Reference on EC 3.4.24.B12 - ADAMTS5 endopeptidase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Bos taurus (Q9TT92), Homo sapiens (Q9UNA0), Mus musculus (Q9R001)
Vankemmelbeke, M.N.; Holen, I.; Wilson, A.G.; Ilic, M.Z.; Handley, C.J.; Kelner, G.S.; Clark, M.; Liu, C.; Maki, R.A.; Burnett, D.; Buttle, D.J.
Expression and activity of ADAMTS-5 in synovium
Eur. J. Biochem.
268
1259-1268
2001
Homo sapiens, Bos taurus (Q9TT92), Bos taurus
Vankemmelbeke, M.N.; Jones, G.C.; Fowles, C.; Ilic, M.Z.; Handley, C.J.; Day, A.J.; Knight, C.G.; Mort, J.S.; Buttle, D.J.
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters
Eur. J. Biochem.
270
2394-2403
2003
Homo sapiens (Q9UNA0)
Kashiwagi, M.; Tortorella, M.; Nagase, H.; Brew, K.
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
J. Biol. Chem.
276
12501-12504
2001
Homo sapiens
Malfait, A.M.; Liu, R.Q.; Ijiri, K.; Komiya, S.; Tortorella, M.D.
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage
J. Biol. Chem.
277
22201-22208
2002
Homo sapiens
Nakada, M.; Miyamori, H.; Kita, D.; Takahashi, T.; Yamashita, J.; Sato, H.; Miura, R.; Yamaguchi, Y.; Okada, Y.
Human glioblastomas overexpress ADAMTS-5 that degrades brevican
Acta Neuropathol.
110
239-246
2005
Homo sapiens (Q9UHI8), Homo sapiens
Zeng, W.; Corcoran, C.; Collins-Racie, L.A.; LaVallie, E.R.; Morris, E.A.; Flannery, C.R.
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18
Biochim. Biophys. Acta
1760
517-524
2006
Homo sapiens (Q9UNA0), Homo sapiens
Miguel, R.F.; Pollak, A.; Lubec, G.
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimers and Picks disease
Brain Res. Mol. Brain Res.
133
1-5
2005
Homo sapiens (Q9UHI8), Homo sapiens
Held-Feindt, J.; Paredes, E.B.; Bloemer, U.; Seidenbecher, C.; Stark, A.M.; Mehdorn, H.M.; Mentlein, R.
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas
Int. J. Cancer
118
55-61
2005
Homo sapiens
Tortorella, M.D.; Arner, E.C.; Hills, R.; Easton, A.; Korte-Sarfaty, J.; Fok, K.; Wittwer, A.J.; Liu, R.Q.; Malfait, A.M.
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes
J. Biol. Chem.
279
17554-17561
2004
Homo sapiens
Song, R.H.; Tortorella, M.D.; Malfait, A.M.; Alston, J.T.; Yang, Z.; Arner, E.C.; Griggs, D.W.
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
Arthritis Rheum.
56
575-585
2007
Homo sapiens
Sharghi-Namini, S.; Fan, H.; Sulochana, K.N.; Potturi, P.; Xiang, W.; Chong, Y.S.; Wang, Z.; Yang, H.; Ge, R.
The first but not the second thrombospondin type 1 repeat of ADAMTS5 functions as an angiogenesis inhibitor
Biochem. Biophys. Res. Commun.
371
215-219
2008
Homo sapiens
Bursavich, M.G.; Gilbert, A.M.; Lombardi, S.; Georgiadis, K.E.; Reifenberg, E.; Flannery, C.R.; Morris, E.A.
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)
Bioorg. Med. Chem. Lett.
17
1185-1188
2007
Homo sapiens
Gilbert, A.M.; Bursavich, M.G.; Lombardi, S.; Georgiadis, K.E.; Reifenberg, E.; Flannery, C.R.; Morris, E.A.
5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
Bioorg. Med. Chem. Lett.
17
1189-1192
2007
Homo sapiens
Bondeson, J.; Wainwright, S.; Hughes, C.; Caterson, B.
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review
Clin. Exp. Rheumatol.
26
139-145
2008
Homo sapiens, Mus musculus
Fosang, A.J.; Rogerson, F.M.; East, C.J.; Stanton, H.
ADAMTS-5: the story so far
Eur. Cell Mater.
15
11-26
2008
Bos taurus, Homo sapiens, Mus musculus
Gendron, C.; Kashiwagi, M.; Lim, N.H.; Enghild, J.J.; Thogersen, I.B.; Hughes, C.; Caterson, B.; Nagase, H.
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4
J. Biol. Chem.
282
18294-18306
2007
Homo sapiens
Shieh, H.S.; Mathis, K.J.; Williams, J.M.; Hills, R.L.; Wiese, J.F.; Benson, T.E.; Kiefer, J.R.; Marino, M.H.; Carroll, J.N.; Leone, J.W.; Malfait, A.M.; Arner, E.C.; Tortorella, M.D.; Tomasselli, A.
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)
J. Biol. Chem.
283
1501-1507
2008
Homo sapiens
Fushimi, K.; Troeberg, L.; Nakamura, H.; Lim, N.H.; Nagase, H.
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
J. Biol. Chem.
283
6706-6716
2008
Homo sapiens
Mosyak, L.; Georgiadis, K.; Shane, T.; Svenson, K.; Hebert, T.; McDonagh, T.; Mackie, S.; Olland, S.; Lin, L.; Zhong, X.; Kriz, R.; Reifenberg, E.L.; Collins-Racie, L.A.; Corcoran, C.; Freeman, B.; Zollner, R.; Marvell, T.; Vera, M.; Sum, P.E.; Lavallie, E.R.; Stahl, M.; Somers, W.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
Protein Sci.
17
16-21
2008
Homo sapiens
Gilbert, A.M.; Bursavich, M.G.; Lombardi, S.; Georgiadis, K.E.; Reifenberg, E.; Flannery, C.R.; Morris, E.A.
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)
Bioorg. Med. Chem. Lett.
18
6454-6457
2008
Homo sapiens (Q9UNA0)
Shiozaki, M.; Maeda, K.; Miura, T.; Ogoshi, Y.; Haas, J.; Fryer, A.M.; Laird, E.R.; Littmann, N.M.; Andrews, S.W.; Josey, J.A.; Mimura, T.; Shinozaki, Y.; Yoshiuchi, H.; Inaba, T.
Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (aggrecanase-2) inhibitors
Bioorg. Med. Chem. Lett.
19
1575-1580
2009
Homo sapiens (Q9UNA0)
Pockert, A.J.; Richardson, S.M.; Le Maitre, C.L.; Lyon, M.; Deakin, J.A.; Buttle, D.J.; Freemont, A.J.; Hoyland, J.A.
Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration
Arthritis Rheum.
60
482-491
2009
Homo sapiens
Miwa, H.E.; Gerken, T.A.; Huynh, T.D.; Duesler, L.R.; Cotter, M.; Hering, T.M.
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5
Biochim. Biophys. Acta
1790
161-172
2009
Homo sapiens
Hamel, M.G.; Ajmo, J.M.; Leonardo, C.C.; Zuo, F.; Sandy, J.D.; Gottschall, P.E.
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
Exp. Neurol.
210
428-440
2008
Homo sapiens
Troeberg, L.; Fushimi, K.; Khokha, R.; Emonard, H.; Ghosh, P.; Nagase, H.
Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
FASEB J.
22
3515-3524
2008
Homo sapiens (Q9UNA0)
Takizawa, M.; Yatabe, T.; Okada, A.; Chijiiwa, M.; Mochizuki, S.; Ghosh, P.; Okada, Y.
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
FEBS Lett.
582
2945-2949
2008
Homo sapiens
Demircan, K.; Gunduz, E.; Gunduz, M.; Beder, L.B.; Hirohata, S.; Nagatsuka, H.; Cengiz, B.; Cilek, M.Z.; Yamanaka, N.; Shimizu, K.; Ninomiya, Y.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer
Head Neck
10
793-801
2009
Homo sapiens
Willems, S.H.; Tape, C.J.; Stanley, P.L.; Taylor, N.A.; Mills, I.G.; Neal, D.E.; McCafferty, J.; Murphy, G.
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17
Biochem. J.
428
439-450
2010
Homo sapiens
Lim, N.H.; Kashiwagi, M.; Visse, R.; Jones, J.; Enghild, J.J.; Brew, K.; Nagase, H.
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Biochem. J.
431
113-122
2010
Homo sapiens (Q9UNA0), Homo sapiens
Shiozaki, M.; Imai, H.; Maeda, K.; Miura, T.; Yasue, K.; Suma, A.; Yokota, M.; Ogoshi, Y.; Haas, J.; Fryer, A.M.; Laird, E.R.; Littmann, N.M.; Andrews, S.W.; Josey, J.A.; Mimura, T.; Shinozaki, Y.; Yoshiuchi, H.; Inaba, T.
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (aggrecanase-2) inhibitors
Bioorg. Med. Chem. Lett.
19
6213-6217
2009
Homo sapiens
Cappelli, A.; Nannicini, C.; Valenti, S.; Giuliani, G.; Anzini, M.; Mennuni, L.; Giordani, A.; Caselli, G.; Stasi, L.P.; Makovec, F.; Giorgi, G.; Vomero, S.
Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors
ChemMedChem
5
739-748
2010
Homo sapiens
Longpre, J.; McCulloch, D.; Koo, B.; Alexander, J.; Apte, S.; Leduc, R.
Characterization of proADAMTS5 processing by proprotein convertases
Int. J. Biochem. Cell Biol.
41
1116-1126
2009
Homo sapiens
Tortorella, M.D.; Tomasselli, A.G.; Mathis, K.J.; Schnute, M.E.; Woodard, S.S.; Munie, G.; Williams, J.M.; Caspers, N.; Wittwer, A.J.; Malfait, A.M.; Shieh, H.S.
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
J. Biol. Chem.
284
24185-24191
2009
Homo sapiens (Q9UNA0)
Steinmeyer, J.; Kordelle, J.; Stuerz, H.
In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage
J. Orthop. Res.
28
828-833
2010
Homo sapiens
Tsuzaka, K.; Itami, Y.; Takeuchi, T.; Shinozaki, N.; Morishita, T.
ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis
J. Rheumatol.
37
1454-1460
2010
Homo sapiens
Troeberg, L.; Fushimi, K.; Scilabra, S.D.; Nakamura, H.; Dive, V.; Thogersen, I.B.; Enghild, J.J.; Nagase, H.
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
Matrix Biol.
28
463-469
2009
Homo sapiens
Echtermeyer, F.; Bertrand, J.; Dreier, R.; Meinecke, I.; Neugebauer, K.; Fuerst, M.; Lee, Y.J.; Song, Y.W.; Herzog, C.; Theilmeier, G.; Pap, T.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
Nat. Med.
15
1072-1076
2009
Homo sapiens
Durigova, M.; Troeberg, L.; Nagase, H.; Roughley, P.J.; Mort, J.S.
Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage
Eur. Cell Mater.
21
31-45
2011
Homo sapiens
Verma, P.; Dalal, K.
ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis
J. Cell. Biochem.
112
3507-3514
2011
Homo sapiens
Durigova, M.; Nagase, H.; Mort, J.S.; Roughley, P.J.
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein
Matrix Biol.
30
145-153
2011
Homo sapiens
Shieh, H.S.; Tomasselli, A.G.; Mathis, K.J.; Schnute, M.E.; Woodard, S.S.; Caspers, N.; Williams, J.M.; Kiefer, J.R.; Munie, G.; Wittwer, A.; Malfait, A.M.; Tortorella, M.D.
Structure analysis reveals the flexibility of the ADAMTS-5 active site
Protein Sci.
20
735-744
2011
Homo sapiens (Q9UNA0)
Kumar, S.; Sharghi-Namini, S.; Rao, N.; Ge, R.
ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity
Am. J. Pathol.
181
1056-1068
2012
Homo sapiens
Filou, S.; Stylianou, M.; Triantaphyllidou, I.E.; Papadas, T.; Mastronikolis, N.S.; Goumas, P.D.; Papachristou, D.J.; Ravazoula, P.; Skandalis, S.S.; Vynios, D.H.
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
Biochimie
95
725-734
2013
Homo sapiens
Atobe, M.; Maekawara, N.; Ishiguro, N.; Sogame, S.; Suenaga, Y.; Kawanishi, M.; Suzuki, H.; Jinno, N.; Tanaka, E.; Miyoshi, S.
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors
Bioorg. Med. Chem. Lett.
23
2106-2110
2013
Homo sapiens, Homo sapiens (Q9UNA0)
Sogame, S.; Suenaga, Y.; Atobe, M.; Kawanishi, M.; Tanaka, E.; Miyoshi, S.
Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping
Eur. J. Med. Chem.
71
250-258
2014
Homo sapiens (Q9UNA0)
Durham, T.; Klimkowski, V.; Rito, C.; Marimuthu, J.; Toth, J.; Liu, C.; Durbin, J.; Stout, S.; Adams, L.; Swearingen, C.; Lin, C.; Chambers, M.; Thirunavukkarasu, K.; Wiley, M.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis
J. Med. Chem.
57
10476-10485
2014
Homo sapiens
Filomia, F.; Saxena, P.; Durante, C.; De Rienzo, F.; Cocchi, M.; Menziani, M.
Computational insights into ADAMTS4, ADAMTS5 and MMP13 inhibitor selectivity
Mol. Inform.
31
421-430
2012
Homo sapiens (Q9UNA0)
Wang, Z.; Luo, J.; Iwamoto, S.; Chen, Q.
Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5
Molecules
19
8472-8487
2014
Homo sapiens (Q9UNA0), Homo sapiens
