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Disease on EC 3.5.1.92 - pantetheine hydrolase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.
Urinary vanin-1 as a novel biomarker for early detection of drug-induced acute kidney injury.
Albuminuria
Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Arthritis, Rheumatoid
A sandwich ELISA for detection of soluble GPI-80, a glycosylphosphatidyl-inositol (GPI)-anchored protein on human leukocytes involved in regulation of neutrophil adherence and migration--its release from activated neutrophils and presence in synovial fluid of rheumatoid arthritis patients.
Asthma
Experimental asthma in guinea pigs revisited.
Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.
Carcinogenesis
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Carcinoma
Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Carcinoma, Renal Cell
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.
Cardiovascular Diseases
Diverse biological activities of the vascular non-inflammatory molecules - the Vanin pantetheinases.
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Colitis
Early detection of renal injury using urinary vanin-1 in rats with experimental colitis.
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Colitis-Associated Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Colonic Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Colorectal Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Cystinosis
Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Dermatitis, Atopic
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Diabetes Mellitus, Type 1
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
Diabetes Mellitus, Type 2
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Diabetic Nephropathies
Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy.
Eczema
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Granuloma
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
HIV Infections
Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.
Hydronephrosis
Vanin-1 in Renal Pelvic Urine Reflects Kidney Injury in a Rat Model of Hydronephrosis.
Hypertension
Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.
The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function.
Vanin-1 T26I polymorphism, hypertension and cardiovascular events in two large urban-based prospective studies in Swedes.
Ichthyosis
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Infections
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Dissecting Flavivirus Biology in Salivary Gland Cultures from Fed and Unfed Ixodes scapularis (Black-Legged Tick).
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Inflammatory Bowel Diseases
A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo.
Influenza, Human
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Insulin Resistance
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Kidney Diseases
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Leukemia
Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil differentiation with dimethyl sulfoxide in HL-60 cells.
Leukemia, Myeloid, Acute
Vanin 1 (VNN1) levels predict poor outcome in acute myeloid leukemia.
Liver Diseases
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Lupus Erythematosus, Systemic
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Lymphohistiocytosis, Hemophagocytic
Are all mutant SNARES equal?
Malaria
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria.
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Malaria, Cerebral
Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Metabolic Diseases
Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation.
MiR-122 targets the vanin 1 gene to regulate its expression in chickens.
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.
Neoplasms
Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients.
GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma.
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice.
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Nephritis
Vanin-1 as a potential novel biomarker for active nephritis in systemic lupus erythematosus.
Non-alcoholic Fatty Liver Disease
Analysis of vanin-1 upregulation and lipid accumulation in hepatocytes in response to a high-fat diet and free fatty acids.
Obesity
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
Pancreatic Neoplasms
In vitro and in vivo biological evaluation of O-carboxymethyl chitosan encapsulated metformin nanoparticles for pancreatic cancer therapy.
pantetheine hydrolase deficiency
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue.
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia.
Parasitemia
Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J.
Pneumonia
Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Psoriasis
Expression of the Vanin Gene Family in Normal and Inflamed Human Skin: Induction by Proinflammatory Cytokines.
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature.
Molecular Diagnostics of Psoriasis, Atopic Dermatitis, Allergic Contact Dermatitis and Irritant Contact Dermatitis.
Purpura, Thrombocytopenic, Idiopathic
Value of vanin-1 assessment in adult patients with primary immune thrombocytopenia.
Pyelonephritis
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Q Fever
Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Renal Insufficiency, Chronic
Commentary: Urinary vanin-1 and chronic kidney disease in hypertensive patients.
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Urinary vanin-1 associated with chronic kidney disease in hypertensive patients: A pilot study.
Reperfusion Injury
Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease.
Sarcoma
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity.
Scleroderma, Systemic
Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
Sepsis
Plasma Vanin-1 as a Novel Biomarker of Sepsis for Trauma Patients: A Prospective Multicenter Cohort Study.
Shock, Septic
MicroRNA-203 Acts as a Potent Suppressor in Septic Shock by Alleviating Lung Injury via Inhibition of VNN1.
Starvation
Red emission ratio fluorescent probe for the activity of vanin-1 and imaging in vivo.
Thymoma
Glycosylphosphatidyl inositol-anchored protein (GPI-80) gene expression is correlated with human thymoma stage.
Tuberculosis, Pulmonary
Kayne, Pagel and O'shaughnessy's Pulmonary Tuberculosis.
Urinary Tract Infections
Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.