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IUBMB Comments The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330
Synonyms
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2NI denitrase
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2NI nitrohydrolase
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NnhA
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2-nitroimidazole + H2O = imidazol-2-one + nitrite
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hydrolysis
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2-nitroimidazole nitrohydrolase
The enzyme catalyses the initial step in the biodegradation of 2-nitroimidazole by the soil bacterium Mycobacterium sp. JS330
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2-nitroimidazole + H2O
imidazol-2-one + nitrite
benznidazole + H2O
N-benzyl-2-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)acetamide + nitrite
additional information
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2-nitroimidazole + H2O
imidazol-2-one + nitrite
Substrates: -
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2-nitroimidazole + H2O
imidazol-2-one + nitrite
Substrates: -
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benznidazole + H2O
N-benzyl-2-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)acetamide + nitrite
Substrates: -
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benznidazole + H2O
N-benzyl-2-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)acetamide + nitrite
Substrates: -
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additional information
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Substrates: no activity with 4-nitroimidazole, metronidazole, 2,4-dinitroimidazole, 3-nitro-1,2,4-triazol-5-one, nitazoxanide, or tizoxanide
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additional information
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Substrates: no activity with 4-nitroimidazole, metronidazole, 2,4-dinitroimidazole, 3-nitro-1,2,4-triazol-5-one, nitazoxanide, or tizoxanide
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additional information
?
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Substrates: no activity with 4-nitroimidazole, metronidazole, 2,4-dinitroimidazole, 3-nitro-1,2,4-triazol-5-one, nitazoxanide, or tizoxanide
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2-nitroimidazole + H2O
imidazol-2-one + nitrite
2-nitroimidazole + H2O
imidazol-2-one + nitrite
Substrates: -
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2-nitroimidazole + H2O
imidazol-2-one + nitrite
Substrates: -
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additional information
no cofactors required, no oxygen consumption
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additional information
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no cofactors required, no oxygen consumption
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0.011
substrate benznidazole, pH 7.2, 24°C
0.0236
substrate 2-nitroimidazole, pH 7.2, 24°C
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UniProt
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UniProt
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metabolism
Initial step in the biodegradation of 2-nitroimidazole by Mycobacterium sp. JS330. This is the first hydrolytic enzyme involved in elimination of the nitro group. The organism grows on 2-nitroimidazole as sole carbon source.
metabolism
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Initial step in the biodegradation of 2-nitroimidazole by Mycobacterium sp. JS330. This is the first hydrolytic enzyme involved in elimination of the nitro group. The organism grows on 2-nitroimidazole as sole carbon source.
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NNHA_MYCS0
Mycobacterium sp. (strain JS330)
379
0
42028
Swiss-Prot
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expressed in Escherichia coli
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Qu, Y.; Spain, J.C.
Catabolic pathway for 2-nitroimidazole involves a novel nitrohydrolase that also confers drug resistance
Environ. Microbiol.
13
1010-1017
2011
Mycobacterium sp. (F4ZCI3), Mycobacterium sp., Mycobacterium sp. JS330 (F4ZCI3)
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