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Information on EC 3.5.4.42 - N-isopropylammelide isopropylaminohydrolase

for references in articles please use BRENDA:EC3.5.4.42
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IUBMB Comments
Requires Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. It can hydrolyse other N-substituted amino dihydroxy-s-triazine molecules, and prefers substrates with linear N-alkyl groups to those with branched alkyl groups.
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The enzyme appears in viruses and cellular organisms
Synonyms
amidase, N-isopropylammelide, AtzC, IAIA, N-isopropylammelide amidase, N-isopropylammelide isopropylamidohydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-isopropylammelide + H2O = cyanuric acid + isopropylamine
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Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine
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