Disease on EC 3.4.24.B10 - ADAM12 endopeptidase and Organism(s) Homo sapiens
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adam12 endopeptidase deficiency
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
adam12 endopeptidase deficiency
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Adenocarcinoma
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Adenocarcinoma of Lung
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma.
Adenocarcinoma of Lung
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
Adenoma
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Alzheimer Disease
A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.
Alzheimer Disease
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
Alzheimer Disease
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.
Ameloblastoma
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
Amyotrophic Lateral Sclerosis
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Arthritis
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
Arthritis
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Arthritis
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
Arthritis, Experimental
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Arthritis, Rheumatoid
ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.
Arthritis, Rheumatoid
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Asthma
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
Asthma
ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma.
Atherosclerosis
Expression and cellular localization of metalloproteases ADAMs in high graded carotid artery lesions.
Bone Cysts, Aneurysmal
[Expression of a disintegrin-like and metalloproteinase protein 8 and 12 in the giant cell lesions of jaw]
Bone Resorption
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Breast Diseases
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Breast Neoplasms
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
Breast Neoplasms
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Breast Neoplasms
Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a.
Breast Neoplasms
ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer.
Breast Neoplasms
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
Breast Neoplasms
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Breast Neoplasms
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
Breast Neoplasms
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
Breast Neoplasms
ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells.
Breast Neoplasms
ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer.
Breast Neoplasms
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
Breast Neoplasms
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer.
Breast Neoplasms
An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer.
Breast Neoplasms
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein.
Breast Neoplasms
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells.
Breast Neoplasms
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Breast Neoplasms
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Breast Neoplasms
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.
Breast Neoplasms
How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.
Breast Neoplasms
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
Breast Neoplasms
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Breast Neoplasms
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
Breast Neoplasms
Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29.
Breast Neoplasms
Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.
Breast Neoplasms
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Breast Neoplasms
Potential of fluorescent metalloproteinase substrates for cancer detection.
Breast Neoplasms
Proteomic screening identifies the zonula occludens protein ZO-1 as a new partner for ADAM12 in invadopodia-like structures.
Breast Neoplasms
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
Breast Neoplasms
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Breast Neoplasms
Urinary concentrations of ADAM 12 from breast cancer patients pre- and post-surgery vs. cancer-free controls: a clinical study for biomarker validation.
Breast Neoplasms
Urinary metalloproteinases: noninvasive biomarkers for breast cancer risk assessment.
Carcinogenesis
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Carcinogenesis
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Carcinogenesis
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
Carcinogenesis
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Carcinogenesis
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
Carcinoma
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Carcinoma
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Carcinoma
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
Carcinoma
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Carcinoma
Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity.
Carcinoma
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Carcinoma
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Carcinoma
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Carcinoma
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
Carcinoma
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Carcinoma
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Carcinoma
Using Tumor-Infiltrating Immune Cells and a ceRNA Network Model to Construct a Prognostic Analysis Model of Thyroid Carcinoma.
Carcinoma, Ductal
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
Carcinoma, Hepatocellular
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Carcinoma, Hepatocellular
Biomarker to distinguish hepatocellular carcinoma from cholangiocarcinoma by serum a disintegrin and metalloprotease 12.
Carcinoma, Hepatocellular
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Carcinoma, Mucoepidermoid
HIF-1?, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma.
Carcinoma, Ovarian Epithelial
Novel surface targets and serum biomarkers from the ovarian cancer vasculature.
Cardiomegaly
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
Cardiomegaly
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy.
Cardiomegaly
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Cardiomegaly
Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.
Cardiomegaly
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
Cardiomegaly
[Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy]
Cardiovascular Diseases
The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.
Central Nervous System Diseases
ADAM12 is expressed by astrocytes during experimental demyelination.
Cholangiocarcinoma
Biomarker to distinguish hepatocellular carcinoma from cholangiocarcinoma by serum a disintegrin and metalloprotease 12.
Cholangiocarcinoma
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Cholestasis, Intrahepatic
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Choriocarcinoma
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Colonic Neoplasms
Integrated bioinformatics analysis of key genes involved in progress of colon cancer.
Colorectal Neoplasms
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Colorectal Neoplasms
Expression of ADAMTS12 in Colorectal Cancer-Associated Stroma Prevents Cancer Development and Is a Good Prognostic Indicator of Colorectal Cancer.
