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EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Cleavage of Phe1-/-Val, His5-/-Leu, Ala14-/-Leu, Gly20-/-Glu, Gly23-/-Phe and Phe24-/-Phe bonds in insulin B chain as well as N-blocked dipeptides
Synonyms
Leucostoma neutral proteinase, Leucostoma peptidase A,
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Leucostoma neutral proteinase
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Leucostoma peptidase A
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Leucostoma peptidase A
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Cleavage of Phe1-/-Val, His5-/-Leu, Ala14-/-Leu, Gly20-/-Glu, Gly23-/-Phe and Phe24-/-Phe bonds in insulin B chain as well as N-blocked dipeptides
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hydrolysis of peptide bond
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endopeptidase
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casein + H2O
hydrolyzed casein
Hemoglobin + H2O
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Hemoglobin + H2O
Hydrolyzed hemoglobin
insulin + H2O
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oxidized, B-chain
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N-acetyl-Gly-Lys-OH + H2O
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N-acetyl-Gly-Lys-OMe + H2O
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N-acetyl-L-tyrosine ethyl ester + H2O
N-acetyl-L-tyrosine + ethanol
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N-Benzoyl-L-arginine ethyl ester + H2O
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N-benzyloxycarbonyl -Gly-Phe-NH3 + H2O
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N-benzyloxycarbonyl -Gly-Phe-OMe + H2O
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N-benzyloxycarbonyl -Gly-Trp-OH + H2O
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N-benzyloxycarbonyl -Gly-Tyr-OH + H2O
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N-benzyloxycarbonyl -Leu-Tyr-OH + H2O
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N-benzyloxycarbonyl -Trp-Trp-OH + H2O
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N-benzyloxycarbonyl-Gly-Arg-OH + H2O
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oxidized insulin B chain + H2O
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cleavage specificity towards Leu and Phe residues in the P1' position
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poly-lysine + H2O
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poly-phenylalanine + H2O
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poly-tryptophan + H2O
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poly-tyrosine + H2O
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additional information
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no activity toward Bz-L-Arg-OEt or L-Leu-NHPhNO2
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casein + H2O
hydrolyzed casein
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casein + H2O
hydrolyzed casein
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Hemoglobin + H2O
Hydrolyzed hemoglobin
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denatured
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Hemoglobin + H2O
Hydrolyzed hemoglobin
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denatured
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Ca2+
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metalloenzyme, contains Ca2+ and Zn2+ in the ratio 2 : 1
Ca2+
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enzyme contains 2 mol zinc per mol protein
Ca2+
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metalloenzyme, contains Ca2+ and Zn2+ in the ratio 2 : 1
Zn2+
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metalloenzyme, contains Ca2+ and Zn2+ in the ratio 2:1
Zn2+
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enzyme contains 1 mol zinc per mol protein
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1,10-phenanthroline
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5 mM inhibits in the presence of 10 mM Ca2+
5,5'-dithiobis(2-nitrobenzoate)
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p-chloromercuribenzoate
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EDTA
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EDTA
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completely inhibits
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brenda
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brenda
western cotton mouth moccasin
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brenda
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brenda
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brenda
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Q4QG67_LEIMA
528
0
57750
TrEMBL
Mitochondrion (Reliability: 4)
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22400
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sedimentation equilibrium
22500
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sedimentation equilibrium
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side-chain modification
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glycoprotein
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Prescott, J.M.; Wagner, F.W.
Leucostoma peptidase A
Methods Enzymol.
45
397-404
1976
Agkistrodon piscivorus leucostoma
brenda
Spiekerman, A.M.; Fredericks, K.K.; Wagner, F.W.; Prescott, J.M.
Leucostoma peptidase A: a metalloprotease from snake venom
Biochim. Biophys. Acta
293
464-475
1973
Agkistrodon piscivorus leucostoma
brenda
Oshima, G.; Iwanaga, S.; Suzuki, T.
Some properties of proteinase b in the venom of Agkistrodon halys blomhoffii
Biochim. Biophys. Acta
250
416-427
1971
Gloydius blomhoffii
brenda
Wagner, F.W.
Leucolysin
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
648-649
2004
Agkistrodon piscivorus leucostoma
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brenda
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