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Information on EC 3.5.99.6 - glucosamine-6-phosphate deaminase

for references in articles please use BRENDA:EC3.5.99.6
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IUBMB Comments
The enzyme uses ring opening and isomerization of the aldose-ketose type to convert the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which then hydrolyses to yield fructose 6-phosphate and ammonia. N-Acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
oscillin, gnpda, glucosamine 6-phosphate deaminase, glcn6p deaminase, glucosamine 6-phosphate isomerase, glucosamine-6p deaminase, glcn-6-p isomerase, glucosamine-p isomerase, smu.636 protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha-D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
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