Colorectal Neoplasms
Methylation status of ADAM12 promoter are associated with its expression levels in colorectal cancer.
Colorectal Neoplasms
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients.
Demyelinating Diseases
ADAM12 is expressed by astrocytes during experimental demyelination.
Dermatomyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Diabetes Mellitus, Type 1
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Down Syndrome
ADAM 12 as a first-trimester maternal serum marker in screening for Down syndrome.
Down Syndrome
ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome.
Down Syndrome
ADAM 12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome.
Down Syndrome
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy.
Down Syndrome
ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome.
Down Syndrome
Effect of a new marker, ADAM12, on Down risk figures in first trimester screening.
Down Syndrome
First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker.
Down Syndrome
First-trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?
Down Syndrome
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Down Syndrome
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Down Syndrome
Maternal serum ADAM12 in Chinese women undergoing screening for aneuploidy in the first trimester.
Down Syndrome
Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation.
Down Syndrome
Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21.
Down Syndrome
Modeling Down syndrome screening performance using first-trimester serum markers.
Down Syndrome
OP25.06: Maternal serum ADAM 12 levels in Down syndrome pregnancies during the first trimester.
Down Syndrome
Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies.
Down Syndrome
The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.
Down Syndrome
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
Down Syndrome
[Second trimester screening for trisomy 21 using ADAM12-S as a maternal serum marker].
Dyskeratosis Congenita
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Encephalomyelitis
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Encephalomyelitis, Autoimmune, Experimental
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Encephalomyelitis, Autoimmune, Experimental
ADAM12 is expressed by astrocytes during experimental demyelination.
Endometriosis
Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.
Esophageal Neoplasms
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Esophageal Neoplasms
Methylation status of ADAM12 promoter are associated with its expression levels in colorectal cancer.
Esophagitis
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma.
Fetal Growth Retardation
ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts.
Fetal Growth Retardation
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
Fetal Growth Retardation
First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction.
Fetal Growth Retardation
First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system.
Fetal Growth Retardation
Predictive value of biochemical marker ADAM-12 at first trimester of pregnancy for hypertension and intrauterine growth restriction.
Fetal Growth Retardation
Review: the ADAM metalloproteinases - novel regulators of trophoblast invasion?
Fibromatosis, Aggressive
Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
Giant Cell Tumor of Bone
[Expression of ADAM12 (Meltrin-alpha) gene in giant cell tumor of bone]
Giant Cell Tumors
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
Giant Cell Tumors
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
Glioblastoma
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.
Glioma
SP1-Mediated Upregulation of lncRNA LINC01614 Functions a ceRNA for miR-383 to Facilitate Glioma Progression Through Regulation of ADAM12.
Head and Neck Neoplasms
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Heart Failure
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
HELLP Syndrome
Maternal serum ADAM-12 as a potential marker for different adverse pregnancy outcomes.
Hepatitis B
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Hyperglycemia
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Hypersensitivity
Role of A Disintegrin and Metalloprotease-12 in Neutrophil Recruitment Induced by Airway Epithelium.
Hypertension
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
Hypertension
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Hypertension
Predictive value of biochemical marker ADAM-12 at first trimester of pregnancy for hypertension and intrauterine growth restriction.
Hypertension, Pregnancy-Induced
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
Infections
Human Polymorphisms in Placentally Expressed Genes and Their Association With Susceptibility to Congenital Trypanosoma cruzi Infection.
Influenza, Human
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Insulin Resistance
Microfibrillar-associated protein 5 is linked with markers of obesity-related extracellular matrix remodeling and inflammation.
Intervertebral Disc Degeneration
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
Intervertebral Disc Degeneration
Expression of ADAMTS-7 and ADAMTS-12 in Nucleus Pulposus during Degeneration of Rat Caudal Intervetebral Disc.
Intervertebral Disc Degeneration
Negative effects of ADAMTS-7 and ADAMTS-12 on endplate cartilage differentiation.
Kashin-Beck Disease
A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.
Keloid
Identification of unique gene expression patterns within different lesional sites of keloids.
Leiomyoma
Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas.
Leukemia
Aberrant Methylation of Tumour Suppressor Gene ADAM12 in Chronic Lympocytic Leukemia Patients: Application of Methylation Specific-PCR Technique.
Liver Neoplasms
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Liver Neoplasms
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
Liver Neoplasms
RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis.
Lung Diseases, Interstitial
Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis.
Lung Neoplasms
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Lung Neoplasms
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Lung Neoplasms
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Lung Neoplasms
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
Lymphatic Metastasis
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Lymphatic Metastasis
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Lymphoma, Non-Hodgkin
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Malaria
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Multiple Sclerosis
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Multiple Sclerosis
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Muscular Dystrophies
ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy.
Muscular Dystrophies
Animal models for muscular dystrophy; mechanism of disease and potential therapy.
Muscular Dystrophy, Duchenne
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Muscular Dystrophy, Duchenne
Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice.
Myositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Myositis, Inclusion Body
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Neoplasm Metastasis
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Neoplasm Metastasis
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Neoplasm Metastasis
Adam12 and lnc015192 act as ceRNAs in breast cancer by regulating miR-34a.
Neoplasm Metastasis
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Neoplasm Metastasis
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
Neoplasm Metastasis
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
Neoplasm Metastasis
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Neoplasm Metastasis
Breast Cancer Recurrence Risk Assessment: Is Non-Invasive Monitoring an Option?
Neoplasm Metastasis
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Neoplasm Metastasis
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.
Neoplasm Metastasis
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Neoplasm Metastasis
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Neoplasm Metastasis
Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.
Neoplasm Metastasis
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
Neoplasm Metastasis
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Neoplasm Metastasis
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Neoplasm, Residual
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Neoplasms
A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma.
Neoplasms
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer.
Neoplasms
A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development.
Neoplasms
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Neoplasms
A disintegrin and metalloproteinase-12 (ADAM12): function, roles in disease progression, and clinical implications.
Neoplasms
A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix.
Neoplasms
Aberrant Methylation of Tumour Suppressor Gene ADAM12 in Chronic Lympocytic Leukemia Patients: Application of Methylation Specific-PCR Technique.
Neoplasms
ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes.
Neoplasms
ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage.
Neoplasms
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
Neoplasms
ADAM12 expression predicts clinical outcome in estrogen receptor-positive breast cancer.
Neoplasms
ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling.
Neoplasms
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Neoplasms
ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.
Neoplasms
ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme.
Neoplasms
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Neoplasms
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
Neoplasms
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
Neoplasms
ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.
Neoplasms
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.
Neoplasms
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.
Neoplasms
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
Neoplasms
ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis.
Neoplasms
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
Neoplasms
An ADAM12 and FAK positive feedback loop amplifies the interaction signal of tumor cells with extracellular matrix to promote esophageal cancer metastasis.
Neoplasms
Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein.
Neoplasms
Cell-surface Metalloprotease ADAM12 is Internalized by a Clathrin- and Grb2-dependent Mechanism.
Neoplasms
Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion.
Neoplasms
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.
Neoplasms
Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells.
Neoplasms
Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice.
Neoplasms
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Neoplasms
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Neoplasms
Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.
Neoplasms
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
Neoplasms
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Neoplasms
Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12.
Neoplasms
Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.
Neoplasms
HIF-1?, NOTCH1, ADAM12, and HB-EGF are overexpressed in mucoepidermoid carcinoma.
Neoplasms
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Neoplasms
Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics.
Neoplasms
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Neoplasms
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis.
Neoplasms
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Neoplasms
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
Neoplasms
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
Neoplasms
Metalloprotease-disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells.
Neoplasms
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer.
Neoplasms
Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype.
Neoplasms
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Neoplasms
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
Neoplasms
Performance of first trimester biochemical markers and mean arterial pressure in prediction of early-onset pre-eclampsia.
Neoplasms
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Neoplasms
Preoperative serum ADAM12 levels as a stromal marker for overall survival and benefit of adjuvant therapy in patients with resected pancreatic and periampullary cancer.
Neoplasms
Quantitative proteomics and biochemical analyses reveal the role of endoplasmin in the regulation of the expression and secretion of A Disintegrin And Metalloproteinase 12.
Neoplasms
Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.
Neoplasms
Role of hypoxia-related proteins in invasion of ameloblastoma cells: crosstalk between NOTCH1, HIF-1?, ADAM-12, and HB-EGF.
Neoplasms
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
Neoplasms
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
Neoplasms
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Neoplasms
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
Neoplasms
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
Neoplasms
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.
Neoplasms
The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12.
Neoplasms
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Neoplasms
Tumor necrosis factor-? alters integrins and metalloprotease ADAM12 levels and signaling in differentiating myoblasts.
Neoplasms
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Neoplasms
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Neoplasms
Urinary concentrations of ADAM 12 from breast cancer patients pre- and post-surgery vs. cancer-free controls: a clinical study for biomarker validation.
Neoplasms
Z-DNA-forming silencer in the first exon regulates human ADAM-12 gene expression.
Neoplasms
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
Neuroinflammatory Diseases
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Osteoarthritis
Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population.
Osteoarthritis
Association of ADAM 12 polymorphisms with the risk of knee osteoarthritis: meta-analysis of 5048 cases and 6848 controls.
Osteoarthritis
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Osteoarthritis
Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
Osteoarthritis
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Osteoarthritis
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.
Osteoarthritis
Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study.
Osteoarthritis
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Osteoarthritis
The association of ADAM12 polymorphism with osteoarthritis susceptibility: a meta-analysis.
Osteoarthritis, Knee
Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis.
Osteoarthritis, Knee
Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population.
Osteoarthritis, Knee
Association between ADAM12 polymorphism and knee osteoarthritis in Thai population.
Osteoarthritis, Knee
Association between ADAM12 Single-Nucleotide Polymorphisms and Knee Osteoarthritis: A Meta-Analysis.
Osteoarthritis, Knee
Association of ADAM 12 polymorphisms with the risk of knee osteoarthritis: meta-analysis of 5048 cases and 6848 controls.
Osteoarthritis, Knee
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Osteoarthritis, Knee
Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population.
Osteoarthritis, Knee
Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis.
Osteoarthritis, Knee
Genetic effects of rs3740199 polymorphism in ADAM12 gene on knee osteoarthritis: a meta-analysis.
Osteoarthritis, Knee
Lack of association between MMP13 (rs3819089), ADAM12 (rs3740199-rs1871054) and ADAMTS14 (rs4747096) genotypes and advanced-stage knee osteoarthritis.
Osteoarthritis, Knee
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort.
Osteoarthritis, Knee
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Osteoarthritis, Knee
Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population.
Osteolysis
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Osteolysis
Increased expression and processing of ADAM 12 (meltrin-alpha) in osteolysis associated with aseptic loosening of total hip replacement implants.
Osteophyte
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Osteophyte
Association study of candidate genes for the prevalence and progression of knee osteoarthritis.
Osteosarcoma
A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis.
Ovarian Neoplasms
ADAM12 is a prognostic factor associated with an aggressive molecular subtype of high-grade serous ovarian carcinoma.
Ovarian Neoplasms
The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.
Pancreatic Neoplasms
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Pancreatic Neoplasms
Aspartate ?-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Peripheral Arterial Disease
ADAM12: a genetic modifier of preclinical peripheral arterial disease.
Peripheral Arterial Disease
Role of genetics in peripheral arterial disease outcomes; significance of limb-salvage quantitative locus-1 genes.
Pituitary Neoplasms
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Pituitary Neoplasms
Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.
Pituitary Neoplasms
Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT-20 and TtT/GF by affecting expression of MMP-14 and ADAM12.
Placenta Previa
Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia.
Placenta Previa
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
Polymyositis
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
Pre-Eclampsia
ADAM12 and PAPP-A: Candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts.
Pre-Eclampsia
Differential Expression of HrtA1 and ADAM12 in Placentas from Preeclamptic and Normotensive Pregnancies.
Pre-Eclampsia
Efficiency of first-trimester uterine artery Doppler, a-disintegrin and metalloprotease 12, pregnancy-associated plasma protein a, and maternal characteristics in the prediction of preeclampsia.
Pre-Eclampsia
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading.
Pre-Eclampsia
First trimester maternal serum analytes and second trimester uterine artery Doppler in the prediction of preeclampsia and fetal growth restriction.
Pre-Eclampsia
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
Pre-Eclampsia
First-trimester placental protein 13 and placental growth factor: markers for identification of women destined to develop early-onset pre-eclampsia.
Pre-Eclampsia
Maternal characteristics, mean arterial pressure and serum markers in early prediction of preeclampsia.
Pre-Eclampsia
Metalloprotease (ADAM12-S) as a Predictor of Preeclampsia: Correlation with Severity, Maternal Complications, Fetal Outcome, and Doppler Parameters.
Pre-Eclampsia
Mid-Trimester Maternal ADAM12 Levels Differ According to Fetal Gender in Pregnancies Complicated by Preeclampsia.
Pre-Eclampsia
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Pre-Eclampsia
Placental levels of total oxidative and anti-oxidative status, ADAMTS-12 and decorin in early- and late-onset severe preeclampsia.
Pre-Eclampsia
Repeated Measures of Placental Growth Factor, Placental Protein 13, and A Disintegrin and Metalloprotease 12 at First and Second Trimesters for Preeclampsia Screening.
Pre-Eclampsia
Review: the ADAM metalloproteinases - novel regulators of trophoblast invasion?
Pre-Eclampsia
The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia.
Pre-Eclampsia
Total oxidative and anti-oxidative status, and ADAMTS-12 levels in placenta previa and early-onset severe preeclampsia.
Pre-Eclampsia
Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation.
Pregnancy, Ectopic
A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy.
Pregnancy, Ectopic
Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy.
Pregnancy, Ectopic
Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location.
Pregnancy, Ectopic
Predicting first trimester pregnancy outcome: derivation of a multiple marker test.
Premature Birth
First-trimester prediction of preterm birth using ADAM12, PAPP-A, uterine artery Doppler, and maternal characteristics.
Prostatic Neoplasms
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
Prostatic Neoplasms
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Rhabdomyosarcoma
ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation.
Rhabdomyosarcoma, Embryonal
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
Rhinitis, Allergic
Role of A Disintegrin and Metalloprotease-12 in Neutrophil Recruitment Induced by Airway Epithelium.
Rubella
Are the fusion processes involved in birth, life and death of the cell depending on tilted insertion of peptides into membranes?
Scleroderma, Diffuse
Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.
Scleroderma, Systemic
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome.
Scleroderma, Systemic
Perivascular Cells in Diffuse Cutaneous Systemic Sclerosis Overexpress Activated ADAM12 and Are Involved in Myofibroblast Transdifferentiation and Development of Fibrosis.
Scleroderma, Systemic
Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis.
Skin Neoplasms
Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.
Small Cell Lung Carcinoma
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
Small Cell Lung Carcinoma
Expression of ADAM12 is regulated by E2F1 in small cell lung cancer.
Small Cell Lung Carcinoma
SILAC Quantitative Proteomics and Biochemical Analyses Reveal a Novel Molecular Mechanism by Which ADAM12S Promotes the Proliferation, Migration, and Invasion of Small Cell Lung Cancer Cells through Upregulating Hexokinase 1.
Squamous Cell Carcinoma of Head and Neck
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Squamous Cell Carcinoma of Head and Neck
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Stomach Neoplasms
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma.
Stomach Neoplasms
Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix.
Stomach Neoplasms
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer.
Stomach Neoplasms
The regulatory relationship and function of LncRNA FAM225A-miR-206-ADAM12 in gastric cancer.
Stomach Neoplasms
Urinary ADAM12 and MMP-9/NGAL Complex Detect the Presence of Gastric Cancer.
Stroke
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Synovitis
Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
Synovitis
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Thyroid Neoplasms
The Role of LINC00284 in the Development of Thyroid Cancer via Its Regulation of the MicroRNA-30d-5p-Mediated ADAM12/Notch Axis.
Tricuspid Valve Insufficiency
First trimester ultrasound tests alone or in combination with first trimester serum tests for Down's syndrome screening.
Triple Negative Breast Neoplasms
ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Phenotypic Diversity of Breast Cancer-Related Mutations in Metalloproteinase-Disintegrin ADAM12.
Trisomy 13 Syndrome
Adding ADAM12 in risk calculation program does not improve the detection rate of trisomies 18 and 13 in first trimester screening.
Trisomy 13 Syndrome
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Trisomy 13 Syndrome
Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy.
Trisomy 18 Syndrome
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy.
Trisomy 18 Syndrome
Adding ADAM12 in risk calculation program does not improve the detection rate of trisomies 18 and 13 in first trimester screening.
Trisomy 18 Syndrome
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Trisomy 18 Syndrome
The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18.
Turner Syndrome
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Turner Syndrome
Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy.
Turner Syndrome
[Correlation of a disintegrin and metalloprotease 12 level in maternal serum during the first trimester with pregnancy outcome]
Urinary Bladder Neoplasms
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Uterine Cervical Neoplasms
Increased ADAM12 Expression Predicts Poor Prognosis in Cervical Cancer Patients before General Anesthesia.
Vascular Diseases
Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation.