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Disease on EC 3.4.24.B10 - ADAM12 endopeptidase and Organism(s) Homo sapiens

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DISEASE
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adam12 endopeptidase deficiency
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Adenocarcinoma
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Adenocarcinoma of Lung
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma.
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
Adenoma
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Alzheimer Disease
A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.
Ameloblastoma
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
Amyotrophic Lateral Sclerosis
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Arthritis
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.
Comparative review on left-handed Z-DNA.
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
The role of ADAMTSs in arthritis.
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
Arthritis, Experimental
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Arthritis, Rheumatoid
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Asthma
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
DiffGRN: differential gene regulatory network analysis.
Expression of ADAMs and their inhibitors in sputum from patients with asthma.
Astrocytoma
ADAM 12: a putative marker of oligodendrogliomas?
Atherosclerosis
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Expression and cellular localization of metalloproteases ADAMs in high graded carotid artery lesions.
Bone Cysts, Aneurysmal
[Expression of a disintegrin-like and metalloproteinase protein 8 and 12 in the giant cell lesions of jaw]
Bone Resorption
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Brain Neoplasms
ADAM 12: a putative marker of oligodendrogliomas?
Breast Diseases
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Breast Neoplasms
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a.
ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer.
ADAM12 induces estrogen-independence in breast cancer cells.
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling.
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells.
ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer.
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein.
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells.
Cellular roles of ADAM12 in health and disease.
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Endocrine resistance in breast cancer.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.
How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.
Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.
Molecular profiling of ADAM12 gene in breast cancers.
Molecular profiling of ADAM12 in human bladder cancer.
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Potential of fluorescent metalloproteinase substrates for cancer detection.
Proteomic screening identifies the zonula occludens protein ZO-1 as a new partner for ADAM12 in invadopodia-like structures.
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Urinary concentrations of ADAM 12 from breast cancer patients pre- and post-surgery vs. cancer-free controls: a clinical study for biomarker validation.
Urinary metalloproteinases: noninvasive biomarkers for breast cancer risk assessment.
Carcinogenesis
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
Carcinoma
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.
Identification of ADAM12 as a Novel Basigin Sheddase.
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Using Tumor-Infiltrating Immune Cells and a ceRNA Network Model to Construct a Prognostic Analysis Model of Thyroid Carcinoma.
Carcinoma, Ductal
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
Carcinoma, Hepatocellular
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Biomarker to distinguish hepatocellular carcinoma from cholangiocarcinoma by serum a disintegrin and metalloprotease 12.
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Carcinoma, Mucoepidermoid
HIF-1?, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma.
Carcinoma, Ovarian Epithelial
Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
Cardiomegaly
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
[Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy]
[The role of HB-EGF in angiotensin II--signaling]
Cardiovascular Diseases
The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.
Central Nervous System Diseases
ADAM12 is expressed by astrocytes during experimental demyelination.
Cholangiocarcinoma
Biomarker to distinguish hepatocellular carcinoma from cholangiocarcinoma by serum a disintegrin and metalloprotease 12.
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Cholestasis, Intrahepatic
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Choriocarcinoma
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Colitis
ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.
Colonic Neoplasms
Integrated bioinformatics analysis of key genes involved in progress of colon cancer.
Colorectal Neoplasms
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Expression of ADAMTS12 in Colorectal Cancer-Associated Stroma Prevents Cancer Development and Is a Good Prognostic Indicator of Colorectal Cancer.
Methylation status of ADAM12 promoter are associated with its expression levels in colorectal cancer.
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
COVID-19
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19.
Demyelinating Diseases
ADAM12 is expressed by astrocytes during experimental demyelination.
Dermatomyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Diabetes Mellitus, Type 1
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Down Syndrome
ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.
ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome.
ADAM 12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome.
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy.
ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome.
ADAM12-s in coelomic fluid and maternal serum in early pregnancy.
ADAM12: a novel first-trimester maternal serum marker for Down syndrome.
Effect of a new marker, ADAM12, on Down risk figures in first trimester screening.
First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker.
First- and second-trimester ADAM12s in Down syndrome screening.
First-trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Maternal serum ADAM12 in Chinese women undergoing screening for aneuploidy in the first trimester.
Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation.
Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21.
Modeling Down syndrome screening performance using first-trimester serum markers.
OP25.06: Maternal serum ADAM 12 levels in Down syndrome pregnancies during the first trimester.
Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies.
The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
[Second trimester screening for trisomy 21 using ADAM12-S as a maternal serum marker].
Dyskeratosis Congenita
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Encephalomyelitis
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
ADAM12 is expressed by astrocytes during experimental demyelination.
Encephalomyelitis, Autoimmune, Experimental
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
ADAM12 is expressed by astrocytes during experimental demyelination.
Endometriosis
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Esophageal Neoplasms
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Methylation status of ADAM12 promoter are associated with its expression levels in colorectal cancer.
Esophagitis
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma.
Fetal Growth Retardation
ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts.
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction.
First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system.
Predictive value of biochemical marker ADAM-12 at first trimester of pregnancy for hypertension and intrauterine growth restriction.
Review: the ADAM metalloproteinases - novel regulators of trophoblast invasion?
Fibromatosis, Aggressive
Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
Gene expression in aggressive fibromatosis.
Giant Cell Tumor of Bone
[Expression of ADAM12 (Meltrin-alpha) gene in giant cell tumor of bone]
Giant Cell Tumors
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
[Expression of ADAM12 (Meltrin-alpha) gene in giant cell tumor of bone]
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
Glioblastoma
ADAM12 is expressed by astrocytes during experimental demyelination.
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion.
Glioma
SP1-Mediated Upregulation of lncRNA LINC01614 Functions a ceRNA for miR-383 to Facilitate Glioma Progression Through Regulation of ADAM12.
Head and Neck Neoplasms
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Heart Failure
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
HELLP Syndrome
Maternal serum ADAM-12 as a potential marker for different adverse pregnancy outcomes.
Hepatitis B
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Hyperglycemia
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Hypersensitivity
Role of A Disintegrin and Metalloprotease-12 in Neutrophil Recruitment Induced by Airway Epithelium.
Hypertension
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Predictive value of biochemical marker ADAM-12 at first trimester of pregnancy for hypertension and intrauterine growth restriction.
Hypertension, Pregnancy-Induced
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
Infections
Human Polymorphisms in Placentally Expressed Genes and Their Association With Susceptibility to Congenital Trypanosoma cruzi Infection.
Influenza, Human
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Insulin Resistance
Microfibrillar-associated protein 5 is linked with markers of obesity-related extracellular matrix remodeling and inflammation.
Intervertebral Disc Degeneration
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Expression of ADAMTS-7 and ADAMTS-12 in Nucleus Pulposus during Degeneration of Rat Caudal Intervetebral Disc.
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
Kashin-Beck Disease
A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.
Keloid
Identification of unique gene expression patterns within different lesional sites of keloids.
Leiomyoma
Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas.
Leukemia
Aberrant Methylation of Tumour Suppressor Gene ADAM12 in Chronic Lympocytic Leukemia Patients: Application of Methylation Specific-PCR Technique.
Liver Neoplasms
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Lung Diseases, Interstitial
Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis.
Lung Injury
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19.
Lung Neoplasms
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Expression of ADAM12 is regulated by E2F1 in small cell lung cancer.
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
Lymphatic Metastasis
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Lymphoma, Non-Hodgkin
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Malaria
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Melanoma
Molecular Profiling of ADAM12 and ADAM17 Genes in Human Malignant Melanoma.
Multiple Sclerosis
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Muscular Dystrophies
ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy.
Animal models for muscular dystrophy; mechanism of disease and potential therapy.
Muscular Dystrophy, Duchenne
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice.
Myositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Myositis, Inclusion Body
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Neoplasm Metastasis
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a.
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling.
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Breast Cancer Recurrence Risk Assessment: Is Non-Invasive Monitoring an Option?
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Hypoxia enhances aggressiveness of cholangiocarcinoma cells.
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.
Role of hypoxia-related proteins in adenoid cystic carcinoma invasion.
