Disease on EC 3.6.1.13 - ADP-ribose diphosphatase

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DISEASE
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African Swine Fever
The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates.
Breast Neoplasms
Expression of Oncogenic Drivers in 3D Cell Culture Depends on Nuclear ATP Synthesis by NUDT5.
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Cat-Scratch Disease
Structure of a Nudix hydrolase (MutT) in the Mg(2+)-bound state from Bartonella henselae, the bacterium responsible for cat scratch fever.
Colorectal Neoplasms
MutT-related proteins are novel progression and prognostic markers for colorectal cancer.
Cysts
Specific ADP-ribose pyrophosphatase from Artemia cysts and rat liver: effects of nitroprusside, fluoride and ionic strength.
Diabetes Mellitus, Type 2
No evidence of diabetes-specific CD38 (ADP ribosil cyclase/cyclic ADP-ribose hydrolase) autoantibodies by liquid-phase immunoprecipitation.
Endometrial Neoplasms
Differential expression of NUDT9 at different phases of the menstrual cycle and in different components of normal and neoplastic human endometrium.
Infections
AtNUDT7, a negative regulator of basal immunity in Arabidopsis, modulates two distinct defense response pathways and is involved in maintaining redox homeostasis.
Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes.
InvA protein: a nudix hydrolase required for infection by pathogenic leptospira in cell lines and animals.
Oral vaccination of mice with Trichinella spiralis nudix hydrolase DNA vaccine delivered by attenuated Salmonella elicited protective immunity.
Retraction. InvA protein is a Nudix hydrolase required for infection by pathogenic Leptospira in cell lines and animals.
Subcellular localization of rickettsial invasion protein, InvA.
Neoplasm Metastasis
Expression of Oncogenic Drivers in 3D Cell Culture Depends on Nuclear ATP Synthesis by NUDT5.
MutT-related proteins are novel progression and prognostic markers for colorectal cancer.
Neoplasms
Expression of Oncogenic Drivers in 3D Cell Culture Depends on Nuclear ATP Synthesis by NUDT5.
NUDT expression is predictive of prognosis in patients with clear cell renal cell carcinoma.
The ADP-ribose reactive NUDIX hydrolase isoforms can modulate HIF-1? in cancer cells.
Obesity
The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients.
Trichinellosis
Molecular identification of Trichinella spiralis nudix hydrolase and its induced protective immunity against trichinellosis in BALB/c mice.
Tuberculosis
High precision multi-genome scale reannotation of enzyme function by EFICAz.
Identification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.
Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification, and A to C mutation avoidance.
Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis.