R.; McLennan, A.G.; Gooley, P.R.
Structure and substrate-binding mechanism of human Ap4A hydrolase
J. Biol. Chem.
280
8471-8481
2005
Homo sapiens (P50583), Homo sapiens
Winward, L.; Whitfield, W.G.; Woodman, T.J.; McLennan, A.G.; Safrany, S.T.
Characterisation of a bis(5-nucleosyl)-tetraphosphatase (asymmetrical) from Drosophila melanogaster
Int. J. Biochem. Cell Biol.
39
943-954
2007
Drosophila melanogaster (Q4V6M1), Drosophila melanogaster
Szurmak, B.; Wyslouch-Cieszyeska, A.; Wszelaka-Rylik, M.; Bal, W.; Dobrzanska, M.
A diadenosine 5',5''-P1P4 tetraphosphate (Ap4A) hydrolase from Arabidopsis thaliana that is activated preferentially by Mn2+ ions
Acta Biochim. Pol.
55
151-160
2008
Arabidopsis thaliana (Q9C6Z2), Arabidopsis thaliana
Guranowski, A.; Starzynska, E.; Pietrowska-Borek, M.; Rejman, D.; Blackburn, G.M.
Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases
FEBS J.
276
1546-1553
2009
Homo sapiens, Lupinus angustifolius
Jeyakanthan, J.; Kanaujia, S.P.; Nishida, Y.; Nakagawa, N.; Praveen, S.; Shinkai, A.; Kuramitsu, S.; Yokoyama, S.; Sekar, K.
Free and ATP-bound structures of Ap4A hydrolase from Aquifex aeolicus V5
Acta Crystallogr. Sect. D
66
116-124
2010
Aquifex aeolicus (O66548), Aquifex aeolicus
Branson, K.M.; Mertens, H.D.; Swarbrick, J.D.; Fletcher, J.I.; Kedzierski, L.; Gayler, K.R.; Gooley, P.R.; Smith, B.J.
Discovery of inhibitors of lupin diadenosine 5,5-P1,P4-tetraphosphate hydrolase by virtual screening
Biochemistry
48
7614-7620
2009
Lupinus angustifolius (O04841)
Vasilenko, N.; Moshynskyy, I.; Zakhartchouk, A.
SARS coronavirus protein 7a interacts with human Ap4A-hydrolase
Virol. J.
7
31
2010
Homo sapiens (P50583), Homo sapiens
Arczewska, K.D.; Baumeier, C.; Kassahun, H.; Sengupta, T.; Bjoras, M.; Kusmierek, J.T.; Nilsen, H.
Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability
DNA Repair
10
176-187
2011
Caenorhabditis elegans (Q9U2M7), Caenorhabditis elegans, Caenorhabditis elegans Bristol N2 (Q9U2M7)
Wu, M.; Chong, L.S.; Capolicchio, S.; Jessen, H.J.; Resnick, A.C.; Fiedler, D.
Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues
Angew. Chem. Int. Ed. Engl.
53
7192-7197
2014
Homo sapiens (O95989)
Ge, H.; Chen, X.; Yang, W.; Niu, L.; Teng, M.
Crystal structure of wild-type and mutant human Ap4A hydrolase
Biochem. Biophys. Res. Commun.
432
16-21
2013
Homo sapiens (P50583), Homo sapiens
Barta, M.L.; Lovell, S.; Sinclair, A.N.; Battaile, K.P.; Hefty, P.S.
Chlamydia trachomatis CT771 (nudH) is an asymmetric Ap4A hydrolase
Biochemistry
53
214-224
2014
Chlamydia trachomatis
Osman, W.; Endo, S.; Oh-Hashi, K.; Kitamura, Y.; Kitade, Y.
Molecular characterization and mutational analysis of recombinant diadenosine 5',5''-P1,P4-tetraphosphate hydrolase from Plasmodium falciparum
Biol. Pharm. Bull.
35
1191-1196
2012
Plasmodium falciparum (C0H4F3), Plasmodium falciparum
Albright, R.A.; Chang, W.C.; Robert, D.; Ornstein, D.L.; Cao, W.; Liu, L.; Redick, M.E.; Young, J.I.; De La Cruz, E.M.; Braddock, D.T.
NPP4 is a procoagulant enzyme on the surface of vascular endothelium
Blood
120
4432-4440
2012
Homo sapiens (Q9Y6X5)
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