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
TWIST1 induces metastasis through ADAM12.
Neoplasm, Residual
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Neoplasms
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma.
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development.
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix.
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
A substrate-optimized electrophoretic mobility shift assay for ADAM12.
Aberrant Methylation of Tumour Suppressor Gene ADAM12 in Chronic Lympocytic Leukemia Patients: Application of Methylation Specific-PCR Technique.
ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes.
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
ADAM 12: a putative marker of oligodendrogliomas?
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer.
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
ADAM12 induces estrogen-independence in breast cancer cells.
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.
ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling.
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
ADAM12 is expressed by astrocytes during experimental demyelination.
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
ADAMs in cancer cell proliferation and progression.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein.
Catalytic properties of ADAM12 and its domain deletion mutants.
Cell-surface Metalloprotease ADAM12 is Internalized by a Clathrin- and Grb2-dependent Mechanism.
Cellular roles of ADAM12 in health and disease.
Comparative review on left-handed Z-DNA.
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.
Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells.
Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Expression of CDCP1 and ADAM12 in the ovarian cancer microenvironment.
Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.
Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Hierarchy of ADAM12 binding to integrins in tumor cells.
HIF-1?, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma.
Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.
Identification of ADAM12 as a Novel Basigin Sheddase.
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics.
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Intracellular processing of metalloprotease disintegrin ADAM12.
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
Metalloprotease-disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Molecular profiling of ADAM12 gene in breast cancers.
Molecular profiling of ADAM12 in human bladder cancer.
NF-?B and STAT3 cooperatively induce IL6 in starved cancer cells.
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
Performance of first trimester biochemical markers and mean arterial pressure in prediction of early-onset pre-eclampsia.
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12.
Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Role of ADAMs in cancer formation and progression.
Role of hypoxia-related proteins in adenoid cystic carcinoma invasion.
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
Targeting ADAM12 in human disease: head, body or tail?
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
The role of ADAMs in disease pathophysiology.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Tumor necrosis factor-? alters integrins and metalloprotease ADAM12 levels and signaling in differentiating myoblasts.
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Urinary concentrations of ADAM 12 from breast cancer patients pre- and post-surgery vs. cancer-free controls: a clinical study for biomarker validation.
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
[Expression of ADAM12 (Meltrin-alpha) gene in giant cell tumor of bone]
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
Neuroinflammatory Diseases
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Obesity
Large-scale in silico mapping of complex quantitative traits in inbred mice.
Role of meltrin {alpha} (ADAM12) in obesity induced by high- fat diet.
Oligodendroglioma
ADAM 12: a putative marker of oligodendrogliomas?
Osteoarthritis
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population.
Association of ADAM 12 polymorphisms with the risk of knee osteoarthritis: meta-analysis of 5048 cases and 6848 controls.
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study.
Targeting ADAM12 in human disease: head, body or tail?
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
The association of ADAM12 polymorphism with osteoarthritis susceptibility: a meta-analysis.
Osteoarthritis, Knee
Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis.
Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population.
Association between ADAM12 polymorphism and knee osteoarthritis in Thai population.
Association between ADAM12 Single-Nucleotide Polymorphisms and Knee Osteoarthritis: A Meta-Analysis.
Association of ADAM 12 polymorphisms with the risk of knee osteoarthritis: meta-analysis of 5048 cases and 6848 controls.
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis.
Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis.
Lack of association between MMP13 (rs3819089), ADAM12 (rs3740199-rs1871054) and ADAMTS14 (rs4747096) genotypes and advanced-stage knee osteoarthritis.
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort.
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population.
Osteolysis
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Increased expression and processing of ADAM 12 (meltrin-alpha) in osteolysis associated with aseptic loosening of total hip replacement implants.
Osteophyte
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Association study of candidate genes for the prevalence and progression of knee osteoarthritis.
Osteosarcoma
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Ovarian Neoplasms
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Expression of CDCP1 and ADAM12 in the ovarian cancer microenvironment.
The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.
Pancreatic Neoplasms
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Aspartate ?-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Pancreatitis
ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.
Peripheral Arterial Disease
ADAM12: a genetic modifier of preclinical peripheral arterial disease.
Role of genetics in peripheral arterial disease outcomes; significance of limb-salvage quantitative locus-1 genes.
Pituitary Neoplasms
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT-20 and TtT/GF by affecting expression of MMP-14 and ADAM12.
Placenta Previa
Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia.
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
Polymyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Pre-Eclampsia
ADAM 12 and PAPP-A at 14-17 weeks' gestation as biomarkers of pre-eclampsia.
ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts.
ADAM12-s in coelomic fluid and maternal serum in early pregnancy.
ADAM12s in maternal serum as a potential marker of pre-eclampsia.
Differential Expression of HrtA1 and ADAM12 in Placentas from Preeclamptic and Normotensive Pregnancies.
Efficiency of first-trimester uterine artery Doppler, a-disintegrin and metalloprotease 12, pregnancy-associated plasma protein a, and maternal characteristics in the prediction of preeclampsia.
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction.
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
First-trimester placental protein 13 and placental growth factor: markers for identification of women destined to develop early-onset pre-eclampsia.
Maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia.
Metalloprotease (ADAM12-S) as a Predictor of Preeclampsia: Correlation with Severity, Maternal Complications, Fetal Outcome, and Doppler Parameters.
Mid-Trimester Maternal ADAM12 Levels Differ According to Fetal Gender in Pregnancies Complicated by Preeclampsia.
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Placental levels of total oxidative and anti-oxidative status, ADAMTS-12 and decorin in early- and late-onset severe preeclampsia.
Preeclampsia: increased expression of soluble ADAM 12.
Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.
Repeated Measures of Placental Growth Factor, Placental Protein 13, and A Disintegrin and Metalloprotease 12 at First and Second Trimesters for Preeclampsia Screening.
Review: the ADAM metalloproteinases - novel regulators of trophoblast invasion?
The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia.
Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia.
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation.
Pregnancy, Ectopic
A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy.
Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy.
Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location.
Predicting first trimester pregnancy outcome: derivation of a multiple marker test.
Premature Birth
First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics.
Prostatic Neoplasms
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Rhabdomyosarcoma
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation.
Regulation of ADAM12 cell-surface expression by protein kinase C epsilon.
Rhabdomyosarcoma, Embryonal
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
Rhinitis, Allergic
Role of A Disintegrin and Metalloprotease-12 in Neutrophil Recruitment Induced by Airway Epithelium.
Rubella
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Scleroderma, Diffuse
Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.
Scleroderma, Systemic
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.
Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis.
Sepsis
ADAMTS-12: Functions and Challenges for a Complex Metalloprotease.
Skin Neoplasms
Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.
Small Cell Lung Carcinoma
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Expression of ADAM12 is regulated by E2F1 in small cell lung cancer.
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Squamous Cell Carcinoma of Head and Neck
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Stomach Neoplasms
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma.
Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix.
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.
The regulatory relationship and function of LncRNA FAM225A-miR-206-ADAM12 in gastric cancer.
Urinary ADAM12 and MMP-9/NGAL Complex Detect the Presence of Gastric Cancer.
Stroke
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Synovitis
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Thyroid Neoplasms
The Role of LINC00284 in the Development of Thyroid Cancer via Its Regulation of the MicroRNA-30d-5p-Mediated ADAM12/Notch Axis.
Tricuspid Valve Insufficiency
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Triple Negative Breast Neoplasms
ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple-Negative Breast Cancer.
An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer.
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Trisomy 13 Syndrome
Adding ADAM12 in risk calculation program does not improve the detection rate of trisomies 18 and 13 in first trimester screening.
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy.
Trisomy 18 Syndrome
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy.
Adding ADAM12 in risk calculation program does not improve the detection rate of trisomies 18 and 13 in first trimester screening.
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.
Turner Syndrome
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy.
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
Urinary Bladder Neoplasms
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Identification of ADAM12 as a Novel Basigin Sheddase.
Molecular profiling of ADAM12 in human bladder cancer.
Uterine Cervical Neoplasms
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Vascular Diseases
Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation.