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Information on EC 3.5.4.15 - guanosine deaminase
for references in articles please use BRENDA:EC3.5.4.15
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EC Tree 3 Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.15 guanosine deaminase
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
- 3.5.4.15
- nucleoside
- purine
-
deamination
- xanthosine
- phosphorylase
- ribose
- ammonia
- cytidine
- ribonucleosides
-
salvage
- deaminases
- pyrimidine
- hydrolases
-
reappraisal
- monophosphate
- algae
- medicine
showSynonyms
guanosine deaminase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
GSDA
guanosine aminase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
guanosine + H2O = xanthosine + NH3
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Deamination
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
guanosine aminohydrolase
-
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CAS REGISTRY NUMBER
COMMENTARY
9067-85-0
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Substrates: no activity with adenine, adenosine, AMP, guanine, GMP, cytosine, cytidine, CMP, cyclic GMP, pterine, and tetrahydrofolate
Products: -
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?
2'-deoxyguanosine + H2O
2'-deoxyxanthosine + NH3
-
Substrates: -
Products: -
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?
2'-deoxyguanosine + H2O
2'-deoxyxanthosine + NH3
-
Substrates: -
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?
2'-deoxyguanosine + H2O
2'-deoxyxanthosine + NH3
-
Substrates: -
Products: -
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?
2'-deoxyguanosine + H2O
2'-deoxyxanthosine + NH3
-
Substrates: -
Products: -
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?
8-azaguanosine + H2O
8-azaxanthosine + NH3
-
Substrates: -
Products: -
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?
8-azaguanosine + H2O
8-azaxanthosine + NH3
-
Substrates: -
Products: -
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?
guanosine + H2O
xanthosine + NH3
Substrates: -
Products: -
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?
guanosine + H2O
xanthosine + NH3
-
Substrates: -
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyguanosine + H2O
2'-deoxyxanthosine + NH3
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with adenine, adenosine, AMP, guanine, GMP, cytosine, cytidine, CMP, cyclic GMP, pterine, and tetrahydrofolate
Products: -
Products: -
?
guanosine + H2O
xanthosine + NH3
Substrates: -
Products: -
Products: -
?
guanosine + H2O
xanthosine + NH3
-
Substrates: -
Products: -
Products: -
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Hepatitis
Adenosine deaminase and guanosine deaminase activities in sera of patients with viral hepatitis.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
62.4 - 486
-
different brain areas, activity via nucleoside phosphorylase and guanine deaminase
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
accumulation of guanosine in a guanosine deaminase mutant strongly enhances dark stress symptoms
metabolism
metabolism
purine nucleotide catabolism depends to a great extent on the guanosine deaminase reaction
metabolism
the enzyme is involved in purine nucleoside catabolism
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). GSDA_ARATH
185
0
20002
Swiss-Prot
other Location (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Davies, L.P.; Taylor, K.M.
Rat brain guanine deaminase; correlation with regional levels of cyclic GMP phosphodiesterase
J. Neurochem.
33
951-952
1979
Rattus norvegicus
brenda
Zielke, C.L.; Suelter, C.H.
Purine, purine nucleoside, and purine nucleotide aminohydrolases
Enzyme
4
47-78
1971
Pseudomonas putida, Pseudomonas putida No. 149
-
brenda
Ishida, Y.; Shirafuji, H.; Kida, M.; Yoneda, M.
Studies on the guanosine degrading system in bacterial cell. Part III. Purification and properties of guanosine deaminase
Agric. Biol. Chem.
33
384-390
1969
Pseudomonas putida, Pseudomonas putida No. 149
-
brenda
Kalkan, A.; Bulut, V.; Erel, O.; Avci, S.; Bingol, N.K.
Adenosine deaminase and guanosine deaminase activities in sera of patients with viral hepatitis
Mem. Inst. Oswaldo Cruz
94
383-386
1999
Homo sapiens
brenda
Negishi, O.; Ozawa, T.; Imagawa, H.
Guanosine deaminase and guanine deaminase from tea leaves
Biosci. Biotechnol. Biochem.
58
1277-1281
1994
Camellia sinensis
-
brenda
Dahncke, K.; Witte, C.P.
Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis
Plant Cell
25
4101-4109
2013
Arabidopsis thaliana
brenda
Baccolini, C.; Witte, C.P.
AMP and GMP catabolism in Arabidopsis converge on xanthosine, which is degraded by a nucleoside hydrolase heterocomplex
Plant Cell
31
734-751
2019
Arabidopsis thaliana (Q94BU8), Arabidopsis thaliana
brenda
Schroeder, R.Y.; Zhu, A.; Eubel, H.; Dahncke, K.; Witte, C.P.
The ribokinases of Arabidopsis thaliana and Saccharomyces cerevisiae are required for ribose recycling from nucleotide catabolism, which in plants is not essential to survive prolonged dark stress
New Phytol.
217
233-244
2018
Arabidopsis thaliana (Q94BU8), Arabidopsis thaliana
brenda
EXTERNAL LINKS (specific for EC-Number 3.5.4.15)
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Release 2023.1 (January 2023)
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