Reference on EC 3.5.4.25 - GTP cyclohydrolase II
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Blau, N.; Niederwieser, A.
GTP-cyclohydrolases: a review
J. Clin. Chem. Clin. Biochem.
23
169-176
1985
Escherichia coli, Meyerozyma guilliermondii
Foor, F.; Brown, G.M.
GTP cyclohydrolase II from Escherichia coli
Methods Enzymol.
66
303-307
1980
Escherichia coli
Foor, F.; Brown, G.M.
Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli
J. Biol. Chem.
250
3545-3551
1975
Escherichia coli
Herz, S.; Eberhardt, S.; Bacher, A.
Biosynthesis of riboflavin in plants. The rib A gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Phytochemistry
53
723-731
2000
Arabidopsis thaliana
Bacher, A.; Richter, G.; Ritz, H.; Eberhardt, S.; Fischer, M.; Krieger, C.
Biosynthesis of riboflavin: GTP-cyclohydrolase II, deaminase, and reductase
Methods Enzymol.
280
382-389
1997
Escherichia coli
Bereswill, S.; Fassbinder, F.; Vlzing, C.; Covacci, A.; Haas, R.; Kist, M.
Hemolytic properties and riboflavin synthesis of Helicobacter pylori: cloning and functional characterization of the ribA gene encoding GTP-cyclohydrolase II that confers hemolytic activity to Escherichia coli
Med. Microbiol. Immunol.
186
177-187
1998
Helicobacter pylori
Kobayashi, M.; Ohara-Nemoto, Y.; Kaneko, M.; Hayakawa, H.; Sekiguchi, M.; Yamamoto, K.
Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
J. Biol. Chem.
273
26394-26399
1988
Escherichia coli
Kaiser, J.; Schramek, N.; Eberhardt, S.; Puttmer, S.; Schuster, M.; Bacher, A.
Biosynthesis of vitamin B2. An essential zinc ion at the catalytic site of GTP cyclohydrolase II
Eur. J. Biochem.
269
5264-5270
2002
Escherichia coli
Ritz, H.; Schramek, N.; Bracher, A.; Herz, S.; Eisenreich, W.; Richter, G.; Bacher, A.
Biosynthesis of riboflavin: studies on the mechanism of GTP cyclohydrolase II
J. Biol. Chem.
276
22273-22277
2001
Escherichia coli
Schramek, N.; Bracher, A.; Bacher, A.
Biosynthesis of riboflavin. Single turnover kinetic analysis of GTP cyclohydrolase II
J. Biol. Chem.
276
44157-44162
2001
Escherichia coli
Ren, J.; Kotaka, M.; Lockyer, M.; Lamb, H.K.; Hawkins, A.R.; Stammers, D.K.
GTP cyclohydrolase II structure and mechanism
J. Biol. Chem.
280
36912-36919
2005
Escherichia coli
Huembelin, M.; Griesser, V.; Keller, T.; Schurter, W.; Haiker, M.; Hohmann, H.P.; Ritz, H.; Richter, G.; Bacher, A.; Van Loon, A.P.G.M.
GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase are rate-limiting enzymes in riboflavin synthesis of an industrial Bacillus subtilis strain used for riboflavin production
J. Indust. Microbiol. Biotechnol.
22
1-7
1999
Bacillus subtilis
-
Spoonamore, J.E.; Dahlgran, A.L.; Jacobsen, N.E.; Bandarian, V.
Evolution of new function in the GTP cyclohydrolase II proteins of Streptomyces coelicolor
Biochemistry
45
12144-12155
2006
Streptomyces coelicolor
Spoonamore, J.E.; Bandarian, V.
Understanding functional divergence in proteins by studying intragenomic homologues
Biochemistry
47
2592-2600
2008
Streptomyces coelicolor (O88011), Streptomyces coelicolor (Q9EWJ8), Streptomyces coelicolor (Q9KYI5), Streptomyces coelicolor
Lehmann, M.; Degen, S.; Hohmann, H.P.; Wyss, M.; Bacher, A.; Schramek, N.
Biosynthesis of riboflavin. Screening for an improved GTP cyclohydrolase II mutant
FEBS J.
276
4119-4129
2009
Bacillus subtilis
Sengupta, S.; Chandra, T.
Molecular and structural characterization of GTP-cyclohydrolase II in Eremothecium ashbyi NRRL Y-1363: cDNA cloning, comparative sequence analysis and molecular modeling
Fungal Biol.
114
731-738
2010
Eremothecium ashbyi (A6MYZ0), Eremothecium ashbyi, Eremothecium ashbyi NRRL Y-1363 (A6MYZ0), Eremothecium ashbyi NRRL Y-1363
Singh, M.; Kumar, P.; Karthikeyan, S.
Structural basis for pH dependent monomer-dimer transition of 3,4-dihydroxy 2-butanone-4-phosphate synthase domain from Mycobacterium tuberculosis
J. Struct. Biol.
174
374-384
2011
Mycobacterium tuberculosis
Asai, S.; Mase, K.; Yoshioka, H.
A key enzyme for flavin synthesis is required for nitric oxide and reactive oxygen species production in disease resistance
Plant J.
62
911-924
2010
Nicotiana benthamiana (D6RUS9), Nicotiana benthamiana
Singh, M.; Kumar, P.; Yadav, S.; Gautam, R.; Sharma, N.; Karthikeyan, S.
The crystal structure reveals the molecular mechanism of bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (Rv1415) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. D
69
1633-1644
2013
Mycobacterium tuberculosis (P9WHF1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WHF1)
Graewert, T.; Fischer, M.; Bacher, A.
Structures and reaction mechanisms of GTP cyclohydrolases
IUBMB Life
65
310-322
2013
Escherichia coli (P0A7I7)
Joo, M.; Yoo, H.; Kim, H.; Kwon, H.
ToxB encodes a canonical GTP cyclohydrolase II in toxoflavin biosynthesis and ribA expression restored toxoflavin production in a DELTAtoxB mutant
J. Korean Soc. Appl. Biol. Chem.
58
877-885
2015
Burkholderia glumae (Q8RS38), Burkholderia glumae BGR1 (Q8RS38)
-
Yadav, S.; Karthikeyan, S.
Structural and biochemical characterization of GTP cyclohydrolase II from Helicobacter pylori reveals its redox dependent catalytic activity
J. Struct. Biol.
192
100-115
2015
Helicobacter pylori (O08315), Helicobacter pylori, Helicobacter pylori ATCC 700392 (O08315)
Lister, J.
Larval but not adult xanthophore pigmentation in zebrafish requires GTP cyclohydrolase 2 (gch2) function
Pigment Cell Melanoma Res.
32
724-727
2019
Danio rerio (Q6IQV5)
-
Nasuno, R.; Suzuki, S.; Oiki, S.; Hagiwara, D.; Takagi, H.
Identification and functional analysis of GTP cyclohydrolase II in Candida glabrata in response to nitrosative stress
Front. Microbiol.
13
825121
2022
Nakaseomyces glabratus (Q6FUD7), Nakaseomyces glabratus KUE100-1 (Q6FUD7)
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