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It was initially thought that N1-acetylspermidine was the substrate for this deacetylase reaction but this has since been disproved by Marchant et al. .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
acetylpolyamine amidohydrolase, APAH, HDAC10
, histone deacetylase 10, N1-acetylspermidine amidohydrolase, N1-acetylspermidine deacetylase, N8-acetyl-monoacetylspermidine deacetylase, N8-acetylspermidine deacetylase, polyamine deacetylase, zHDAC10, more
N8-acetylspermidine + H2O = acetate + spermidine