Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.4.24.61 - nardilysin

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chesneau, V.; Pierotti, A.R.; Barre, N.; Creminon, C.; Tougard, C.; Cohen, P.
Isolation and characterization of a dibasic selective metalloendopeptidase from rat testes that cleaves at the amino terminus of arginine residues
J. Biol. Chem.
269
2056-2061
1994
Rattus norvegicus
Manually annotated by BRENDA team
Gomez, S.; Gluschankof, P.; Morel, A.; Cohen, P.
The somatostatin-28 convertase of rat brain cortex is associated with secretory granule membranes
J. Biol. Chem.
260
10541-10545
1985
Rattus norvegicus
Manually annotated by BRENDA team
Gluschankof, P.; Gomez, S.; Morel, A.; Cohen, P.
Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex
J. Biol. Chem.
262
9615-9620
1987
Rattus norvegicus
Manually annotated by BRENDA team
Pierotti, A.R.; Prat, A.; Chesneau, V.; Gaudoux, F.; Leseney, A.M.; Foulon, T.; Cohen, P.
N-Arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes
Proc. Natl. Acad. Sci. USA
91
6078-6082
1994
Rattus norvegicus
Manually annotated by BRENDA team
Cohen, P.; Pierotti, A.R.; Chesneau, V.; Foulon, T.; Prat, A.
N-arginine dibasic convertase
Methods Enzymol.
248
703-716
1995
Rattus norvegicus
Manually annotated by BRENDA team
Cohen, P.; Clamagirand, C.; Gluschankof, P.; Gomez, S.; Creminon, C.; Plevrakis, I.; Clavreul, C.; Fahy, C.; Boussetta, H.; et al.
Somatostatin-28 and pro-ocytocin/neurophysin convertases: basic pair selective endoproteases involved in pro-hormone processing in the rat brain cortex and bovine corpus luteum
Biochimie
70
17-23
1988
Rattus norvegicus
Manually annotated by BRENDA team
Foulon, T.; Cadel, S.; Prat, A.; Chesneau, V.; Hospital, V.; Segretain, D.; Cohen, P.
NRD convertase and aminopeptidase B: two processing metallopeptidases with a selectivity for basic residues
Ann. Endocrinol. (Paris)
58
357-364
1997
Rattus norvegicus
Manually annotated by BRENDA team
Csuhai, E.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Kinetic analysis of spermine binding to NRD convertase
Arch. Biochem. Biophys.
362
291-300
1999
Rattus norvegicus
Manually annotated by BRENDA team
Ma, Z.; Chow, K.M.; Csuhai, E.; Hersh, L.B.
The use of proteolysis to study the structure of nardilysin
Arch. Biochem. Biophys.
401
198-204
2002
Mus musculus
Manually annotated by BRENDA team
Chow, K.M.; Oakley, O.; Goodman, J.; Ma, Z.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
Nardilysin cleaves peptides at monobasic sites
Biochemistry
42
2239-2244
2003
Mus musculus
Manually annotated by BRENDA team
Chow, K.M.; Csuhai, E.; Juliano, M.A.; St Pyrek, J.; Juliano, L.; Hersh, L.B.
Studies on the subsite specificity of rat nardilysin (N-arginine dibasic convertase)
J. Biol. Chem.
275
19545-19551
2000
Rattus norvegicus
Manually annotated by BRENDA team
Ma, Z.; Chow, K.M.; Yao, J.; Hersh, L.B.
Nuclear shuttling of the peptidase nardilysin
Arch. Biochem. Biophys.
422
153-160
2004
Mus musculus
Manually annotated by BRENDA team
Ma, Z.; Wang, X.; Hockman, S.; Snow, E.C.; Hersh, L.B.
Subcellular localization of nardilysin during mouse oocyte maturation
Arch. Biochem. Biophys.
434
187-194
2005
Mus musculus
Manually annotated by BRENDA team
Chow, K.M.; Ma, Z.; Cai, J.; Pierce, W.M.; Hersh, L.B.
Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase
Biochim. Biophys. Acta
1723
292-301
2005
Rattus norvegicus
Manually annotated by BRENDA team
Fontes, G.; Lajoix, A.D.; Bergeron, F.; Cadel, S.; Prat, A.; Foulon, T.; Gross, R.; Dalle, S.; Le-Nguyen, D.; Tribillac, F.; Bataille, D.
Miniglucagon (MG)-generating endopeptidase, which processes glucagon into MG, is composed of N-arginine dibasic convertase and aminopeptidase B
Endocrinology
146
702-712
2005
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Nishi, E.; Hiraoka, Y.; Yoshida, K.; Okawa, K.; Kita, T.
Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme
J. Biol. Chem.
281
31164-31172
2006
Homo sapiens (O43847)
Manually annotated by BRENDA team
Stricker, R.; Chow, K.M.; Walther, D.; Hanck, T.; Hersh, L.B.; Reiser, G.
Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity
J. Neurochem.
98
343-354
2006
Rattus norvegicus
Manually annotated by BRENDA team
Hiraoka, Y.; Yoshida, K.; Ohno, M.; Matsuoka, T.; Kita, T.; Nishi, E.
Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases
Biochem. Biophys. Res. Commun.
370
154-158
2008
Homo sapiens
Manually annotated by BRENDA team
Hiraoka, Y.; Ohno, M.; Yoshida, K.; Okawa, K.; Tomimoto, H.; Kita, T.; Nishi, E.
Enhancement of alpha-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin
J. Neurochem.
102
1595-1605
2007
Homo sapiens
Manually annotated by BRENDA team
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Truebner, K.; Bogerts, B.; Reiser, G.
Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons
Neuroscience
146
1513-1523
2007
Homo sapiens
Manually annotated by BRENDA team
Bernstein, H.G.; Stricker, R.; Lendeckel, U.; Bertram, I.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Reiser, G.
Reduced neuronal co-localisation of nardilysin and the putative alpha-secretases ADAM10 and ADAM17 in Alzheimers disease and Down syndrome brains
Age (Dordr. )
31
11-25
2009
Homo sapiens
Manually annotated by BRENDA team
Korovkina, V.P.; Stamnes, S.J.; Brainard, A.M.; England, S.K.
Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium
Am. J. Physiol. Cell Physiol.
296
C433-C440
2009
Homo sapiens
Manually annotated by BRENDA team
Ohno, M.; Hiraoka, Y.; Matsuoka, T.; Tomimoto, H.; Takao, K.; Miyakawa, T.; Oshima, N.; Kiyonari, H.; Kimura, T.; Kita, T.; Nishi, E.
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
Nat. Neurosci.
12
1506-1513
2009
Mus musculus
Manually annotated by BRENDA team
Kessler, J.H.; Khan, S.; Seifert, U.; Le Gall, S.; Chow, K.M.; Paschen, A.; Bres-Vloemans, S.A.; de Ru, A.; van Montfoort, N.; Franken, K.L.; Benckhuijsen, W.E.; Brooks, J.M.; van Hall, T.; Ray, K.; Mulder, A.; Doxiadis, I.I.; van Swieten, P.F.; Overkleeft, H.S.; Prat, A.; Tomkinson, B.; Neefjes, J.; Klo, K.l.o.e.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes
Nat. Immunol.
12
45-53
2011
Homo sapiens
Manually annotated by BRENDA team
Borrmann, C.; Stricker, R.; Reiser, G.
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1)
Cell Tissue Res.
346
89-98
2011
Homo sapiens
Manually annotated by BRENDA team
Li, J.; Chu, M.; Wang, S.; Chan, D.; Qi, S.; Wu, M.; Zhou, Z.; Li, J.; Nishi, E.; Qin, J.; Wong, J.
Identification and Characteriation of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation
J. Biol. Chem.
287
10089-10098
2012
Homo sapiens (O43847)
Manually annotated by BRENDA team
Borrmann, C.; Stricker, R.; Reiser, G.
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin alpha1; ADAP1) in neuroblastoma cells
Neurochem. Int.
59
936-944
2011
Homo sapiens
Manually annotated by BRENDA team
Bernstein, H.; Stricker, R.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Trbner, K.; Reiser, G.
Nardilysin in human brain diseases: both friend and foe
Amino Acids
45
269-278
2013
Homo sapiens (O43847), Homo sapiens
Manually annotated by BRENDA team
Kanda, K.; Komekado, H.; Sawabu, T.; Ishizu, S.; Nakanishi, Y.; Nakatsuji, M.; Akitake-Kawano, R.; Ohno, M.; Hiraoka, Y.; Kawada, M.; Kawada, K.; Sakai, Y.; Matsumoto, K.; Kunichika, M.; Kimura, T.; Seno, H.; Nishi, E.; Chiba, T.
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-alpha
EMBO Mol. Med.
4
396-411
2012
Homo sapiens (O43847), Homo sapiens
Manually annotated by BRENDA team
Hiraoka, Y.; Matsuoka, T.; Ohno, M.; Nakamura, K.; Saijo, S.; Matsumura, S.; Nishi, K.; Sakamoto, J.; Chen, P.; Inoue, K.; Fushiki, T.; Kita, T.; Kimura, T.; Nishi, E.
Critical roles of nardilysin in the maintenance of body temperature homoeostasis
Nat. Commun.
5
3224
2014
Mus musculus (Q8BHG1)
Manually annotated by BRENDA team
Ohno, M.; Hiraoka, Y.; Lichtenthaler, S.; Nishi, K.; Saijo, S.; Matsuoka, T.; Tomimoto, H.; Araki, W.; Takahashi, R.; Kita, T.; Kimura, T.; Nishi, E.
Nardilysin prevents amyloid plaque formation by enhancing alpha-secretase activity in an Alzheimers disease mouse model
Neurobiol. Aging
35
213-222
2014
Mus musculus (Q8BHG1), Mus musculus
Manually annotated by BRENDA team
Segretain, D.; Gilleron, J.; Bacro, J.N.; Di Marco, M.; Carette, D.; Pointis, G.
Ultrastructural localization and distribution of nardilysin in mammalian male germ cells
Basic Clin. Androl.
26
5
2016
Mus musculus (Q8BHG1), Mus musculus
Manually annotated by BRENDA team
Yoh, T.; Hatano, E.; Kasai, Y.; Fuji, H.; Nishi, K.; Toriguchi, K.; Sueoka, H.; Ohno, M.; Seo, S.; Iwaisako, K.; Taura, K.; Yamaguchi, R.; Kurokawa, M.; Fujimoto, J.; Kimura, T.; Uemoto, S.; Nishi, E.
Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection
Clin. Cancer Res.
25
619-628
2019
Homo sapiens (O43847), Homo sapiens
Manually annotated by BRENDA team
Chen, F.H.; Wang, Y.; Jiang, Y.X.; Zhang, G.H.; Wang, Z.M.; Yang, H.
Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction
Clin. Chim. Acta
494
8-13
2019
Homo sapiens (O43847), Homo sapiens
Manually annotated by BRENDA team
Nishi, K.; Sato, Y.; Ohno, M.; Hiraoka, Y.; Saijo, S.; Sakamoto, J.; Chen, P.M.; Morita, Y.; Matsuda, S.; Iwasaki, K.; Sugizaki, K.; Harada, N.; Mukumoto, Y.; Kiyonari, H.; Furuyama, K.; Kawaguchi, Y.; Uemoto, S.; Kita, T.; Inagaki, N.; Kimura, T.; Nishi, E.
Nardilysin is required for maintaining pancreatic beta-cell function
Diabetes
65
3015-3027
2016
Mus musculus (Q8BHG1)
Manually annotated by BRENDA team
Ikuta, K.; Fukuda, A.; Ogawa, S.; Masuo, K.; Goto, N.; Hiramatsu, Y.; Tsuda, M.; Kimura, Y.; Matsumoto, Y.; Kimura, Y.; Maruno, T.; Kanda, K.; Nishi, K.; Takaori, K.; Uemoto, S.; Takaishi, S.; Chiba, T.; Nishi, E.; Seno, H.
Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice
Gut
68
882-892
2019
Mus musculus (Q8BHG1)
Manually annotated by BRENDA team
Kanda, K.; Sakamoto, J.; Matsumoto, Y.; Ikuta, K.; Goto, N.; Morita, Y.; Ohno, M.; Nishi, K.; Eto, K.; Kimura, Y.; Nakanishi, Y.; Ikegami, K.; Yoshikawa, T.; Fukuda, A.; Kawada, K.; Sakai, Y.; Ito, A.; Yoshida, M.; Kimura, T.; Chiba, T.; Nishi, E.; Seno, H.
Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation
JCI Insight
3
91316
2018
Homo sapiens (O43847), Homo sapiens, Mus musculus (Q8BHG1)
Manually annotated by BRENDA team
Kimura, Y.; Ikuta, K.; Kimura, T.; Chiba, T.; Oshima, H.; Oshima, M.; Nishi, E.; Seno, H.
Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach
Sci. Rep.
7
43052
2017
Mus musculus (Q8BHG1), Mus musculus
Manually annotated by BRENDA team